GREMLIN Database
ARTJ - ABC transporter arginine-binding protein 1
UniProt: P30860 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11628
Length: 243 (224)
Sequences: 20448 (14577)
Seq/√Len: 973.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_K63_T3.3751.00
26_G81_Y3.3471.00
130_G168_I3.2871.00
57_Q226_A2.7861.00
90_I95_S2.3721.00
24_N63_T2.3641.00
138_Q152_S2.3471.00
153_Y162_D2.2791.00
102_T225_A2.2631.00
77_K97_Q2.1021.00
90_I206_G2.0711.00
75_S81_Y2.0641.00
138_Q142_Q2.0581.00
155_S158_N2.0411.00
24_N65_T2.0241.00
98_V208_A2.0011.00
99_S217_L1.9841.00
22_K61_E1.9751.00
128_R151_V1.9381.00
159_A171_V1.9221.00
57_Q223_A1.9201.00
232_T235_K1.9201.00
209_V217_L1.9071.00
92_P95_S1.8931.00
55_C62_C1.8831.00
53_A56_K1.8821.00
38_G44_V1.8791.00
173_G178_V1.8481.00
234_Q238_D1.8481.00
162_D167_R1.8351.00
217_L221_N1.7971.00
225_A229_A1.7891.00
119_K123_D1.7541.00
128_R149_K1.7451.00
25_F51_A1.6851.00
114_K166_G1.6801.00
209_V220_L1.6791.00
120_T123_D1.6701.00
53_A232_T1.6701.00
75_S80_K1.6661.00
53_A227_I1.6441.00
112_I178_V1.6391.00
102_T221_N1.6371.00
38_G42_E1.6211.00
85_I207_I1.6161.00
106_E204_G1.5991.00
53_A57_Q1.5891.00
140_Y144_Q1.5741.00
114_K117_T1.5581.00
214_K218_E1.5251.00
67_H75_S1.5011.00
210_R213_N1.5011.00
133_N154_D1.4721.00
110_V175_T1.4141.00
72_L84_V1.4121.00
49_D239_Q1.4111.00
57_Q230_D1.3981.00
25_F83_A1.3961.00
219_K222_N1.3901.00
218_E222_N1.3821.00
101_T221_N1.3781.00
15_F19_A1.3781.00
139_K143_D1.3721.00
175_T179_N1.3711.00
29_A66_N1.3531.00
36_S44_V1.3411.00
37_I66_N1.3401.00
58_M223_A1.3371.00
54_L223_A1.3141.00
48_I52_K1.3131.00
128_R169_D1.3101.00
127_K169_D1.3021.00
99_S212_D1.2981.00
162_D168_I1.2841.00
14_T17_A1.2831.00
223_A226_A1.2751.00
51_A85_I1.2581.00
109_A137_H1.2331.00
16_G20_A1.2301.00
79_R210_R1.2291.00
60_A219_K1.2191.00
73_I98_V1.2161.00
142_Q152_S1.1961.00
52_K64_F1.1911.00
113_A170_G1.1871.00
46_F237_S1.1851.00
129_I170_G1.1841.00
74_P77_K1.1771.00
161_I164_K1.1741.00
228_K233_Y1.1721.00
226_A230_D1.1691.00
88_M208_A1.1661.00
74_P78_F1.1551.00
219_K223_A1.1531.00
99_S214_K1.1361.00
161_I165_N1.1361.00
223_A227_I1.1351.00
47_D104_Y1.1291.00
214_K217_L1.1191.00
111_V170_G1.1161.00
68_A71_S1.1151.00
133_N152_S1.1091.00
154_D158_N1.0951.00
15_F18_S1.0951.00
21_E60_A1.0951.00
130_G153_Y1.0941.00
163_L168_I1.0651.00
44_V49_D1.0641.00
153_Y159_A1.0631.00
99_S211_P1.0591.00
180_E184_T1.0581.00
131_M138_Q1.0531.00
