GREMLIN Database
FLIH - Flagellar assembly protein FliH
UniProt: P31068 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11656
Length: 228 (200)
Sequences: 1511 (1239)
Seq/√Len: 87.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_G71_G4.1871.00
63_G67_G3.9331.00
59_G63_G3.6481.00
74_E78_Q3.1871.00
82_Q86_E3.0711.00
83_G87_A2.8231.00
124_A128_A2.8131.00
69_K73_Q2.7831.00
194_L198_G2.7461.00
78_Q82_Q2.5171.00
63_G71_G2.4871.00
66_Q70_Q2.4311.00
86_E90_Q2.3751.00
70_Q74_E2.3491.00
65_Q69_K2.3401.00
71_G75_G2.3201.00
50_Q54_Q2.2521.00
77_A81_E2.1861.00
47_L51_A2.1851.00
69_K72_Y2.1851.00
127_A219_L2.1251.00
79_G83_G2.1201.00
58_A62_E2.0331.00
64_R68_H2.0051.00
60_I67_G1.9281.00
59_G67_G1.8801.00
60_I64_R1.8481.00
73_Q77_A1.8401.00
133_G149_Q1.8251.00
88_K92_A1.8161.00
164_R200_K1.8051.00
68_H72_Y1.7591.00
60_I63_G1.7161.00
55_G59_G1.6731.00
84_L88_K1.6621.00
61_A64_R1.6571.00
209_D214_T1.6321.00
44_L48_Q1.6281.00
43_Q47_L1.6261.00
40_L44_L1.5711.00
72_Y76_L1.5641.00
170_L174_D1.5191.00
41_E45_A1.5011.00
64_R67_G1.4861.00
76_L80_L1.4770.99
49_M53_E1.4500.99
81_E85_A1.4440.99
38_P42_Q1.4360.99
43_Q46_Q1.4340.99
49_M52_H1.4300.99
62_E66_Q1.4250.99
61_A65_Q1.4230.99
77_A80_L1.4160.99
44_L51_A1.4130.99
57_Q61_A1.4050.99
165_V188_L1.3950.99
195_H213_A1.3830.99
129_R135_T1.3810.99
51_A55_G1.3770.99
45_A49_M1.3690.99
65_Q68_H1.3500.99
98_M105_F1.3340.99
168_D196_P1.3270.99
198_G209_D1.3270.99
169_D197_G1.3240.99
166_H194_L1.3130.99
198_G211_S1.3120.99
64_R71_G1.3040.99
39_S43_Q1.3040.99
85_A89_S1.2980.99
84_L87_A1.2620.98
80_L84_L1.2290.98
202_S207_D1.2250.98
30_E34_E1.2200.98
135_T139_D1.2010.98
81_E84_L1.1580.97
170_L190_G1.1530.97
131_V219_L1.1520.97
44_L47_L1.1440.97
26_V29_E1.1430.97
67_G75_G1.1310.97
43_Q51_A1.1300.97
34_E38_P1.1290.97
42_Q46_Q1.1220.97
68_H74_E1.1220.97
91_Q94_I1.1050.96
72_Y78_Q1.0900.96
75_G79_G1.0860.96
37_E40_L1.0630.95
55_G63_G1.0530.95
80_L83_G1.0520.95
128_A132_I1.0340.95
111_A115_V1.0260.94
135_T138_V1.0220.94
130_Q133_G1.0210.94
171_Q175_D1.0130.94
28_P32_I1.0100.94
89_S93_P1.0100.94
32_I35_E0.9980.93
45_A48_Q0.9950.93
24_P27_E0.9870.93
166_H196_P0.9660.92
92_A96_A0.9600.92
35_E39_S0.9600.92
195_H198_G0.9550.92
36_A40_L0.9510.92
56_Y60_I0.9470.91
170_L188_L0.9320.91
87_A91_Q0.9250.90
56_Y63_G0.9250.90
129_R220_C0.9130.90
154_E206_G0.9120.90
25_I29_E0.9110.90
130_Q215_R0.9040.89
80_L87_A0.9000.89
169_D196_P0.8930.89
149_Q215_R0.8850.88
132_I135_T0.8830.88
82_Q85_A0.8810.88
117_A148_Q0.8800.88
164_R191_D0.8720.88
48_Q51_A0.8700.88
167_P190_G0.8650.87
39_S42_Q0.8620.87
47_L55_G0.8600.87
194_L211_S0.8580.87
173_V188_L0.8570.87
29_E33_I0.8570.87
31_T35_E0.8530.87
53_E57_Q0.8510.86
48_Q52_H0.8500.86
40_L51_A0.8400.86
60_I71_G0.8340.85
83_G86_E0.8240.85
96_A100_Q0.8200.84
166_H169_D0.8140.84
73_Q76_L0.8120.84
46_Q50_Q0.8120.84
44_L55_G0.8050.83
72_Y82_Q0.8040.83
134_Q142_A0.8030.83
108_T206_G0.8000.83
147_I199_C0.7920.82
60_I70_Q0.7910.82
177_L188_L0.7890.82
210_A214_T0.7890.82
103_S107_T0.7860.82
40_L47_L0.7840.82
48_Q54_Q0.7810.81
94_I97_R0.7720.81
25_I28_P0.7670.80
166_H198_G0.7600.80
63_G66_Q0.7560.79
155_P206_G0.7510.79
99_Q103_S0.7510.79
127_A131_V0.7470.78
68_H71_G0.7430.78
84_L90_Q0.7410.78
56_Y59_G0.7410.78
