GREMLIN Database
MODF - Putative molybdenum transport ATP-binding protein ModF
UniProt: P31060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11677
Length: 490 (380)
Sequences: 531 (360)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_N278_N7.5751.00
386_D391_D4.2771.00
303_L458_V3.9871.00
120_A129_L3.9211.00
287_E471_H3.8911.00
138_T343_S3.4151.00
263_L266_G3.3341.00
339_G420_P3.2540.99
303_L424_I3.0940.99
267_V278_N3.0870.99
299_K460_H3.0600.99
191_V194_R2.9280.99
290_Q469_I2.6870.98
264_N317_D2.6230.97
356_R381_V2.5900.97
206_G213_L2.4510.96
120_A123_F2.4340.96
139_G299_K2.2730.94
258_E285_P2.2690.94
267_V277_N2.2650.94
121_Q126_T2.2490.94
390_I410_A2.2340.93
190_L392_K2.0630.90
356_R395_A2.0530.90
385_L390_I2.0390.90
161_E193_N2.0310.90
139_G460_H2.0240.89
355_V402_L2.0050.89
420_P423_L1.9830.88
284_N287_E1.9670.88
167_D301_T1.9660.88
143_K170_S1.9640.88
230_Q235_E1.9470.88
189_V240_V1.9250.87
204_F216_T1.9120.87
360_L381_V1.8790.86
100_R103_A1.8590.85
243_P246_D1.8540.85
161_E403_S1.8390.84
301_T460_H1.8340.84
221_E386_D1.8260.84
359_I459_S1.8240.84
167_D299_K1.8070.83
349_Y440_I1.7890.83
97_D100_R1.7890.83
138_T345_L1.7870.82
121_Q180_S1.7750.82
163_F171_R1.7590.81
140_E190_L1.7300.80
100_R104_E1.7250.80
161_E308_G1.7190.80
203_Q409_L1.7110.80
167_D460_H1.6860.79
215_E218_A1.6810.78
131_R134_K1.6810.78
388_L416_L1.6800.78
261_I456_L1.6620.78
178_L220_E1.6510.77
304_S310_H1.6280.76
230_Q233_H1.5910.74
443_F447_L1.5850.74
427_E460_H1.5770.74
385_L395_A1.5760.74
459_S464_D1.5730.73
99_G104_E1.5310.71
238_E241_Q1.4980.70
165_G281_W1.4940.69
187_T194_R1.4900.69
232_A235_E1.4830.69
258_E376_R1.4810.69
291_I412_I1.4780.69
295_N460_H1.4710.68
364_F374_S1.4710.68
277_N480_G1.4640.68
291_I475_F1.4620.68
299_K427_E1.4500.67
403_S406_Q1.4490.67
185_G195_F1.4480.67
337_H421_T1.4400.66
159_L178_L1.4330.66
308_G381_V1.4210.65
167_D427_E1.4190.65
382_Q395_A1.4140.65
228_V231_L1.4120.65
137_S299_K1.4060.65
315_S423_L1.4050.65
260_R422_L1.4020.64
186_I190_L1.3860.63
138_T301_T1.3850.63
137_S460_H1.3760.63
295_N299_K1.3740.63
375_D379_K1.3650.62
346_H407_Q1.3590.62
137_S167_D1.3570.62
239_G244_E1.3500.61
181_L300_S1.3470.61
321_F332_W1.3450.61
266_G481_L1.3440.61
299_K343_S1.3420.61
230_Q234_S1.3220.60
150_L186_I1.3180.59
224_Q248_P1.3160.59
239_G242_L1.3120.59
145_L358_V1.2910.58
217_G222_L1.2880.58
356_R382_Q1.2790.57
259_P284_N1.2700.57
139_G427_E1.2610.56
429_L457_F1.2590.56
