GREMLIN Database
3PASE - Inorganic triphosphatase
UniProt: P30871 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11603
Length: 433 (407)
Sequences: 1139 (869)
Seq/√Len: 43.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
286_Q305_E5.0041.00
283_L305_E4.2651.00
182_T186_Q3.1031.00
183_G186_Q3.0441.00
366_R406_A2.7421.00
236_W257_A2.7231.00
283_L286_Q2.7121.00
58_R69_K2.5711.00
69_K191_K2.5571.00
162_E191_K2.5251.00
228_A264_T2.4391.00
160_E191_K2.4361.00
56_R191_K2.4321.00
56_R160_E2.4211.00
366_R373_T2.2691.00
373_T406_A2.2601.00
58_R191_K2.2411.00
252_E255_L2.2181.00
69_K160_E2.2041.00
128_K139_E2.1951.00
406_A410_R2.1941.00
58_R160_E2.1571.00
56_R69_K2.1411.00
256_A377_D2.1330.99
56_R162_E2.1180.99
240_E306_T2.0700.99
255_L259_S2.0160.99
69_K81_R2.0140.99
252_E377_D1.9340.99
146_E153_A1.9310.99
366_R369_L1.9100.99
69_K143_D1.9100.99
252_E366_R1.8990.99
255_L369_L1.8930.99
172_L175_A1.8910.99
252_E406_A1.8890.99
142_L157_C1.8810.99
81_R191_K1.8750.99
143_D191_K1.8600.99
369_L406_A1.8440.99
267_L378_S1.8420.98
69_K162_E1.8400.98
44_P117_Q1.8360.98
373_T377_D1.8280.98
172_L178_L1.8260.98
259_S369_L1.7840.98
58_R162_E1.7650.98
179_V182_T1.7140.98
64_Y91_P1.7050.97
255_L406_A1.6990.97
126_R143_D1.6890.97
252_E373_T1.6800.97
252_E256_A1.6760.97
176_N179_V1.6550.97
252_E259_S1.6520.97
8_K191_K1.6370.97
36_L56_R1.6330.97
366_R410_R1.6250.97
178_L182_T1.6230.97
56_R83_E1.6220.97
36_L160_E1.6180.97
370_P373_T1.6060.96
373_T410_R1.6050.96
402_H410_R1.5910.96
81_R162_E1.5770.96
369_L373_T1.5710.96
69_K83_E1.5530.96
255_L366_R1.5460.95
297_A301_V1.5430.95
252_E369_L1.5410.95
366_R377_D1.5410.95
175_A178_L1.5350.95
175_A183_G1.5160.95
4_E8_K1.5150.95
124_F156_I1.5120.95
369_L377_D1.5110.95
256_A406_A1.5100.95
252_E410_R1.5090.95
373_T402_H1.5050.95
366_R402_H1.4990.95
58_R81_R1.4960.95
254_V291_I1.4950.95
402_H406_A1.4910.95
255_L373_T1.4880.94
178_L184_L1.4860.94
4_E191_K1.4780.94
259_S366_R1.4690.94
81_R160_E1.4590.94
373_T376_I1.4470.94
353_L368_Q1.4400.93
366_R370_P1.4380.93
158_E191_K1.4360.93
172_L183_G1.4330.93
10_I187_G1.4210.93
376_I406_A1.4200.93
259_S410_R1.4170.93
40_Y69_K1.4150.93
260_L380_L1.4130.93
255_L410_R1.4110.93
264_T381_L1.4100.93
143_D162_E1.4010.92
369_L410_R1.3970.92
6_E191_K1.3820.92
174_L178_L1.3820.92
370_P406_A1.3680.92
256_A373_T1.3670.91
36_L69_K1.3660.91
83_E191_K1.3650.91
6_E69_K1.3640.91
141_A159_L1.3620.91
8_K162_E1.3560.91
172_L182_T1.3550.91
56_R143_D1.3550.91
259_S373_T1.3530.91
256_A292_A1.3420.91
225_L229_L1.3410.91
4_E162_E1.3400.91
