GREMLIN Database
YDEH - Diguanylate cyclase YdeH
UniProt: P31129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11643
Length: 296 (267)
Sequences: 20879 (17923)
Seq/√Len: 1096.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_I131_M4.1701.00
197_R200_E2.9861.00
162_M226_G2.8771.00
138_P142_V2.8281.00
276_G285_M2.7951.00
143_L211_I2.7331.00
168_R281_R2.6691.00
160_Y255_R2.6291.00
147_F262_L2.5711.00
279_T285_M2.5031.00
31_H115_A2.3391.00
162_M251_A2.2331.00
137_L189_A2.1751.00
34_V112_S2.0731.00
142_V146_S2.0681.00
183_V186_R2.0281.00
143_L203_Y1.9771.00
160_Y222_A1.9751.00
126_T130_N1.9351.00
167_D250_T1.8991.00
234_D282_N1.8851.00
261_P264_V1.8741.00
230_C284_C1.8651.00
184_V247_I1.8401.00
146_S149_H1.8171.00
276_G283_R1.8171.00
26_L45_D1.8051.00
275_E279_T1.7961.00
259_E268_R1.7871.00
124_L128_R1.7451.00
225_A228_R1.7171.00
187_T191_Y1.7131.00
233_V249_V1.6901.00
32_S53_Q1.6651.00
150_Q153_N1.6581.00
187_T190_T1.6491.00
275_E285_M1.6341.00
267_G271_R1.6291.00
137_L202_V1.6271.00
130_N142_V1.6221.00
166_I188_L1.6131.00
150_Q215_K1.6011.00
195_W228_R1.5881.00
205_Y211_I1.5881.00
195_W232_L1.5721.00
159_L256_A1.5561.00
91_L95_E1.5421.00
162_M214_V1.5371.00
142_V145_E1.5341.00
192_L202_V1.5321.00
179_L267_G1.5261.00
146_S201_T1.5211.00
37_D42_E1.5191.00
49_Y52_C1.5181.00
146_S203_Y1.5071.00
164_L249_V1.4491.00
127_I136_G1.4441.00
214_V225_A1.4431.00
19_I23_Y1.4381.00
218_N221_E1.4301.00
164_L251_A1.4231.00
279_T283_R1.4191.00
188_L233_V1.4131.00
34_V43_I1.4001.00
32_S114_T1.3991.00
173_N181_G1.3951.00
56_R92_A1.3831.00
248_T282_N1.3741.00
190_T193_A1.3731.00
268_R287_I1.3711.00
48_S52_C1.3661.00
187_T238_I1.3661.00
180_I183_V1.3531.00
196_T202_V1.3501.00
239_T244_H1.3471.00
133_V141_R1.3441.00
227_V230_C1.3341.00
275_E278_Q1.3271.00
163_L273_M1.3261.00
168_R171_L1.3251.00
153_N215_K1.3241.00
232_L235_N1.3131.00
79_H82_M1.3131.00
183_V187_T1.3131.00
253_V286_F1.2941.00
34_V50_G1.2891.00
163_L205_Y1.2881.00
146_S150_Q1.2851.00
130_N141_R1.2711.00
230_C234_D1.2441.00
196_T212_I1.2431.00
122_I126_T1.2391.00
148_D262_L1.2291.00
88_E96_N1.2271.00
223_C227_V1.2261.00
256_A265_V1.2201.00
163_L266_I1.2191.00
130_N138_P1.2151.00
150_Q159_L1.2051.00
223_C286_F1.1991.00
189_A202_V1.1981.00
46_N50_G1.1981.00
180_I240_H1.1921.00
226_G284_C1.1871.00
226_G253_V1.1861.00
91_L97_H1.1861.00
205_Y266_I1.1791.00
194_S232_L1.1761.00
23_Y27_V1.1631.00
254_S268_R1.1541.00
100_D115_A1.1491.00
130_N145_E1.1451.00
223_C284_C1.1371.00
264_V268_R1.1371.00
138_P201_T1.1341.00
240_H243_G1.1221.00
35_A111_L1.1111.00
123_Y126_T1.1051.00
51_L57_W1.1051.00
132_D204_R1.1051.00
29_M33_V1.1011.00
250_T276_G1.0981.00
226_G251_A1.0961.00
254_S265_V1.0941.00
171_L175_T1.0891.00
72_V76_D1.0871.00
22_H26_L1.0861.00
128_R141_R1.0831.00
122_I125_L1.0801.00
87_R101_A1.0751.00
159_L213_I1.0701.00
148_D152_R1.0691.00
170_K174_D1.0671.00
