GREMLIN Database
SMF - Protein smf
UniProt: P30852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11604
Length: 374 (351)
Sequences: 3818 (3068)
Seq/√Len: 163.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_G179_H4.4881.00
216_S243_Q4.0851.00
172_N200_D3.5731.00
146_R178_R3.1941.00
253_P256_N2.8321.00
163_S186_L2.7671.00
144_L183_A2.6391.00
165_A186_L2.6261.00
271_I282_N2.6201.00
98_V192_A2.5831.00
109_Q141_T2.4521.00
125_W254_I2.4171.00
185_S189_Q2.3671.00
154_K185_S2.2821.00
313_L341_Q2.2261.00
125_W250_L2.2161.00
73_H81_F2.2151.00
334_P337_E2.1581.00
248_F282_N2.1161.00
111_A222_V2.1051.00
98_V194_V2.1041.00
112_V130_C2.0961.00
264_W268_Q2.0871.00
127_R158_Q2.0541.00
229_L260_E2.0401.00
317_V322_T2.0221.00
151_V155_A1.9951.00
126_G225_V1.9811.00
126_G130_C1.9771.00
132_T276_P1.9741.00
327_V338_V1.9441.00
310_F348_A1.9331.00
134_A159_V1.9261.00
67_L72_H1.9081.00
12_S63_S1.9011.00
126_G155_A1.8851.00
209_P235_V1.8291.00
111_A219_S1.8131.00
119_S258_G1.8041.00
328_A338_V1.8041.00
177_R180_A1.8021.00
74_L95_A1.7741.00
112_V152_A1.7581.00
227_A231_S1.7381.00
85_Q220_K1.7331.00
118_H148_I1.7221.00
229_L264_W1.7161.00
221_G248_F1.7111.00
183_A193_L1.7091.00
76_P79_S1.7041.00
129_F223_L1.6951.00
21_M94_G1.6731.00
61_E65_C1.6651.00
166_V214_I1.6411.00
267_K274_T1.6381.00
323_P326_V1.6321.00
197_F210_R1.6201.00
166_V218_L1.6151.00
150_G182_L1.6151.00
97_F198_P1.5971.00
89_T243_Q1.5871.00
260_E274_T1.5871.00
118_H123_E1.5781.00
309_P337_E1.5681.00
328_A335_V1.5651.00
73_H98_V1.5591.00
130_C155_A1.5511.00
110_L140_I1.5471.00
171_L195_S1.5421.00
115_S118_H1.5421.00
317_V351_I1.5411.00
316_N331_A1.5401.00
225_V250_L1.5371.00
310_F344_E1.5341.00
174_I183_A1.5291.00
134_A161_G1.5231.00
180_A184_A1.5121.00
30_K33_H1.5121.00
65_C68_E1.5081.00
252_G259_S1.4931.00
181_R185_S1.4801.00
104_A192_A1.4701.00
249_A262_P1.4511.00
267_K278_E1.4371.00
222_V240_A1.4341.00
185_S188_E1.4311.00
216_S236_T1.4291.00
99_E187_L1.4231.00
346_E353_A1.4101.00
307_A310_F1.4071.00
66_W70_P1.3941.00
155_A159_V1.3851.00
101_E162_V1.3811.00
266_I272_L1.3761.00
130_C134_A1.3661.00
354_V360_R1.3651.00
223_L273_V1.3621.00
249_A266_I1.3531.00
101_E105_L1.3491.00
322_T330_R1.3451.00
197_F207_N1.3441.00
110_L223_L1.3421.00
158_Q185_S1.3411.00
217_G243_Q1.3391.00
139_T162_V1.3341.00
72_H99_E1.3271.00
204_L207_N1.3201.00
240_A247_V1.3171.00
127_R154_K1.3011.00
219_S222_V1.3001.00
164_I192_A1.2861.00
16_L20_D1.2791.00
263_H274_T1.2791.00
5_E61_E1.2781.00
75_I98_V1.2751.00
256_N259_S1.2741.00
89_T217_G1.2641.00
131_E158_Q1.2611.00
139_T164_I1.2481.00
169_N174_I1.2421.00
121_Y254_I1.2281.00
78_D87_L1.2271.00
17_Y20_D1.2221.00
144_L165_A1.2171.00
32_S36_A1.2171.00
138_V280_L1.2071.00
28_V37_V1.2071.00
264_W267_K1.2041.00
