GREMLIN Database
GLMM - Phosphoglucosamine mutase
UniProt: P31120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11553
Length: 445 (432)
Sequences: 10929 (6764)
Seq/√Len: 325.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_K317_E4.1151.00
228_R232_E4.0571.00
186_T244_G3.7871.00
178_V234_A3.6111.00
252_H360_H3.3141.00
227_A231_A3.1731.00
53_I211_V2.8621.00
176_K200_N2.8381.00
163_K196_E2.8361.00
31_W69_A2.8331.00
44_K72_S2.7361.00
291_E303_R2.7271.00
428_E432_T2.7071.00
90_T157_R2.6751.00
192_N196_E2.6701.00
302_A314_K2.6341.00
228_R231_A2.6291.00
35_K132_E2.5291.00
156_G160_E2.4131.00
59_E75_F2.4011.00
268_R297_L2.3651.00
240_F345_G2.3051.00
45_I66_L2.2391.00
39_R132_E2.2301.00
249_M348_V2.2281.00
23_P57_M2.1921.00
30_G62_L2.1901.00
47_I63_E2.1221.00
62_L97_I2.1201.00
66_L97_I2.1181.00
48_G84_V2.0911.00
357_M361_D2.0911.00
176_K202_I2.0771.00
203_A206_C2.0571.00
34_G66_L2.0501.00
33_A95_A2.0391.00
292_L295_K2.0311.00
405_R426_E2.0251.00
436_H440_D1.9861.00
271_L299_I1.9801.00
178_V228_R1.9791.00
49_K59_E1.9591.00
15_R107_Y1.9581.00
49_K55_G1.9491.00
46_I93_A1.9481.00
268_R272_R1.9381.00
56_Y60_S1.9351.00
427_D430_Q1.8921.00
268_R365_G1.8691.00
128_A131_A1.8641.00
291_E295_K1.8641.00
432_T436_H1.8631.00
131_A135_K1.8591.00
34_G69_A1.8471.00
132_E135_K1.8461.00
35_K69_A1.8021.00
156_G192_N1.8011.00
86_Y90_T1.7661.00
33_A113_F1.7471.00
39_R128_A1.7311.00
121_L129_I1.7211.00
265_I351_A1.7151.00
159_I193_V1.7041.00
430_Q433_E1.7041.00
44_K74_L1.7031.00
431_V435_A1.6871.00
31_W35_K1.6841.00
15_R108_D1.6771.00
255_N364_S1.6761.00
238_I345_G1.6721.00
314_K318_K1.6711.00
396_A399_E1.6241.00
397_E400_A1.6161.00
27_L61_A1.6161.00
202_I232_E1.6141.00
160_E196_E1.6021.00
433_E437_R1.5981.00
130_E134_E1.5531.00
292_L369_F1.5461.00
358_S361_D1.5441.00
423_V435_A1.5431.00
252_H358_S1.5431.00
294_L299_I1.5251.00
380_A383_G1.5201.00
393_A397_E1.5061.00
313_E317_E1.4971.00
227_A230_L1.4961.00
296_Q365_G1.4871.00
192_N195_R1.4821.00
191_P195_R1.4641.00
210_G213_I1.4471.00
253_E360_H1.4381.00
279_G300_P1.4371.00
42_S72_S1.4321.00
181_C206_C1.4251.00
26_V111_I1.4191.00
15_R18_D1.4181.00
429_A433_E1.4171.00
43_R94_E1.4091.00
44_K94_E1.4081.00
66_L71_L1.4071.00
27_L64_A1.3961.00
51_T78_P1.3941.00
156_G196_E1.3891.00
391_V394_V1.3881.00
282_G301_F1.3831.00
311_V323_G1.3771.00
191_P206_C1.3711.00
263_M324_A1.3671.00
27_L68_A1.3641.00
16_V54_S1.3601.00
304_A314_K1.3551.00
86_Y161_F1.3551.00
46_I87_L1.3541.00
266_I332_L1.3481.00
357_M365_G1.3461.00
229_V237_G1.3441.00
396_A400_A1.3381.00
223_R226_Q1.3331.00
36_V125_V1.3311.00
125_V128_A1.3281.00
177_I236_L1.3261.00
272_R355_N1.3191.00
49_K56_Y1.3041.00
34_G71_L1.2951.00
40_H128_A1.2881.00
175_L235_D1.2781.00