88_E98_W1.0611.00
145_E149_H1.0601.00
46_N51_L1.0571.00
166_I249_V1.0551.00
42_E65_D1.0551.00
172_V184_V1.0491.00
271_R287_I1.0471.00
32_S47_H1.0421.00
93_I97_H1.0401.00
51_L58_I1.0361.00
131_M142_V1.0321.00
231_Q234_D1.0271.00
270_D274_Y1.0221.00
217_A221_E1.0171.00
36_R112_S1.0171.00
230_C282_N1.0171.00
254_S269_A1.0161.00
154_A159_L1.0151.00
227_V231_Q1.0121.00
140_R144_D1.0081.00
100_D120_Y1.0021.00
67_D71_Y1.0021.00
186_R190_T1.0011.00
27_V48_S1.0011.00
57_W60_H1.0001.00
222_A253_V0.9981.00
37_D40_K0.9951.00
159_L265_V0.9941.00
169_F185_L0.9921.00
48_S51_L0.9881.00
21_A35_A0.9871.00
260_E268_R0.9841.00
253_V284_C0.9761.00
222_A226_G0.9691.00
167_D281_R0.9671.00
58_I62_G0.9611.00
56_R60_H0.9581.00
230_C251_A0.9541.00
178_H270_D0.9471.00
144_D263_D0.9451.00
101_A114_T0.9451.00
142_V201_T0.9411.00
163_L211_I0.9411.00
131_M138_P0.9311.00
176_Y243_G0.9291.00
45_D58_I0.9251.00
144_D262_L0.9161.00
94_V97_H0.9161.00
256_A259_E0.9141.00
90_M96_N0.9101.00
124_L127_I0.9081.00
164_L212_I0.8981.00
36_R43_I0.8971.00
280_G283_R0.8961.00
226_G230_C0.8921.00
135_T185_L0.8901.00
161_L266_I0.8901.00
143_L213_I0.8891.00
133_V144_D0.8871.00
211_I266_I0.8861.00
79_H83_H0.8801.00
154_A256_A0.8781.00
144_D148_D0.8781.00
162_M253_V0.8771.00
191_Y237_A0.8731.00
221_E224_R0.8721.00
196_T200_E0.8701.00
165_D277_K0.8671.00
32_S50_G0.8671.00
157_L216_A0.8591.00
209_E270_D0.8581.00
183_V241_S0.8581.00
224_R228_R0.8561.00
180_I243_G0.8541.00
200_E225_A0.8521.00
164_L192_L0.8481.00
191_Y238_I0.8421.00
151_L256_A0.8401.00
70_P74_L0.8381.00
138_P203_Y0.8351.00
179_L263_D0.8301.00
165_D208_E0.8301.00
22_H25_W0.8301.00
50_G54_F0.8291.00
206_G209_E0.8261.00
147_F213_I0.8261.00
176_Y245_I0.8231.00
252_G269_A0.8181.00
37_D44_T0.8161.00
191_Y232_L0.8151.00
142_V203_Y0.8111.00
98_W121_K0.8071.00
196_T229_I0.8071.00
262_L266_I0.8031.00
207_G274_Y0.7961.00
24_Q28_S0.7951.00
258_P286_F0.7931.00
219_D255_R0.7901.00
117_L121_K0.7891.00
162_M212_I0.7861.00
170_K274_Y0.7851.00
172_V245_I0.7841.00
143_L147_F0.7831.00
264_V267_G0.7811.00
179_L183_V0.7771.00
160_Y253_V0.7751.00
69_L72_V0.7751.00
77_S80_Q0.7731.00
260_E264_V0.7621.00
163_L269_A0.7621.00
196_T225_A0.7501.00
103_F110_L0.7501.00
276_G280_G0.7481.00
255_R286_F0.7481.00
34_V114_T0.7481.00
111_L116_A0.7461.00
184_V238_I0.7441.00
238_I247_I0.7411.00
173_N207_G0.7401.00
31_H49_Y0.7301.00
237_A246_N0.7291.00
271_R275_E0.7291.00
86_G121_K0.7271.00
46_N61_L0.7261.00
68_E72_V0.7231.00
186_R189_A0.7221.00
127_I130_N0.7211.00
26_L33_V0.7141.00
71_Y74_L0.7131.00
165_D274_Y0.7131.00
214_V222_A0.7121.00
39_S42_E0.7111.00
217_A222_A0.7111.00
112_S116_A0.7081.00
192_L229_I0.7071.00
167_D248_T0.7031.00
202_V212_I0.7001.00
20_D24_Q0.6991.00
160_Y226_G0.6981.00
36_R110_L0.6901.00
154_A158_N0.6891.00
191_Y195_W0.6871.00
222_A255_R0.6851.00
32_S49_Y0.6831.00
258_P268_R0.6801.00
63_P66_N0.6781.00
