GREMLIN Database
KCH - Voltage-gated potassium channel Kch
UniProt: P31069 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11606
Length: 417 (358)
Sequences: 402 (295)
Seq/√Len: 15.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_T189_G4.1271.00
181_E206_I3.9271.00
185_T190_D3.3950.99
186_V189_G3.1290.99
182_T185_T3.0320.98
187_G190_D2.9090.98
186_V190_D2.8980.98
157_G161_L2.8640.97
303_V306_K2.6520.96
38_I41_M2.6280.96
155_T161_L2.6070.96
177_Y189_G2.5950.95
40_G44_N2.5910.95
158_A161_L2.5860.95
38_I42_S2.4790.94
34_I41_M2.4340.93
182_T188_Y2.4290.93
31_G41_M2.3860.93
195_S198_A2.2760.91
77_N100_L2.2260.90
177_Y185_T2.1910.89
157_G160_Y2.1830.89
182_T190_D2.1770.89
156_Y161_L2.1670.89
181_E199_R2.1290.88
102_Y105_H2.1230.88
151_L161_L2.1200.87
110_L125_L2.1160.87
245_H312_C2.1100.87
97_L105_H2.0450.85
151_L160_Y2.0390.85
181_E189_G2.0340.85
181_E185_T2.0330.85
99_A114_I2.0320.85
177_Y190_D2.0280.85
35_F38_I2.0190.85
34_I38_I1.9920.84
189_G206_I1.9810.84
139_G149_T1.9800.83
182_T187_G1.9750.83
182_T186_V1.9720.83
27_V30_N1.9690.83
272_I303_V1.9680.83
111_K124_L1.9220.82
156_Y159_L1.9110.81
185_T188_Y1.9050.81
89_W92_S1.9050.81
154_S161_L1.9040.81
181_E190_D1.8680.80
35_F39_Y1.7900.77
351_L367_L1.7830.76
333_K360_D1.7810.76
152_F155_T1.7700.76
151_L154_S1.7470.75
116_F124_L1.7410.75
245_H296_G1.7400.74
177_Y187_G1.7360.74
148_T156_Y1.7300.74
38_I44_N1.7290.74
182_T189_G1.7000.73
34_I44_N1.6850.72
184_S206_I1.6760.72
120_T124_L1.6640.71
38_I43_V1.6630.71
111_K116_F1.6310.69
139_G146_S1.6270.69
33_L40_G1.6100.68
153_Y157_G1.5860.67
99_A105_H1.5780.67
190_D206_I1.5730.67
139_G159_L1.5630.66
153_Y158_A1.5610.66
124_L131_F1.5510.65
305_K310_D1.5410.65
381_E389_S1.5290.64
41_M44_N1.5260.64
181_E186_V1.5160.64
115_G120_T1.5110.63
36_K44_N1.5030.63
376_V383_N1.5000.63
115_G118_I1.4870.62
116_F119_F1.4810.62
122_V125_L1.4790.62
174_T199_R1.4760.61
73_F117_C1.4730.61
32_L36_K1.4670.61
33_L38_I1.4550.60
270_T313_R1.4520.60
181_E187_G1.4310.59
77_N96_L1.4180.58
364_S385_D1.4170.58
272_I306_K1.4160.58
298_S345_V1.4140.58
345_V367_L1.4130.58
108_P112_F1.3890.57
31_G35_F1.3880.57
151_L158_A1.3700.56
99_A117_C1.3700.56
37_T41_M1.3640.55
376_V385_D1.3640.55
212_V294_I1.3490.54
255_A262_L1.3470.54
177_Y181_E1.3380.54
258_T262_L1.3340.54
33_L42_S1.3310.53
110_L132_S1.3300.53
154_S157_G1.3290.53
248_V271_V1.3220.53
99_A120_T1.3130.52
36_K40_G1.3130.52
153_Y156_Y1.3050.52
118_I122_V1.3020.52
138_A157_G1.3000.52
124_L128_R1.2950.51
153_Y161_L1.2880.51
99_A102_Y1.2840.51
81_L86_K1.2800.50
28_F32_L1.2790.50
155_T158_A1.2750.50
207_I275_L1.2630.49
296_G306_K1.2600.49
96_L105_H1.2530.49
156_Y160_Y1.2470.49
152_F158_A1.2400.48
190_D193_P1.2380.48
182_T198_A1.2380.48
63_A70_L1.2310.48
377_L385_D1.2290.47
149_T161_L1.2240.47
138_A146_S1.2220.47
142_F146_S1.2090.46
31_G42_S1.2020.46