139_D142_A0.7400.78
105_F116_I0.7200.76
117_A216_W0.7160.75
38_P41_E0.7160.75
27_E31_T0.7110.75
134_Q139_D0.7110.75
37_E41_E0.7100.75
171_Q174_D0.7080.75
220_C223_A0.7070.74
159_G204_D0.7000.74
212_V219_L0.7000.74
33_I36_A0.6960.73
151_L206_G0.6910.73
166_H170_L0.6890.73
90_Q94_I0.6870.72
29_E32_I0.6870.72
62_E65_Q0.6830.72
34_E37_E0.6820.72
144_I148_Q0.6820.72
24_P28_P0.6810.72
89_S92_A0.6810.72
63_G68_H0.6740.71
40_L43_Q0.6740.71
163_L221_R0.6700.70
113_D155_P0.6690.70
206_G220_C0.6650.70
113_D116_I0.6620.70
23_V26_V0.6600.69
43_Q48_Q0.6600.69
183_L207_D0.6540.69
108_T111_A0.6530.68
26_V30_E0.6510.68
36_A44_L0.6510.68
50_Q53_E0.6500.68
129_R132_I0.6480.68
143_L197_G0.6460.68
70_Q73_Q0.6450.68
134_Q145_K0.6400.67
68_H78_Q0.6390.67
147_I163_L0.6390.67
109_L113_D0.6370.67
181_L185_G0.6350.66
24_P31_T0.6330.66
199_C214_T0.6320.66
186_W215_R0.6290.66
94_I102_V0.6290.66
59_G71_G0.6270.65
218_E221_R0.6240.65
149_Q153_Q0.6240.65
57_Q60_I0.6230.65
83_G88_K0.6230.65
48_Q55_G0.6220.65
86_E89_S0.6180.64
85_A88_K0.6170.64
152_Q163_L0.6160.64
200_K207_D0.6160.64
51_A59_G0.6150.64
165_V170_L0.6140.64
162_Q187_R0.6130.64
143_L169_D0.6130.64
163_L201_V0.6130.64
66_Q69_K0.6120.64
25_I30_E0.6070.63
174_D190_G0.6060.63
150_L154_E0.6010.62
37_E48_Q0.6000.62
80_L86_E0.5960.61
76_L82_Q0.5950.61
57_Q63_G0.5930.61
83_G91_Q0.5920.61
164_R202_S0.5910.61
96_A99_Q0.5900.61
76_L86_E0.5890.61
54_Q58_A0.5880.60
61_A71_G0.5880.60
209_D215_R0.5850.60
77_A85_A0.5840.60
36_A39_S0.5820.60
126_E129_R0.5820.60
51_A56_Y0.5760.59
46_Q49_M0.5730.58
150_L208_L0.5710.58
131_V215_R0.5710.58
213_A217_Q0.5690.58
124_A183_L0.5690.58
76_L79_G0.5680.58
58_A61_A0.5660.58
136_P143_L0.5630.57
32_I39_S0.5620.57
201_V208_L0.5580.56
107_T110_D0.5580.56
64_R70_Q0.5570.56
52_H56_Y0.5560.56
32_I36_A0.5560.56
207_D216_W0.5560.56
102_V105_F0.5520.56
107_T111_A0.5510.56
178_G203_A0.5510.56
98_M101_L0.5500.55
198_G210_A0.5490.55
197_G215_R0.5480.55
167_P198_G0.5470.55
42_Q45_A0.5430.54
80_L90_Q0.5430.54
164_R189_R0.5410.54
200_K211_S0.5400.54
211_S215_R0.5390.54
57_Q77_A0.5390.54
172_R196_P0.5360.54
87_A90_Q0.5350.53
74_E77_A0.5320.53
154_E161_P0.5290.53
136_P142_A0.5280.52
175_D193_T0.5280.52
166_H195_H0.5280.52
29_E45_A0.5270.52
128_A222_L0.5250.52
39_S50_Q0.5250.52
33_I44_L0.5230.52
198_G214_T0.5200.51
29_E40_L0.5200.51
119_R202_S0.5190.51
161_P201_V0.5180.51
114_S137_T0.5170.51
94_I99_Q0.5150.51
27_E30_E0.5150.51
151_L170_L0.5130.50
105_F113_D0.5120.50
60_I66_Q0.5120.50
52_H55_G0.5110.50
37_E44_L0.5100.50
155_P203_A0.5100.50
106_Q110_D0.5090.50
104_E107_T0.5080.50
25_I31_T0.5070.50
155_P215_R0.5070.50
102_V161_P0.5070.50
157_F206_G0.5060.49
92_A100_Q0.5040.49
29_E36_A0.5020.49
199_C209_D0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dm9A 2 0.4649 99.7 0.597 Contact Map
3v6iA 1 0.7807 99.5 0.662 Contact Map
4efaE 1 0.8728 99.4 0.684 Contact Map
3lg8A 1 0.4035 97.9 0.814 Contact Map
2lc0A 1 0.4605 93.3 0.877 Contact Map
2wssS 1 0.6623 88.6 0.891 Contact Map
3v6iB 1 0.443 13.7 0.94 Contact Map
1fc6A 1 0.5307 13.7 0.94 Contact Map
3ghgA 2 0.6886 13.7 0.94 Contact Map
1deqA 1 0.7149 9.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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