221_E249_S1.2510.55
165_G342_S1.2390.55
167_D426_D1.2370.54
103_A452_E1.2360.54
283_V303_L1.2340.54
412_I440_I1.2280.54
232_A236_Q1.2250.54
262_V282_Q1.2250.54
278_N381_V1.2160.53
385_L410_A1.2140.53
143_K174_L1.2090.53
212_T221_E1.2000.52
408_R441_R1.1950.52
430_Q437_R1.1930.52
300_S449_S1.1920.52
218_A221_E1.1900.52
281_W289_W1.1800.51
233_H237_L1.1780.51
212_T265_N1.1740.51
139_G301_T1.1600.50
189_V424_I1.1570.50
206_G290_Q1.1550.49
276_L279_L1.1500.49
343_S348_D1.1460.49
165_G345_L1.1420.49
142_R165_G1.1320.48
139_G295_N1.1310.48
97_D101_T1.1230.47
404_W408_R1.1200.47
389_G392_K1.1200.47
99_G103_A1.1200.47
316_N457_F1.1200.47
164_D171_R1.1180.47
332_W335_K1.1170.47
293_G298_G1.1120.47
293_G296_G1.1120.47
140_E156_L1.1030.46
346_H349_Y1.1000.46
266_G413_V1.0990.46
408_R437_R1.0960.46
240_V244_E1.0950.46
349_Y412_I1.0920.45
231_L237_L1.0900.45
343_S460_H1.0870.45
230_Q237_L1.0840.45
349_Y384_W1.0770.45
125_I206_G1.0750.44
149_A196_D1.0720.44
297_A340_Y1.0670.44
362_G418_K1.0660.44
165_G401_S1.0650.44
407_Q420_P1.0630.44
213_L465_A1.0600.44
142_R437_R1.0570.43
239_G251_R1.0570.43
342_S346_H1.0560.43
212_T252_H1.0540.43
128_L131_R1.0530.43
187_T193_N1.0520.43
140_E432_L1.0460.43
249_S253_A1.0440.43
368_G371_Q1.0440.43
299_K426_D1.0400.42
246_D250_A1.0340.42
179_A200_E1.0330.42
142_R193_N1.0330.42
142_R358_V1.0330.42
408_R469_I1.0330.42
345_L430_Q1.0290.42
231_L239_G1.0250.41
147_C163_F1.0230.41
150_L154_P1.0230.41
234_S237_L1.0220.41
175_A410_A1.0210.41
123_F280_S1.0210.41
161_E404_W1.0200.41
142_R408_R1.0180.41
297_A300_S1.0180.41
227_L231_L1.0170.41
277_N341_V1.0140.41
140_E157_L1.0120.41
406_Q412_I1.0110.41
163_F430_Q1.0080.40
479_G482_Y1.0030.40
181_L188_L1.0020.40
304_S338_I1.0010.40
231_L235_E0.9990.40
187_T191_V0.9990.40
345_L358_V0.9950.40
320_L479_G0.9930.39
211_C429_L0.9920.39
165_G430_Q0.9890.39
127_A392_K0.9880.39
358_V399_F0.9880.39
371_Q442_R0.9830.39
142_R145_L0.9820.39
349_Y437_R0.9810.39
304_S415_A0.9810.39
309_D399_F0.9780.39
233_H236_Q0.9670.38
263_L458_V0.9670.38
143_K339_G0.9650.38
222_L253_A0.9630.38
191_V201_F0.9610.38
210_D387_I0.9590.37
422_L472_R0.9580.37
238_E396_D0.9580.37
295_N300_S0.9560.37
159_L162_P0.9550.37
97_D104_E0.9480.37
194_R308_G0.9470.37
437_R464_D0.9450.37
154_P399_F0.9390.36
186_I205_A0.9390.36
248_P251_R0.9370.36
477_P480_G0.9310.36
343_S429_L0.9300.36
295_N366_S0.9270.36
228_V240_V0.9200.35
125_I170_S0.9170.35
408_R430_Q0.9170.35
291_I470_T0.9170.35
