SMF - ECOLI - GREMLIN Contacts

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SMF - Protein smf

UniProt:	P30852	Sequences: MVDTEIWLRLMSISSLYGDDMVRIAHWVAKQSHIDAVVLQQTGLTLRQAQRFLSFPRKSIESSLCWLEQPNHHLIPADSEFYPPQLLATTDYPGALFVEGELHALHSFQLAVVGSRAHSWYGERWGRLFCETLATRGVTITSGLARGIDGVAHKAALQVNGVSIAVLGNGLNTIHPRRHARLAASLLEQGGALVSEFPLDVPPLAYNFPRRNRIISGLSKGVLVVEAALRSGSLVTARCALEQGREVFALPGPIGNPGSEGPHWLIKQGAILVTEPEEILENLQFGLHWLPDAPENSFYSPDQQDVALPFPELLANVGDEVTPVDVVAERAGQPVPEVVTQLLELELAGWIAAVPGGYVRLRRACHVRRTNVFV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11604
Length:	374 (351)
Sequences:	3818 (3068)
Seq/√Len:	163.8

ECOLI - SMF
BACSU - SMF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
150_G	179_H	4.488	1.00
216_S	243_Q	4.085	1.00
172_N	200_D	3.573	1.00
146_R	178_R	3.194	1.00
253_P	256_N	2.832	1.00
163_S	186_L	2.767	1.00
144_L	183_A	2.639	1.00
165_A	186_L	2.626	1.00
271_I	282_N	2.620	1.00
98_V	192_A	2.583	1.00
109_Q	141_T	2.452	1.00
125_W	254_I	2.417	1.00
185_S	189_Q	2.367	1.00
154_K	185_S	2.282	1.00
313_L	341_Q	2.226	1.00
125_W	250_L	2.216	1.00
73_H	81_F	2.215	1.00
334_P	337_E	2.158	1.00
248_F	282_N	2.116	1.00
111_A	222_V	2.105	1.00
98_V	194_V	2.104	1.00
112_V	130_C	2.096	1.00
264_W	268_Q	2.087	1.00
127_R	158_Q	2.054	1.00
229_L	260_E	2.040	1.00
317_V	322_T	2.022	1.00
151_V	155_A	1.995	1.00
126_G	225_V	1.981	1.00
126_G	130_C	1.977	1.00
132_T	276_P	1.974	1.00
327_V	338_V	1.944	1.00
310_F	348_A	1.933	1.00
134_A	159_V	1.926	1.00
67_L	72_H	1.908	1.00
12_S	63_S	1.901	1.00
126_G	155_A	1.885	1.00
209_P	235_V	1.829	1.00
111_A	219_S	1.813	1.00
119_S	258_G	1.804	1.00
328_A	338_V	1.804	1.00
177_R	180_A	1.802	1.00
74_L	95_A	1.774	1.00
112_V	152_A	1.758	1.00
227_A	231_S	1.738	1.00
85_Q	220_K	1.733	1.00
118_H	148_I	1.722	1.00
229_L	264_W	1.716	1.00
221_G	248_F	1.711	1.00
183_A	193_L	1.709	1.00
76_P	79_S	1.704	1.00
129_F	223_L	1.695	1.00
21_M	94_G	1.673	1.00
61_E	65_C	1.665	1.00
166_V	214_I	1.641	1.00
267_K	274_T	1.638	1.00
323_P	326_V	1.632	1.00
197_F	210_R	1.620	1.00
166_V	218_L	1.615	1.00
150_G	182_L	1.615	1.00
97_F	198_P	1.597	1.00
89_T	243_Q	1.587	1.00
260_E	274_T	1.587	1.00
118_H	123_E	1.578	1.00
309_P	337_E	1.568	1.00
328_A	335_V	1.565	1.00
73_H	98_V	1.559	1.00
130_C	155_A	1.551	1.00
110_L	140_I	1.547	1.00
171_L	195_S	1.542	1.00
115_S	118_H	1.542	1.00
317_V	351_I	1.541	1.00
316_N	331_A	1.540	1.00
225_V	250_L	1.537	1.00
310_F	344_E	1.534	1.00
174_I	183_A	1.529	1.00
134_A	161_G	1.523	1.00
180_A	184_A	1.512	1.00
30_K	33_H	1.512	1.00
65_C	68_E	1.508	1.00
252_G	259_S	1.493	1.00
181_R	185_S	1.480	1.00
104_A	192_A	1.470	1.00
249_A	262_P	1.451	1.00
267_K	278_E	1.437	1.00
