GREMLIN Database
YAFC - Uncharacterized HTH-type transcriptional regulator YafC
UniProt: P30864 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11649
Length: 304 (286)
Sequences: 79947 (58052)
Seq/√Len: 3432.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_S76_E3.6011.00
17_S26_Q3.3901.00
157_R290_S2.6751.00
98_D140_V2.6011.00
69_R83_E2.4311.00
13_S26_Q2.2941.00
230_C237_A2.2931.00
114_P292_H2.2081.00
172_Y188_H2.2051.00
158_P161_N2.1891.00
161_N267_P2.1881.00
94_L125_S2.1621.00
163_Y241_D2.1621.00
158_P267_P2.1161.00
22_R25_E2.0741.00
47_V62_E2.0641.00
94_L123_T2.0541.00
10_I37_A2.0471.00
16_E71_Q2.0451.00
181_T184_D2.0231.00
161_N265_E1.9951.00
227_K247_E1.9861.00
69_R76_E1.9761.00
12_V71_Q1.9711.00
114_P288_F1.9611.00
12_V67_F1.9581.00
231_L252_E1.9321.00
12_V16_E1.9291.00
13_S16_E1.9211.00
96_R125_S1.9041.00
191_L235_G1.9001.00
10_I34_V1.8951.00
13_S17_S1.8941.00
165_K241_D1.8891.00
15_V59_L1.8731.00
73_I77_M1.8671.00
231_L247_E1.8511.00
168_A256_L1.8201.00
67_F71_Q1.8021.00
20_F38_V1.7691.00
51_N58_S1.7161.00
66_Y80_A1.7091.00
189_I217_G1.6931.00
165_K255_E1.6931.00
156_A269_S1.6801.00
65_R83_E1.6721.00
177_G184_D1.6221.00
15_V67_F1.6111.00
115_F285_F1.5851.00
134_N139_K1.5801.00
17_S22_R1.5771.00
16_E26_Q1.5671.00
12_V70_V1.5631.00
11_F67_F1.5461.00
155_R274_S1.5401.00
10_I29_Q1.5151.00
7_E37_A1.5081.00
133_I137_E1.4991.00
90_T121_E1.4991.00
21_S31_N1.4851.00
157_R272_Y1.4731.00
7_E44_K1.4711.00
19_S22_R1.4651.00
69_R72_S1.4651.00
30_A33_A1.4491.00
7_E40_K1.4481.00
48_S51_N1.4451.00
61_E64_E1.4361.00
115_F122_V1.4271.00
13_S27_L1.4241.00
147_G269_S1.4171.00
286_I290_S1.4101.00
278_V282_I1.4011.00
12_V74_L1.4011.00
145_R271_V1.3991.00
155_R272_Y1.3961.00
69_R79_A1.3791.00
4_T7_E1.3781.00
200_N204_I1.3661.00
73_I80_A1.3651.00
105_L224_E1.3591.00
92_R121_E1.3461.00
272_Y286_I1.3451.00
134_N140_V1.3371.00
5_S77_M1.3241.00
284_A287_D1.3191.00
53_T58_S1.3171.00
135_L143_A1.3141.00
162_S242_Y1.3121.00
136_I153_S1.3111.00
114_P118_R1.3041.00
170_P252_E1.3011.00
270_A286_I1.2951.00
66_Y81_E1.2821.00
76_E79_A1.2821.00
142_V282_I1.2811.00
142_V270_A1.2801.00
168_A236_I1.2731.00
116_R217_G1.2671.00
118_R288_F1.2651.00
226_L237_A1.2571.00
247_E252_E1.2491.00
44_K81_E1.2441.00
188_H236_I1.2441.00
68_R72_S1.2341.00
228_Q231_L1.2171.00
69_R80_A1.2081.00
241_D245_D1.2021.00
116_R189_I1.1971.00
241_D255_E1.1921.00
65_R68_R1.1911.00
245_D249_A1.1861.00
113_K117_E1.1851.00
11_F50_L1.1851.00
158_P269_S1.1841.00
29_Q33_A1.1831.00
64_E68_R1.1721.00
39_K43_M1.1681.00
178_K254_V1.1651.00
170_P254_V1.1611.00
128_S131_T1.1511.00
11_F15_V1.1471.00
207_S212_H1.1461.00
173_I188_H1.1401.00
156_A271_V1.1391.00
36_R40_K1.1361.00
11_F49_L1.1241.00
113_K232_S1.1211.00
114_P117_E1.1191.00
36_R39_K1.1181.00
191_L226_L1.1081.00
179_P259_D1.0961.00
189_I215_K1.0941.00
72_S79_A1.0851.00
20_F57_L1.0831.00
95_L285_F1.0821.00
287_D290_S1.0811.00
35_S39_K1.0781.00
8_L70_V1.0711.00
14_V23_A1.0691.00
227_K231_L1.0671.00
255_E258_A1.0671.00
6_E9_A1.0661.00