67_L74_L1.2041.00
6_I32_S1.2041.00
181_R184_A1.2021.00
110_L133_L1.2021.00
113_V237_A1.2011.00
311_P315_A1.2011.00
221_G273_V1.1961.00
223_L250_L1.1871.00
167_L193_L1.1861.00
119_S226_E1.1801.00
5_E60_I1.1801.00
223_L279_I1.1761.00
125_W255_G1.1741.00
123_E151_V1.1651.00
246_E283_L1.1611.00
84_P87_L1.1591.00
153_H163_S1.1541.00
89_T92_Y1.1501.00
14_S17_Y1.1501.00
107_S139_T1.1451.00
22_V26_H1.1411.00
7_W76_P1.1401.00
62_S65_C1.1381.00
118_H151_V1.1311.00
112_V223_L1.1271.00
171_L193_L1.1251.00
6_I9_R1.1221.00
344_E348_A1.1191.00
75_I81_F1.1181.00
38_V41_Q1.1081.00
115_S233_S1.1071.00
133_L279_I1.0991.00
184_A188_E1.0961.00
129_F276_P1.0941.00
63_S199_L1.0921.00
66_W72_H1.0891.00
144_L193_L1.0891.00
85_Q88_A1.0861.00
65_C69_Q1.0851.00
238_R242_E1.0841.00
91_D239_C1.0841.00
308_L311_P1.0841.00
248_F279_I1.0710.99
331_A338_V1.0690.99
72_H171_L1.0670.99
168_G207_N1.0620.99
328_A331_A1.0580.99
170_G203_P1.0570.99
77_A87_L1.0550.99
235_V239_C1.0500.99
84_P88_A1.0490.99
324_V338_V1.0480.99
313_L327_V1.0340.99
7_W78_D1.0240.99
109_Q139_T1.0230.99
196_E213_R1.0220.99
140_I152_A1.0190.99
89_T216_S1.0150.99
277_E281_E1.0130.99
72_H199_L1.0110.99
98_V102_L1.0100.99
130_C140_I1.0070.99
121_Y125_W1.0050.99
131_E135_T1.0030.99
127_R155_A1.0030.99
64_L68_E1.0030.99
59_S62_S1.0020.99
45_T48_Q0.9990.99
259_S262_P0.9960.99
144_L167_L0.9920.99
273_V279_I0.9890.99
248_F273_V0.9860.99
274_T278_E0.9830.99
167_L171_L0.9820.99
333_Q338_V0.9820.99
31_Q34_I0.9820.99
216_S222_V0.9750.99
129_F250_L0.9750.99
237_A265_L0.9710.99
324_V328_A0.9660.99
11_M97_F0.9600.99
234_L237_A0.9580.99
326_V330_R0.9520.99
128_L132_T0.9500.99
121_Y259_S0.9480.99
267_K271_I0.9460.99
29_A33_H0.9440.99
39_L43_G0.9420.99
111_A215_I0.9360.99
263_H272_L0.9300.99
148_I225_V0.9290.98
169_N203_P0.9270.98
141_T219_S0.9230.98
51_R54_S0.9200.98
77_A92_Y0.9170.98
171_L183_A0.9130.98
134_A155_A0.9120.98
201_V207_N0.9100.98
310_F341_Q0.9080.98
144_L186_L0.8970.98
33_H36_A0.8960.98
91_D243_Q0.8930.98
67_L97_F0.8920.98
140_I156_A0.8880.98
173_T202_P0.8870.98
88_A245_R0.8870.98
136_R277_E0.8830.98
306_V310_F0.8810.98
233_S237_A0.8760.98
81_F102_L0.8760.98
66_W69_Q0.8730.98
133_L140_I0.8700.98
306_V311_P0.8680.98
127_R151_V0.8640.98
56_P59_S0.8630.98
42_T45_T0.8600.98
124_R255_G0.8570.97
150_G154_K0.8550.97
129_F273_V0.8540.97
322_T326_V0.8530.97
246_E271_I0.8530.97
75_I79_S0.8520.97
17_Y206_Y0.8510.97
124_R128_L0.8510.97
164_I194_V0.8470.97
322_T327_V0.8470.97
126_G151_V0.8450.97
29_A34_I0.8430.97
74_L97_F0.8400.97
99_E171_L0.8390.97
271_I281_E0.8390.97
110_L221_G0.8380.97
28_V34_I0.8380.97
107_S162_V0.8360.97
227_A234_L0.8340.97
103_H192_A0.8340.97
256_N263_H0.8320.97
343_L347_L0.8260.97
131_E159_V0.8250.97
306_V350_W0.8250.97
169_N197_F0.8250.97
306_V348_A0.8210.97