478_D481_L0.9170.35
356_R396_D0.9160.35
297_A479_G0.9140.35
189_V277_N0.9120.35
141_T190_L0.9120.35
143_K408_R0.9110.35
121_Q406_Q0.9080.35
349_Y430_Q0.9040.34
221_E264_N0.9030.34
191_V412_I0.8940.34
299_K432_L0.8940.34
265_N272_D0.8930.34
220_E382_Q0.8920.34
383_Q386_D0.8920.34
166_L211_C0.8900.34
340_Y383_Q0.8890.33
408_R411_L0.8860.33
316_N429_L0.8850.33
241_Q244_E0.8840.33
160_D298_G0.8820.33
160_D293_G0.8820.33
160_D296_G0.8820.33
231_L234_S0.8800.33
346_H408_R0.8780.33
118_Q122_Q0.8740.33
359_I413_V0.8730.33
176_E267_V0.8690.32
232_A244_E0.8660.32
288_H408_R0.8650.32
373_V376_R0.8640.32
237_L248_P0.8630.32
240_V248_P0.8600.32
226_A231_L0.8590.32
250_A264_N0.8580.32
322_G456_L0.8570.32
141_T409_L0.8560.32
200_E242_L0.8550.32
238_E248_P0.8550.32
467_A470_T0.8530.32
312_Q468_C0.8500.31
300_S453_T0.8490.31
249_S391_D0.8400.31
426_D460_H0.8380.31
395_A417_V0.8370.31
171_R430_Q0.8350.31
243_P250_A0.8330.30
350_R367_I0.8320.30
120_A317_D0.8300.30
178_L240_V0.8300.30
151_M320_L0.8280.30
232_A265_N0.8280.30
133_F174_L0.8270.30
218_A386_D0.8260.30
263_L306_V0.8250.30
210_D379_K0.8250.30
156_L198_I0.8230.30
348_D398_P0.8190.30
280_S395_A0.8190.30
123_F418_K0.8180.30
163_F174_L0.8120.29
299_K406_Q0.8090.29
165_G437_R0.8060.29
343_S461_H0.8050.29
100_R185_G0.8020.29
232_A242_L0.8010.29
144_T450_E0.8000.29
162_P193_N0.8000.29
359_I363_Y0.8000.29
227_L237_L0.7970.29
157_L420_P0.7960.29
339_G414_R0.7950.28
125_I473_L0.7940.28
307_T318_L0.7940.28
309_D342_S0.7930.28
142_R164_D0.7930.28
301_T343_S0.7920.28
392_K395_A0.7890.28
346_H430_Q0.7860.28
146_L423_L0.7850.28
200_E236_Q0.7840.28
462_A472_R0.7840.28
345_L458_V0.7810.28
219_K222_L0.7800.28
161_E385_L0.7800.28
163_F404_W0.7750.27
163_F429_L0.7750.27
185_G189_V0.7740.27
165_G408_R0.7730.27
165_G339_G0.7720.27
163_F444_V0.7720.27
137_S427_E0.7710.27
428_P431_G0.7700.27
97_D398_P0.7690.27
209_A265_N0.7690.27
408_R461_H0.7660.27
434_P438_Q0.7660.27
246_D252_H0.7620.27
406_Q460_H0.7600.27
177_R202_V0.7590.27
131_R135_Y0.7580.27
275_I389_G0.7570.27
399_F429_L0.7570.27
287_E390_I0.7560.27
182_H188_L0.7510.26
240_V243_P0.7500.26
335_K407_Q0.7500.26
242_L375_D0.7470.26
165_G182_H0.7450.26
359_I381_V0.7440.26
292_V472_R0.7440.26
402_L412_I0.7430.26
196_D440_I0.7430.26
409_L430_Q0.7410.26
187_T343_S0.7410.26
264_N449_S0.7410.26
191_V458_V0.7390.26
203_Q211_C0.7370.26
240_V246_D0.7370.26
259_P323_R0.7360.26
224_Q246_D0.7360.26
374_S377_Q0.7340.25
