AAS - ECOLI - GREMLIN Contacts

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AAS - Bifunctional protein Aas

UniProt:	P31119	Sequences: MLFSFFRNLCRVLYRVRVTGDTQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVAMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRMPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEAEQHDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11679
Length:	719 (546)
Sequences:	11287 (9312)
Seq/√Len:	398.5

ECOLI - AAS ENTF ACSA PRPE
BACSU - PPSB PPSC PPSE SRFAC DHBF
HALSA - Q9HRY8 Q9HQU8 Q9HSM3
SULSO - Q97UX8 Q97U22 Q97WQ0 Q97WQ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
367_E	384_V	4.887	1.00
637_S	673_Y	4.391	1.00
556_L	599_V	3.724	1.00
257_R	283_A	3.508	1.00
255_G	366_E	3.182	1.00
386_S	565_N	3.159	1.00
238_L	277_A	2.938	1.00
408_R	434_E	2.833	1.00
255_G	565_N	2.813	1.00
204_E	212_S	2.807	1.00
247_I	251_Y	2.749	1.00
285_M	294_L	2.721	1.00
545_L	557_Q	2.641	1.00
300_A	372_F	2.634	1.00
145_F	161_T	2.564	1.00
238_L	357_L	2.531	1.00
213_A	217_F	2.491	1.00
600_R	608_Q	2.460	1.00
506_R	524_V	2.457	1.00
242_L	277_A	2.425	1.00
253_V	280_R	2.382	1.00
256_E	304_K	2.357	1.00
521_S	542_A	2.347	1.00
235_R	239_T	2.317	1.00
572_K	575_V	2.314	1.00
154_R	158_P	2.285	1.00
553_G	610_Q	2.283	1.00
259_G	303_I	2.235	1.00
213_A	216_R	2.173	1.00
225_E	228_N	2.149	1.00
386_S	389_S	2.137	1.00
660_T	688_I	2.137	1.00
296_S	379_H	2.136	1.00
224_V	434_E	2.130	1.00
449_E	453_D	2.109	1.00
464_T	489_E	2.106	1.00
217_F	220_G	2.086	1.00
389_S	517_A	2.086	1.00
211_L	238_L	2.078	1.00
182_R	186_G	2.071	1.00
257_R	370_I	2.066	1.00
542_A	558_L	2.065	1.00
221_K	231_P	2.060	1.00
523_N	606_F	2.021	1.00
224_V	454_R	2.015	1.00
602_D	608_Q	2.015	1.00
244_V	270_A	2.006	1.00
174_D	177_R	1.997	1.00
544_L	599_V	1.988	1.00
407_D	457_T	1.987	1.00
253_V	256_E	1.978	1.00
660_T	690_Y	1.969	1.00
439_P	442_L	1.969	1.00
553_G	598_I	1.968	1.00
399_T	538_P	1.964	1.00
630_E	645_A	1.931	1.00
541_D	583_N	1.925	1.00
602_D	606_F	1.920	1.00
145_F	157_F	1.914	1.00
661_T	694_M	1.911	1.00
541_D	559_K	1.910	1.00
268_S	415_L	1.876	1.00
257_R	281_M	1.868	1.00
254_E	366_E	1.861	1.00
367_E	565_N	1.852	1.00
219_A	235_R	1.838	1.00
544_L	607_V	1.825	1.00
559_K	592_W	1.824	1.00
365_E	386_S	1.799	1.00
658_L	688_I	1.789	1.00
153_K	156_L	1.789	1.00
370_I	568_L	1.777	1.00
205_T	208_E	1.767	1.00
442_L	446_I	1.765	1.00
363_Q	366_E	1.751	1.00
615_R	704_F	1.730	1.00
251_Y	329_R	1.725	1.00
165_L	169_Q	1.701	1.00
648_S	651_S	1.700	1.00
241_T	277_A	1.691	1.00
186_G	189_L	1.689	1.00