84_V88_M1.0431.00
163_L171_V1.0341.00
118_Y123_D1.0301.00
215_A219_K1.0221.00
49_D52_K1.0061.00
67_H81_Y1.0001.00
115_K189_G1.0001.00
185_N188_L0.9951.00
51_A64_F0.9941.00
49_D240_W0.9931.00
222_N226_A0.9931.00
83_A220_L0.9871.00
232_T236_I0.9871.00
46_F236_I0.9861.00
25_F62_C0.9811.00
52_K56_K0.9801.00
157_Q161_I0.9801.00
37_I41_N0.9791.00
113_A117_T0.9761.00
101_T220_L0.9751.00
102_T228_K0.9731.00
93_E96_K0.9621.00
73_I88_M0.9601.00
50_L233_Y0.9581.00
43_I48_I0.9411.00
164_K185_N0.9371.00
132_E135_T0.9331.00
139_K142_Q0.9321.00
158_N161_I0.9291.00
29_A43_I0.9261.00
221_N225_A0.9201.00
164_K187_Q0.9041.00
51_A62_C0.8991.00
54_L220_L0.8971.00
83_A209_V0.8951.00
57_Q232_T0.8921.00
32_P36_S0.8901.00
108_S175_T0.8851.00
100_F208_A0.8841.00
156_Y173_G0.8831.00
140_Y143_D0.8831.00
227_I232_T0.8821.00
95_S211_P0.8811.00
20_A24_N0.8811.00
13_F16_G0.8661.00
233_Y237_S0.8651.00
23_I83_A0.8621.00
37_I43_I0.8611.00
42_E52_K0.8591.00
234_Q237_S0.8591.00
92_P96_K0.8541.00
130_G159_A0.8511.00
107_N176_A0.8491.00
151_V162_D0.8451.00
77_K98_V0.8391.00
53_A223_A0.8361.00
51_A207_I0.8351.00
71_S75_S0.8341.00
91_T94_R0.8221.00
50_L227_I0.8191.00
124_L170_G0.8161.00
221_N224_L0.8151.00
122_A125_K0.8101.00
58_M219_K0.8071.00
46_F233_Y0.8001.00
84_V208_A0.7981.00
215_A218_E0.7961.00
13_F17_A0.7951.00
27_V64_F0.7931.00
23_I60_A0.7931.00
24_N82_D0.7881.00
89_D203_T0.7861.00
235_K238_D0.7841.00
106_E202_G0.7821.00
226_A229_A0.7771.00
227_I230_D0.7771.00
17_A20_A0.7751.00
51_A83_A0.7741.00
125_K147_E0.7721.00
69_F72_L0.7701.00
235_K239_Q0.7691.00
83_A207_I0.7671.00
22_K60_A0.7651.00
34_F105_Y0.7611.00
57_Q227_I0.7581.00
111_V172_F0.7551.00
54_L58_M0.7491.00
23_I55_C0.7481.00
73_I77_K0.7451.00
213_N216_L0.7401.00
164_K189_G0.7371.00
90_I103_P0.7311.00
27_V48_I0.7231.00
52_K62_C0.7201.00
17_A21_E0.7201.00
222_N225_A0.7171.00
142_Q150_T0.7161.00
180_E183_K0.7101.00
54_L85_I0.7091.00
151_V168_I0.7071.00
27_V86_S0.7071.00
107_N175_T0.7031.00
141_I150_T0.7021.00
145_H148_V0.7001.00
101_T207_I0.6991.00
158_N162_D0.6981.00
227_I233_Y0.6981.00
76_L98_V0.6951.00
218_E221_N0.6911.00
71_S74_P0.6911.00
160_F164_K0.6901.00
53_A236_I0.6891.00
179_N183_K0.6891.00
65_T80_K0.6891.00
14_T18_S0.6881.00
25_F64_F0.6861.00
79_R212_D0.6831.00
44_V240_W0.6771.00
108_S201_F0.6741.00
67_H72_L0.6741.00
110_V178_V0.6741.00
38_G41_N0.6741.00
227_I231_G0.6701.00
103_P106_E0.6701.00
76_L81_Y0.6691.00
