GREMLIN Database
YEDE - UPF0394 inner membrane protein YedE
UniProt: P31064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11660
Length: 401 (319)
Sequences: 392 (274)
Seq/√Len: 15.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_L280_V5.8831.00
120_I336_I5.0451.00
160_W250_W4.0261.00
22_I267_V3.6621.00
161_F296_L3.1900.99
43_G87_M3.1230.98
249_M258_A3.0610.98
265_M269_A2.8740.97
121_I297_L2.8650.97
29_T271_G2.7670.97
157_I296_L2.6560.96
45_F87_M2.6550.96
125_G294_G2.6300.96
80_D85_L2.4990.94
249_M255_T2.4990.94
122_A302_I2.4750.94
49_G331_V2.4170.93
88_F313_M2.3430.92
134_L302_I2.2570.90
43_G231_F2.2570.90
122_A301_G2.2430.90
242_F261_I2.2390.90
105_M321_V2.2130.89
208_L212_L2.2110.89
27_L227_F2.2080.89
191_D195_R2.1380.87
345_A348_L2.1090.87
71_L336_I2.1080.87
142_P268_S2.0880.86
22_I178_Q2.0850.86
149_W153_I2.0300.84
108_S170_I2.0110.84
141_I149_W2.0060.84
132_C308_C2.0050.84
98_A237_R1.9720.83
27_L43_G1.9240.81
134_L310_T1.9020.80
30_Y35_T1.8740.79
263_I267_V1.8590.79
122_A155_T1.8580.79
45_F245_A1.8140.77
262_I270_I1.8010.76
94_A98_A1.7820.76
310_T326_V1.7730.75
150_F288_G1.7470.74
26_I267_V1.7160.73
195_R201_M1.6970.72
128_L349_A1.6900.72
94_A155_T1.6790.71
119_G313_M1.6660.70
208_L211_A1.6570.70
160_W163_A1.6290.69
224_A283_K1.5990.67
302_I314_Y1.5920.67
18_I200_G1.5840.66
209_G212_L1.5820.66
20_A234_L1.5800.66
147_H150_F1.5760.66
104_R320_Q1.5710.66
240_I264_G1.5550.65
228_G328_L1.5360.64
93_A222_G1.5360.64
153_I157_I1.5320.64
53_L331_V1.5290.64
351_D355_I1.5200.63
199_L206_G1.4910.62
207_M270_I1.4690.60
160_W164_R1.4620.60
170_I175_V1.4610.60
327_G330_N1.4520.59
320_Q323_Y1.4470.59
193_A199_L1.4470.59
286_W348_L1.4150.57
344_F348_L1.4140.57
240_I305_A1.3790.55
302_I310_T1.3730.55
57_G89_G1.3700.55
52_L126_A1.3570.54
134_L155_T1.3560.54
245_A302_I1.3500.54
302_I326_V1.3490.54
240_I302_I1.3430.53
71_L120_I1.3390.53
345_A350_T1.3230.52
147_H286_W1.3170.52
29_T275_Y1.3130.52
105_M178_Q1.3070.51
88_F198_R1.3030.51
243_T251_I1.3020.51
146_L149_W1.2950.51
156_A246_F1.2930.51
122_A245_A1.2750.49
89_G213_L1.2700.49
73_G213_L1.2630.49
222_G226_L1.2600.49
35_T163_A1.2370.47
247_R318_E1.2320.47
134_L326_V1.2290.47
164_R303_V1.2110.46
196_R203_V1.2070.46
143_Q231_F1.2020.45
170_I224_A1.2010.45
303_V354_K1.2010.45
45_F237_R1.2000.45
120_I332_I1.1880.45
161_F300_F1.1860.44
163_A240_I1.1860.44
246_F261_I1.1840.44
196_R201_M1.1840.44
22_I119_G1.1810.44
104_R126_A1.1800.44
18_I262_I1.1770.44
203_V207_M1.1700.44
163_A341_W1.1680.43
158_G247_R1.1540.43
22_I26_I1.1520.43
352_W356_N1.1480.42