26_V58_L1.2761.00
36_V132_E1.2751.00
361_D364_S1.2721.00
53_I210_G1.2681.00
300_P318_K1.2631.00
176_K232_E1.2591.00
267_A280_A1.2571.00
12_I29_L1.2531.00
63_E67_A1.2531.00
432_T435_A1.2521.00
30_G111_I1.2461.00
145_L149_S1.2461.00
435_A439_A1.2431.00
6_Y134_E1.2411.00
236_L349_L1.2351.00
222_V256_K1.2351.00
205_G224_A1.2331.00
131_A134_E1.2311.00
425_G431_V1.2291.00
215_A218_G1.2251.00
162_C343_V1.2201.00
430_Q434_F1.2161.00
269_E354_R1.2101.00
165_T347_Q1.2041.00
225_L239_A1.2001.00
49_K75_F1.1961.00
355_N358_S1.1901.00
273_Q354_R1.1811.00
79_M83_A1.1771.00
66_L73_A1.1761.00
162_C346_L1.1741.00
230_L253_E1.1691.00
236_L352_M1.1631.00
36_V128_A1.1621.00
30_G66_L1.1591.00
161_F164_A1.1571.00
122_P125_V1.1561.00
47_I62_L1.1531.00
157_R160_E1.1461.00
155_A189_I1.1431.00
197_L346_L1.1401.00
302_A318_K1.1361.00
45_I95_A1.1351.00
43_R71_L1.1331.00
128_A132_E1.1321.00
176_K233_K1.1291.00
142_S145_L1.1281.00
160_E164_A1.1261.00
269_E273_Q1.1241.00
264_Y289_G1.1201.00
374_V436_H1.1151.00
390_S394_V1.1151.00
426_E430_Q1.1091.00
405_R430_Q1.1071.00
153_D156_G1.1041.00
194_L345_G1.0971.00
59_E63_E1.0921.00
238_I249_M1.0901.00
88_T96_G1.0871.00
124_A128_A1.0861.00
282_G286_S1.0841.00
282_G303_R1.0771.00
90_T161_F1.0751.00
225_L250_V1.0751.00
352_M362_L1.0701.00
97_I111_I1.0681.00
264_Y293_A1.0671.00
62_L99_I1.0651.00
63_E75_F1.0651.00
33_A97_I1.0621.00
155_A192_N1.0611.00
12_I113_F1.0601.00
389_E393_A1.0591.00
271_L279_G1.0561.00
91_F154_A1.0471.00
84_V98_V1.0461.00
86_Y157_R1.0431.00
350_A354_R1.0431.00
286_S290_L1.0411.00
251_D255_N1.0401.00
161_F165_T1.0401.00
390_S393_A1.0391.00
23_P61_A1.0381.00
61_A65_G1.0371.00
67_A149_S1.0341.00
204_I228_R1.0331.00
159_I196_E1.0311.00
392_K396_A1.0311.00
293_A297_L1.0311.00
291_E301_F1.0301.00
179_V194_L1.0291.00
94_E116_I1.0271.00
32_A133_M1.0271.00
167_P350_A1.0261.00
372_I432_T1.0231.00
202_I234_A1.0221.00
289_G362_L1.0191.00
48_G98_V1.0151.00
84_V96_G1.0141.00
127_E130_E1.0081.00
80_P83_A1.0041.00
159_I189_I1.0021.00
31_W68_A1.0001.00
137_I140_V1.0001.00
187_Y206_C0.9981.00
127_E131_A0.9971.00
310_Y313_E0.9971.00
186_T240_F0.9921.00
194_L349_L0.9921.00
179_V186_T0.9891.00
38_A71_L0.9871.00
226_Q230_L0.9821.00
378_Y383_G0.9821.00
62_L66_L0.9791.00
398_V434_F0.9781.00
271_L297_L0.9771.00
221_D224_A0.9761.00
187_Y191_P0.9761.00
205_G217_V0.9751.00
195_R203_A0.9741.00
175_L352_M0.9731.00
51_T208_P0.9711.00
141_D144_E0.9601.00
332_L347_Q0.9601.00
76_T79_M0.9571.00
60_S64_A0.9551.00
374_V439_A0.9531.00
179_V240_F0.9511.00
294_L301_F0.9501.00
178_V202_I0.9421.00
146_G149_S0.9411.00
275_Q278_G0.9411.00
54_S57_M0.9401.00
178_V232_E0.9381.00
160_E163_K0.9381.00
315_M320_W0.9321.00
263_M290_L0.9291.00