36_S240_W0.6671.00
130_G162_D0.6661.00
225_A228_K0.6631.00
101_T209_V0.6581.00
48_I64_F0.6581.00
18_S21_E0.6551.00
76_L84_V0.6541.00
26_G72_L0.6541.00
65_T81_Y0.6531.00
76_L210_R0.6521.00
94_R100_F0.6521.00
58_M216_L0.6471.00
17_A60_A0.6461.00
99_S213_N0.6401.00
128_R168_I0.6361.00
50_L224_L0.6311.00
116_D166_G0.6291.00
28_S69_F0.6281.00
153_Y168_I0.6281.00
55_C58_M0.6271.00
186_P189_G0.6261.00
108_S199_Q0.6251.00
16_G19_A0.6221.00
77_K210_R0.6201.00
109_A172_F0.6191.00
100_F206_G0.6171.00
108_S202_G0.6171.00
28_S35_E0.6161.00
112_I160_F0.6121.00
55_C60_A0.6121.00
51_A55_C0.6101.00
111_V124_L0.6091.00
164_K188_L0.6081.00
132_E156_Y0.6061.00
69_F88_M0.6041.00
227_I236_I0.6031.00
141_I172_F0.6021.00
88_M98_V0.5991.00
29_A37_I0.5991.00
207_I220_L0.5941.00
90_I100_F0.5931.00
47_D87_G0.5911.00
28_S132_E0.5891.00
29_A35_E0.5881.00
129_I141_I0.5871.00
31_Y87_G0.5861.00
39_A44_V0.5821.00
173_G177_V0.5811.00
187_Q190_V0.5801.00
89_D94_R0.5791.00
31_Y69_F0.5771.00
117_T169_D0.5771.00
231_G234_Q0.5771.00
27_V43_I0.5761.00
32_P184_T0.5761.00
101_T224_L0.5761.00
57_Q219_K0.5741.00
136_T203_T0.5741.00
197_D200_Y0.5731.00
131_M152_S0.5721.00
49_D236_I0.5721.00
23_I216_L0.5661.00
178_V182_L0.5641.00
26_G84_V0.5621.00
65_T75_S0.5611.00
231_G235_K0.5581.00
101_T217_L0.5561.00
196_T199_Q0.5561.00
162_D165_N0.5511.00
89_D136_T0.5501.00
185_N189_G0.5501.00
105_Y205_L0.5471.00
56_K232_T0.5451.00
112_I182_L0.5451.00
13_F210_R0.5441.00
35_E86_S0.5431.00
209_V213_N0.5431.00
26_G75_S0.5361.00
107_N205_L0.5321.00
131_M150_T0.5301.00
151_V167_R0.5281.00
20_A82_D0.5271.00
236_I239_Q0.5251.00
181_W184_T0.5241.00
179_N182_L0.5241.00
110_V195_V0.5231.00
140_Y201_F0.5181.00
99_S209_V0.5131.00
26_G67_H0.5111.00
174_D177_V0.5101.00
69_F94_R0.5101.00
102_T224_L0.5081.00
182_L185_N0.5061.00
133_N138_Q0.5051.00
118_Y127_K0.5041.00
43_I66_N0.5031.00
141_I145_H0.5031.00
95_S99_S0.5021.00
40_N44_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kbrA 4 0.93 100 0.239 Contact Map
4powA 1 0.9095 100 0.239 Contact Map
3k4uA 5 0.9177 100 0.246 Contact Map
3hv1A 2 0.9794 100 0.25 Contact Map
2vhaA 2 0.9671 100 0.251 Contact Map
1xt8A 1 0.9218 100 0.252 Contact Map
1pb7A 1 0.9424 100 0.254 Contact Map
4ohnA 1 0.9588 100 0.257 Contact Map
2ieeA 1 0.9342 100 0.257 Contact Map
3i6vA 1 0.8724 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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