125_Y144_Q1.3390.91
235_Q257_A1.3390.91
143_D158_E1.3380.91
8_K160_E1.3330.90
139_E160_E1.3320.90
98_L104_P1.3310.90
137_Q165_S1.3220.90
9_F175_A1.3180.90
369_L376_I1.3130.90
229_L261_V1.3120.90
176_N180_S1.3080.90
255_L376_I1.3030.89
58_R83_E1.2990.89
361_L364_R1.2920.89
123_D148_K1.2910.89
36_L58_R1.2900.89
260_L264_T1.2830.89
58_R158_E1.2820.89
120_F195_G1.2810.89
46_N200_Q1.2690.88
350_A394_W1.2660.88
261_V313_L1.2650.88
376_I410_R1.2650.88
264_T268_F1.2630.88
366_R376_I1.2470.87
37_L123_D1.2450.87
56_R81_R1.2420.87
36_L191_K1.2380.87
380_L395_L1.2330.87
35_Q125_Y1.2260.86
6_E56_R1.2230.86
6_E58_R1.2180.86
252_E376_I1.2160.86
259_S370_P1.2080.85
377_D406_A1.2070.85
272_V316_W1.2050.85
259_S377_D1.2030.85
377_D380_L1.2020.85
249_A253_Q1.2020.85
259_S406_A1.1980.85
222_E322_W1.1840.84
377_D410_R1.1820.84
266_M281_R1.1770.84
39_I118_P1.1760.84
376_I380_L1.1730.84
69_K126_R1.1640.83
81_R143_D1.1630.83
58_R143_D1.1520.83
256_A366_R1.1520.83
38_N124_F1.1510.83
66_M195_G1.1490.82
178_L183_G1.1490.82
139_E164_L1.1480.82
40_Y191_K1.1460.82
65_E156_I1.1450.82
377_D402_H1.1380.82
69_K158_E1.1370.82
163_L171_V1.1350.82
147_V195_G1.1320.81
158_E194_R1.1280.81
252_E370_P1.1260.81
170_A183_G1.1250.81
297_A300_A1.1230.81
243_W250_A1.1220.81
259_S376_I1.1210.81
169_R173_K1.1160.81
83_E158_E1.1140.80
66_M192_A1.1120.80
9_F183_G1.1110.80
256_A259_S1.1020.80
242_L250_A1.1020.80
170_A186_Q1.1010.80
255_L377_D1.0960.79
126_R162_E1.0950.79
170_A175_A1.0850.79
259_S292_A1.0850.79
340_R344_I1.0830.78
70_V84_Y1.0810.78
175_A184_L1.0790.78
8_K81_R1.0770.78
392_Q396_E1.0720.78
138_I161_L1.0690.78
9_F186_Q1.0660.77
126_R158_E1.0630.77
136_S170_A1.0590.77
139_E191_K1.0590.77
379_I394_W1.0530.76
168_T172_L1.0530.76
292_A370_P1.0520.76
172_L184_L1.0500.76
83_E162_E1.0500.76
214_H384_G1.0490.76
126_R191_K1.0450.76
256_A410_R1.0440.76
368_Q372_L1.0290.75
377_D399_Q1.0270.75
4_E69_K1.0260.75
56_R67_T1.0260.75
292_A369_L1.0220.74
300_A303_S1.0200.74
239_H257_A1.0150.74
36_L162_E1.0140.74
252_E402_H1.0140.74
126_R160_E1.0110.73
67_T160_E1.0090.73
128_K141_A1.0000.73
83_E143_D0.9990.73
180_S183_G0.9960.72
143_D160_E0.9940.72
252_E262_R0.9930.72
4_E143_D0.9880.72
8_K56_R0.9870.72
142_L159_L0.9840.71
172_L186_Q0.9820.71
4_E158_E0.9810.71
255_L292_A0.9790.71
251_K291_I0.9760.71
36_L40_Y0.9730.71
175_A182_T0.9730.71
8_K69_K0.9730.71
83_E126_R0.9730.71
4_E56_R0.9700.70
239_H242_L0.9680.70
136_S164_L0.9670.70
8_K58_R0.9610.70
353_L372_L0.9610.70
256_A369_L0.9590.69
252_E292_A0.9570.69
369_L402_H0.9510.69