32_A132_E0.9271.00
59_E99_I0.9271.00
115_S125_V0.9241.00
292_L296_Q0.9241.00
333_L337_T0.9231.00
229_V250_V0.9201.00
64_A68_A0.9091.00
138_S141_D0.9081.00
394_V397_E0.9071.00
25_F29_L0.9021.00
55_G109_N0.8971.00
202_I228_R0.8941.00
141_D145_L0.8931.00
261_Q368_M0.8931.00
222_V225_L0.8921.00
280_A294_L0.8891.00
87_L154_A0.8891.00
121_L125_V0.8871.00
154_A157_R0.8861.00
265_I363_C0.8841.00
46_I76_T0.8821.00
176_K235_D0.8811.00
38_A43_R0.8801.00
183_N205_G0.8791.00
163_K197_L0.8771.00
351_A355_N0.8771.00
123_D310_Y0.8731.00
322_I330_V0.8701.00
261_Q363_C0.8701.00
360_H364_S0.8681.00
262_I330_V0.8681.00
249_M262_I0.8661.00
270_G347_Q0.8641.00
319_G333_L0.8631.00
221_D225_L0.8621.00
262_I348_V0.8601.00
359_L363_C0.8581.00
376_V439_A0.8581.00
49_K78_P0.8571.00
77_G188_H0.8561.00
272_R297_L0.8471.00
79_M98_V0.8451.00
29_L133_M0.8441.00
130_E133_M0.8431.00
230_L233_K0.8411.00
280_A290_L0.8411.00
190_A240_F0.8401.00
388_H391_V0.8391.00
398_V401_A0.8391.00
226_Q256_K0.8391.00
293_A296_Q0.8331.00
23_P27_L0.8321.00
431_V434_F0.8301.00
238_I247_V0.8301.00
40_H125_V0.8281.00
30_G65_G0.8261.00
436_H439_A0.8251.00
177_I349_L0.8251.00
140_V145_L0.8231.00
37_L95_A0.8231.00
421_V439_A0.8211.00
222_V248_I0.8201.00
251_D360_H0.8191.00
372_I435_A0.8161.00
189_I342_I0.8111.00
296_Q369_F0.8111.00
190_A342_I0.8111.00
175_L349_L0.8101.00
48_G79_M0.8071.00
247_V344_A0.8061.00
72_S150_R0.8011.00
349_L352_M0.8001.00
347_Q350_A0.7991.00
216_E221_D0.7981.00
139_C142_S0.7981.00
177_I199_A0.7971.00
268_R366_M0.7961.00
305_K310_Y0.7951.00
121_L126_E0.7951.00
35_K39_R0.7951.00
287_N324_A0.7931.00
74_L93_A0.7911.00
389_E392_K0.7901.00
263_M280_A0.7901.00
48_G76_T0.7881.00
330_V344_A0.7861.00
268_R293_A0.7831.00
205_G214_N0.7821.00
295_K301_F0.7811.00
334_D337_T0.7801.00
382_S386_L0.7791.00
78_P185_A0.7771.00
269_E351_A0.7771.00
238_I349_L0.7751.00
425_G430_Q0.7751.00
38_A69_A0.7751.00
166_F346_L0.7711.00
264_Y287_N0.7701.00
88_T95_A0.7691.00
51_T185_A0.7661.00
240_F341_G0.7661.00
282_G291_E0.7641.00
123_D126_E0.7641.00
155_A188_H0.7631.00
381_G385_P0.7631.00
126_E129_I0.7600.99
10_D283_T0.7590.99
266_I351_A0.7580.99
225_L237_G0.7580.99
220_T224_A0.7570.99
250_V256_K0.7560.99
262_I266_I0.7550.99
281_V323_G0.7520.99
44_K93_A0.7500.99
152_V156_G0.7490.99
321_R334_D0.7490.99
74_L152_V0.7490.99
378_Y381_G0.7470.99
357_M362_L0.7470.99
30_G34_G0.7460.99
140_V146_G0.7450.99
83_A155_A0.7450.99
401_A437_R0.7430.99
290_L324_A0.7420.99
437_R440_D0.7410.99
24_D28_K0.7400.99
284_L409_L0.7400.99
153_D157_R0.7390.99
61_A64_A0.7390.99
143_A146_G0.7380.99
281_V314_K0.7350.99
67_A148_A0.7330.99
90_T154_A0.7310.99
392_K397_E0.7280.99
329_H339_G0.7270.99
106_F211_V0.7270.99
312_L331_I0.7270.99
