DKGB - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DKGB - 2,5-diketo-D-gluconic acid reductase B

UniProt:	P30863	Sequences: MAIPAFGLGTFRLKDDVVISSVITALELGYRAIDTAQIYDNEAAVGQAIAESGVPRHELYITTKIWIENLSKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIPLMEKAIAAVGAENIATNQIELSPYLQNRKVVAWAKQHGIHITSYMTLAYGKALKDEVIARIAAKHNATPAQVILAWAMGEGYSVIPSSTKRKNLESNLKAQNLQLDAEDKKAIAALDCNDRLVSPEGLAPEWD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11648
Length:	267 (244)
Sequences:	32465 (20991)
Seq/√Len:	1343.8

ECOLI - DKGB DKGA YDHF YAJO YDJG GPR YEAE TAS YDBC
BACSU - GR YTBE YCSN GS69 YRPG IOLS YCCK YQKF
HALSA - Q9HS02 Q9HNN3 Q9HPH9 Q9HQU7 Q9HQT1 Q9HSE6
SULSO - Q97UG6 Q97UV9 Q97U17 Q97V56 Q97ZZ1 Q97UJ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_T	229_E	3.117	1.00
80_K	122_L	2.875	1.00
50_A	87_R	2.709	1.00
199_H	243_D	2.641	1.00
15_D	47_Q	2.618	1.00
240_D	243_D	2.452	1.00
19_I	51_E	2.393	1.00
79_L	117_A	2.390	1.00
76_I	116_E	2.376	1.00
76_I	120_Q	2.273	1.00
24_T	28_L	2.268	1.00
198_K	246_A	2.076	1.00
115_L	119_K	2.044	1.00
19_I	47_Q	2.030	1.00
81_E	85_K	1.972	1.00
167_W	171_H	1.970	1.00
193_A	197_A	1.964	1.00
90_Y	124_R	1.958	1.00
213_G	244_K	1.948	1.00
116_E	120_Q	1.938	1.00
225_R	229_E	1.876	1.00
55_P	58_E	1.864	1.00
241_A	245_K	1.860	1.00
198_K	243_D	1.856	1.00
24_T	225_R	1.842	1.00
168_A	175_I	1.835	1.00
72_K	116_E	1.800	1.00
194_R	246_A	1.800	1.00
7_G	32_A	1.790	1.00
201_A	237_L	1.770	1.00
28_L	229_E	1.724	1.00
25_A	30_Y	1.683	1.00
95_L	150_T	1.682	1.00
214_E	248_A	1.663	1.00
116_E	119_K	1.635	1.00
72_K	76_I	1.624	1.00
14_K	17_V	1.616	1.00
174_H	217_S	1.610	1.00
137_E	141_A	1.607	1.00
28_L	232_L	1.588	1.00
61_I	88_T	1.584	1.00
19_I	23_I	1.583	1.00
43_A	85_K	1.578	1.00
24_T	27_E	1.575	1.00
191_V	194_R	1.574	1.00
65_I	94_T	1.572	1.00
137_E	167_W	1.568	1.00
23_I	51_E	1.563	1.00
19_I	48_A	1.547	1.00
76_I	80_K	1.545	1.00
202_T	230_S	1.544	1.00
245_K	249_A	1.542	1.00
209_A	237_L	1.532	1.00
63_T	91_V	1.529	1.00
63_T	82_S	1.526	1.00
65_I	75_L	1.520	1.00
233_K	236_N	1.517	1.00
113_A	116_E	1.517	1.00
79_L	94_T	1.504	1.00
62_T	95_L	1.487	1.00
15_D	19_I	1.463	1.00
10_T	33_I	1.448	1.00
77_P	81_E	1.437	1.00
37_Q	78_S	1.432	1.00
17_V	20_S	1.402	1.00
26_L	59_L	1.397	1.00
163_K	166_A	1.397	1.00
201_A	205_Q	1.387	1.00
132_T	135_L	1.379	1.00
140_I	171_H	1.370	1.00
166_A	170_Q	1.365	1.00
80_K	84_Q	1.364	1.00