353_A356_G0.8200.97
77_A82_Y0.8200.97
8_L97_F0.8160.97
249_A270_A0.8140.97
25_A31_Q0.8100.96
130_C161_G0.8090.96
263_H266_I0.8020.96
86_L214_I0.8010.96
228_A233_S0.7950.96
58_K61_E0.7950.96
85_Q245_R0.7950.96
226_E259_S0.7940.96
339_V343_L0.7920.96
76_P95_A0.7900.96
160_N189_Q0.7890.96
169_N173_T0.7890.96
120_W124_R0.7890.96
241_L244_G0.7860.96
168_G209_P0.7860.96
124_R127_R0.7850.96
73_H102_L0.7850.96
7_W21_M0.7830.96
237_A247_V0.7800.96
238_R268_Q0.7770.95
136_R280_L0.7770.95
306_V314_L0.7770.95
207_N210_R0.7750.95
108_F220_K0.7740.95
168_G197_F0.7720.95
132_T135_T0.7690.95
67_L199_L0.7670.95
101_E104_A0.7660.95
39_L42_T0.7630.95
99_E184_A0.7600.95
16_L21_M0.7580.95
123_E154_K0.7570.95
165_A183_A0.7550.95
63_S67_L0.7550.95
123_E127_R0.7540.95
173_T183_A0.7540.95
309_P312_E0.7540.95
109_Q219_S0.7520.95
239_C242_E0.7450.94
86_L217_G0.7440.94
115_S228_A0.7440.94
221_G282_N0.7430.94
264_W274_T0.7410.94
262_P266_I0.7410.94
121_Y255_G0.7380.94
9_R35_D0.7380.94
49_A52_F0.7370.94
172_N201_V0.7330.94
224_V249_A0.7320.94
221_G279_I0.7310.94
173_T200_D0.7300.94
24_I34_I0.7290.94
30_K34_I0.7290.94
120_W123_E0.7280.94
8_L74_L0.7260.94
198_P201_V0.7260.94
104_A162_V0.7240.93
352_A360_R0.7220.93
44_L49_A0.7210.93
113_V233_S0.7190.93
307_A312_E0.7180.93
41_Q45_T0.7160.93
221_G271_I0.7160.93
248_F271_I0.7160.93
21_M34_I0.7110.93
46_L50_Q0.7090.93
324_V357_G0.7080.93
224_V237_A0.7060.93
42_T46_L0.7040.92
249_A252_G0.7040.92
354_V357_G0.7030.92
85_Q109_Q0.7020.92
354_V359_V0.7010.92
119_S259_S0.7000.92
308_L312_E0.6990.92
275_E278_E0.6990.92
235_V238_R0.6960.92
187_L193_L0.6960.92
175_H203_P0.6930.92
154_K158_Q0.6930.92
309_P341_Q0.6920.92
119_S256_N0.6910.92
7_W31_Q0.6890.92
103_H106_H0.6880.92
121_Y253_P0.6880.92
102_L105_L0.6870.92
62_S66_W0.6870.92
131_E155_A0.6820.91
141_T215_I0.6820.91
67_L71_N0.6800.91
234_L265_L0.6780.91
334_P338_V0.6770.91
20_D23_R0.6680.90
314_L350_W0.6680.90
53_L56_P0.6680.90
176_P179_H0.6670.90
22_V77_A0.6670.90
333_Q337_E0.6650.90
255_G260_E0.6650.90
209_P227_A0.6640.90
66_W199_L0.6640.90
97_F199_L0.6620.90
117_A258_G0.6620.90
121_Y256_N0.6620.90
126_G148_I0.6600.90
40_Q43_G0.6580.90
49_A53_L0.6560.90
203_P207_N0.6560.90
135_T159_V0.6550.90
215_I236_T0.6490.89
63_S66_W0.6470.89
257_P260_E0.6430.89
50_Q53_L0.6360.88
105_L192_A0.6360.88
249_A259_S0.6350.88
250_L254_I0.6340.88
42_T47_R0.6340.88
84_P106_H0.6340.88
45_T49_A0.6320.88
252_G263_H0.6310.88
141_T164_I0.6290.88
48_Q52_F0.6280.87
82_Y87_L0.6280.87
335_V339_V0.6280.87
316_N327_V0.6270.87
155_A161_G0.6250.87
134_A156_A0.6250.87
173_T177_R0.6240.87
168_G195_S0.6240.87
318_G322_T0.6230.87
18_G210_R0.6220.87
13_I52_F0.6220.87
354_V358_Y0.6220.87
314_L322_T0.6190.87
186_L191_G0.6170.87
168_G235_V0.6150.86
231_S269_G0.6130.86
