RNB - ECOLI - GREMLIN Contacts

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RNB - Exoribonuclease 2

UniProt:	P30850	Sequences: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSKLDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11620
Length:	644 (613)
Sequences:	3691 (2269)
Seq/√Len:	91.6

ECOLI - RNB RNR
BACSU - RNR
HALSA - Q9HM91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_E	299_E	4.781	1.00
289_S	293_T	4.713	1.00
278_V	306_E	4.678	1.00
565_A	625_D	4.224	1.00
181_E	240_K	3.934	1.00
131_E	146_E	3.840	1.00
193_T	278_V	3.680	1.00
203_A	314_D	3.675	1.00
44_Y	73_A	3.666	1.00
215_K	223_Q	3.498	1.00
563_R	625_D	3.413	1.00
195_L	215_K	3.098	1.00
219_D	287_T	3.014	1.00
221_K	287_T	2.960	1.00
175_P	178_V	2.847	1.00
59_R	80_E	2.819	1.00
281_V	305_I	2.805	1.00
176_D	180_T	2.775	1.00
394_I	489_L	2.710	1.00
227_A	283_A	2.691	1.00
412_I	528_T	2.669	1.00
493_A	507_N	2.571	1.00
44_Y	62_A	2.518	1.00
317_S	321_E	2.516	1.00
185_E	188_V	2.489	1.00
236_A	239_S	2.487	1.00
47_P	50_Q	2.484	1.00
302_A	512_K	2.466	1.00
90_V	97_L	2.432	1.00
566_A	578_V	2.422	1.00
190_E	301_F	2.421	1.00
212_L	389_V	2.409	1.00
285_R	301_F	2.392	1.00
90_V	119_N	2.370	1.00
197_F	305_I	2.351	1.00
39_D	59_R	2.336	1.00
61_I	77_E	2.335	1.00
63_V	74_E	2.325	1.00
26_V	51_M	2.304	1.00
24_G	36_L	2.295	1.00
568_I	618_Y	2.267	1.00
223_Q	285_R	2.258	1.00
197_F	308_K	2.252	1.00
274_R	277_E	2.243	1.00
317_S	383_R	2.217	1.00
369_G	373_E	2.208	1.00
246_K	527_I	2.190	1.00
281_V	303_A	2.164	1.00
283_A	303_A	2.164	1.00
287_T	296_D	2.150	1.00
565_A	623_V	2.108	1.00
88_G	99_I	2.092	1.00
23_E	59_R	2.068	1.00
576_M	589_I	2.067	1.00
232_T	505_M	2.061	1.00
596_A	599_D	2.044	1.00
149_Q	166_A	2.023	1.00
415_V	478_S	2.014	1.00
302_A	516_K	2.010	1.00
249_A	534_R	2.003	1.00
327_Q	338_R	1.996	1.00
225_I	285_R	1.985	1.00
349_E	353_N	1.959	1.00
250_F	534_R	1.958	1.00
204_S	365_R	1.946	1.00
597_V	611_Q	1.927	1.00
600_E	612_I	1.924	1.00
398_I	489_L	1.924	1.00
563_R	627_T	1.923	1.00
196_D	336_Q	1.915	1.00
182_M	185_E	1.904	1.00
412_I	506_I	1.894	1.00
288_L	395_A	1.891	1.00
175_P	244_A	1.888	1.00
252_N	538_N	1.886	1.00
208_M	310_K	1.867	1.00
417_M	482_G	1.866	1.00
126_D	153_F	1.857	1.00
192_L	285_R	1.854	1.00
415_V	482_G	1.834	1.00
216_A	342_Q	1.833	1.00
217_L	221_K	1.811	1.00
36_L	46_I	1.808	1.00
574_G	577_R	1.794	1.00
205_T	208_M	1.787	1.00
529_V	533_E	1.780	1.00
27_K	37_E	1.766	1.00