239_T242_E0.6771.00
231_Q235_N0.6751.00
36_R66_N0.6701.00
134_L185_L0.6661.00
161_L265_V0.6641.00
78_A82_M0.6641.00
173_N182_D0.6631.00
240_H245_I0.6611.00
220_E223_C0.6601.00
192_L212_I0.6591.00
193_A202_V0.6571.00
77_S81_H0.6531.00
146_S213_I0.6521.00
50_G114_T0.6471.00
140_R182_D0.6441.00
147_F151_L0.6411.00
183_V240_H0.6381.00
60_H92_A0.6361.00
251_A284_C0.6321.00
35_A45_D0.6301.00
70_P73_R0.6281.00
99_Q114_T0.6271.00
110_L113_F0.6251.00
212_I229_I0.6241.00
190_T194_S0.6241.00
134_L186_R0.6231.00
93_I96_N0.6181.00
227_V284_C0.6181.00
200_E214_V0.6181.00
219_D223_C0.6151.00
268_R272_A0.6141.00
161_L211_I0.6101.00
153_N157_L0.6101.00
180_I245_I0.6081.00
272_A287_I0.6081.00
184_V240_H0.6051.00
172_V180_I0.6011.00
69_L75_M0.6011.00
197_R225_A0.6011.00
68_E71_Y0.6001.00
144_D203_Y0.6001.00
125_L128_R0.6001.00
155_E260_E0.5991.00
188_L247_I0.5991.00
48_S58_I0.5991.00
237_A244_H0.5981.00
160_Y217_A0.5981.00
86_G100_D0.5981.00
151_L159_L0.5981.00
71_Y76_D0.5971.00
150_Q201_T0.5961.00
233_V238_I0.5951.00
25_W28_S0.5931.00
24_Q27_V0.5921.00
141_R144_D0.5901.00
129_S139_G0.5891.00
188_L192_L0.5891.00
136_G186_R0.5851.00
250_T281_R0.5851.00
174_D274_Y0.5851.00
25_W111_L0.5831.00
165_D173_N0.5791.00
178_H274_Y0.5771.00
70_P76_D0.5741.00
69_L73_R0.5721.00
197_R228_R0.5711.00
263_D267_G0.5701.00
74_L78_A0.5691.00
157_L199_Y0.5681.00
78_A83_H0.5671.00
69_L74_L0.5661.00
103_F106_F0.5631.00
184_V208_E0.5631.00
172_V240_H0.5611.00
217_A255_R0.5601.00
230_C249_V0.5581.00
179_L241_S0.5541.00
110_L114_T0.5521.00
150_Q213_I0.5481.00
167_D280_G0.5481.00
149_H153_N0.5481.00
24_Q111_L0.5481.00
29_M32_S0.5471.00
19_I22_H0.5471.00
123_Y127_I0.5471.00
78_A81_H0.5471.00
176_Y180_I0.5451.00
143_L205_Y0.5411.00
35_A44_T0.5411.00
131_M137_L0.5351.00
145_E148_D0.5351.00
103_F112_S0.5321.00
72_V78_A0.5311.00
178_H181_G0.5311.00
211_I269_A0.5301.00
33_V113_F0.5291.00
25_W35_A0.5281.00
33_V45_D0.5281.00
259_E264_V0.5261.00
150_Q154_A0.5251.00
21_A25_W0.5241.00
146_S215_K0.5241.00
153_N156_P0.5231.00
36_R103_F0.5221.00
166_I185_L0.5191.00
149_H215_K0.5171.00
69_L76_D0.5151.00
188_L238_I0.5141.00
23_Y45_D0.5131.00
201_T213_I0.5131.00
272_A276_G0.5091.00
163_L208_E0.5091.00
26_L47_H0.5081.00
43_I47_H0.5081.00
156_P199_Y0.5081.00
46_N54_F0.5071.00
268_R271_R0.5061.00
73_R76_D0.5031.00
155_E256_A0.5021.00
25_W29_M0.5021.00
56_R61_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h54A 2 0.9358 100 0.35 Contact Map
1w25A 2 0.9797 100 0.367 Contact Map
4j40A 2 0.0068 100 0.405 Contact Map
3tvkA 1 0.5777 100 0.415 Contact Map
3pjxA 1 0.598 100 0.416 Contact Map
3mtkA 2 0.5473 100 0.418 Contact Map
3ezuA 2 0.8682 100 0.428 Contact Map
3ignA 1 0.5507 100 0.436 Contact Map
4rnhA 2 0.5473 100 0.437 Contact Map
3i5cA 2 0.6351 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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