222_V	240_A	1.434	1.00
185_S	188_E	1.431	1.00
216_S	236_T	1.429	1.00
99_E	187_L	1.423	1.00
346_E	353_A	1.410	1.00
307_A	310_F	1.407	1.00
66_W	70_P	1.394	1.00
155_A	159_V	1.385	1.00
101_E	162_V	1.381	1.00
266_I	272_L	1.376	1.00
130_C	134_A	1.366	1.00
354_V	360_R	1.365	1.00
223_L	273_V	1.362	1.00
249_A	266_I	1.353	1.00
101_E	105_L	1.349	1.00
322_T	330_R	1.345	1.00
197_F	207_N	1.344	1.00
110_L	223_L	1.342	1.00
158_Q	185_S	1.341	1.00
217_G	243_Q	1.339	1.00
139_T	162_V	1.334	1.00
72_H	99_E	1.327	1.00
204_L	207_N	1.320	1.00
240_A	247_V	1.317	1.00
127_R	154_K	1.301	1.00
219_S	222_V	1.300	1.00
164_I	192_A	1.286	1.00
16_L	20_D	1.279	1.00
263_H	274_T	1.279	1.00
5_E	61_E	1.278	1.00
75_I	98_V	1.275	1.00
256_N	259_S	1.274	1.00
89_T	217_G	1.264	1.00
131_E	158_Q	1.261	1.00
139_T	164_I	1.248	1.00
169_N	174_I	1.242	1.00
121_Y	254_I	1.228	1.00
78_D	87_L	1.227	1.00
17_Y	20_D	1.222	1.00
144_L	165_A	1.217	1.00
32_S	36_A	1.217	1.00
138_V	280_L	1.207	1.00
28_V	37_V	1.207	1.00
264_W	267_K	1.204	1.00
67_L	74_L	1.204	1.00
6_I	32_S	1.204	1.00
181_R	184_A	1.202	1.00
110_L	133_L	1.202	1.00
113_V	237_A	1.201	1.00
311_P	315_A	1.201	1.00
221_G	273_V	1.196	1.00
223_L	250_L	1.187	1.00
167_L	193_L	1.186	1.00
119_S	226_E	1.180	1.00
5_E	60_I	1.180	1.00
223_L	279_I	1.176	1.00
125_W	255_G	1.174	1.00
123_E	151_V	1.165	1.00
246_E	283_L	1.161	1.00
84_P	87_L	1.159	1.00
153_H	163_S	1.154	1.00
89_T	92_Y	1.150	1.00
14_S	17_Y	1.150	1.00
107_S	139_T	1.145	1.00
22_V	26_H	1.141	1.00
7_W	76_P	1.140	1.00
62_S	65_C	1.138	1.00
118_H	151_V	1.131	1.00
112_V	223_L	1.127	1.00
171_L	193_L	1.125	1.00
6_I	9_R	1.122	1.00
344_E	348_A	1.119	1.00
75_I	81_F	1.118	1.00
38_V	41_Q	1.108	1.00
115_S	233_S	1.107	1.00
133_L	279_I	1.099	1.00
184_A	188_E	1.096	1.00
129_F	276_P	1.094	1.00
63_S	199_L	1.092	1.00
66_W	72_H	1.089	1.00
144_L	193_L	1.089	1.00
85_Q	88_A	1.086	1.00
65_C	69_Q	1.085	1.00
238_R	242_E	1.084	1.00
91_D	239_C	1.084	1.00
308_L	311_P	1.084	1.00
248_F	279_I	1.071	0.99
331_A	338_V	1.069	0.99
72_H	171_L	1.067	0.99
168_G	207_N	1.062	0.99
328_A	331_A	1.058	0.99
170_G	203_P	1.057	0.99
77_A	87_L	1.055	0.99
235_V	239_C	1.050	0.99
84_P	88_A	1.049	0.99
324_V	338_V	1.048	0.99
313_L	327_V	1.034	0.99
7_W	78_D	1.024	0.99
109_Q	139_T	1.023	0.99
196_E	213_R	1.022	0.99
140_I	152_A	1.019	0.99
89_T	216_S	1.015	0.99
277_E	281_E	1.013	0.99
72_H	199_L	1.011	0.99
98_V	102_L	1.010	0.99
130_C	140_I	1.007	0.99
121_Y	125_W	1.005	0.99
131_E	135_T	1.003	0.99
127_R	155_A	1.003	0.99
64_L	68_E	1.003	0.99
59_S	62_S	1.002	0.99
45_T	48_Q	0.999	0.99
259_S	262_P	0.996	0.99
144_L	167_L	0.992	0.99
273_V	279_I	0.989	0.99
248_F	273_V	0.986	0.99