23_E	61_I	1.764	1.00
534_R	537_L	1.754	1.00
200_I	388_I	1.745	1.00
130_A	145_A	1.738	1.00
221_K	290_A	1.734	1.00
178_V	244_A	1.728	1.00
557_K	560_T	1.717	1.00
217_L	223_Q	1.714	1.00
503_G	531_M	1.713	1.00
574_G	588_F	1.713	1.00
341_A	345_Q	1.709	1.00
181_E	239_S	1.705	1.00
431_L	464_L	1.703	1.00
589_I	624_I	1.701	1.00
246_K	530_Q	1.700	1.00
591_A	609_T	1.670	1.00
283_A	301_F	1.667	1.00
255_P	545_V	1.660	1.00
85_R	131_E	1.655	1.00
367_I	378_V	1.654	1.00
369_G	375_L	1.643	1.00
288_L	294_I	1.638	1.00
293_T	350_W	1.633	1.00
214_A	339_L	1.632	1.00
133_R	146_E	1.630	1.00
412_I	531_M	1.609	1.00
196_D	308_K	1.605	1.00
227_A	303_A	1.603	1.00
192_L	303_A	1.602	1.00
213_F	227_A	1.601	1.00
345_Q	384_I	1.600	1.00
427_L	431_L	1.599	1.00
250_F	503_G	1.596	1.00
223_Q	287_T	1.593	1.00
102_D	127_W	1.590	1.00
225_I	283_A	1.588	1.00
341_A	344_C	1.579	1.00
216_A	339_L	1.565	1.00
113_R	118_L	1.559	1.00
549_L	552_R	1.555	1.00
348_G	391_E	1.551	1.00
221_K	295_E	1.551	1.00
427_L	468_I	1.550	1.00
348_G	387_R	1.550	1.00
242_D	502_Y	1.545	1.00
59_R	79_V	1.537	1.00
417_M	476_E	1.530	1.00
226_V	286_M	1.528	1.00
217_L	220_D	1.519	1.00
183_L	186_G	1.509	1.00
383_R	386_N	1.501	1.00
197_F	281_V	1.496	1.00
242_D	509_R	1.489	1.00
186_G	193_T	1.488	1.00
275_A	307_S	1.483	1.00
62_A	75_P	1.480	1.00
276_N	306_E	1.474	1.00
630_E	639_I	1.472	1.00
282_L	511_L	1.452	1.00
198_V	336_Q	1.449	0.99
474_F	536_R	1.446	0.99
36_L	62_A	1.419	0.99
264_R	268_D	1.418	0.99
373_E	552_R	1.416	0.99
186_G	304_T	1.414	0.99
367_I	376_D	1.413	0.99
222_L	339_L	1.409	0.99
403_V	407_K	1.400	0.99
135_H	143_F	1.392	0.99
298_I	399_C	1.389	0.99
319_W	334_A	1.388	0.99
551_A	631_V	1.387	0.99
420_D	473_S	1.381	0.99
282_L	512_K	1.378	0.99
286_M	399_C	1.378	0.99
287_T	295_E	1.376	0.99
320_L	341_A	1.375	0.99
214_A	340_L	1.365	0.99
25_V	59_R	1.362	0.99
98_A	109_A	1.362	0.99
315_Q	330_S	1.353	0.99
298_I	403_V	1.350	0.99
530_Q	534_R	1.350	0.99
608_G	617_V	1.347	0.99
568_I	576_M	1.344	0.99
36_L	60_I	1.337	0.99
631_V	638_I	1.336	0.99
269_D	274_R	1.336	0.99
581_V	623_V	1.325	0.99
555_K	633_M	1.323	0.99
467_R	607_N	1.320	0.99
328_P	331_E	1.319	0.99
348_G	352_H	1.312	0.99
454_R	457_D	1.309	0.99
402_R	406_D	1.297	0.99
181_E	236_A	1.295	0.99
216_A	290_A	1.294	0.99
28_A	51_M	1.293	0.99
212_L	340_L	1.293	0.99
341_A	384_I	1.291	0.99
340_L	392_A	1.290	0.99
21_R	61_I	1.290	0.99
315_Q	326_W	1.289	0.99
217_L	287_T	1.285	0.99
