GREMLIN Database
ARTI - Putative ABC transporter arginine-binding protein 2
UniProt: P30859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11625
Length: 243 (224)
Sequences: 21080 (15099)
Seq/√Len: 1008.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A81_V3.6621.00
130_G168_I3.5691.00
22_T63_T3.5071.00
57_E226_K2.8421.00
153_Y162_D2.4211.00
90_I95_E2.4021.00
138_Q152_P2.3601.00
102_T225_E2.2671.00
24_R63_T2.2411.00
75_S81_V2.1861.00
90_I206_G2.1061.00
155_S158_N2.0831.00
55_C62_C2.0521.00
24_R65_S2.0521.00
138_Q142_M2.0411.00
22_T61_T2.0371.00
77_K97_Q2.0271.00
98_V208_A2.0201.00
38_D44_V1.9971.00
232_T235_T1.9861.00
53_A56_K1.9651.00
99_L217_Q1.9441.00
209_V217_Q1.9351.00
159_A171_V1.9311.00
92_P95_E1.9171.00
128_K151_V1.9011.00
234_E238_N1.8761.00
57_E223_A1.8691.00
225_E229_K1.8661.00
173_G178_V1.8591.00
217_Q221_N1.8231.00
162_D167_R1.8111.00
120_S123_Q1.7901.00
128_K149_T1.7641.00
25_F51_A1.7351.00
102_T221_N1.7211.00
209_V220_L1.7071.00
111_F178_V1.6701.00
53_A232_T1.6581.00
75_S80_R1.6441.00
85_M207_I1.6351.00
53_A57_E1.6091.00
53_A227_V1.5941.00
119_T123_Q1.5711.00
101_T221_N1.5681.00
106_D204_G1.5461.00
214_T218_Q1.5211.00
113_G166_G1.4991.00
140_F144_K1.4981.00
113_G116_G1.4811.00
133_N154_D1.4771.00
210_R213_N1.4761.00
67_Q75_S1.4531.00
57_E230_D1.4151.00
49_D239_K1.4111.00
37_I66_N1.4081.00
72_L84_V1.3931.00
25_F83_A1.3731.00
36_S44_V1.3691.00
54_L223_A1.3491.00
218_Q222_T1.3451.00
58_I223_A1.3301.00
15_L19_A1.3291.00
128_K169_D1.3291.00
175_T179_T1.3271.00
38_D42_Q1.3271.00
219_K222_T1.3251.00
99_L212_G1.3111.00
109_A175_T1.3061.00
139_K143_D1.3061.00
52_Q64_F1.2881.00
48_V52_Q1.2881.00
223_A226_K1.2711.00
51_A85_M1.2651.00
127_K169_D1.2641.00
29_A66_N1.2581.00
88_M208_A1.2461.00
162_D168_I1.2411.00
114_Q187_K1.2341.00
73_I98_V1.2291.00
142_M152_P1.2081.00
130_G153_Y1.2041.00
164_Q187_K1.2041.00
16_S20_A1.1961.00
74_P77_K1.1931.00
79_R210_R1.1891.00
163_L188_L1.1711.00
46_F237_Y1.1701.00
223_A227_V1.1691.00
129_V170_G1.1651.00
112_V170_G1.1631.00
228_K233_Y1.1631.00
219_K223_A1.1471.00
114_Q189_A1.1451.00
60_A219_K1.1441.00
47_D104_Y1.1431.00
161_L164_Q1.1401.00
161_L165_N1.1291.00
99_L214_T1.1281.00
226_K230_D1.1161.00
115_Q189_A1.1101.00
153_Y159_A1.0901.00
74_P78_F1.0871.00
154_D158_N1.0811.00
21_E60_A1.0781.00
110_L170_G1.0781.00
131_V138_Q1.0761.00
84_V88_M1.0741.00
99_L211_Q1.0711.00
15_L18_T1.0701.00
133_N152_P1.0491.00