377_L383_N1.2000.46
271_V281_K1.1970.46
35_F42_S1.1950.46
210_I367_L1.1730.44
149_T159_L1.1670.44
245_H323_A1.1600.44
120_T123_F1.1580.43
294_I307_A1.1440.43
39_Y42_S1.1370.42
211_T215_T1.1340.42
31_G34_I1.1320.42
177_Y186_V1.1280.42
111_K118_I1.1220.41
30_N41_M1.1160.41
112_F120_T1.1110.41
258_T306_K1.1100.41
110_L122_V1.1100.41
73_F99_A1.1050.41
247_I312_C1.1040.40
113_S127_L1.1030.40
146_S161_L1.0860.39
283_L289_D1.0760.39
112_F248_V1.0730.39
152_F156_Y1.0690.39
109_W115_G1.0670.38
274_N359_P1.0640.38
261_Q393_N1.0580.38
27_V34_I1.0570.38
296_G303_V1.0490.37
333_K359_P1.0460.37
151_L157_G1.0430.37
115_G121_L1.0370.37
148_T161_L1.0360.37
110_L387_L1.0300.36
298_S328_V1.0270.36
77_N90_A1.0260.36
107_Y122_V1.0260.36
140_T150_L1.0240.36
113_S124_L1.0230.36
82_L123_F1.0230.36
119_F124_L1.0210.36
149_T153_Y1.0190.36
110_L118_I1.0190.36
363_L391_L1.0190.36
329_V359_P1.0160.36
348_S361_I1.0130.36
181_E188_Y1.0060.35
188_Y389_S1.0040.35
328_V385_D1.0040.35
149_T156_Y1.0000.35
174_T201_F0.9940.35
176_F270_T0.9930.35
73_F105_H0.9840.34
279_D282_Q0.9810.34
139_G151_L0.9770.34
103_T387_L0.9770.34
33_L36_K0.9720.33
326_A345_V0.9710.33
184_S189_G0.9700.33
34_I42_S0.9690.33
110_L115_G0.9680.33
65_A121_L0.9680.33
110_L124_L0.9670.33
114_I124_L0.9670.33
155_T308_G0.9660.33
85_A98_I0.9650.33
32_L39_Y0.9620.33
30_N38_I0.9580.33
258_T303_V0.9540.33
96_L99_A0.9500.32
210_I363_L0.9440.32
36_K42_S0.9430.32
108_P115_G0.9400.32
30_N34_I0.9370.32
79_I337_S0.9360.32
107_Y120_T0.9360.32
80_G102_Y0.9310.31
92_S98_I0.9290.31
181_E386_M0.9290.31
138_A161_L0.9270.31
218_T323_A0.9270.31
140_T143_A0.9250.31
144_F152_F0.9190.31
315_I332_A0.9180.31
376_V389_S0.9170.31
133_H136_A0.9170.31
147_F184_S0.9140.31
364_S371_E0.9140.31
107_Y111_K0.9100.30
111_K115_G0.9090.30
78_S248_V0.9050.30
81_L102_Y0.8980.30
186_V325_N0.8950.30
28_F39_Y0.8900.29
328_V337_S0.8900.29
110_L119_F0.8860.29
113_S120_T0.8860.29
262_L297_D0.8830.29
245_H250_G0.8830.29
329_V341_T0.8810.29
31_G39_Y0.8800.29
154_S271_V0.8790.29
105_H117_C0.8770.29
117_C390_M0.8740.29
369_G377_L0.8720.29
184_S237_N0.8710.28
187_G193_P0.8680.28
149_T158_A0.8670.28
152_F157_G0.8640.28
109_W117_C0.8640.28
141_I161_L0.8620.28
111_K114_I0.8600.28
146_S152_F0.8600.28
31_G44_N0.8580.28
27_V38_I0.8560.28
176_F294_I0.8540.28
246_F309_I0.8530.28
29_L43_V0.8470.27
190_D195_S0.8460.27
121_L124_L0.8450.27
262_L272_I0.8450.27
205_V213_F0.8440.27
33_L41_M0.8410.27
178_F202_T0.8360.27
212_V372_I0.8350.27
245_H304_L0.8340.27
153_Y159_L0.8330.27
367_L374_A0.8330.27
80_G114_I0.8320.27
141_I154_S0.8290.27
223_P255_A0.8270.26
375_R378_N0.8240.26
202_T294_I0.8240.26
302_S345_V0.8230.26
109_W112_F0.8210.26
109_W118_I0.8180.26
31_G38_I0.8180.26
157_G201_F0.8150.26
309_I312_C0.8140.26
177_Y188_Y0.8140.26
246_F342_V0.8130.26
328_V364_S0.8090.26
172_L249_C0.8030.25
247_I307_A0.8030.25