408_R412_I0.7330.25
263_L281_W0.7320.25
461_H464_D0.7320.25
189_V260_R0.7320.25
180_S212_T0.7310.25
197_E420_P0.7290.25
271_N465_A0.7280.25
207_V410_A0.7270.25
130_D455_L0.7250.25
309_D414_R0.7220.25
411_L414_R0.7210.25
306_V333_D0.7210.25
305_L318_L0.7200.25
390_I394_T0.7190.25
365_D368_G0.7190.25
295_N301_T0.7190.25
210_D240_V0.7180.25
169_A276_L0.7170.25
210_D266_G0.7150.25
148_Q459_S0.7150.25
126_T232_A0.7140.25
458_V475_F0.7130.24
307_T459_S0.7110.24
344_S440_I0.7100.24
273_R320_L0.7070.24
306_V397_A0.7060.24
227_L232_A0.7050.24
122_Q176_E0.7030.24
117_M300_S0.7010.24
100_R399_F0.7000.24
97_D141_T0.6990.24
220_E390_I0.6990.24
217_G454_Q0.6990.24
255_P467_A0.6960.24
358_V459_S0.6940.24
193_N409_L0.6940.24
125_I465_A0.6900.23
138_T411_L0.6860.23
258_E390_I0.6840.23
210_D390_I0.6830.23
264_N294_P0.6830.23
188_L210_D0.6820.23
438_Q473_L0.6820.23
304_S458_V0.6790.23
170_S173_Q0.6780.23
145_L348_D0.6780.23
320_L383_Q0.6770.23
136_L294_P0.6770.23
283_V291_I0.6750.23
396_D422_L0.6750.23
220_E250_A0.6740.23
99_G399_F0.6730.23
356_R391_D0.6730.23
194_R270_Y0.6700.23
143_K336_K0.6690.23
221_E444_V0.6670.22
197_E354_T0.6660.22
149_A268_V0.6640.22
112_D115_R0.6630.22
343_S358_V0.6630.22
321_F326_G0.6620.22
113_A130_D0.6610.22
437_R441_R0.6600.22
349_Y399_F0.6600.22
301_T432_L0.6590.22
392_K456_L0.6590.22
360_L378_Q0.6550.22
179_A248_P0.6550.22
356_R386_D0.6540.22
177_R188_L0.6510.22
456_L475_F0.6500.22
406_Q461_H0.6500.22
250_A253_A0.6490.22
179_A183_Q0.6490.22
141_T464_D0.6480.22
220_E277_N0.6480.22
190_L374_S0.6470.22
410_A421_T0.6470.22
253_A376_R0.6460.22
309_D358_V0.6450.22
305_L415_A0.6450.22
303_L455_L0.6450.22
343_S346_H0.6440.21
143_K361_S0.6400.21
229_A234_S0.6400.21
191_V338_I0.6390.21
192_L440_I0.6380.21
351_V417_V0.6380.21
235_E243_P0.6370.21
139_G426_D0.6370.21
289_W429_L0.6360.21
249_S257_N0.6360.21
228_V235_E0.6350.21
271_N315_S0.6350.21
205_A219_K0.6340.21
412_I437_R0.6320.21
345_L411_L0.6320.21
118_Q205_A0.6290.21
123_F306_V0.6270.21
215_E458_V0.6240.21
142_R461_H0.6240.21
138_T299_K0.6240.21
165_G361_S0.6230.21
119_L123_F0.6200.20
241_Q252_H0.6190.20
301_T406_Q0.6190.20
242_L249_S0.6180.20
172_Q263_L0.6160.20
301_T427_E0.6160.20
100_R398_P0.6150.20
261_I320_L0.6140.20
142_R464_D0.6120.20
145_L309_D0.6120.20
192_L461_H0.6090.20
275_I308_G0.6080.20
326_G335_K0.6070.20
432_L460_H0.6070.20
159_L350_R0.6070.20
176_E220_E0.6060.20
289_W418_K0.6030.20
465_A468_C0.6020.20
352_S362_G0.5990.20