197_F201_V0.6120.86
63_S97_F0.6110.86
18_G94_G0.6110.86
271_I278_E0.6100.86
118_H258_G0.6090.86
28_V35_D0.6080.86
313_L338_V0.6070.86
353_A357_G0.6050.85
313_L345_L0.6050.85
126_G152_A0.6040.85
81_F103_H0.6000.85
10_L34_I0.5980.85
102_L106_H0.5920.84
337_E341_Q0.5920.84
221_G246_E0.5910.84
22_V92_Y0.5890.84
40_Q44_L0.5880.84
314_L317_V0.5870.84
314_L345_L0.5850.84
278_E281_E0.5830.83
115_S258_G0.5830.83
134_A160_N0.5830.83
224_V233_S0.5800.83
221_G283_L0.5800.83
13_I34_I0.5770.83
25_A33_H0.5770.83
126_G134_A0.5760.83
182_L186_L0.5760.83
6_I35_D0.5750.82
248_F283_L0.5730.82
130_C151_V0.5730.82
144_L174_I0.5720.82
259_S263_H0.5710.82
129_F132_T0.5710.82
105_L164_I0.5700.82
25_A29_A0.5680.82
20_D46_L0.5670.82
171_L199_L0.5660.82
125_W129_F0.5660.82
168_G202_P0.5650.81
153_H165_A0.5640.81
138_V285_F0.5610.81
316_N330_R0.5600.81
96_L194_V0.5600.81
227_A262_P0.5590.81
88_A244_G0.5580.81
252_G262_P0.5580.81
82_Y214_I0.5570.80
17_Y21_M0.5570.80
58_K62_S0.5550.80
323_P359_V0.5550.80
209_P269_G0.5540.80
279_I283_L0.5530.80
307_A341_Q0.5530.80
122_G252_G0.5510.80
43_G50_Q0.5500.80
31_Q35_D0.5480.79
315_A333_Q0.5480.79
231_S234_L0.5470.79
139_T156_A0.5470.79
44_L48_Q0.5460.79
167_L195_S0.5460.79
22_V25_A0.5460.79
216_S239_C0.5450.79
117_A228_A0.5440.79
11_M21_M0.5440.79
8_L11_M0.5440.79
321_V354_V0.5430.79
340_T344_E0.5420.79
52_F55_F0.5420.79
34_I39_L0.5410.79
133_L276_P0.5400.78
108_F138_V0.5400.78
152_A156_A0.5390.78
20_D48_Q0.5390.78
33_H37_V0.5380.78
128_L255_G0.5380.78
129_F279_I0.5360.78
38_V42_T0.5330.78
194_V215_I0.5320.77
9_R34_I0.5320.77
318_G360_R0.5310.77
55_F60_I0.5290.77
267_K272_L0.5290.77
142_S149_D0.5280.77
156_A161_G0.5250.76
167_L183_A0.5240.76
25_A34_I0.5240.76
5_E64_L0.5230.76
334_P341_Q0.5230.76
169_N183_A0.5220.76
241_L246_E0.5210.76
20_D45_T0.5210.76
121_Y274_T0.5200.76
317_V327_V0.5190.76
30_K37_V0.5180.76
210_R239_C0.5180.76
183_A195_S0.5170.75
339_V344_E0.5170.75
17_Y23_R0.5170.75
307_A311_P0.5150.75
142_S153_H0.5140.75
302_D308_L0.5140.75
154_K181_R0.5140.75
107_S194_V0.5140.75
11_M95_A0.5110.75
276_P279_I0.5100.74
89_T214_I0.5070.74
25_A94_G0.5060.74
133_L138_V0.5040.74
51_R55_F0.5020.73
115_S227_A0.5020.73
19_D91_D0.5010.73
136_R276_P0.5010.73
324_V339_V0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3majA 2 0.9198 100 0.182 Contact Map
3uqzA 2 0.7433 100 0.349 Contact Map
4ljrA 2 0.5642 100 0.443 Contact Map
3quaA 2 0.4225 100 0.663 Contact Map
2iz6A 4 0.4064 100 0.715 Contact Map
1rcuA 3 0.4144 100 0.716 Contact Map
1wekA 5 0.5241 100 0.727 Contact Map
1wehA 1 0.4064 100 0.727 Contact Map
3sbxA 2 0.4251 100 0.74 Contact Map
1t35A 5 0.4358 100 0.749 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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