284_C	300_F	1.277	0.99
197_F	227_A	1.276	0.99
294_I	399_C	1.262	0.99
35_F	43_S	1.257	0.99
525_D	529_V	1.257	0.99
193_T	304_T	1.256	0.99
127_W	163_V	1.253	0.99
239_S	243_K	1.250	0.98
315_Q	329_E	1.250	0.98
213_F	225_I	1.249	0.98
54_V	75_P	1.247	0.98
502_Y	509_R	1.247	0.98
250_F	538_N	1.246	0.98
339_L	342_Q	1.242	0.98
86_F	130_A	1.240	0.98
84_T	131_E	1.236	0.98
334_A	338_R	1.236	0.98
512_K	516_K	1.234	0.98
493_A	510_L	1.232	0.98
575_G	588_F	1.230	0.98
244_A	247_I	1.229	0.98
282_L	302_A	1.227	0.98
300_F	399_C	1.223	0.98
320_L	338_R	1.215	0.98
280_P	304_T	1.212	0.98
311_L	333_I	1.211	0.98
284_C	399_C	1.207	0.98
294_I	395_A	1.207	0.98
60_I	75_P	1.206	0.98
576_M	594_L	1.199	0.98
126_D	150_Y	1.191	0.98
26_V	34_G	1.190	0.98
479_T	528_T	1.189	0.98
249_A	531_M	1.186	0.98
265_E	270_L	1.184	0.98
214_A	336_Q	1.182	0.98
165_L	259_I	1.177	0.98
551_A	638_I	1.171	0.98
25_V	37_E	1.169	0.98
37_E	43_S	1.166	0.98
213_F	283_A	1.165	0.98
309_A	329_E	1.162	0.98
451_K	455_E	1.156	0.97
91_Q	100_V	1.152	0.97
319_W	337_V	1.151	0.97
170_L	541_A	1.148	0.97
99_I	147_L	1.147	0.97
129_V	149_Q	1.146	0.97
61_I	79_V	1.135	0.97
317_S	386_N	1.133	0.97
384_I	388_I	1.127	0.97
318_D	324_G	1.126	0.97
50_Q	65_H	1.124	0.97
571_I	576_M	1.122	0.97
213_F	308_K	1.122	0.97
99_I	145_A	1.122	0.97
602_V	606_E	1.120	0.97
167_R	544_D	1.120	0.97
168_H	544_D	1.119	0.97
436_L	461_T	1.118	0.97
289_S	295_E	1.114	0.97
448_G	451_K	1.111	0.97
203_A	315_Q	1.109	0.97
252_N	541_A	1.109	0.97
131_E	148_T	1.108	0.97
619_K	622_D	1.107	0.97
312_V	315_Q	1.105	0.97
164_T	548_W	1.104	0.97
99_I	130_A	1.099	0.97
456_L	464_L	1.098	0.97
99_I	128_A	1.092	0.96
103_H	167_R	1.092	0.96
326_W	330_S	1.088	0.96
160_P	549_L	1.086	0.96
164_T	541_A	1.075	0.96
599_D	611_Q	1.075	0.96
602_V	605_Q	1.074	0.96
590_P	593_F	1.072	0.96
90_V	99_I	1.067	0.96
61_I	76_E	1.066	0.96
589_I	593_F	1.064	0.96
85_R	148_T	1.063	0.96
197_F	213_F	1.063	0.96
404_L	507_N	1.060	0.96
250_F	531_M	1.059	0.96
224_L	392_A	1.057	0.96
320_L	337_V	1.057	0.96
192_L	301_F	1.056	0.96
626_V	640_A	1.054	0.96
201_D	210_D	1.054	0.96
275_A	309_A	1.052	0.96
26_V	54_V	1.050	0.96
185_E	233_A	1.049	0.96
197_F	212_L	1.047	0.95
171_E	537_L	1.046	0.95
510_L	514_V	1.045	0.95
190_E	285_R	1.043	0.95
34_G	75_P	1.038	0.95
611_Q	614_G	1.036	0.95
326_W	329_E	1.036	0.95
321_E	383_R	1.035	0.95
208_M	274_R	1.035	0.95
403_V	514_V	1.033	0.95
22_A	62_A	1.031	0.95
202_S	316_V	1.030	0.95