119_Y284_A1.0661.00
125_S219_S1.0651.00
115_F288_F1.0621.00
65_R69_R1.0621.00
13_S23_A1.0561.00
73_I76_E1.0511.00
288_F292_H1.0481.00
37_A40_K1.0461.00
111_L289_L1.0431.00
283_R287_D1.0411.00
110_P232_S1.0391.00
220_S226_L1.0381.00
157_R286_I1.0361.00
167_I255_E1.0351.00
9_A78_A1.0331.00
180_E184_D1.0301.00
136_I151_D1.0211.00
169_S233_G1.0211.00
228_Q232_S1.0171.00
59_L63_G1.0171.00
201_T204_I1.0031.00
81_E85_M1.0001.00
182_I260_K0.9911.00
163_Y265_E0.9901.00
167_I244_I0.9871.00
246_K250_R0.9871.00
166_I236_I0.9761.00
29_Q34_V0.9731.00
127_V130_E0.9691.00
10_I27_L0.9661.00
78_A82_S0.9661.00
115_F119_Y0.9651.00
75_Q79_A0.9651.00
14_V20_F0.9611.00
78_A81_E0.9601.00
15_V50_L0.9571.00
168_A172_Y0.9541.00
66_Y70_V0.9521.00
134_N137_E0.9391.00
11_F59_L0.9381.00
192_G216_Y0.9381.00
288_F291_E0.9321.00
118_R291_E0.9311.00
220_S229_L0.9281.00
279_S282_I0.9261.00
172_Y175_R0.9221.00
40_K43_M0.9211.00
23_A34_V0.9161.00
11_F41_L0.9051.00
50_L57_L0.9011.00
98_D145_R0.9001.00
111_L288_F0.8951.00
22_R26_Q0.8891.00
47_V84_I0.8881.00
140_V143_A0.8881.00
65_R87_T0.8821.00
98_D143_A0.8791.00
190_C214_V0.8781.00
101_T222_S0.8781.00
15_V63_G0.8771.00
123_T215_K0.8761.00
147_G267_P0.8711.00
273_Y276_R0.8651.00
127_V131_T0.8631.00
68_R71_Q0.8601.00
18_G58_S0.8571.00
72_S75_Q0.8511.00
206_R210_Q0.8501.00
53_T56_Q0.8491.00
172_Y189_I0.8451.00
21_S25_E0.8411.00
6_E37_A0.8411.00
97_I142_V0.8401.00
154_L271_V0.8381.00
173_I178_K0.8351.00
184_D187_Q0.8311.00
203_P207_S0.8291.00
27_L34_V0.8271.00
62_E87_T0.8271.00
172_Y176_Y0.8241.00
167_I237_A0.8241.00
122_V281_R0.8241.00
153_S274_S0.8231.00
287_D291_E0.8211.00
247_E250_R0.8201.00
155_R158_P0.8191.00
168_A173_I0.8191.00
189_I216_Y0.8131.00
278_V283_R0.8121.00
132_I136_I0.8111.00
174_S188_H0.8061.00
93_G281_R0.8041.00
5_S74_L0.8031.00
62_E84_I0.8001.00
176_Y189_I0.8001.00
15_V18_G0.7981.00
11_F66_Y0.7921.00
113_K234_N0.7921.00
18_G64_E0.7891.00
77_M80_A0.7871.00
244_I247_E0.7861.00
39_K48_S0.7851.00
31_N35_S0.7801.00
181_T259_D0.7781.00
14_V38_V0.7741.00
14_V50_L0.7731.00
183_D186_K0.7731.00
79_A83_E0.7711.00
201_T205_A0.7711.00
77_M81_E0.7701.00
16_E67_F0.7701.00
116_R234_N0.7691.00
18_G56_Q0.7631.00
62_E65_R0.7621.00
17_S23_A0.7601.00
169_S234_N0.7581.00
76_E80_A0.7581.00
229_L234_N0.7471.00
203_P206_R0.7461.00
91_P119_Y0.7451.00
111_L292_H0.7451.00
167_I239_L0.7441.00
142_V285_F0.7441.00
7_E10_I0.7441.00
280_T284_A0.7441.00
96_R140_V0.7421.00
118_R284_A0.7421.00
171_D175_R0.7341.00
99_A104_V0.7301.00
85_M88_R0.7291.00
9_A13_S0.7281.00
20_F34_V0.7221.00
70_V73_I0.7201.00
14_V34_V0.7191.00
114_P291_E0.7181.00
136_I154_L0.7171.00
115_F284_A0.7161.00
80_A84_I0.7161.00
59_L64_E0.7141.00
163_Y257_M0.7121.00
51_N60_T0.7121.00
186_K212_H0.7071.00
240_S243_M0.7021.00
58_S64_E0.7001.00
169_S172_Y0.6991.00
71_Q75_Q0.6991.00
222_S225_T0.6911.00
200_N219_S0.6901.00
206_R209_G0.6891.00
33_A37_A0.6851.00
51_N56_Q0.6851.00
168_A174_S0.6821.00
141_D282_I0.6821.00
175_R254_V0.6811.00
62_E66_Y0.6801.00
96_R141_D0.6801.00
168_A254_V0.6801.00