210_L	273_F	1.682	1.00
523_N	532_T	1.679	1.00
443_H	446_I	1.665	1.00
185_A	189_L	1.663	1.00
408_R	456_C	1.660	1.00
436_F	456_C	1.656	1.00
181_R	185_A	1.651	1.00
271_V	307_F	1.644	1.00
644_T	694_M	1.642	1.00
295_T	299_T	1.640	1.00
365_E	388_K	1.638	1.00
204_E	208_E	1.632	1.00
238_L	242_L	1.628	1.00
659_F	708_K	1.627	1.00
298_I	303_I	1.626	1.00
392_A	539_G	1.619	1.00
244_V	274_G	1.616	1.00
583_N	590_R	1.609	1.00
212_S	216_R	1.605	1.00
260_L	271_V	1.601	1.00
256_E	280_R	1.601	1.00
187_E	191_Q	1.596	1.00
555_R	594_D	1.590	1.00
450_L	454_R	1.590	1.00
182_R	189_L	1.588	1.00
460_F	519_V	1.577	1.00
246_R	358_A	1.577	1.00
309_S	312_F	1.569	1.00
147_R	157_F	1.568	1.00
225_E	266_G	1.565	1.00
159_Q	163_H	1.556	1.00
296_S	372_F	1.555	1.00
242_L	246_R	1.553	1.00
617_A	626_L	1.537	1.00
152_V	157_F	1.524	1.00
211_L	277_A	1.521	1.00
225_E	229_F	1.520	1.00
232_D	270_A	1.520	1.00
644_T	702_P	1.512	1.00
622_E	682_L	1.508	1.00
619_I	647_K	1.496	1.00
407_D	482_R	1.492	1.00
232_D	266_G	1.490	1.00
224_V	231_P	1.489	1.00
485_V	510_G	1.485	1.00
648_S	654_E	1.483	1.00
632_L	678_G	1.479	1.00
657_V	689_R	1.479	1.00
436_F	450_L	1.479	1.00
408_R	436_F	1.478	1.00
421_L	460_F	1.477	1.00
182_R	185_A	1.475	1.00
310_R	335_D	1.469	1.00
188_M	192_I	1.468	1.00
414_P	418_S	1.468	1.00
438_Y	450_L	1.464	1.00
225_E	230_T	1.428	1.00
586_G	590_R	1.419	1.00
221_K	224_V	1.406	1.00
240_K	267_I	1.404	1.00
207_Y	387_H	1.402	1.00
291_V	295_T	1.402	1.00
183_K	186_G	1.399	1.00
635_G	642_H	1.398	1.00
636_V	678_G	1.396	1.00
398_K	431_T	1.396	1.00
542_A	556_L	1.395	1.00
455_S	480_R	1.392	1.00
186_G	190_H	1.382	1.00
393_N	519_V	1.381	1.00
221_K	434_E	1.377	1.00
289_A	297_A	1.375	1.00
276_I	368_A	1.371	1.00
645_A	658_L	1.369	1.00
362_Q	366_E	1.366	1.00
647_K	654_E	1.362	1.00
389_S	563_I	1.358	1.00
691_L	694_M	1.357	1.00
659_F	710_W	1.354	1.00
300_A	572_K	1.348	1.00
158_P	162_L	1.346	1.00
209_S	391_L	1.331	1.00
460_F	487_G	1.326	1.00
383_V	564_M	1.326	1.00
207_Y	362_Q	1.319	1.00
228_N	439_P	1.317	1.00
300_A	379_H	1.316	1.00
151_L	156_L	1.315	1.00
598_I	613_A	1.312	1.00
189_L	193_M	1.311	1.00
510_G	519_V	1.310	1.00
520_V	558_L	1.297	1.00
542_A	599_V	1.290	1.00
206_L	390_I	1.289	1.00
666_T	669_K	1.287	1.00
181_R	189_L	1.285	1.00
460_F	510_G	1.279	1.00
458_V	483_Y	1.277	1.00
291_V	315_K	1.272	1.00
283_A	301_A	1.268	1.00
299_T	379_H	1.267	1.00
166_P	170_V	1.266	1.00
163_H	185_A	1.265	1.00
393_N	518_P	1.261	1.00
573_P	577_E	1.249	1.00
413_L	421_L	1.245	1.00
250_K	353_L	1.244	1.00
673_Y	678_G	1.244	1.00
632_L	674_A	1.243	1.00