274_T	278_E	0.983	0.99
167_L	171_L	0.982	0.99
333_Q	338_V	0.982	0.99
31_Q	34_I	0.982	0.99
216_S	222_V	0.975	0.99
129_F	250_L	0.975	0.99
237_A	265_L	0.971	0.99
324_V	328_A	0.966	0.99
11_M	97_F	0.960	0.99
234_L	237_A	0.958	0.99
326_V	330_R	0.952	0.99
128_L	132_T	0.950	0.99
121_Y	259_S	0.948	0.99
267_K	271_I	0.946	0.99
29_A	33_H	0.944	0.99
39_L	43_G	0.942	0.99
111_A	215_I	0.936	0.99
263_H	272_L	0.930	0.99
148_I	225_V	0.929	0.98
169_N	203_P	0.927	0.98
141_T	219_S	0.923	0.98
51_R	54_S	0.920	0.98
77_A	92_Y	0.917	0.98
171_L	183_A	0.913	0.98
134_A	155_A	0.912	0.98
201_V	207_N	0.910	0.98
310_F	341_Q	0.908	0.98
144_L	186_L	0.897	0.98
33_H	36_A	0.896	0.98
91_D	243_Q	0.893	0.98
67_L	97_F	0.892	0.98
140_I	156_A	0.888	0.98
173_T	202_P	0.887	0.98
88_A	245_R	0.887	0.98
136_R	277_E	0.883	0.98
306_V	310_F	0.881	0.98
233_S	237_A	0.876	0.98
81_F	102_L	0.876	0.98
66_W	69_Q	0.873	0.98
133_L	140_I	0.870	0.98
306_V	311_P	0.868	0.98
127_R	151_V	0.864	0.98
56_P	59_S	0.863	0.98
42_T	45_T	0.860	0.98
124_R	255_G	0.857	0.97
150_G	154_K	0.855	0.97
129_F	273_V	0.854	0.97
322_T	326_V	0.853	0.97
246_E	271_I	0.853	0.97
75_I	79_S	0.852	0.97
17_Y	206_Y	0.851	0.97
124_R	128_L	0.851	0.97
164_I	194_V	0.847	0.97
322_T	327_V	0.847	0.97
126_G	151_V	0.845	0.97
29_A	34_I	0.843	0.97
74_L	97_F	0.840	0.97
99_E	171_L	0.839	0.97
271_I	281_E	0.839	0.97
110_L	221_G	0.838	0.97
28_V	34_I	0.838	0.97
107_S	162_V	0.836	0.97
227_A	234_L	0.834	0.97
103_H	192_A	0.834	0.97
256_N	263_H	0.832	0.97
343_L	347_L	0.826	0.97
131_E	159_V	0.825	0.97
306_V	350_W	0.825	0.97
169_N	197_F	0.825	0.97
306_V	348_A	0.821	0.97
353_A	356_G	0.820	0.97
77_A	82_Y	0.820	0.97
8_L	97_F	0.816	0.97
249_A	270_A	0.814	0.97
25_A	31_Q	0.810	0.96
130_C	161_G	0.809	0.96
263_H	266_I	0.802	0.96
86_L	214_I	0.801	0.96
228_A	233_S	0.795	0.96
58_K	61_E	0.795	0.96
85_Q	245_R	0.795	0.96
226_E	259_S	0.794	0.96
339_V	343_L	0.792	0.96
76_P	95_A	0.790	0.96
160_N	189_Q	0.789	0.96
169_N	173_T	0.789	0.96
120_W	124_R	0.789	0.96
241_L	244_G	0.786	0.96
168_G	209_P	0.786	0.96
124_R	127_R	0.785	0.96
73_H	102_L	0.785	0.96
7_W	21_M	0.783	0.96
237_A	247_V	0.780	0.96
238_R	268_Q	0.777	0.95
136_R	280_L	0.777	0.95
306_V	314_L	0.777	0.95
207_N	210_R	0.775	0.95
108_F	220_K	0.774	0.95
168_G	197_F	0.772	0.95
132_T	135_T	0.769	0.95
67_L	199_L	0.767	0.95
101_E	104_A	0.766	0.95
39_L	42_T	0.763	0.95
99_E	184_A	0.760	0.95
16_L	21_M	0.758	0.95
123_E	154_K	0.757	0.95
165_A	183_A	0.755	0.95
63_S	67_L	0.755	0.95
123_E	127_R	0.754	0.95
173_T	183_A	0.754	0.95
309_P	312_E	0.754	0.95
109_Q	219_S	0.752	0.95
239_C	242_E	0.745	0.94
86_L	217_G	0.744	0.94
115_S	228_A	0.744	0.94
221_G	282_N	0.743	0.94