290_T296_S0.9500.69
40_Y58_R0.9420.68
342_A346_L0.9410.68
256_A405_I0.9400.68
370_P410_R0.9390.68
38_N60_E0.9390.68
6_E162_E0.9380.68
399_Q403_H0.9380.68
139_E143_D0.9380.68
172_L176_N0.9350.67
158_E162_E0.9340.67
258_I288_E0.9330.67
221_V271_I0.9290.67
239_H381_L0.9290.67
168_T175_A0.9270.67
140_I159_L0.9220.66
240_E244_V0.9200.66
256_A376_I0.9170.66
56_R126_R0.9170.66
239_H253_Q0.9170.66
6_E83_E0.9170.66
170_A174_L0.9160.66
219_A223_Q0.9160.66
124_F141_A0.9110.65
11_V142_L0.9090.65
43_T111_D0.9070.65
65_E85_N0.9040.65
69_K139_E0.9010.65
269_G281_R0.8990.64
253_Q381_L0.8980.64
60_E244_V0.8980.64
262_R373_T0.8980.64
286_Q290_T0.8970.64
334_I337_S0.8960.64
228_A232_A0.8910.64
55_L68_M0.8900.64
4_E40_Y0.8900.64
336_D340_R0.8890.64
370_P377_D0.8890.64
120_F196_Y0.8880.63
86_V98_L0.8880.63
6_E143_D0.8870.63
292_A406_A0.8850.63
105_N302_Y0.8850.63
56_R158_E0.8830.63
57_I64_Y0.8770.62
5_I88_L0.8770.62
204_A401_L0.8770.62
411_I415_H0.8710.62
122_T145_G0.8700.62
179_V184_L0.8690.62
179_V183_G0.8660.61
233_L313_L0.8630.61
63_R87_A0.8620.61
262_R410_R0.8600.61
5_I374_R0.8600.61
167_D170_A0.8600.61
255_L370_P0.8590.61
8_K143_D0.8580.61
8_K158_E0.8580.61
112_L311_L0.8580.61
4_E160_E0.8570.61
382_L386_Y0.8550.60
6_E158_E0.8550.60
262_R406_A0.8520.60
6_E160_E0.8480.60
35_Q123_D0.8470.60
66_M145_G0.8470.60
283_L309_A0.8460.60
341_F346_L0.8380.59
232_A235_Q0.8370.59
83_E160_E0.8360.59
253_Q256_A0.8350.59
170_A182_T0.8310.58
13_H157_C0.8310.58
4_E58_R0.8300.58
297_A413_I0.8270.58
183_G187_G0.8270.58
370_P376_I0.8240.58
11_V272_V0.8230.58
149_A199_A0.8230.58
192_A196_Y0.8220.57
37_L121_S0.8200.57
145_G156_I0.8190.57
260_L292_A0.8180.57
287_C305_E0.8150.57
263_H309_A0.8130.57
147_V156_I0.8100.56
181_Q186_Q0.8090.56
195_G198_L0.8090.56
229_L265_L0.8090.56
124_F145_G0.8080.56
380_L410_R0.8050.56
14_S144_Q0.8040.56
236_W254_V0.8010.55
280_L312_A0.8000.55
7_L172_L0.7990.55
367_D370_P0.7940.55
67_T191_K0.7930.55
49_R196_Y0.7890.54
68_M98_L0.7880.54
175_A186_Q0.7850.54
207_I210_T0.7830.54
52_D286_Q0.7820.54
255_L402_H0.7810.54
255_L262_R0.7800.53
256_A402_H0.7780.53
286_Q306_T0.7780.53
342_A349_H0.7750.53
281_R365_Y0.7730.53
230_E318_V0.7660.52
284_L309_A0.7660.52
134_D170_A0.7620.52
290_T305_E0.7620.52
33_P125_Y0.7620.52
62_G125_Y0.7610.52
67_T85_N0.7600.52
266_M374_R0.7570.51
59_G64_Y0.7570.51
6_E36_L0.7560.51
57_I65_E0.7540.51
228_A381_L0.7540.51
279_H283_L0.7530.51
172_L179_V0.7530.51
292_A410_R0.7520.51
305_E309_A0.7500.51
292_A366_R0.7500.51
4_E81_R0.7460.50
368_Q414_E0.7450.50
31_H129_W0.7450.50