319_W	330_S	1.028	0.95
203_A	312_V	1.027	0.95
198_V	311_L	1.027	0.95
587_A	640_A	1.022	0.95
197_F	225_I	1.022	0.95
415_V	476_E	1.020	0.95
404_L	511_L	1.018	0.95
251_T	258_N	1.016	0.95
364_Y	584_G	1.015	0.95
182_M	188_V	1.015	0.95
153_F	156_D	1.013	0.95
599_D	616_T	1.012	0.95
401_A	493_A	1.012	0.95
27_K	56_H	1.012	0.95
224_L	288_L	1.011	0.95
278_V	304_T	1.006	0.94
405_R	491_A	1.004	0.94
202_S	312_V	1.003	0.94
344_C	391_E	1.001	0.94
431_L	452_L	1.000	0.94
595_H	599_D	0.996	0.94
222_L	346_R	0.994	0.94
38_V	41_Q	0.994	0.94
219_D	295_E	0.992	0.94
402_R	491_A	0.988	0.94
54_V	60_I	0.988	0.94
632_R	635_T	0.987	0.94
300_F	400_A	0.983	0.94
198_V	337_V	0.977	0.93
449_F	471_F	0.976	0.93
631_V	635_T	0.966	0.93
62_A	73_A	0.965	0.93
221_K	289_S	0.965	0.93
130_A	147_L	0.963	0.93
64_I	71_E	0.962	0.93
431_L	436_L	0.960	0.93
128_A	147_L	0.960	0.93
366_F	546_G	0.957	0.93
161_W	545_V	0.953	0.93
276_N	307_S	0.952	0.93
365_R	380_E	0.952	0.93
351_R	391_E	0.951	0.93
628_I	638_I	0.948	0.92
118_L	146_E	0.946	0.92
192_L	197_F	0.942	0.92
207_D	499_I	0.941	0.92
560_T	564_F	0.941	0.92
428_A	438_V	0.934	0.92
401_A	507_N	0.934	0.92
75_P	78_L	0.932	0.92
232_T	512_K	0.930	0.92
244_A	248_R	0.930	0.92
210_D	313_Y	0.929	0.92
286_M	294_I	0.929	0.92
88_G	130_A	0.928	0.92
110_I	145_A	0.928	0.92
217_L	295_E	0.927	0.92
20_P	63_V	0.927	0.92
311_L	337_V	0.926	0.91
343_I	392_A	0.925	0.91
34_G	51_M	0.924	0.91
182_M	186_G	0.922	0.91
346_R	349_E	0.921	0.91
199_T	208_M	0.919	0.91
477_I	494_T	0.919	0.91
531_M	534_R	0.916	0.91
384_I	387_R	0.916	0.91
576_M	618_Y	0.916	0.91
220_D	290_A	0.915	0.91
300_F	403_V	0.912	0.91
83_L	135_H	0.911	0.91
102_D	163_V	0.909	0.91
407_K	514_V	0.908	0.91
551_A	636_R	0.905	0.91
585_A	638_I	0.904	0.90
576_M	624_I	0.902	0.90
233_A	302_A	0.900	0.90
119_N	122_F	0.898	0.90
382_R	386_N	0.897	0.90
197_F	283_A	0.897	0.90
213_F	303_A	0.897	0.90
631_V	634_E	0.896	0.90
567_E	581_V	0.895	0.90
456_L	465_D	0.892	0.90
566_A	580_L	0.890	0.90
373_E	556_D	0.890	0.90
210_D	500_R	0.890	0.90
319_W	338_R	0.889	0.90
233_A	512_K	0.889	0.90
56_H	105_L	0.888	0.90
577_R	588_F	0.887	0.90
109_A	112_C	0.886	0.90
44_Y	64_I	0.886	0.90
356_L	361_R	0.884	0.89
318_D	322_N	0.884	0.89
93_K	96_R	0.881	0.89
207_D	390_E	0.881	0.89
284_C	400_A	0.878	0.89
405_R	413_Y	0.876	0.89
429_A	605_Q	0.874	0.89
314_D	318_D	0.873	0.89
195_L	213_F	0.872	0.89
354_H	489_L	0.870	0.89
380_E	386_N	0.870	0.89