264_W	274_T	0.741	0.94
262_P	266_I	0.741	0.94
121_Y	255_G	0.738	0.94
9_R	35_D	0.738	0.94
49_A	52_F	0.737	0.94
172_N	201_V	0.733	0.94
224_V	249_A	0.732	0.94
221_G	279_I	0.731	0.94
173_T	200_D	0.730	0.94
24_I	34_I	0.729	0.94
30_K	34_I	0.729	0.94
120_W	123_E	0.728	0.94
8_L	74_L	0.726	0.94
198_P	201_V	0.726	0.94
104_A	162_V	0.724	0.93
352_A	360_R	0.722	0.93
44_L	49_A	0.721	0.93
113_V	233_S	0.719	0.93
307_A	312_E	0.718	0.93
41_Q	45_T	0.716	0.93
221_G	271_I	0.716	0.93
248_F	271_I	0.716	0.93
21_M	34_I	0.711	0.93
46_L	50_Q	0.709	0.93
324_V	357_G	0.708	0.93
224_V	237_A	0.706	0.93
42_T	46_L	0.704	0.92
249_A	252_G	0.704	0.92
354_V	357_G	0.703	0.92
85_Q	109_Q	0.702	0.92
354_V	359_V	0.701	0.92
119_S	259_S	0.700	0.92
308_L	312_E	0.699	0.92
275_E	278_E	0.699	0.92
235_V	238_R	0.696	0.92
187_L	193_L	0.696	0.92
175_H	203_P	0.693	0.92
154_K	158_Q	0.693	0.92
309_P	341_Q	0.692	0.92
119_S	256_N	0.691	0.92
7_W	31_Q	0.689	0.92
103_H	106_H	0.688	0.92
121_Y	253_P	0.688	0.92
102_L	105_L	0.687	0.92
62_S	66_W	0.687	0.92
131_E	155_A	0.682	0.91
141_T	215_I	0.682	0.91
67_L	71_N	0.680	0.91
234_L	265_L	0.678	0.91
334_P	338_V	0.677	0.91
20_D	23_R	0.668	0.90
314_L	350_W	0.668	0.90
53_L	56_P	0.668	0.90
176_P	179_H	0.667	0.90
22_V	77_A	0.667	0.90
333_Q	337_E	0.665	0.90
255_G	260_E	0.665	0.90
209_P	227_A	0.664	0.90
66_W	199_L	0.664	0.90
97_F	199_L	0.662	0.90
117_A	258_G	0.662	0.90
121_Y	256_N	0.662	0.90
126_G	148_I	0.660	0.90
40_Q	43_G	0.658	0.90
49_A	53_L	0.656	0.90
203_P	207_N	0.656	0.90
135_T	159_V	0.655	0.90
215_I	236_T	0.649	0.89
63_S	66_W	0.647	0.89
257_P	260_E	0.643	0.89
50_Q	53_L	0.636	0.88
105_L	192_A	0.636	0.88
249_A	259_S	0.635	0.88
250_L	254_I	0.634	0.88
42_T	47_R	0.634	0.88
84_P	106_H	0.634	0.88
45_T	49_A	0.632	0.88
252_G	263_H	0.631	0.88
141_T	164_I	0.629	0.88
48_Q	52_F	0.628	0.87
82_Y	87_L	0.628	0.87
335_V	339_V	0.628	0.87
316_N	327_V	0.627	0.87
155_A	161_G	0.625	0.87
134_A	156_A	0.625	0.87
173_T	177_R	0.624	0.87
168_G	195_S	0.624	0.87
318_G	322_T	0.623	0.87
18_G	210_R	0.622	0.87
13_I	52_F	0.622	0.87
354_V	358_Y	0.622	0.87
314_L	322_T	0.619	0.87
186_L	191_G	0.617	0.87
168_G	235_V	0.615	0.86
231_S	269_G	0.613	0.86
197_F	201_V	0.612	0.86
63_S	97_F	0.611	0.86
18_G	94_G	0.611	0.86
271_I	278_E	0.610	0.86
118_H	258_G	0.609	0.86
28_V	35_D	0.608	0.86
313_L	338_V	0.607	0.86
353_A	357_G	0.605	0.85
313_L	345_L	0.605	0.85
126_G	152_A	0.604	0.85
81_F	103_H	0.600	0.85
10_L	34_I	0.598	0.85
102_L	106_H	0.592	0.84
337_E	341_Q	0.592	0.84
221_G	246_E	0.591	0.84
22_V	92_Y	0.589	0.84
40_Q	44_L	0.588	0.84
314_L	317_V	0.587	0.84
314_L	345_L	0.585	0.84
278_E	281_E	0.583	0.83
115_S	258_G	0.583	0.83