209_G214_A0.7990.25
116_F121_L0.7990.25
66_P118_I0.7980.25
128_R272_I0.7950.25
43_V317_A0.7910.25
376_V381_E0.7900.25
115_G130_D0.7880.25
333_K358_H0.7850.25
65_A331_S0.7850.25
230_N266_G0.7820.25
210_I333_K0.7820.25
176_F300_D0.7780.24
183_M368_F0.7760.24
350_N354_I0.7750.24
245_H293_V0.7730.24
117_C121_L0.7720.24
88_A97_L0.7700.24
118_I280_I0.7690.24
253_I372_I0.7670.24
138_A158_A0.7640.24
35_F43_V0.7620.24
291_A339_V0.7580.24
81_L105_H0.7550.23
97_L100_L0.7550.23
111_K120_T0.7510.23
138_A156_Y0.7510.23
27_V33_L0.7510.23
299_N379_G0.7500.23
99_A106_F0.7450.23
92_S100_L0.7450.23
209_G376_V0.7450.23
360_D366_Q0.7450.23
33_L283_L0.7440.23
34_I40_G0.7420.23
29_L32_L0.7380.23
367_L377_L0.7380.23
250_G323_A0.7350.23
110_L114_I0.7330.23
298_S342_V0.7310.22
95_L191_I0.7310.22
262_L342_V0.7270.22
122_V126_I0.7270.22
345_V359_P0.7270.22
116_F120_T0.7230.22
139_G143_A0.7210.22
385_D389_S0.7180.22
152_F161_L0.7180.22
264_Q277_E0.7160.22
27_V42_S0.7150.22
372_I381_E0.7130.22
194_V210_I0.7120.22
118_I131_F0.7120.22
119_F122_V0.7120.22
120_T125_L0.7120.22
115_G119_F0.7110.22
142_F156_Y0.7090.22
344_A369_G0.7090.22
255_A311_R0.7040.21
113_S198_A0.7010.21
389_S394_S0.7010.21
208_S246_F0.6970.21
281_K284_E0.6910.21
77_N102_Y0.6870.21
294_I341_T0.6860.21
333_K340_K0.6860.21
139_G158_A0.6840.21
148_T152_F0.6800.20
109_W122_V0.6790.20
118_I125_L0.6790.20
113_S122_V0.6790.20
155_T160_Y0.6780.20
203_I361_I0.6780.20
232_L315_I0.6770.20
293_V317_A0.6760.20
140_T270_T0.6750.20
150_L157_G0.6750.20
277_E298_S0.6750.20
69_M391_L0.6730.20
184_S187_G0.6720.20
178_F193_P0.6700.20
148_T151_L0.6700.20
181_E193_P0.6690.20
123_F127_L0.6650.20
145_I159_L0.6650.20
255_A308_G0.6640.20
247_I309_I0.6610.20
151_L155_T0.6600.20
329_V354_I0.6570.20
250_G330_L0.6570.20
28_F43_V0.6560.20
189_G193_P0.6560.20
255_A315_I0.6550.20
149_T368_F0.6540.20
79_I84_R0.6530.19
96_L102_Y0.6520.19
122_V127_L0.6520.19
110_L120_T0.6510.19
218_T389_S0.6510.19
107_Y124_L0.6500.19
284_E315_I0.6490.19
143_A152_F0.6490.19
114_I119_F0.6480.19
376_V386_M0.6480.19
27_V40_G0.6470.19
202_T323_A0.6470.19
386_M390_M0.6460.19
40_G119_F0.6440.19
107_Y125_L0.6420.19
124_L132_S0.6420.19
215_T219_S0.6420.19
139_G161_L0.6420.19
287_L297_D0.6410.19
125_L128_R0.6390.19
217_M291_A0.6370.19
108_P382_I0.6370.19
341_T360_D0.6360.19
202_T387_L0.6340.19
117_C123_F0.6310.19
66_P259_I0.6300.19
66_P339_V0.6300.19
153_Y340_K0.6290.19
199_R255_A0.6280.19
107_Y116_F0.6280.19
80_G99_A0.6260.19
37_T42_S0.6260.19
91_I310_D0.6260.19
101_I117_C0.6240.18
36_K121_L0.6230.18
216_S344_A0.6200.18
144_F151_L0.6190.18
177_Y199_R0.6180.18
249_C350_N0.6180.18
283_L382_I0.6160.18
32_L176_F0.6150.18
139_G144_F0.6150.18
59_L144_F0.6150.18
103_T217_M0.6140.18
139_G154_S0.6130.18
107_Y119_F0.6120.18
31_G37_T0.6120.18
259_I269_V0.6110.18
272_I387_L0.6110.18
147_F154_S0.6110.18