44_E47_R1.1480.42
147_H288_G1.1450.42
207_M274_S1.1380.42
350_T355_I1.1380.42
353_D356_N1.1380.42
321_V324_W1.1360.42
197_F270_I1.1340.42
35_T223_L1.1150.41
94_A240_I1.1070.40
153_I274_S1.1030.40
348_L356_N1.0960.39
350_T356_N1.0930.39
195_R202_L1.0900.39
22_I35_T1.0890.39
116_I179_K1.0850.39
46_T127_R1.0810.39
352_W357_L1.0800.39
98_A104_R1.0790.39
222_G237_R1.0790.39
265_M288_G1.0650.38
242_F320_Q1.0620.38
252_T257_M1.0490.37
95_A253_G1.0470.37
195_R198_R1.0450.37
25_G29_T1.0390.36
39_W301_G1.0390.36
191_D201_M1.0380.36
238_A256_H1.0350.36
141_I296_L1.0290.36
134_L265_M1.0290.36
155_T240_I1.0290.36
242_F302_I1.0280.36
178_Q262_I1.0270.36
153_I179_K1.0260.36
35_T301_G1.0230.36
122_A134_L1.0220.36
152_A255_T1.0130.35
56_F332_I1.0130.35
40_A135_A1.0110.35
196_R200_G1.0020.35
153_I277_Q0.9980.34
224_A266_A0.9970.34
91_C303_V0.9940.34
252_T261_I0.9890.34
74_S77_T0.9830.34
94_A233_L0.9820.33
193_A201_M0.9790.33
18_I253_G0.9770.33
257_M306_G0.9760.33
261_I320_Q0.9750.33
91_C138_F0.9710.33
34_I275_Y0.9680.33
231_F242_F0.9660.33
112_I116_I0.9640.33
351_D356_N0.9610.32
201_M209_G0.9570.32
96_L197_F0.9500.32
352_W355_I0.9490.32
57_G73_G0.9450.32
87_M121_I0.9450.32
193_A198_R0.9340.31
302_I305_A0.9310.31
18_I249_M0.9280.31
111_R114_Q0.9270.31
147_H291_A0.9230.31
94_A264_G0.9230.31
134_L245_A0.9200.30
138_F265_M0.9110.30
29_T270_I0.9110.30
275_Y298_F0.9100.30
194_R316_A0.9040.30
134_L240_I0.9030.30
231_F261_I0.9020.30
255_T259_K0.8980.29
246_F249_M0.8980.29
348_L353_D0.8970.29
87_M91_C0.8960.29
142_P149_W0.8950.29
235_I265_M0.8930.29
239_Q247_R0.8930.29
350_T353_D0.8920.29
160_W270_I0.8910.29
32_F314_Y0.8890.29
243_T254_R0.8880.29
119_G299_G0.8870.29
49_G314_Y0.8860.29
200_G204_F0.8850.29
146_L157_I0.8850.29
155_T231_F0.8810.29
153_I296_L0.8790.28
26_I93_A0.8680.28
122_A310_T0.8620.28
146_L303_V0.8620.28
216_M254_R0.8620.28
17_P259_K0.8580.28
134_L242_F0.8560.27
88_F194_R0.8510.27
29_T105_M0.8480.27
226_L250_W0.8430.27
22_I138_F0.8350.27
15_W226_L0.8350.27
142_P235_I0.8340.26
344_F350_T0.8320.26
87_M314_Y0.8310.26
230_G354_K0.8280.26
87_M258_A0.8230.26
87_M327_G0.8220.26
134_L303_V0.8220.26
245_A310_T0.8200.26
205_F212_L0.8200.26
204_F275_Y0.8170.26
217_N220_K0.8150.26
57_G357_L0.8120.25
22_I179_K0.8100.25
52_L331_V0.8070.25
24_A116_I0.8010.25
326_V330_N0.8010.25
112_I202_L0.8000.25
325_W328_L0.7970.25
158_G241_C0.7970.25
255_T258_A0.7940.25
32_F42_T0.7940.25
49_G313_M0.7930.25
234_L250_W0.7920.25
137_F298_F0.7890.25
321_V330_N0.7880.24
160_W200_G0.7850.24
279_G330_N0.7850.24
245_A258_A0.7840.24
