GREMLIN Database
YAFE - Uncharacterized protein YafE
UniProt: P30866 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11651
Length: 207 (173)
Sequences: 8370 (6729)
Seq/√Len: 511.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_N140_L3.3051.00
27_A49_Q2.8441.00
23_Y50_G2.8001.00
19_A46_T2.6421.00
33_V47_T2.6271.00
76_D79_A2.6131.00
88_L92_G2.5691.00
57_F62_F2.5661.00
83_E86_R2.5381.00
3_G70_S2.5221.00
30_L47_T2.4351.00
65_V88_L2.4051.00
30_L49_Q2.3061.00
4_L10_T2.2251.00
21_V62_F2.2101.00
27_A31_D2.1031.00
78_G137_E2.0611.00
65_V84_V2.0241.00
63_D89_K1.9941.00
84_V94_L1.9911.00
4_L22_A1.9751.00
32_V35_Q1.9461.00
10_T20_V1.9231.00
67_S70_S1.8901.00
3_G67_S1.8351.00
83_E87_I1.8251.00
70_S74_W1.8051.00
88_L94_L1.7511.00
50_G56_P1.7471.00
22_A33_V1.7311.00
52_A74_W1.7201.00
10_T22_A1.7061.00
11_F36_A1.7051.00
11_F37_A1.5831.00
22_A47_T1.5611.00
78_G82_R1.5561.00
74_W80_A1.4771.00
55_L83_E1.4761.00
21_V48_R1.4721.00
59_D86_R1.4701.00
24_D30_L1.4621.00
132_L136_N1.4521.00
55_L87_I1.4471.00
80_A84_V1.4351.00
25_L51_Y1.4311.00
48_R57_F1.4181.00
53_E74_W1.3801.00
31_D35_Q1.3721.00
88_L140_L1.3481.00
58_A61_A1.3351.00
79_A82_R1.3131.00
12_G15_Q1.3031.00
24_D29_M1.3021.00
52_A70_S1.3001.00
28_H31_D1.2951.00
156_S159_A1.2941.00
77_V134_L1.2831.00
31_D34_A1.2621.00
133_T137_E1.2421.00
107_R110_W1.2221.00
78_G134_L1.1981.00
68_R97_M1.1921.00
21_V46_T1.1821.00
6_Q29_M1.1601.00
37_A47_T1.1591.00
84_V88_L1.1561.00
57_F87_I1.1421.00
30_L34_A1.1311.00
108_D112_Q1.1251.00
4_L33_V1.1211.00
37_A45_I1.1101.00
51_Y54_S1.1101.00
71_A74_W1.1081.00
127_A130_E1.0981.00
164_P167_L1.0971.00
14_A44_N1.0931.00
65_V87_I1.0881.00
128_S132_L1.0841.00
13_A66_I1.0761.00
71_A96_V1.0731.00
56_P83_E1.0601.00
4_L30_L1.0581.00
69_Y72_H1.0441.00
111_L115_E1.0241.00
10_T47_T1.0071.00
11_F15_Q1.0071.00
71_A81_L1.0011.00
109_I113_T0.9961.00
59_D83_E0.9961.00
157_W161_M0.9831.00
21_V57_F0.9751.00
9_P68_R0.9731.00
64_I93_R0.9731.00
9_P66_I0.9711.00
54_S79_A0.9601.00
133_T136_N0.9461.00
26_S29_M0.9451.00
71_A80_A0.9431.00
3_G74_W0.9421.00
99_V103_G0.9371.00
69_Y99_V0.9331.00
107_R111_L0.9251.00
160_R163_T0.9161.00
157_W160_R0.9111.00
12_G16_N0.9111.00
62_F87_I0.9101.00
163_T167_L0.9051.00
52_A80_A0.9031.00
155_S159_A0.9021.00
69_Y73_H0.8981.00
85_N138_A0.8831.00
11_F47_T0.8801.00
108_D111_L0.8791.00
53_E75_H0.8751.00
162_R165_E0.8661.00
94_L135_I0.8621.00
4_L24_D0.8551.00
36_A39_A0.8481.00
54_S83_E0.8481.00
23_Y48_R0.8351.00
50_G55_L0.8281.00
69_Y97_M0.8201.00
130_E133_T0.8191.00
35_Q39_A0.8131.00
158_V162_R0.8121.00
111_L114_V0.8101.00
4_L23_Y0.8101.00
72_H98_D0.8081.00
81_L135_I0.7911.00
17_V20_V0.7901.00
158_V163_T0.7881.00
124_R130_E0.7871.00
60_N90_P0.7851.00
78_G138_A0.7801.00
160_R164_P0.7731.00
35_Q38_E0.7691.00
100_M104_H0.7661.00
23_Y55_L0.7651.00
25_L49_Q0.7631.00