214_T217_Q1.0461.00
163_L171_V1.0461.00
46_F236_I1.0361.00
163_L168_I1.0291.00
68_A71_S1.0241.00
51_A64_F1.0181.00
67_Q81_V1.0091.00
44_V49_D1.0071.00
180_E184_D1.0041.00
37_I41_N1.0011.00
93_E96_K0.9971.00
12_G215_E0.9841.00
50_L233_Y0.9841.00
57_E232_T0.9791.00
83_A220_L0.9781.00
109_A190_A0.9721.00
49_D52_Q0.9721.00
25_F62_C0.9721.00
145_H148_I0.9721.00
73_I88_M0.9701.00
215_E219_K0.9661.00
101_T220_L0.9641.00
222_T226_K0.9531.00
132_Q135_T0.9521.00
130_G159_A0.9471.00
112_V191_V0.9461.00
139_K142_M0.9431.00
52_Q56_K0.9381.00
102_T228_K0.9381.00
51_A62_C0.9341.00
43_I48_V0.9331.00
112_V116_G0.9321.00
221_N225_E0.9281.00
232_T236_I0.9231.00
83_A209_V0.9131.00
227_V232_T0.9121.00
151_V162_D0.9121.00
157_Q161_L0.9111.00
158_N161_L0.9041.00
100_F208_A0.9011.00
164_Q185_N0.8981.00
54_L220_L0.8831.00
77_K98_V0.8791.00
20_A24_R0.8771.00
91_T94_R0.8761.00
49_D240_W0.8701.00
118_Y123_Q0.8681.00
50_L227_V0.8651.00
32_P36_S0.8631.00
108_S175_T0.8571.00
42_Q52_Q0.8551.00
13_F16_S0.8511.00
221_N224_L0.8451.00
140_F143_D0.8441.00
71_S75_S0.8401.00
92_P96_K0.8391.00
17_A21_E0.8371.00
233_Y237_Y0.8351.00
95_E211_Q0.8341.00
156_Y173_G0.8331.00
46_F233_Y0.8311.00
29_A43_I0.8301.00
17_A60_A0.8301.00
89_D203_T0.8261.00
14_S17_A0.8261.00
37_I43_I0.8251.00
107_N176_A0.8211.00
234_E237_Y0.8201.00
23_I60_A0.8181.00
12_G16_S0.8121.00
235_T238_N0.8091.00
51_A207_I0.8041.00
12_G15_L0.8031.00
27_T64_F0.8021.00
23_I83_A0.7971.00
84_V208_A0.7961.00
69_F72_L0.7901.00
53_A223_A0.7861.00
227_V230_D0.7841.00
58_I219_K0.7831.00
124_L170_G0.7731.00
18_T21_E0.7721.00
51_A83_A0.7661.00
17_A20_A0.7651.00
34_F105_Y0.7591.00
215_E218_Q0.7521.00
57_E227_V0.7511.00
83_A207_I0.7511.00
24_R82_E0.7491.00
73_I77_K0.7481.00
117_K189_A0.7461.00
226_K229_K0.7391.00
111_F188_L0.7351.00
22_T60_A0.7341.00
122_D125_K0.7331.00
54_L58_I0.7311.00
23_I55_C0.7241.00
110_L172_F0.7241.00
227_V231_G0.7231.00
112_V189_A0.7191.00
235_T239_K0.7121.00
76_L98_V0.7111.00
151_V168_I0.7081.00
107_N175_T0.7061.00
101_T207_I0.7051.00
222_T225_E0.7041.00
227_V233_Y0.6981.00
27_T48_V0.6981.00
52_Q62_C0.6981.00
14_S18_T0.6891.00
65_S80_R0.6881.00
158_N162_D0.6851.00
142_M150_T0.6841.00
179_T183_K0.6831.00
53_A236_I0.6811.00
130_G162_D0.6791.00
76_L84_V0.6761.00
76_L81_V0.6751.00
71_S74_P0.6741.00
141_I150_T0.6651.00
94_R100_F0.6631.00
79_R212_G0.6581.00
67_Q72_L0.6571.00
160_K164_Q0.6561.00
28_E35_E0.6551.00
25_F64_F0.6531.00