403_V	515_I	0.868	0.89
430_L	467_R	0.868	0.89
170_L	259_I	0.866	0.89
207_D	253_Y	0.865	0.88
164_T	545_V	0.864	0.88
21_R	76_E	0.864	0.88
28_A	107_K	0.863	0.88
213_F	285_R	0.862	0.88
240_K	243_K	0.859	0.88
578_V	589_I	0.859	0.88
201_D	393_M	0.856	0.88
98_A	111_P	0.854	0.88
201_D	253_Y	0.854	0.88
92_G	97_L	0.853	0.88
354_H	398_I	0.853	0.88
26_V	36_L	0.853	0.88
292_G	343_I	0.851	0.88
323_T	327_Q	0.850	0.88
128_A	150_Y	0.849	0.88
192_L	305_I	0.849	0.88
253_Y	500_R	0.846	0.87
36_L	75_P	0.846	0.87
333_I	337_V	0.845	0.87
55_M	83_L	0.844	0.87
598_R	612_I	0.843	0.87
134_R	144_Y	0.842	0.87
554_L	628_I	0.841	0.87
404_L	411_G	0.840	0.87
311_L	330_S	0.838	0.87
571_I	609_T	0.838	0.87
336_Q	339_L	0.838	0.87
453_R	456_L	0.836	0.87
382_R	387_R	0.836	0.87
227_A	285_R	0.836	0.87
195_L	225_I	0.836	0.87
255_P	374_V	0.835	0.87
396_A	495_W	0.831	0.86
452_L	456_L	0.831	0.86
316_V	320_L	0.829	0.86
309_A	315_Q	0.828	0.86
201_D	500_R	0.824	0.86
272_S	499_I	0.823	0.86
65_H	74_E	0.823	0.86
175_P	247_I	0.822	0.86
220_D	287_T	0.819	0.86
298_I	402_R	0.819	0.86
155_D	160_P	0.817	0.85
170_L	537_L	0.812	0.85
286_M	395_A	0.811	0.85
526_E	530_Q	0.810	0.85
30_E	33_F	0.809	0.85
225_I	301_F	0.808	0.85
209_D	500_R	0.802	0.84
580_L	583_N	0.801	0.84
238_G	243_K	0.801	0.84
447_D	451_K	0.801	0.84
210_D	393_M	0.801	0.84
553_F	557_K	0.800	0.84
596_A	616_T	0.799	0.84
122_F	128_A	0.797	0.84
26_V	75_P	0.797	0.84
54_V	78_L	0.796	0.84
171_E	247_I	0.795	0.84
81_P	135_H	0.791	0.84
208_M	312_V	0.791	0.84
50_Q	72_S	0.789	0.83
216_A	335_E	0.786	0.83
210_D	253_Y	0.786	0.83
196_D	213_F	0.785	0.83
199_T	307_S	0.785	0.83
313_Y	500_R	0.785	0.83
46_I	50_Q	0.785	0.83
103_H	106_L	0.784	0.83
123_K	126_D	0.784	0.83
404_L	510_L	0.783	0.83
367_I	375_L	0.782	0.83
97_L	124_E	0.781	0.83
317_S	384_I	0.779	0.83
565_A	581_V	0.778	0.83
472_Q	485_F	0.778	0.83
201_D	209_D	0.778	0.83
576_M	593_F	0.774	0.82
201_D	313_Y	0.774	0.82
436_L	459_Q	0.773	0.82
350_W	353_N	0.773	0.82
342_Q	346_R	0.772	0.82
22_A	38_V	0.772	0.82
292_G	346_R	0.770	0.82
462_G	579_R	0.770	0.82
413_Y	481_P	0.768	0.82
210_D	261_M	0.765	0.81
90_V	147_L	0.764	0.81
196_D	309_A	0.763	0.81
249_A	530_Q	0.763	0.81
393_M	497_S	0.762	0.81
194_A	308_K	0.762	0.81
314_D	383_R	0.762	0.81
311_L	315_Q	0.759	0.81
338_R	341_A	0.757	0.81
109_A	113_R	0.757	0.81
28_A	34_G	0.757	0.81
343_I	346_R	0.755	0.81
208_M	264_R	0.755	0.81
45_F	48_P	0.755	0.81
460_P	623_V	0.753	0.80