348_L354_K0.7820.24
49_G320_Q0.7810.24
142_P265_M0.7810.24
90_G319_G0.7790.24
180_V194_R0.7780.24
159_S238_A0.7730.24
116_I160_W0.7730.24
126_A247_R0.7710.24
126_A330_N0.7710.24
240_I243_T0.7710.24
206_G216_M0.7680.24
212_L230_G0.7650.24
21_V38_F0.7640.23
23_A197_F0.7630.23
158_G232_G0.7600.23
163_A254_R0.7590.23
18_I226_L0.7590.23
204_F207_M0.7580.23
23_A203_V0.7580.23
243_T303_V0.7570.23
153_I292_V0.7540.23
161_F331_V0.7530.23
56_F179_K0.7520.23
150_F298_F0.7510.23
46_T338_A0.7500.23
93_A203_V0.7500.23
292_V300_F0.7500.23
39_W203_V0.7490.23
16_A249_M0.7490.23
245_A277_Q0.7480.23
134_L271_G0.7480.23
173_I350_T0.7480.23
149_W265_M0.7480.23
93_A233_L0.7470.23
157_I346_P0.7450.23
124_F337_L0.7360.22
156_A328_L0.7330.22
124_F342_D0.7320.22
50_G338_A0.7300.22
205_F214_T0.7290.22
230_G262_I0.7270.22
206_G316_A0.7260.22
28_S223_L0.7260.22
173_I190_P0.7260.22
260_A302_I0.7250.22
228_G262_I0.7230.22
156_A230_G0.7230.22
226_L230_G0.7200.22
163_A253_G0.7200.22
232_G241_C0.7180.22
171_F199_L0.7160.22
313_M327_G0.7150.22
238_A350_T0.7140.21
157_I226_L0.7130.21
30_Y87_M0.7060.21
13_K203_V0.7060.21
165_F337_L0.7060.21
137_F242_F0.7040.21
245_A305_A0.7030.21
85_L336_I0.7030.21
142_P179_K0.7010.21
26_I277_Q0.7010.21
131_G299_G0.7010.21
177_M222_G0.6980.21
160_W226_L0.6980.21
246_F250_W0.6970.21
130_M291_A0.6940.21
289_P293_I0.6930.21
97_W153_I0.6850.20
161_F271_G0.6810.20
137_F269_A0.6790.20
112_I197_F0.6780.20
122_A326_V0.6760.20
247_R306_G0.6740.20
89_G300_F0.6740.20
235_I246_F0.6720.20
203_V226_L0.6720.20
235_I311_G0.6710.20
240_I326_V0.6690.20
102_K173_I0.6680.20
116_I196_R0.6670.20
242_F256_H0.6660.20
142_P248_D0.6650.20
23_A202_L0.6640.20
217_N346_P0.6630.20
130_M338_A0.6610.20
143_Q261_I0.6610.20
240_I310_T0.6610.20
208_L213_L0.6610.20
125_G297_L0.6600.20
99_N197_F0.6600.20
104_R318_E0.6600.20
239_Q306_G0.6590.19
48_W283_K0.6580.19
29_T268_S0.6570.19
193_A197_F0.6560.19
141_I292_V0.6520.19
194_R266_A0.6470.19
157_I196_R0.6450.19
15_W270_I0.6430.19
24_A177_M0.6410.19
93_A193_A0.6390.19
52_L80_D0.6390.19
122_A242_F0.6380.19
227_F332_I0.6380.19
211_A296_L0.6370.19
196_R199_L0.6350.19
116_I153_I0.6330.19
321_V347_A0.6330.19
305_A326_V0.6330.19
255_T274_S0.6330.19
126_A314_Y0.6320.19
195_R208_L0.6320.19
158_G162_G0.6300.18
176_K246_F0.6280.18
200_G253_G0.6260.18
20_A24_A0.6260.18
147_H245_A0.6250.18
259_K315_R0.6250.18
134_L137_F0.6250.18
344_F353_D0.6250.18
349_A353_D0.6230.18
88_F119_G0.6230.18
156_A181_S0.6200.18
262_I297_L0.6160.18
140_G145_S0.6150.18
158_G319_G0.6150.18
35_T227_F0.6140.18