26_A72_L0.6471.00
103_P106_D0.6451.00
13_F17_A0.6421.00
54_L85_M0.6391.00
207_I220_L0.6381.00
90_I103_P0.6351.00
14_S20_A0.6351.00
27_T86_A0.6351.00
225_E228_K0.6331.00
213_N216_L0.6301.00
128_K168_I0.6301.00
180_E183_K0.6271.00
125_K147_E0.6271.00
101_T209_V0.6251.00
218_Q221_N0.6231.00
33_P36_S0.6221.00
99_L213_N0.6191.00
65_S81_V0.6181.00
36_S240_W0.6161.00
48_V64_F0.6161.00
44_V240_W0.6151.00
51_A55_C0.6131.00
55_C58_I0.6111.00
50_L224_L0.6111.00
143_D146_P0.6101.00
31_Y69_F0.6101.00
89_D94_R0.6061.00
113_G187_K0.6051.00
28_E69_F0.6041.00
88_M98_V0.6031.00
69_F94_R0.5991.00
28_E132_Q0.5941.00
178_V182_L0.5941.00
106_D197_D0.5921.00
69_F88_M0.5911.00
100_F206_G0.5911.00
31_Y87_G0.5891.00
55_C60_A0.5831.00
153_Y168_I0.5811.00
58_I216_L0.5801.00
77_K210_R0.5791.00
47_D87_G0.5741.00
109_A178_V0.5721.00
141_I172_F0.5711.00
179_T190_A0.5711.00
188_L191_V0.5701.00
32_P184_D0.5641.00
16_S19_A0.5631.00
101_T217_Q0.5631.00
110_L124_L0.5621.00
227_V236_I0.5621.00
76_L210_R0.5621.00
182_L185_N0.5621.00
27_T43_I0.5601.00
101_T224_L0.5601.00
90_I100_F0.5601.00
107_N205_L0.5601.00
29_A35_E0.5591.00
99_L209_V0.5581.00
35_E86_A0.5561.00
132_Q156_Y0.5541.00
136_T203_T0.5511.00
173_G177_V0.5511.00
108_S196_T0.5501.00
132_Q159_A0.5491.00
209_V213_N0.5491.00
111_F160_K0.5481.00
89_D136_T0.5481.00
181_W184_D0.5461.00
160_K188_L0.5461.00
131_V152_P0.5461.00
162_D165_N0.5451.00
105_Y205_L0.5421.00
181_W185_N0.5401.00
26_A67_Q0.5381.00
29_A37_I0.5371.00
231_G234_E0.5331.00
57_E219_K0.5321.00
144_K147_E0.5311.00
56_K232_T0.5311.00
231_G235_T0.5301.00
26_A84_V0.5281.00
164_Q188_L0.5281.00
115_Q166_G0.5271.00
13_F20_A0.5201.00
21_E219_K0.5161.00
116_G169_D0.5151.00
28_E86_A0.5151.00
182_L186_P0.5141.00
13_F210_R0.5121.00
109_A192_G0.5121.00
49_D236_I0.5091.00
141_I145_H0.5071.00
18_T219_K0.5051.00
133_N138_Q0.5051.00
102_T224_L0.5041.00
32_P180_E0.5031.00
111_F182_L0.5001.00
51_A54_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kbrA 4 0.9218 100 0.228 Contact Map
3delB 1 0.8889 100 0.237 Contact Map
4powA 1 0.9177 100 0.238 Contact Map
3hv1A 2 0.9671 100 0.238 Contact Map
1pb7A 1 0.9424 100 0.239 Contact Map
2y7iA 2 0.9342 100 0.241 Contact Map
4ohnA 1 0.9465 100 0.244 Contact Map
2vhaA 2 0.9547 100 0.245 Contact Map
3k4uA 5 0.9095 100 0.248 Contact Map
1xt8A 1 0.93 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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