394_V	430_L	1.242	1.00
193_M	601_F	1.241	1.00
187_E	192_I	1.240	1.00
193_M	550_I	1.240	1.00
263_P	309_S	1.237	1.00
407_D	433_A	1.233	1.00
385_H	564_M	1.232	1.00
583_N	592_W	1.225	1.00
667_R	688_I	1.219	1.00
260_L	272_I	1.211	1.00
508_L	524_V	1.201	1.00
310_R	334_E	1.200	1.00
289_A	418_S	1.197	1.00
398_K	427_T	1.194	1.00
238_L	241_T	1.192	1.00
516_C	520_V	1.192	1.00
543_R	585_R	1.192	1.00
557_Q	594_D	1.191	1.00
233_S	236_K	1.188	1.00
148_L	151_L	1.184	1.00
211_L	241_T	1.178	1.00
410_M	438_Y	1.176	1.00
703_D	706_T	1.172	1.00
281_M	367_E	1.168	1.00
627_E	630_E	1.168	1.00
310_R	332_Y	1.166	1.00
626_L	645_A	1.165	1.00
230_T	266_G	1.164	1.00
269_A	425_L	1.164	1.00
223_C	266_G	1.162	1.00
267_I	309_S	1.159	1.00
424_G	460_F	1.158	1.00
543_R	583_N	1.157	1.00
581_A	592_W	1.150	1.00
492_Q	495_T	1.147	1.00
575_V	579_P	1.144	1.00
537_L	540_M	1.143	1.00
301_A	372_F	1.143	1.00
483_Y	508_L	1.140	1.00
207_Y	276_I	1.134	1.00
671_Q	688_I	1.133	1.00
181_R	184_I	1.130	1.00
471_R	498_L	1.126	1.00
564_M	580_T	1.126	1.00
210_L	214_M	1.122	1.00
411_S	437_L	1.122	1.00
274_G	278_R	1.119	1.00
550_I	601_F	1.117	1.00
393_N	487_G	1.110	1.00
467_G	495_T	1.102	1.00
157_F	160_I	1.099	1.00
619_I	654_E	1.097	1.00
587_E	590_R	1.094	1.00
499_W	507_I	1.089	1.00
148_L	156_L	1.088	1.00
271_V	275_A	1.087	1.00
214_M	238_L	1.086	1.00
181_R	186_G	1.085	1.00
251_Y	305_T	1.080	1.00
615_R	630_E	1.077	1.00
540_M	562_N	1.074	1.00
655_A	687_D	1.073	1.00
246_R	354_M	1.071	1.00
230_T	240_K	1.071	1.00
208_E	211_L	1.068	1.00
487_G	519_V	1.064	1.00
253_V	258_I	1.063	1.00
407_D	458_V	1.063	1.00
221_K	233_S	1.060	1.00
336_L	340_V	1.060	1.00
308_T	312_F	1.060	1.00
403_F	433_A	1.055	1.00
467_G	492_Q	1.052	1.00
210_L	238_L	1.051	1.00
428_P	433_A	1.050	1.00
385_H	517_A	1.044	1.00
255_G	367_E	1.043	1.00
535_R	606_F	1.042	1.00
446_I	449_E	1.041	1.00
160_I	163_H	1.035	1.00
209_S	395_E	1.033	1.00
147_R	152_V	1.030	1.00
384_V	568_L	1.028	1.00
516_C	558_L	1.024	1.00
553_G	613_A	1.021	1.00
486_A	491_L	1.021	1.00
388_K	561_P	1.018	1.00
293_G	628_M	1.014	1.00
292_K	296_S	1.012	1.00
249_E	353_L	1.012	1.00
466_L	486_A	1.010	1.00
493_E	497_Q	1.009	1.00
491_L	509_E	1.008	1.00
184_I	187_E	1.008	1.00
247_I	250_K	1.008	1.00
671_Q	675_R	1.006	1.00
223_C	269_A	1.006	1.00
335_D	338_A	1.002	1.00
247_I	331_V	1.000	1.00
313_L	332_Y	0.998	1.00
394_V	427_T	0.993	1.00
500_Q	527_A	0.991	1.00
484_V	499_W	0.988	1.00
392_A	561_P	0.988	1.00
410_M	451_V	0.987	1.00
659_F	707_L	0.986	1.00
296_S	300_A	0.984	1.00
272_I	425_L	0.983	1.00