36_V40_H0.7260.99
401_A433_E0.7250.99
434_F437_R0.7230.99
423_V431_V0.7210.99
223_R227_A0.7190.99
113_F129_I0.7190.99
429_A432_T0.7160.99
247_V341_G0.7150.99
216_E219_A0.7140.99
295_K300_P0.7130.99
178_V237_G0.7120.99
71_L94_E0.7120.99
406_G425_G0.7120.99
288_M424_E0.7110.99
370_P428_E0.7110.99
156_G159_I0.7110.99
167_P170_L0.7090.99
179_V190_A0.7090.99
215_A221_D0.7080.99
87_L91_F0.7050.99
229_V234_A0.7050.99
236_L249_M0.7020.99
215_A219_A0.7020.99
145_L148_A0.7010.99
388_H393_A0.7010.99
46_I91_F0.7010.99
188_H192_N0.7010.99
183_N214_N0.6990.99
255_N261_Q0.6990.99
175_L236_L0.6970.99
35_K38_A0.6960.99
371_Q375_N0.6960.99
201_V206_C0.6940.99
76_T83_A0.6940.99
159_I192_N0.6930.99
63_E73_A0.6920.99
222_V226_Q0.6920.99
248_I256_K0.6910.99
174_E200_N0.6910.99
266_I347_Q0.6890.99
382_S385_P0.6890.99
159_I163_K0.6880.99
172_L199_A0.6860.99
173_S200_N0.6860.99
125_V129_I0.6850.99
143_A147_K0.6820.99
218_G221_D0.6820.99
30_G97_I0.6820.99
408_V438_I0.6810.99
255_N363_C0.6800.99
257_V359_L0.6790.99
9_T414_G0.6780.99
204_I227_A0.6760.99
434_F438_I0.6740.99
103_H112_K0.6720.99
399_E407_R0.6670.99
91_F157_R0.6660.99
191_P203_A0.6660.99
175_L353_A0.6650.99
263_M322_I0.6650.99
17_G57_M0.6620.99
124_A127_E0.6620.99
129_I133_M0.6610.99
247_V345_G0.6590.99
183_N217_V0.6580.99
194_L199_A0.6570.99
382_S412_K0.6540.98
290_L301_F0.6530.98
348_V359_L0.6520.98
119_T316_Q0.6510.98
237_G250_V0.6490.98
79_M155_A0.6490.98
221_D226_Q0.6490.98
8_G11_G0.6480.98
274_G278_G0.6430.98
397_E401_A0.6430.98
161_F335_K0.6410.98
387_E390_S0.6400.98
271_L294_L0.6380.98
274_G321_R0.6370.98
383_G386_L0.6370.98
28_K133_M0.6360.98
158_Y162_C0.6340.98
399_E402_L0.6320.98
15_R20_P0.6300.98
427_D431_V0.6300.98
166_F170_L0.6300.98
53_I106_F0.6300.98
137_I142_S0.6300.98
352_M355_N0.6300.98
274_G279_G0.6280.98
33_A37_L0.6250.98
117_D316_Q0.6250.98
296_Q366_M0.6200.98
64_A67_A0.6200.98
285_M306_V0.6190.98
137_I145_L0.6190.98
17_G22_T0.6180.98
18_D107_Y0.6170.98
266_I344_A0.6160.98
381_G384_D0.6150.98
297_L366_M0.6130.98
380_A384_D0.6110.98
55_G59_E0.6100.98
388_H392_K0.6100.98
268_R362_L0.6100.98
176_K234_A0.6090.98
395_T410_L0.6080.98
26_V30_G0.6070.98
25_F133_M0.6060.98
279_G302_A0.6060.98
155_A159_I0.6040.97
267_A290_L0.6030.97
26_V61_A0.6030.97
190_A345_G0.6010.97
389_E394_V0.6000.97
393_A396_A0.6000.97
29_L113_F0.6000.97
17_G20_P0.5990.97
126_E130_E0.5990.97
249_M359_L0.5980.97
167_P354_R0.5960.97
148_A151_I0.5960.97
142_S146_G0.5960.97
190_A194_L0.5960.97
363_C366_M0.5950.97
438_I441_A0.5950.97
384_D412_K0.5950.97
143_A148_A0.5950.97
56_Y77_G0.5940.97
395_T398_V0.5930.97
282_G288_M0.5920.97
33_A45_I0.5920.97
378_Y384_D0.5920.97
378_Y412_K0.5910.97
379_T382_S0.5910.97