200_L246_F0.6090.18
120_T129_K0.6090.18
230_N234_K0.6080.18
381_E385_D0.6080.18
140_T160_Y0.6080.18
168_R183_M0.6070.18
139_G156_Y0.6040.18
200_L295_P0.6020.18
114_I121_L0.6020.18
220_I281_K0.6020.18
36_K41_M0.6020.18
364_S367_L0.6010.18
81_L92_S0.5990.18
268_N391_L0.5980.18
150_L180_I0.5960.18
109_W124_L0.5950.17
102_Y219_S0.5950.17
138_A145_I0.5930.17
150_L156_Y0.5920.17
104_L362_I0.5910.17
180_I317_A0.5870.17
107_Y112_F0.5860.17
154_S160_Y0.5850.17
383_N389_S0.5840.17
76_L297_D0.5840.17
258_T335_M0.5840.17
109_W123_F0.5830.17
105_H108_P0.5830.17
118_I124_L0.5820.17
98_I212_V0.5820.17
325_N328_V0.5770.17
281_K309_I0.5760.17
137_A145_I0.5750.17
213_F245_H0.5750.17
104_L118_I0.5740.17
144_F343_L0.5740.17
138_A142_F0.5720.17
327_F344_A0.5720.17
102_Y116_F0.5710.17
316_L342_V0.5710.17
27_V44_N0.5710.17
335_M372_I0.5690.17
283_L286_R0.5690.17
326_A349_K0.5660.17
117_C277_E0.5660.17
106_F317_A0.5640.16
92_S118_I0.5630.16
115_G125_L0.5630.16
366_Q375_R0.5630.16
30_N44_N0.5610.16
85_A102_Y0.5610.16
178_F187_G0.5600.16
115_G126_I0.5600.16
137_A180_I0.5600.16
114_I118_I0.5590.16
28_F204_S0.5580.16
30_N42_S0.5550.16
111_K127_L0.5540.16
261_Q264_Q0.5540.16
90_A220_I0.5540.16
76_L370_S0.5530.16
76_L364_S0.5530.16
117_C120_T0.5520.16
304_L309_I0.5520.16
108_P118_I0.5500.16
27_V31_G0.5500.16
146_S159_L0.5490.16
140_T184_S0.5490.16
339_V361_I0.5460.16
368_F376_V0.5450.16
67_L70_L0.5430.16
323_A347_D0.5420.16
254_L283_L0.5420.16
118_I121_L0.5420.16
98_I261_Q0.5400.16
108_P111_K0.5400.16
114_I117_C0.5390.16
183_M357_V0.5390.16
89_W98_I0.5370.16
331_S354_I0.5340.16
83_F198_A0.5340.16
328_V383_N0.5330.16
133_H137_A0.5290.15
80_G214_A0.5280.15
172_L318_L0.5280.15
93_I162_S0.5270.15
85_A105_H0.5260.15
83_F176_F0.5250.15
88_A222_G0.5240.15
195_S199_R0.5220.15
71_G75_V0.5220.15
259_I353_K0.5210.15
209_G357_V0.5200.15
59_L147_F0.5200.15
51_I54_F0.5180.15
249_C309_I0.5180.15
266_G279_D0.5170.15
89_W96_L0.5170.15
367_L372_I0.5170.15
205_V215_T0.5170.15
74_L201_F0.5160.15
317_A327_F0.5160.15
161_L202_T0.5150.15
114_I120_T0.5130.15
35_F188_Y0.5120.15
89_W99_A0.5110.15
134_S137_A0.5110.15
27_V41_M0.5100.15
40_G176_F0.5100.15
331_S350_N0.5100.15
344_A351_L0.5100.15
354_I357_V0.5090.15
148_T160_Y0.5080.15
181_E298_S0.5050.15
207_I333_K0.5040.15
65_A75_V0.5020.15
125_L154_S0.5010.15
246_F262_L0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.5899 100 0.626 Contact Map
2r9rB 3 0.554 100 0.638 Contact Map
4gx0A 3 0.6571 100 0.664 Contact Map
3nafA 3 0.4365 100 0.682 Contact Map
4bgnA 3 0.4844 100 0.704 Contact Map
3rvyA 3 0.4892 100 0.706 Contact Map
3behA 3 0.5132 100 0.716 Contact Map
1orqC 4 0.4916 100 0.72 Contact Map
4hpfA 3 0.3885 99.9 0.738 Contact Map
3mt5A 5 0.4077 99.9 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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