337_K	340_V	0.982	1.00
672_Q	676_E	0.982	1.00
404_T	407_D	0.980	1.00
650_A	653_G	0.978	1.00
533_V	609_I	0.978	1.00
332_Y	335_D	0.977	1.00
669_K	672_Q	0.973	1.00
537_L	562_N	0.971	1.00
490_K	609_I	0.970	1.00
412_A	462_T	0.970	1.00
635_G	643_A	0.969	1.00
354_M	358_A	0.967	1.00
646_I	659_F	0.966	1.00
240_K	243_F	0.966	1.00
673_Y	676_E	0.964	1.00
239_T	355_P	0.961	1.00
467_G	494_S	0.959	1.00
520_V	540_M	0.957	1.00
423_V	518_P	0.954	1.00
369_L	385_H	0.947	1.00
460_F	463_S	0.947	1.00
263_P	311_Q	0.947	1.00
162_L	182_R	0.947	1.00
413_L	460_F	0.946	1.00
393_N	460_F	0.946	1.00
670_L	688_I	0.944	1.00
660_T	670_L	0.940	1.00
161_T	165_L	0.938	1.00
412_A	461_G	0.936	1.00
200_V	539_G	0.936	1.00
491_L	507_I	0.931	1.00
244_V	307_F	0.931	1.00
637_S	670_L	0.928	1.00
282_P	423_V	0.928	1.00
240_K	270_A	0.926	1.00
541_D	590_R	0.926	1.00
249_E	362_Q	0.925	1.00
156_L	163_H	0.921	1.00
648_S	652_K	0.920	1.00
466_L	499_W	0.918	1.00
263_P	440_S	0.918	1.00
270_A	274_G	0.917	1.00
262_L	309_S	0.916	1.00
421_L	519_V	0.915	1.00
358_A	362_Q	0.910	1.00
497_Q	501_D	0.910	1.00
675_R	681_E	0.909	1.00
451_V	459_L	0.906	1.00
445_R	472_F	0.905	1.00
694_M	702_P	0.904	1.00
411_S	435_V	0.902	1.00
184_I	189_L	0.902	1.00
619_I	624_V	0.899	1.00
212_S	215_Y	0.898	1.00
193_M	196_A	0.898	1.00
188_M	191_Q	0.894	1.00
230_T	267_I	0.894	1.00
421_L	487_G	0.893	1.00
410_M	450_L	0.892	1.00
166_P	169_Q	0.892	1.00
491_L	496_K	0.889	1.00
583_N	586_G	0.889	1.00
296_S	299_T	0.888	1.00
557_Q	581_A	0.886	1.00
630_E	658_L	0.883	1.00
543_R	559_K	0.883	1.00
259_G	285_M	0.882	1.00
261_M	294_L	0.882	1.00
289_A	294_L	0.880	1.00
288_T	440_S	0.877	1.00
262_L	271_V	0.877	1.00
687_D	690_Y	0.874	1.00
156_L	159_Q	0.874	1.00
164_I	168_T	0.873	1.00
371_L	514_T	0.872	1.00
253_V	278_R	0.869	1.00
599_V	609_I	0.869	1.00
516_C	563_I	0.868	1.00
188_M	193_M	0.866	1.00
545_L	592_W	0.866	1.00
210_L	430_L	0.866	1.00
396_Q	538_P	0.863	1.00
249_E	359_Q	0.862	1.00
171_A	177_R	0.861	1.00
206_L	276_I	0.858	1.00
521_S	533_V	0.857	1.00
483_Y	506_R	0.856	1.00
393_N	517_A	0.855	1.00
190_H	194_M	0.853	1.00
292_K	295_T	0.851	1.00
410_M	456_C	0.850	1.00
289_A	698_G	0.848	1.00
152_V	156_L	0.848	1.00
246_R	353_L	0.847	1.00
148_L	152_V	0.847	1.00
224_V	436_F	0.847	1.00
215_Y	357_L	0.846	1.00
532_T	606_F	0.845	1.00
246_R	249_E	0.844	1.00
242_L	357_L	0.844	1.00
263_P	312_F	0.838	1.00
549_G	557_Q	0.836	1.00
172_M	175_A	0.836	1.00
241_T	274_G	0.835	1.00
166_P	182_R	0.834	1.00
353_L	358_A	0.832	1.00
146_S	149_K	0.831	1.00
217_F	235_R	0.831	1.00
396_Q	400_I	0.830	1.00