134_A	160_N	0.583	0.83
224_V	233_S	0.580	0.83
221_G	283_L	0.580	0.83
13_I	34_I	0.577	0.83
25_A	33_H	0.577	0.83
126_G	134_A	0.576	0.83
182_L	186_L	0.576	0.83
6_I	35_D	0.575	0.82
248_F	283_L	0.573	0.82
130_C	151_V	0.573	0.82
144_L	174_I	0.572	0.82
259_S	263_H	0.571	0.82
129_F	132_T	0.571	0.82
105_L	164_I	0.570	0.82
25_A	29_A	0.568	0.82
20_D	46_L	0.567	0.82
171_L	199_L	0.566	0.82
125_W	129_F	0.566	0.82
168_G	202_P	0.565	0.81
153_H	165_A	0.564	0.81
138_V	285_F	0.561	0.81
316_N	330_R	0.560	0.81
96_L	194_V	0.560	0.81
227_A	262_P	0.559	0.81
88_A	244_G	0.558	0.81
252_G	262_P	0.558	0.81
82_Y	214_I	0.557	0.80
17_Y	21_M	0.557	0.80
58_K	62_S	0.555	0.80
323_P	359_V	0.555	0.80
209_P	269_G	0.554	0.80
279_I	283_L	0.553	0.80
307_A	341_Q	0.553	0.80
122_G	252_G	0.551	0.80
43_G	50_Q	0.550	0.80
31_Q	35_D	0.548	0.79
315_A	333_Q	0.548	0.79
231_S	234_L	0.547	0.79
139_T	156_A	0.547	0.79
44_L	48_Q	0.546	0.79
167_L	195_S	0.546	0.79
22_V	25_A	0.546	0.79
216_S	239_C	0.545	0.79
117_A	228_A	0.544	0.79
11_M	21_M	0.544	0.79
8_L	11_M	0.544	0.79
321_V	354_V	0.543	0.79
340_T	344_E	0.542	0.79
52_F	55_F	0.542	0.79
34_I	39_L	0.541	0.79
133_L	276_P	0.540	0.78
108_F	138_V	0.540	0.78
152_A	156_A	0.539	0.78
20_D	48_Q	0.539	0.78
33_H	37_V	0.538	0.78
128_L	255_G	0.538	0.78
129_F	279_I	0.536	0.78
38_V	42_T	0.533	0.78
194_V	215_I	0.532	0.77
9_R	34_I	0.532	0.77
318_G	360_R	0.531	0.77
55_F	60_I	0.529	0.77
267_K	272_L	0.529	0.77
142_S	149_D	0.528	0.77
156_A	161_G	0.525	0.76
167_L	183_A	0.524	0.76
25_A	34_I	0.524	0.76
5_E	64_L	0.523	0.76
334_P	341_Q	0.523	0.76
169_N	183_A	0.522	0.76
241_L	246_E	0.521	0.76
20_D	45_T	0.521	0.76
121_Y	274_T	0.520	0.76
317_V	327_V	0.519	0.76
30_K	37_V	0.518	0.76
210_R	239_C	0.518	0.76
183_A	195_S	0.517	0.75
339_V	344_E	0.517	0.75
17_Y	23_R	0.517	0.75
307_A	311_P	0.515	0.75
142_S	153_H	0.514	0.75
302_D	308_L	0.514	0.75
154_K	181_R	0.514	0.75
107_S	194_V	0.514	0.75
11_M	95_A	0.511	0.75
276_P	279_I	0.510	0.74
89_T	214_I	0.507	0.74
25_A	94_G	0.506	0.74
133_L	138_V	0.504	0.74
51_R	55_F	0.502	0.73
115_S	227_A	0.502	0.73
19_D	91_D	0.501	0.73
136_R	276_P	0.501	0.73
324_V	339_V	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3majA	2	0.9198	100	0.182	Contact Map
3uqzA	2	0.7433	100	0.349	Contact Map
4ljrA	2	0.5642	100	0.443	Contact Map
3quaA	2	0.4225	100	0.663	Contact Map
2iz6A	4	0.4064	100	0.715	Contact Map
1rcuA	3	0.4144	100	0.716	Contact Map
1wekA	5	0.5241	100	0.727	Contact Map
1wehA	1	0.4064	100	0.727	Contact Map
3sbxA	2	0.4251	100	0.74	Contact Map
1t35A	5	0.4358	100	0.749	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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