168_V475_F0.5970.20
349_Y432_L0.5970.20
261_I386_D0.5950.19
142_R281_W0.5940.19
291_I422_L0.5930.19
264_N379_K0.5910.19
390_I460_H0.5910.19
157_L413_V0.5910.19
165_G268_V0.5890.19
417_V440_I0.5880.19
339_G407_Q0.5880.19
104_E452_E0.5880.19
98_T105_I0.5850.19
137_S301_T0.5830.19
97_D102_T0.5810.19
280_S390_I0.5770.19
188_L379_K0.5770.19
362_G424_I0.5750.19
165_G432_L0.5740.19
103_A116_C0.5720.19
310_H346_H0.5710.19
344_S412_I0.5710.19
408_R464_D0.5710.19
169_A200_E0.5700.19
272_D396_D0.5700.19
212_T450_E0.5690.18
139_G167_D0.5670.18
143_K414_R0.5660.18
154_P314_Y0.5660.18
358_V464_D0.5650.18
197_E308_G0.5650.18
301_T426_D0.5640.18
212_T379_K0.5620.18
455_L475_F0.5590.18
264_N373_V0.5560.18
245_P253_A0.5550.18
358_V414_R0.5530.18
126_T189_V0.5520.18
226_A230_Q0.5510.18
170_S417_V0.5510.18
225_Q253_A0.5510.18
290_Q475_F0.5500.18
320_L471_H0.5500.18
137_S295_N0.5480.18
240_V253_A0.5460.18
297_A313_G0.5440.18
169_A212_T0.5430.18
225_Q228_V0.5430.18
139_G343_S0.5430.18
447_L481_L0.5400.17
341_V412_I0.5400.17
145_L148_Q0.5390.17
302_L406_Q0.5390.17
170_S234_S0.5370.17
319_T337_H0.5340.17
157_L178_L0.5320.17
191_V436_N0.5300.17
130_D278_N0.5290.17
237_L240_V0.5260.17
165_G362_G0.5260.17
142_R399_F0.5250.17
262_V322_G0.5250.17
220_E267_V0.5250.17
261_I392_K0.5240.17
150_L188_L0.5230.17
228_V232_A0.5230.17
248_P264_N0.5220.17
125_I143_K0.5220.17
342_S414_R0.5210.17
109_E169_A0.5200.17
142_R309_D0.5200.17
111_K241_Q0.5200.17
121_Q285_P0.5180.17
316_N343_S0.5170.17
342_S410_A0.5170.17
305_L362_G0.5170.17
213_L395_A0.5170.17
444_V463_E0.5170.17
227_L234_S0.5150.17
171_R361_S0.5130.16
181_L371_Q0.5130.16
342_S348_D0.5130.16
241_Q249_S0.5120.16
238_E249_S0.5110.16
266_G420_P0.5110.16
292_V343_S0.5100.16
202_V417_V0.5100.16
428_P433_D0.5100.16
229_A235_E0.5090.16
114_P390_I0.5090.16
184_S251_R0.5080.16
115_R181_L0.5060.16
238_E245_P0.5020.16
432_L464_D0.5010.16
168_V383_Q0.5010.16
159_L164_D0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iw3A 2 0.9102 100 0.434 Contact Map
4finA 2 0.9082 100 0.443 Contact Map
4q9hA 1 0.9531 100 0.446 Contact Map
1yqtA 1 0.9163 100 0.447 Contact Map
3ozxA 1 0.9061 100 0.45 Contact Map
3bk7A 1 0.9286 100 0.45 Contact Map
4f4cA 1 0.9388 100 0.453 Contact Map
3j16B 1 0.9388 100 0.462 Contact Map
3ux8A 2 0.8184 100 0.485 Contact Map
2vf7A 2 0.9469 100 0.531 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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