496_K	507_I	0.829	1.00
156_L	160_I	0.829	1.00
424_G	510_G	0.828	1.00
632_L	635_G	0.827	1.00
447_V	465_F	0.827	1.00
259_G	298_I	0.827	1.00
237_L	270_A	0.826	1.00
601_F	607_V	0.822	1.00
302_E	569_R	0.821	1.00
637_S	669_K	0.821	1.00
162_L	165_L	0.820	1.00
403_F	407_D	0.820	1.00
393_N	424_G	0.820	1.00
521_S	607_V	0.818	1.00
205_T	387_H	0.816	1.00
466_L	484_V	0.816	1.00
523_N	526_M	0.814	1.00
420_G	513_V	0.814	1.00
390_I	518_P	0.813	1.00
632_L	636_V	0.811	1.00
239_T	243_F	0.809	1.00
645_A	656_L	0.808	1.00
536_I	542_A	0.808	1.00
436_F	454_R	0.805	1.00
209_S	430_L	0.802	1.00
508_L	522_I	0.801	1.00
459_L	481_L	0.800	1.00
211_L	357_L	0.800	1.00
261_M	287_Y	0.799	1.00
600_R	610_Q	0.799	1.00
461_G	466_L	0.798	1.00
170_V	177_R	0.796	1.00
630_E	704_F	0.793	1.00
260_L	275_A	0.793	1.00
408_R	457_T	0.793	1.00
355_P	358_A	0.791	1.00
660_T	667_R	0.790	1.00
204_E	209_S	0.788	1.00
185_A	188_M	0.788	1.00
283_A	303_I	0.788	1.00
439_P	446_I	0.785	1.00
237_L	273_F	0.785	1.00
413_L	424_G	0.785	1.00
198_M	399_T	0.782	1.00
147_R	160_I	0.781	1.00
475_P	478_F	0.780	1.00
400_I	524_V	0.778	1.00
331_V	334_E	0.777	1.00
252_S	280_R	0.777	1.00
424_G	519_V	0.772	1.00
157_F	161_T	0.772	1.00
304_K	329_R	0.772	1.00
246_R	357_L	0.768	1.00
428_P	435_V	0.767	1.00
308_T	332_Y	0.763	1.00
292_K	379_H	0.761	1.00
390_I	423_V	0.760	1.00
249_E	361_K	0.760	1.00
258_I	280_R	0.757	1.00
499_W	503_F	0.756	1.00
520_V	542_A	0.751	1.00
305_T	329_R	0.751	1.00
463_S	495_T	0.748	1.00
496_K	525_P	0.748	1.00
262_L	308_T	0.747	1.00
403_F	458_V	0.747	1.00
336_L	339_D	0.746	1.00
397_I	510_G	0.746	1.00
353_L	357_L	0.745	1.00
175_A	179_R	0.744	1.00
183_K	187_E	0.743	1.00
190_H	193_M	0.739	1.00
266_G	270_A	0.738	1.00
163_H	167_P	0.736	1.00
510_G	522_I	0.733	1.00
249_E	358_A	0.733	1.00
649_D	652_K	0.732	1.00
558_L	595_T	0.729	1.00
198_M	539_G	0.729	1.00
261_M	316_G	0.729	1.00
642_H	694_M	0.728	1.00
403_F	427_T	0.727	1.00
639_D	669_K	0.725	1.00
396_Q	537_L	0.723	1.00
372_F	382_G	0.723	1.00
253_V	305_T	0.723	1.00
649_D	654_E	0.720	1.00
284_M	371_L	0.720	1.00
393_N	397_I	0.719	1.00
175_A	178_A	0.717	1.00
657_V	687_D	0.715	1.00
667_R	671_Q	0.713	1.00
460_F	465_F	0.712	1.00
689_R	710_W	0.712	1.00
220_G	406_N	0.712	1.00
167_P	170_V	0.708	1.00
544_L	601_F	0.706	1.00
438_Y	447_V	0.706	1.00
452_Y	477_D	0.704	1.00
229_F	453_D	0.703	1.00
451_V	469_Y	0.700	1.00
272_I	415_L	0.700	1.00
598_I	610_Q	0.700	1.00
185_A	193_M	0.699	1.00
370_I	384_V	0.699	1.00
149_K	156_L	0.699	1.00
530_P	608_Q	0.698	1.00
451_V	480_R	0.698	1.00