106_P111_R0.6130.18
160_W207_M0.6120.18
243_T302_I0.6120.18
223_L262_I0.6120.18
271_G296_L0.6110.18
20_A243_T0.6110.18
77_T339_Y0.6070.18
201_M324_W0.6050.18
346_P354_K0.6040.18
161_F200_G0.6040.18
214_T349_A0.6030.18
161_F242_F0.6010.17
116_I341_W0.6010.17
266_A278_L0.6010.17
120_I171_F0.5950.17
264_G301_G0.5940.17
42_T231_F0.5930.17
347_A355_I0.5920.17
200_G262_I0.5910.17
51_Q338_A0.5880.17
19_P206_G0.5870.17
105_M112_I0.5840.17
264_G305_A0.5840.17
112_I149_W0.5830.17
126_A315_R0.5830.17
266_A336_I0.5820.17
27_L230_G0.5800.17
301_G305_A0.5800.17
96_L99_N0.5800.17
35_T160_W0.5790.17
34_I267_V0.5780.17
50_G127_R0.5780.17
164_R254_R0.5760.17
138_F240_I0.5710.17
102_K221_L0.5690.16
153_I199_L0.5680.16
293_I297_L0.5680.16
87_M164_R0.5670.16
90_G158_G0.5640.16
38_F285_M0.5620.16
265_M310_T0.5600.16
196_R274_S0.5600.16
206_G351_D0.5600.16
235_I244_S0.5580.16
84_I214_T0.5580.16
157_I181_S0.5570.16
142_P313_M0.5570.16
116_I202_L0.5570.16
47_R81_G0.5550.16
92_F101_V0.5550.16
101_V108_S0.5550.16
227_F330_N0.5510.16
180_V267_V0.5500.16
46_T50_G0.5500.16
165_F300_F0.5470.16
19_P238_A0.5450.16
248_D318_E0.5450.16
199_L234_L0.5450.16
241_C247_R0.5440.16
127_R338_A0.5430.16
105_M267_V0.5430.16
231_F320_Q0.5420.16
262_I273_F0.5410.16
95_A318_E0.5410.16
40_A81_G0.5400.16
224_A275_Y0.5380.16
198_R214_T0.5380.16
242_F310_T0.5350.15
29_T264_G0.5340.15
261_I302_I0.5330.15
156_A201_M0.5320.15
75_P196_R0.5310.15
294_G306_G0.5290.15
350_T354_K0.5290.15
126_A254_R0.5290.15
345_A355_I0.5250.15
46_T123_G0.5240.15
34_I128_L0.5230.15
351_D354_K0.5230.15
154_A236_E0.5220.15
55_L270_I0.5220.15
240_I245_A0.5210.15
43_G288_G0.5200.15
197_F297_L0.5200.15
265_M332_I0.5190.15
96_L237_R0.5170.15
53_L71_L0.5160.15
219_P285_M0.5160.15
42_T260_A0.5160.15
126_A256_H0.5150.15
106_P115_A0.5140.15
20_A32_F0.5130.15
324_W328_L0.5130.15
19_P194_R0.5120.15
254_R302_I0.5120.15
17_P261_I0.5100.15
243_T287_A0.5090.15
13_K152_A0.5080.15
160_W314_Y0.5080.15
99_N198_R0.5070.15
180_V274_S0.5040.15
28_S238_A0.5010.14
332_I336_I0.5010.14
35_T167_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.8878 50.5 0.966 Contact Map
2m20A 2 0.1072 41 0.968 Contact Map
1pw4A 1 0.8603 29.7 0.971 Contact Map
2l2tA 2 0.1097 29.6 0.971 Contact Map
2jwaA 2 0.1097 28.3 0.971 Contact Map
2ks1B 1 0.1097 26.6 0.971 Contact Map
3klyA 3 0.5736 21.7 0.972 Contact Map
2kncB 1 0.1347 18.4 0.973 Contact Map
2kluA 1 0.1197 18.4 0.973 Contact Map
2l8sA 1 0.1147 16.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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