21_D28_G0.7440.50
379_I395_L0.7420.50
349_H365_Y0.7400.50
252_E380_L0.7400.50
360_P394_W0.7400.50
260_L366_R0.7380.49
259_S402_H0.7370.49
259_S263_H0.7360.49
57_I88_L0.7340.49
122_T156_I0.7310.49
286_Q300_A0.7300.49
243_W254_V0.7300.49
350_A354_K0.7300.49
263_H377_D0.7290.49
315_E319_S0.7270.48
369_L405_I0.7240.48
148_K151_E0.7230.48
130_L136_S0.7230.48
58_R126_R0.7230.48
58_R67_T0.7220.48
232_A264_T0.7220.48
301_V404_A0.7220.48
294_A298_V0.7220.48
141_A164_L0.7210.48
54_G67_T0.7200.48
379_I391_A0.7200.48
292_A373_T0.7200.48
280_L316_W0.7190.48
40_Y143_D0.7180.48
60_E63_R0.7130.47
375_D398_W0.7130.47
149_A154_E0.7120.47
254_V258_I0.7100.47
175_A179_V0.7090.47
419_E423_Q0.7050.46
68_M367_D0.7030.46
145_G311_L0.7000.46
232_A381_L0.6980.46
6_E81_R0.6970.46
109_P241_E0.6940.45
39_I121_S0.6930.45
47_W51_H0.6930.45
70_V141_A0.6930.45
346_L349_H0.6910.45
54_G196_Y0.6900.45
9_F314_T0.6890.45
274_R277_S0.6880.45
139_E162_E0.6860.45
366_R380_L0.6850.44
369_L380_L0.6840.44
170_A178_L0.6830.44
215_V224_G0.6800.44
267_L382_L0.6780.44
40_Y162_E0.6770.44
140_I294_A0.6770.44
262_R369_L0.6760.44
263_H373_T0.6760.44
260_L376_I0.6750.44
57_I67_T0.6750.44
145_G192_A0.6740.43
40_Y83_E0.6720.43
40_Y56_R0.6720.43
173_K176_N0.6720.43
34_V128_K0.6690.43
376_I402_H0.6660.43
226_E317_L0.6650.43
126_R139_E0.6650.43
166_G171_V0.6640.43
345_H349_H0.6630.42
362_G412_E0.6620.42
299_T304_T0.6610.42
7_L175_A0.6600.42
370_P399_Q0.6590.42
380_L406_A0.6570.42
357_F374_R0.6560.42
251_K379_I0.6550.42
36_L141_A0.6540.42
8_K67_T0.6530.41
258_I398_W0.6510.41
409_Q412_E0.6490.41
135_G299_T0.6480.41
13_H224_G0.6480.41
40_Y126_R0.6450.41
44_P114_S0.6450.41
54_G192_A0.6440.41
127_E144_Q0.6440.41
52_D190_S0.6440.41
58_R139_E0.6430.41
286_Q289_A0.6430.41
149_A190_S0.6420.40
45_D257_A0.6420.40
55_L66_M0.6410.40
67_T156_I0.6410.40
36_L143_D0.6410.40
344_I397_N0.6390.40
373_T380_L0.6380.40
67_T162_E0.6370.40
145_G195_G0.6360.40
274_R278_T0.6360.40
260_L410_R0.6330.40
269_G371_R0.6320.40
380_L402_H0.6310.39
67_T143_D0.6290.39
180_S184_L0.6280.39
260_L377_D0.6270.39
86_V90_E0.6250.39
411_I421_N0.6240.39
40_Y160_E0.6230.39
254_V306_T0.6230.39
232_A409_Q0.6210.39
145_G198_L0.6190.38
8_K36_L0.6190.38
179_V186_Q0.6150.38
139_E159_L0.6140.38
4_E36_L0.6100.38
151_E269_G0.6060.37
390_V394_W0.6060.37
268_F378_S0.6040.37
252_E260_L0.6030.37
393_A397_N0.6030.37
265_L283_L0.5990.37
118_P287_C0.5990.37
36_L158_E0.5970.36
84_Y101_E0.5960.36
45_D208_K0.5960.36
90_E97_Q0.5950.36
119_L127_E0.5950.36
182_T187_G0.5930.36
287_C306_T0.5900.36