64_E67_F0.6801.00
181_T260_K0.6781.00
202_W206_R0.6751.00
183_D210_Q0.6701.00
42_E47_V0.6681.00
93_G122_V0.6681.00
194_T219_S0.6671.00
20_F56_Q0.6651.00
61_E65_R0.6631.00
179_P257_M0.6611.00
187_Q215_K0.6601.00
193_F226_L0.6601.00
123_T219_S0.6591.00
205_A209_G0.6551.00
79_A82_S0.6521.00
218_L229_L0.6521.00
284_A288_F0.6511.00
42_E52_R0.6511.00
171_D233_G0.6511.00
75_Q78_A0.6491.00
138_R273_Y0.6491.00
66_Y84_I0.6471.00
190_C236_I0.6441.00
199_L203_P0.6431.00
205_A208_D0.6431.00
204_I207_S0.6421.00
95_L281_R0.6421.00
9_A12_V0.6421.00
6_E40_K0.6391.00
246_K249_A0.6361.00
99_A108_L0.6351.00
171_D174_S0.6341.00
25_E28_G0.6331.00
69_R73_I0.6321.00
105_L228_Q0.6311.00
38_V42_E0.6271.00
144_I289_L0.6271.00
70_V74_L0.6251.00
104_V128_S0.6201.00
14_V19_S0.6181.00
23_A27_L0.6171.00
163_Y263_P0.6171.00
204_I208_D0.6151.00
96_R127_V0.6101.00
276_R279_S0.6101.00
142_V286_I0.6091.00
166_I185_L0.6031.00
170_P251_G0.6021.00
171_D254_V0.6021.00
166_I238_C0.6011.00
280_T283_R0.6001.00
201_T206_R0.5941.00
82_S86_E0.5881.00
162_S266_M0.5871.00
108_L111_L0.5861.00
135_L271_V0.5861.00
226_L230_C0.5861.00
65_R84_I0.5861.00
194_T221_N0.5851.00
95_L142_V0.5841.00
177_G180_E0.5831.00
272_Y283_R0.5821.00
146_A266_M0.5811.00
174_S177_G0.5811.00
110_P113_K0.5811.00
285_F289_L0.5811.00
110_P114_P0.5811.00
173_I176_Y0.5801.00
30_A36_R0.5741.00
9_A74_L0.5741.00
45_L66_Y0.5731.00
166_I190_C0.5711.00
33_A36_R0.5681.00
6_E10_I0.5681.00
220_S225_T0.5681.00
135_L154_L0.5661.00
59_L67_F0.5651.00
207_S214_V0.5651.00
45_L84_I0.5651.00
47_V51_N0.5641.00
160_F268_F0.5641.00
164_R238_C0.5641.00
229_L235_G0.5621.00
32_S36_R0.5611.00
92_R123_T0.5601.00
199_L202_W0.5581.00
50_L59_L0.5561.00
252_E255_E0.5551.00
195_E219_S0.5541.00
155_R275_D0.5491.00
74_L78_A0.5481.00
172_Y236_I0.5441.00
11_F63_G0.5421.00
174_S180_E0.5381.00
239_L244_I0.5381.00
45_L48_S0.5371.00
186_K213_E0.5361.00
173_I177_G0.5361.00
10_I38_V0.5351.00
133_I139_K0.5301.00
147_G156_A0.5291.00
68_R83_E0.5271.00
223_G240_S0.5251.00
10_I23_A0.5241.00
159_L270_A0.5241.00
20_F31_N0.5221.00
48_S62_E0.5211.00
103_V107_F0.5201.00
282_I286_I0.5191.00
20_F52_R0.5151.00
144_I270_A0.5151.00
105_L222_S0.5141.00
38_V50_L0.5141.00
247_E251_G0.5131.00
168_A175_R0.5131.00
112_I124_L0.5121.00
29_Q37_A0.5121.00
86_E91_P0.5101.00
15_V64_E0.5101.00
93_G119_Y0.5081.00
74_L77_M0.5081.00
82_S85_M0.5081.00
119_Y122_V0.5071.00
231_L250_R0.5061.00
18_G57_L0.5061.00
100_A103_V0.5061.00
93_G121_E0.5021.00
202_W205_A0.5021.00
69_R84_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fzvA 4 0.9408 100 0.097 Contact Map
2esnA 3 0.9605 100 0.1 Contact Map
3hhgA 3 0.9737 100 0.108 Contact Map
1uthA 2 0.7368 100 0.108 Contact Map
3fxqA 3 0.9539 100 0.111 Contact Map
1ixcA 4 0.9507 100 0.114 Contact Map
3szpA 3 0.9539 100 0.115 Contact Map
1al3A 1 0.7072 100 0.118 Contact Map
2h98A 2 0.6875 100 0.123 Contact Map
4x6gA 4 0.9868 100 0.125 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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