82_R138_A0.7621.00
159_A162_R0.7611.00
68_R73_H0.7601.00
110_W114_V0.7571.00
68_R72_H0.7551.00
53_E79_A0.7511.00
132_L145_L0.7491.00
34_A38_E0.7351.00
34_A46_T0.7341.00
64_I95_I0.7321.00
57_F61_A0.7301.00
6_Q32_V0.7291.00
29_M73_H0.7271.00
129_G132_L0.7271.00
9_P12_G0.7251.00
158_V161_M0.7201.00
161_M165_E0.7191.00
53_E80_A0.7171.00
17_V44_N0.7171.00
67_S96_V0.7141.00
109_I112_Q0.7121.00
53_E76_D0.7121.00
93_R96_V0.7101.00
106_V109_I0.7071.00
10_T45_I0.7051.00
59_D87_I0.7031.00
13_A64_I0.7021.00
81_L134_L0.7021.00
170_A175_Q0.7001.00
101_S104_H0.6861.00
73_H98_D0.6861.00
60_N89_K0.6831.00
135_I142_V0.6791.00
119_D122_H0.6771.00
169_D173_I0.6751.00
112_Q115_E0.6741.00
168_V172_R0.6731.00
32_V36_A0.6731.00
143_D147_T0.6691.00
42_L45_I0.6641.00
81_L138_A0.6621.00
56_P87_I0.6611.00
94_L140_L0.6611.00
106_V112_Q0.6601.00
29_M72_H0.6591.00
165_E169_D0.6591.00
15_Q42_L0.6581.00
67_S84_V0.6561.00
162_R166_A0.6541.00
127_A131_W0.6451.00
77_V80_A0.6441.00
164_P168_V0.6441.00
108_D115_E0.6431.00
14_A45_I0.6401.00
163_T166_A0.6351.00
170_A174_Y0.6341.00
11_F42_L0.6321.00
150_L154_F0.6301.00
150_L153_E0.6301.00
22_A45_I0.6271.00
126_Y130_E0.6241.00
107_R114_V0.6241.00
108_D114_V0.6151.00
17_V64_I0.6091.00
56_P86_R0.6091.00
100_M103_G0.6091.00
61_A87_I0.5950.99
115_E118_R0.5950.99
72_H99_V0.5930.99
38_E43_K0.5930.99
10_T13_A0.5900.99
168_V171_I0.5890.99
145_L148_D0.5870.99
67_S72_H0.5860.99
3_G73_H0.5840.99
70_S73_H0.5820.99
118_R121_S0.5820.99
8_R12_G0.5750.99
107_R115_E0.5700.99
96_V135_I0.5680.99
126_Y134_L0.5660.99
118_R122_H0.5630.99
55_L86_R0.5610.99
8_R29_M0.5590.99
73_H99_V0.5580.99
98_D131_W0.5560.99
166_A169_D0.5560.99
157_W163_T0.5510.99
25_L30_L0.5490.99
25_L53_E0.5460.99
81_L85_N0.5460.99
82_R137_E0.5430.99
108_D113_T0.5420.99
8_R11_F0.5410.99
7_G33_V0.5340.99
106_V115_E0.5300.99
167_L172_R0.5300.99
109_I114_V0.5300.99
3_G25_L0.5290.99
157_W164_P0.5290.99
174_Y177_S0.5280.99
28_H32_V0.5280.99
102_P105_P0.5280.99
37_A42_L0.5270.99
14_A20_V0.5270.99
107_R113_T0.5270.99
61_A86_R0.5260.99
64_I92_G0.5260.99
159_A163_T0.5240.99
173_I177_S0.5230.99
9_P97_M0.5170.98
68_R98_D0.5140.98
81_L131_W0.5130.98
106_V110_W0.5130.98
112_Q116_A0.5100.98
128_S145_L0.5090.98
34_A47_T0.5090.98
8_R69_Y0.5070.98
130_E134_L0.5060.98
110_W115_E0.5020.98
24_D69_Y0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl5A 1 1 100 0.353 Contact Map
1xxlA 1 1 100 0.357 Contact Map
4ineA 2 0.9807 100 0.396 Contact Map
4kriA 1 0.9807 100 0.399 Contact Map
3ccfA 1 0.971 100 0.404 Contact Map
2o57A 2 0.9807 100 0.406 Contact Map
2yqzA 1 0.9855 100 0.411 Contact Map
3ujcA 1 0.971 99.9 0.413 Contact Map
4pneA 2 0.9614 99.9 0.416 Contact Map
2p35A 2 0.9517 99.9 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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