22_H184_L0.5900.36
162_E194_R0.5860.35
372_L401_L0.5850.35
66_M120_F0.5850.35
44_P323_Q0.5840.35
29_E221_V0.5830.35
56_R139_E0.5830.35
391_A395_L0.5820.35
4_E83_E0.5820.35
44_P204_A0.5810.35
256_A370_P0.5800.35
5_I122_T0.5790.35
146_E155_P0.5790.35
233_L314_T0.5780.35
338_F399_Q0.5770.35
255_L380_L0.5770.35
48_L158_E0.5770.35
271_I334_I0.5750.35
139_E371_R0.5730.34
220_D223_Q0.5730.34
4_E126_R0.5720.34
271_I277_S0.5710.34
185_R240_E0.5700.34
122_T192_A0.5700.34
159_L375_D0.5690.34
117_Q338_F0.5680.34
246_G381_L0.5650.34
21_D64_Y0.5650.34
237_Q241_E0.5650.34
45_D114_S0.5640.34
127_E413_I0.5640.34
352_E355_S0.5630.33
52_D141_A0.5630.33
236_W306_T0.5630.33
85_N122_T0.5620.33
47_W114_S0.5620.33
81_R284_L0.5610.33
295_V363_D0.5600.33
313_L372_L0.5590.33
54_G57_I0.5530.33
257_A380_L0.5530.33
276_A279_H0.5530.33
222_E323_Q0.5520.33
13_H16_V0.5520.33
65_E310_K0.5490.32
33_P127_E0.5480.32
272_V277_S0.5480.32
284_L372_L0.5470.32
271_I333_K0.5470.32
253_Q406_A0.5470.32
57_I66_M0.5470.32
55_L192_A0.5430.32
36_L81_R0.5430.32
356_V371_R0.5420.32
219_A227_A0.5420.32
8_K139_E0.5410.32
355_S358_C0.5380.31
13_H201_G0.5370.31
6_E40_Y0.5370.31
110_A113_A0.5360.31
365_Y409_Q0.5360.31
65_E147_V0.5340.31
71_A112_L0.5340.31
147_V187_G0.5330.31
155_P304_T0.5330.31
398_W401_L0.5310.31
293_S350_A0.5280.31
313_L317_L0.5270.31
42_E251_K0.5260.30
273_P278_T0.5260.30
314_T318_V0.5250.30
120_F192_A0.5250.30
269_G274_R0.5240.30
174_L183_G0.5240.30
9_F23_L0.5240.30
176_N312_A0.5230.30
123_D270_G0.5230.30
366_R405_I0.5230.30
104_P281_R0.5220.30
193_A197_H0.5220.30
267_L348_R0.5210.30
342_A386_Y0.5200.30
116_V422_N0.5200.30
168_T176_N0.5200.30
130_L139_E0.5200.30
246_G265_L0.5200.30
276_A280_L0.5190.30
325_F333_K0.5190.30
231_L235_Q0.5180.30
40_Y158_E0.5130.29
263_H410_R0.5130.29
148_K206_E0.5110.29
13_H105_N0.5070.29
5_I128_K0.5060.29
44_P383_A0.5050.29
124_F195_G0.5040.29
182_T185_R0.5040.29
167_D171_V0.5040.29
405_I413_I0.5040.29
260_L373_T0.5040.29
243_W381_L0.5020.29
226_E320_K0.5010.28
65_E145_G0.5010.28
416_F422_N0.5010.28
221_V421_N0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a61A 1 0.9815 100 0.287 Contact Map
3e0sA 1 0.4827 100 0.632 Contact Map
2gfgA 2 0.4203 100 0.734 Contact Map
3tj7A 2 0.388 100 0.738 Contact Map
5a67A 1 0.4319 100 0.746 Contact Map
3bhdA 1 0.448 100 0.754 Contact Map
2acaA 2 0.3903 99.9 0.78 Contact Map
3n10A 2 0.388 99.9 0.781 Contact Map
2eenA 2 0.4018 99.9 0.784 Contact Map
2dc4A 2 0.3718 99.9 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0114 seconds.