542_A	607_V	0.694	1.00
244_V	247_I	0.693	1.00
259_G	306_I	0.693	1.00
259_G	301_A	0.693	1.00
159_Q	603_E	0.693	1.00
393_N	520_V	0.692	1.00
634_L	658_L	0.690	1.00
557_Q	592_W	0.690	1.00
269_A	429_L	0.689	1.00
191_Q	194_M	0.688	1.00
422_T	425_L	0.688	1.00
162_L	166_P	0.688	1.00
169_Q	172_M	0.687	1.00
159_Q	162_L	0.687	1.00
160_I	167_P	0.686	1.00
205_T	362_Q	0.686	1.00
642_H	693_Q	0.685	0.99
575_V	578_V	0.685	0.99
236_K	239_T	0.684	0.99
289_A	682_L	0.683	0.99
242_L	358_A	0.683	0.99
232_D	237_L	0.683	0.99
599_V	607_V	0.682	0.99
409_F	428_P	0.682	0.99
438_Y	442_L	0.681	0.99
582_E	589_E	0.680	0.99
467_G	498_L	0.680	0.99
620_A	681_E	0.680	0.99
200_V	561_P	0.680	0.99
152_V	160_I	0.677	0.99
243_F	355_P	0.677	0.99
220_G	434_E	0.676	0.99
643_A	674_A	0.675	0.99
385_H	389_S	0.675	0.99
145_F	160_I	0.674	0.99
221_K	225_E	0.673	0.99
312_F	315_K	0.672	0.99
574_G	578_V	0.671	0.99
412_A	465_F	0.670	0.99
243_F	247_I	0.669	0.99
170_V	174_D	0.668	0.99
397_I	427_T	0.667	0.99
517_A	520_V	0.666	0.99
167_P	171_A	0.666	0.99
487_G	510_G	0.666	0.99
434_E	454_R	0.664	0.99
582_E	591_G	0.664	0.99
643_A	658_L	0.661	0.99
243_F	246_R	0.661	0.99
599_V	610_Q	0.661	0.99
498_L	501_D	0.660	0.99
246_R	355_P	0.660	0.99
664_E	690_Y	0.659	0.99
669_K	673_Y	0.659	0.99
281_M	370_I	0.658	0.99
616_F	625_S	0.658	0.99
184_I	188_M	0.658	0.99
535_R	601_F	0.658	0.99
207_Y	211_L	0.655	0.99
209_S	213_A	0.652	0.99
513_V	516_C	0.652	0.99
495_T	498_L	0.652	0.99
649_D	653_G	0.651	0.99
181_R	187_E	0.651	0.99
409_F	458_V	0.649	0.99
364_P	388_K	0.649	0.99
296_S	572_K	0.648	0.99
284_M	514_T	0.648	0.99
384_V	565_N	0.646	0.99
300_A	569_R	0.646	0.99
421_L	518_P	0.644	0.99
368_A	390_I	0.644	0.99
433_A	457_T	0.644	0.99
684_V	688_I	0.644	0.99
639_D	663_N	0.643	0.99
249_E	360_V	0.642	0.99
185_A	190_H	0.641	0.99
666_T	690_Y	0.641	0.99
211_L	242_L	0.639	0.99
629_V	656_L	0.638	0.99
410_M	447_V	0.638	0.99
393_N	510_G	0.636	0.99
543_R	592_W	0.635	0.99
675_R	684_V	0.634	0.99
313_L	330_W	0.631	0.99
412_A	519_V	0.630	0.99
572_K	578_V	0.629	0.99
163_H	166_P	0.629	0.99
265_A	437_L	0.629	0.99
192_I	195_E	0.628	0.99
286_N	289_A	0.627	0.99
408_R	455_S	0.627	0.99
297_A	382_G	0.626	0.99
186_G	191_Q	0.625	0.99
362_Q	387_H	0.625	0.99
406_N	457_T	0.625	0.99
486_A	510_G	0.625	0.99
231_P	454_R	0.625	0.99
557_Q	579_P	0.623	0.99
211_L	215_Y	0.622	0.99
496_K	500_Q	0.621	0.99
401_A	485_V	0.621	0.99
238_L	352_L	0.619	0.99
313_L	316_G	0.619	0.99
219_A	233_S	0.618	0.99
619_I	622_E	0.618	0.99
261_M	306_I	0.617	0.99
397_I	460_F	0.617	0.99
637_S	674_A	0.617	0.99