169_K	215_G	1.363	1.00
125_E	149_A	1.353	1.00
22_V	48_A	1.351	1.00
95_L	176_T	1.337	1.00
209_A	213_G	1.315	1.00
91_V	123_T	1.304	1.00
229_E	233_K	1.300	1.00
153_I	175_I	1.299	1.00
222_S	227_N	1.292	1.00
246_A	249_A	1.268	1.00
23_I	27_E	1.263	1.00
81_E	84_Q	1.258	1.00
72_K	112_Q	1.254	1.00
194_R	198_K	1.250	1.00
20_S	24_T	1.250	1.00
201_A	206_V	1.247	1.00
140_I	167_W	1.247	1.00
60_Y	93_L	1.234	1.00
117_A	123_T	1.215	1.00
56_R	88_T	1.208	1.00
191_V	246_A	1.199	1.00
123_T	126_I	1.199	1.00
72_K	113_A	1.196	1.00
76_I	113_A	1.192	1.00
86_L	91_V	1.189	1.00
133_I	167_W	1.179	1.00
193_A	203_P	1.176	1.00
46_G	87_R	1.173	1.00
165_V	169_K	1.164	1.00
222_S	228_L	1.164	1.00
42_E	82_S	1.164	1.00
47_Q	87_R	1.161	1.00
202_T	205_Q	1.153	1.00
108_E	142_A	1.150	1.00
99_P	135_L	1.150	1.00
118_K	149_A	1.144	1.00
93_L	150_T	1.139	1.00
155_L	214_E	1.138	1.00
186_A	189_D	1.134	1.00
16_D	20_S	1.124	1.00
56_R	90_Y	1.122	1.00
119_K	144_G	1.119	1.00
74_K	77_P	1.104	1.00
43_A	47_Q	1.099	1.00
73_D	77_P	1.098	1.00
15_D	44_A	1.096	1.00
33_I	45_V	1.081	1.00
137_E	171_H	1.079	1.00
71_S	74_K	1.078	1.00
32_A	62_T	1.077	1.00
32_A	176_T	1.077	1.00
154_E	159_L	1.076	1.00
115_L	118_K	1.072	1.00
194_R	197_A	1.069	1.00
114_L	126_I	1.066	1.00
226_K	229_E	1.063	1.00
79_L	91_V	1.060	1.00
23_I	48_A	1.052	1.00
137_E	170_Q	1.050	1.00
10_T	45_V	1.049	1.00
190_E	194_R	1.042	1.00
80_K	120_Q	1.040	1.00
117_A	122_L	1.039	1.00
96_I	114_L	1.039	1.00
211_A	218_V	1.023	1.00
70_L	96_I	1.017	1.00
31_R	60_Y	1.016	1.00
21_S	228_L	1.012	1.00
195_I	206_V	1.012	1.00
20_S	225_R	1.011	1.00
109_E	112_Q	1.005	1.00
4_P	31_R	0.997	1.00
205_Q	233_K	0.996	1.00
133_I	137_E	0.986	1.00
160_Q	251_D	0.985	1.00
190_E	193_A	0.977	1.00
212_M	234_A	0.972	1.00
157_P	207_I	0.970	1.00
157_P	247_I	0.961	1.00
5_A	235_Q	0.960	1.00
138_K	142_A	0.957	1.00
42_E	85_K	0.956	1.00
158_Y	189_D	0.946	1.00
192_I	203_P	0.941	1.00
92_D	124_R	0.939	1.00
37_Q	74_K	0.937	1.00
176_T	217_S	0.933	1.00
4_P	30_Y	0.932	1.00
150_T	176_T	0.930	1.00
47_Q	51_E	0.926	1.00
162_R	166_A	0.924	1.00
5_A	212_M	0.919	1.00
166_A	169_K	0.912	1.00
76_I	79_L	0.910	1.00
228_L	232_L	0.908	1.00
128_I	148_I	0.907	1.00
112_Q	116_E	0.905	1.00
69_N	74_K	0.903	1.00
49_I	59_L	0.902	1.00
230_S	233_K	0.896	1.00
205_Q	230_S	0.895	1.00
20_S	23_I	0.881	1.00
22_V	33_I	0.881	1.00
118_K	145_A	0.880	1.00
108_E	138_K	0.878	1.00