76_T84_V0.5900.97
267_A322_I0.5900.97
209_N215_A0.5890.97
395_T399_E0.5880.97
10_D373_L0.5880.97
101_A104_N0.5860.97
224_A227_A0.5860.97
27_L31_W0.5860.97
292_L426_E0.5840.97
27_L65_G0.5830.97
165_T343_V0.5820.97
181_C204_I0.5820.97
187_Y208_P0.5820.97
104_N415_T0.5810.97
322_I332_L0.5810.97
28_K134_E0.5810.97
144_E147_K0.5810.97
372_I439_A0.5790.97
378_Y386_L0.5790.97
352_M359_L0.5780.97
257_V265_I0.5770.97
430_Q437_R0.5760.97
437_R441_A0.5760.97
180_D239_A0.5760.97
270_G275_Q0.5760.97
57_M61_A0.5750.97
102_S112_K0.5750.97
401_A434_F0.5750.97
257_V363_C0.5750.97
212_N217_V0.5740.97
235_D252_H0.5730.97
394_V398_V0.5730.97
67_A73_A0.5730.97
122_P126_E0.5700.96
22_T25_F0.5690.96
255_N360_H0.5690.96
138_S142_S0.5680.96
220_T225_L0.5680.96
10_D120_K0.5670.96
375_N418_L0.5640.96
172_L353_A0.5640.96
45_I71_L0.5630.96
264_Y268_R0.5630.96
147_K151_I0.5610.96
228_R234_A0.5600.96
8_G414_G0.5600.96
35_K135_K0.5590.96
379_T383_G0.5580.96
83_A189_I0.5560.96
282_G290_L0.5560.96
288_M292_L0.5550.96
170_L353_A0.5540.96
28_K31_W0.5520.96
239_A250_V0.5490.96
281_V304_A0.5480.96
287_N407_R0.5460.95
179_V201_V0.5460.95
377_R418_L0.5450.95
266_I348_V0.5440.95
104_N108_D0.5440.95
271_L275_Q0.5430.95
302_A320_W0.5430.95
253_E364_S0.5410.95
195_R200_N0.5410.95
392_K398_V0.5410.95
139_C145_L0.5410.95
62_L111_I0.5400.95
139_C144_E0.5400.95
203_A207_E0.5390.95
85_A337_T0.5380.95
23_P64_A0.5370.95
140_V144_E0.5370.95
225_L256_K0.5360.95
374_V435_A0.5360.95
274_G277_R0.5360.95
281_V311_V0.5330.95
171_S353_A0.5330.95
403_G406_G0.5330.95
277_R299_I0.5320.95
406_G434_F0.5310.95
262_I328_G0.5310.95
252_H361_D0.5310.95
26_V62_L0.5300.95
407_R424_E0.5290.95
38_A41_G0.5290.95
308_D339_G0.5270.95
247_V348_V0.5240.94
208_P212_N0.5240.94
258_D261_Q0.5240.94
21_I25_F0.5220.94
190_A201_V0.5220.94
277_R321_R0.5180.94
354_R358_S0.5180.94
428_E431_V0.5160.94
120_K126_E0.5150.94
181_C187_Y0.5140.94
64_A139_C0.5140.94
174_E353_A0.5140.94
399_E409_L0.5130.94
288_M369_F0.5120.94
391_V397_E0.5090.93
104_N112_K0.5070.93
72_S147_K0.5050.93
42_S94_E0.5050.93
289_G369_F0.5030.93
209_N213_I0.5020.93
13_R103_H0.5020.93
103_H245_D0.5020.93
433_E436_H0.5010.93
255_N368_M0.5000.93
142_S149_S0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pdkA 2 0.9843 100 0.09 Contact Map
2f7lA 4 0.9865 100 0.091 Contact Map
1wqaA 3 0.9843 100 0.092 Contact Map
3i3wA 2 0.9843 100 0.095 Contact Map
1tuoA 1 0.9371 100 0.109 Contact Map
3uw2A 1 0.9573 100 0.13 Contact Map
1p5dX 1 0.973 100 0.136 Contact Map
3na5A 2 0.9933 100 0.141 Contact Map
2z0fA 2 0.9506 100 0.142 Contact Map
4hjhA 2 0.9551 100 0.177 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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