642_H	661_T	0.617	0.99
468_H	471_R	0.616	0.99
409_F	433_A	0.614	0.99
331_V	335_D	0.614	0.99
149_K	154_R	0.613	0.99
520_V	562_N	0.612	0.99
257_R	280_R	0.612	0.99
428_P	431_T	0.611	0.99
411_S	424_G	0.611	0.99
463_S	466_L	0.610	0.99
421_L	424_G	0.609	0.99
523_N	531_G	0.609	0.99
194_M	197_R	0.608	0.99
186_G	193_M	0.608	0.99
451_V	456_C	0.604	0.99
261_M	285_M	0.604	0.99
150_G	160_I	0.603	0.99
169_Q	173_P	0.603	0.99
413_L	461_G	0.601	0.99
411_S	422_T	0.601	0.99
412_A	438_Y	0.600	0.99
655_A	686_R	0.598	0.99
171_A	175_A	0.598	0.99
185_A	194_M	0.598	0.99
189_L	194_M	0.597	0.99
662_D	666_T	0.596	0.99
257_R	303_I	0.596	0.99
642_H	696_L	0.595	0.99
487_G	517_A	0.595	0.99
636_V	673_Y	0.594	0.99
257_R	569_R	0.593	0.99
189_L	192_I	0.593	0.99
257_R	367_E	0.592	0.99
236_K	240_K	0.591	0.99
196_A	200_V	0.591	0.99
263_P	288_T	0.590	0.99
242_L	249_E	0.590	0.99
338_A	341_T	0.589	0.98
249_E	278_R	0.589	0.98
409_F	424_G	0.588	0.98
660_T	665_L	0.587	0.98
584_V	592_W	0.587	0.98
192_I	196_A	0.586	0.98
629_V	683_A	0.586	0.98
667_R	690_Y	0.585	0.98
583_N	589_E	0.585	0.98
232_D	240_K	0.582	0.98
181_R	193_M	0.581	0.98
646_I	708_K	0.581	0.98
470_A	498_L	0.581	0.98
513_V	520_V	0.581	0.98
674_A	684_V	0.581	0.98
470_A	499_W	0.580	0.98
665_L	670_L	0.580	0.98
511_Y	533_V	0.580	0.98
397_I	519_V	0.580	0.98
397_I	485_V	0.579	0.98
211_L	214_M	0.579	0.98
452_Y	476_Y	0.579	0.98
306_I	330_W	0.578	0.98
423_V	426_F	0.578	0.98
256_E	305_T	0.578	0.98
261_M	312_F	0.578	0.98
665_L	669_K	0.577	0.98
223_C	232_D	0.577	0.98
559_K	590_R	0.577	0.98
158_P	161_T	0.577	0.98
513_V	517_A	0.576	0.98
400_I	538_P	0.575	0.98
626_L	683_A	0.575	0.98
359_Q	362_Q	0.575	0.98
255_G	280_R	0.574	0.98
215_Y	238_L	0.574	0.98
335_D	339_D	0.573	0.98
393_N	465_F	0.573	0.98
208_E	361_K	0.572	0.98
237_L	241_T	0.571	0.98
145_F	164_I	0.571	0.98
659_F	689_R	0.571	0.98
272_I	426_F	0.570	0.98
460_F	516_C	0.570	0.98
384_V	566_G	0.570	0.98
418_S	699_S	0.570	0.98
427_T	519_V	0.569	0.98
451_V	455_S	0.567	0.98
224_V	408_R	0.566	0.98
306_I	328_V	0.565	0.98
460_F	520_V	0.565	0.98
222_K	234_Y	0.564	0.98
163_H	552_E	0.563	0.98
146_S	151_L	0.562	0.98
196_A	539_G	0.562	0.98
148_L	153_K	0.560	0.98
648_S	709_S	0.559	0.98
630_E	642_H	0.558	0.98
394_V	426_F	0.558	0.98
419_F	422_T	0.555	0.98
484_V	505_L	0.555	0.98
462_T	519_V	0.555	0.98
248_L	252_S	0.554	0.98
392_A	540_M	0.553	0.98
487_G	520_V	0.553	0.98
559_K	583_N	0.552	0.98
449_E	452_Y	0.552	0.98
585_R	592_W	0.552	0.98
555_R	598_I	0.552	0.98
189_L	196_A	0.552	0.98
672_Q	675_R	0.552	0.98