113_A	117_A	0.878	1.00
37_Q	69_N	0.878	1.00
118_K	125_E	0.874	1.00
117_A	120_Q	0.873	1.00
77_P	80_K	0.870	1.00
213_G	238_Q	0.869	1.00
226_K	230_S	0.869	1.00
26_L	55_P	0.864	1.00
224_K	227_N	0.863	1.00
151_N	168_A	0.860	1.00
115_L	144_G	0.857	1.00
245_K	248_A	0.857	1.00
128_I	136_M	0.851	1.00
167_W	170_Q	0.843	1.00
62_T	176_T	0.843	1.00
43_A	84_Q	0.839	1.00
37_Q	85_K	0.838	1.00
112_Q	115_L	0.837	1.00
242_E	246_A	0.834	1.00
76_I	117_A	0.825	1.00
115_L	143_V	0.823	1.00
72_K	109_E	0.818	1.00
126_I	148_I	0.817	1.00
242_E	245_K	0.816	1.00
208_L	234_A	0.814	1.00
130_N	178_Y	0.805	1.00
138_K	141_A	0.804	1.00
214_E	244_K	0.804	1.00
195_I	199_H	0.799	1.00
8_L	25_A	0.795	1.00
136_M	173_I	0.794	1.00
51_E	55_P	0.784	1.00
207_I	211_A	0.782	1.00
115_L	126_I	0.780	1.00
160_Q	248_A	0.777	1.00
141_A	145_A	0.772	1.00
62_T	93_L	0.771	1.00
144_G	147_N	0.770	1.00
37_Q	81_E	0.766	1.00
209_A	234_A	0.766	1.00
28_L	233_K	0.761	1.00
155_L	165_V	0.760	1.00
223_T	227_N	0.758	1.00
180_T	220_P	0.751	1.00
35_T	45_V	0.746	1.00
213_G	241_A	0.746	1.00
165_V	175_I	0.741	1.00
63_T	94_T	0.736	1.00
198_K	240_D	0.735	1.00
140_I	147_N	0.734	1.00
24_T	228_L	0.732	1.00
199_H	240_D	0.730	1.00
177_S	180_T	0.730	1.00
83_L	122_L	0.728	1.00
133_I	164_V	0.728	1.00
18_V	44_A	0.725	1.00
23_I	55_P	0.722	1.00
16_D	19_I	0.721	1.00
10_T	41_N	0.719	1.00
98_W	130_N	0.717	1.00
164_V	168_A	0.712	1.00
30_Y	232_L	0.706	1.00
204_A	230_S	0.704	1.00
82_S	94_T	0.697	1.00
191_V	250_L	0.697	1.00
78_S	81_E	0.695	1.00
26_L	33_I	0.693	1.00
197_A	200_N	0.691	1.00
83_L	88_T	0.690	1.00
75_L	117_A	0.689	1.00
165_V	214_E	0.687	1.00
177_S	218_V	0.682	1.00
79_L	122_L	0.680	1.00
70_L	110_F	0.674	1.00
174_H	216_Y	0.674	1.00
210_W	248_A	0.673	1.00
106_S	109_E	0.671	1.00
111_M	139_A	0.669	1.00
128_I	131_F	0.669	1.00
95_L	127_G	0.668	1.00
111_M	148_I	0.668	1.00
196_A	206_V	0.667	1.00
7_G	220_P	0.664	1.00
21_S	225_R	0.663	1.00
133_I	163_K	0.662	1.00
111_M	143_V	0.657	1.00
211_A	216_Y	0.656	1.00
8_L	13_L	0.655	1.00
6_F	212_M	0.649	1.00
111_M	126_I	0.648	1.00
195_I	243_D	0.647	1.00
12_R	183_Y	0.646	1.00
201_A	233_K	0.646	1.00
239_L	244_K	0.646	1.00
128_I	151_N	0.642	1.00
206_V	239_L	0.641	1.00
7_G	217_S	0.640	1.00
180_T	211_A	0.640	1.00
201_A	236_N	0.638	1.00
199_H	206_V	0.635	1.00
31_R	58_E	0.633	1.00
75_L	110_F	0.633	1.00
155_L	211_A	0.625	1.00
168_A	173_I	0.624	1.00