463_S	486_A	0.551	0.98
205_T	391_L	0.551	0.98
400_I	535_R	0.551	0.98
159_Q	550_I	0.551	0.98
424_G	465_F	0.550	0.98
397_I	537_L	0.549	0.98
269_A	437_L	0.549	0.98
442_L	450_L	0.548	0.98
500_Q	526_M	0.546	0.98
294_L	315_K	0.546	0.98
481_L	484_V	0.544	0.97
225_E	439_P	0.544	0.97
494_S	498_L	0.544	0.97
337_K	341_T	0.542	0.97
460_F	491_L	0.542	0.97
461_G	469_Y	0.542	0.97
557_Q	613_A	0.541	0.97
617_A	647_K	0.541	0.97
186_G	196_A	0.541	0.97
626_L	656_L	0.540	0.97
155_R	603_E	0.540	0.97
415_L	425_L	0.540	0.97
513_V	533_V	0.539	0.97
383_V	514_T	0.539	0.97
516_C	519_V	0.539	0.97
271_V	333_L	0.538	0.97
197_R	541_D	0.537	0.97
447_V	451_V	0.537	0.97
198_M	538_P	0.536	0.97
665_L	690_Y	0.535	0.97
148_L	160_I	0.532	0.97
649_D	655_A	0.531	0.97
401_A	510_G	0.531	0.97
335_D	340_V	0.531	0.97
213_A	218_G	0.531	0.97
399_T	402_D	0.530	0.97
370_I	382_G	0.529	0.97
376_S	627_E	0.529	0.97
395_E	398_K	0.529	0.97
187_E	190_H	0.527	0.97
579_P	613_A	0.527	0.97
275_A	280_R	0.527	0.97
147_R	154_R	0.527	0.97
462_T	510_G	0.526	0.97
203_R	209_S	0.526	0.97
182_R	188_M	0.526	0.97
544_L	556_L	0.526	0.97
213_A	432_G	0.525	0.97
229_F	454_R	0.523	0.97
268_S	272_I	0.522	0.97
203_R	388_K	0.522	0.97
411_S	460_F	0.522	0.97
487_G	513_V	0.521	0.97
659_F	711_V	0.521	0.97
182_R	190_H	0.521	0.97
412_A	424_G	0.521	0.97
181_R	194_M	0.520	0.97
452_Y	479_Y	0.520	0.97
639_D	673_Y	0.520	0.97
496_K	499_W	0.519	0.97
393_N	426_F	0.519	0.97
285_M	298_I	0.518	0.97
659_F	691_L	0.518	0.97
184_I	193_M	0.518	0.97
498_L	502_K	0.516	0.97
541_D	586_G	0.516	0.97
615_R	626_L	0.514	0.96
459_L	484_V	0.514	0.96
494_S	497_Q	0.513	0.96
202_P	561_P	0.513	0.96
214_M	218_G	0.513	0.96
544_L	554_G	0.512	0.96
638_P	673_Y	0.510	0.96
543_R	601_F	0.509	0.96
393_N	421_L	0.508	0.96
668_D	672_Q	0.508	0.96
208_E	212_S	0.507	0.96
262_L	307_F	0.507	0.96
191_Q	195_E	0.507	0.96
398_K	402_D	0.505	0.96
155_R	158_P	0.505	0.96
521_S	558_L	0.503	0.96
409_F	460_F	0.502	0.96
445_R	449_E	0.502	0.96
499_W	505_L	0.501	0.96
427_T	460_F	0.500	0.96
396_Q	510_G	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vsqA	1	0.943	100	0.414	Contact Map
3tsyA	2	0.5772	100	0.446	Contact Map
4dg8A	1	0.6704	100	0.448	Contact Map
4iz6A	2	0.7232	100	0.461	Contact Map
3ni2A	1	0.7038	100	0.47	Contact Map
3g7sA	2	0.6495	100	0.47	Contact Map
1amuA	1	0.6898	100	0.472	Contact Map
1mdbA	1	0.7204	100	0.477	Contact Map
3etcA	2	0.7038	100	0.478	Contact Map
4d4iA	1	0.6356	100	0.478	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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