227_N	230_S	0.614	1.00
57_H	90_Y	0.614	1.00
91_V	94_T	0.613	1.00
118_K	123_T	0.612	1.00
3_I	217_S	0.606	1.00
114_L	118_K	0.604	1.00
22_V	26_L	0.604	1.00
28_L	228_L	0.603	1.00
34_D	152_Q	0.603	1.00
11_F	179_M	0.603	1.00
55_P	59_L	0.602	1.00
13_L	18_V	0.598	1.00
192_I	247_I	0.595	1.00
110_F	113_A	0.595	1.00
27_E	225_R	0.595	1.00
137_E	140_I	0.590	1.00
140_I	143_V	0.586	1.00
67_I	70_L	0.585	1.00
75_L	113_A	0.585	1.00
155_L	175_I	0.584	1.00
26_L	31_R	0.584	1.00
107_V	142_A	0.584	1.00
201_A	209_A	0.584	1.00
83_L	90_Y	0.581	1.00
17_V	225_R	0.580	1.00
158_Y	185_K	0.579	1.00
79_L	83_L	0.577	1.00
179_M	183_Y	0.577	1.00
192_I	207_I	0.573	1.00
14_K	18_V	0.572	1.00
206_V	247_I	0.572	1.00
26_L	58_E	0.571	1.00
222_S	231_N	0.570	1.00
134_P	137_E	0.568	1.00
195_I	246_A	0.568	1.00
243_D	246_A	0.567	1.00
105_V	109_E	0.566	1.00
54_V	59_L	0.564	1.00
135_L	138_K	0.561	1.00
206_V	243_D	0.561	1.00
155_L	160_Q	0.558	1.00
38_I	66_W	0.557	1.00
239_L	243_D	0.557	1.00
21_S	222_S	0.554	1.00
155_L	216_Y	0.553	1.00
106_S	110_F	0.551	1.00
83_L	91_V	0.547	1.00
71_S	110_F	0.542	1.00
25_A	33_I	0.536	1.00
76_I	122_L	0.535	1.00
65_I	70_L	0.532	1.00
8_L	21_S	0.532	1.00
192_I	196_A	0.532	1.00
6_F	235_Q	0.532	1.00
108_E	112_Q	0.531	1.00
115_L	145_A	0.531	1.00
196_A	199_H	0.530	1.00
94_T	114_L	0.529	1.00
195_I	198_K	0.528	1.00
35_T	41_N	0.528	1.00
206_V	237_L	0.528	1.00
65_I	78_S	0.525	1.00
107_V	110_F	0.524	1.00
94_T	123_T	0.524	1.00
196_A	203_P	0.524	1.00
83_L	89_D	0.523	1.00
32_A	60_Y	0.521	1.00
212_M	218_V	0.520	1.00
49_I	55_P	0.520	1.00
33_I	49_I	0.519	1.00
13_L	21_S	0.519	1.00
22_V	45_V	0.518	1.00
99_P	131_F	0.518	1.00
100_S	105_V	0.517	1.00
205_Q	237_L	0.516	1.00
143_V	148_I	0.513	1.00
47_Q	50_A	0.513	1.00
72_K	75_L	0.512	1.00
140_I	173_I	0.510	1.00
107_V	138_K	0.507	1.00
45_V	48_A	0.503	1.00
100_S	104_E	0.503	1.00
96_I	110_F	0.503	1.00
244_K	248_A	0.503	1.00
161_N	166_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3up8A	1	0.9888	100	0.06	Contact Map
4otkA	1	0.9813	100	0.08	Contact Map
2wzmA	1	0.985	100	0.081	Contact Map
1hw6A	1	0.9176	100	0.084	Contact Map
3o0kA	1	0.9326	100	0.085	Contact Map
1mi3A	3	0.9963	100	0.085	Contact Map
1zgdA	1	0.9963	100	0.087	Contact Map
4q3mA	2	0.9775	100	0.088	Contact Map
4wevX	1	0.9513	100	0.088	Contact Map
1us0A	1	0.9963	100	0.09	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.