218_P	221_K	0.751	0.80
565_A	582_D	0.750	0.80
21_R	63_V	0.748	0.80
209_D	393_M	0.748	0.80
89_K	154_G	0.747	0.80
206_E	268_D	0.747	0.80
178_V	181_E	0.746	0.80
22_A	36_L	0.744	0.80
209_D	313_Y	0.744	0.80
133_R	144_Y	0.743	0.80
235_I	266_L	0.743	0.80
123_K	153_F	0.742	0.79
133_R	136_P	0.741	0.79
424_A	449_F	0.741	0.79
348_G	358_F	0.741	0.79
300_F	511_L	0.741	0.79
132_M	135_H	0.740	0.79
202_S	310_K	0.739	0.79
123_K	264_R	0.739	0.79
364_Y	550_Y	0.737	0.79
285_R	299_E	0.737	0.79
331_E	334_A	0.735	0.79
207_D	475_A	0.731	0.78
309_A	333_I	0.730	0.78
547_D	570_D	0.729	0.78
400_A	493_A	0.728	0.78
327_Q	331_E	0.725	0.78
275_A	310_K	0.725	0.78
254_L	545_V	0.724	0.78
628_I	640_A	0.722	0.78
50_Q	74_E	0.722	0.78
495_W	508_H	0.721	0.78
209_D	253_Y	0.718	0.77
320_L	384_I	0.717	0.77
322_N	338_R	0.714	0.77
177_G	240_K	0.712	0.77
578_V	587_A	0.710	0.76
98_A	142_S	0.709	0.76
377_I	585_A	0.709	0.76
207_D	416_H	0.708	0.76
481_P	491_A	0.707	0.76
291_D	346_R	0.707	0.76
567_E	623_V	0.704	0.76
238_G	246_K	0.703	0.76
568_I	624_I	0.702	0.76
55_M	82_F	0.701	0.76
55_M	106_L	0.701	0.76
564_F	628_I	0.701	0.76
344_C	384_I	0.701	0.76
269_D	277_E	0.700	0.75
29_T	33_F	0.700	0.75
344_C	348_G	0.699	0.75
351_R	356_L	0.698	0.75
311_L	319_W	0.697	0.75
202_S	386_N	0.697	0.75
89_K	127_W	0.694	0.75
270_L	279_R	0.691	0.74
414_N	475_A	0.690	0.74
173_E	176_D	0.690	0.74
270_L	277_E	0.688	0.74
207_D	271_C	0.687	0.74
572_S	588_F	0.686	0.74
83_L	86_F	0.686	0.74
132_M	136_P	0.684	0.74
335_E	339_L	0.684	0.74
184_D	187_L	0.684	0.74
506_I	527_I	0.682	0.74
313_Y	393_M	0.681	0.73
393_M	500_R	0.681	0.73
580_L	626_V	0.680	0.73
228_I	393_M	0.679	0.73
46_I	73_A	0.678	0.73
390_E	475_A	0.675	0.73
376_D	557_K	0.672	0.72
601_L	604_S	0.668	0.72
254_L	259_I	0.668	0.72
197_F	214_A	0.668	0.72
347_R	350_W	0.666	0.72
602_V	608_G	0.666	0.72
414_N	501_K	0.666	0.72
436_L	452_L	0.665	0.72
165_L	257_F	0.665	0.72
111_P	144_Y	0.665	0.72
593_F	629_A	0.664	0.72
425_D	428_A	0.664	0.72
566_A	624_I	0.664	0.72
46_I	54_V	0.662	0.71
48_P	52_K	0.662	0.71
390_E	497_S	0.662	0.71
566_A	628_I	0.661	0.71
160_P	548_W	0.660	0.71
224_L	343_I	0.660	0.71
399_C	402_R	0.659	0.71
109_A	145_A	0.658	0.71
563_R	624_I	0.657	0.71
96_R	111_P	0.656	0.71
223_Q	283_A	0.656	0.71
321_E	384_I	0.656	0.71
38_V	44_Y	0.655	0.71
210_D	497_S	0.655	0.71
253_Y	393_M	0.654	0.70
184_D	188_V	0.654	0.70
309_A	332_A	0.650	0.70
463_F	567_E	0.649	0.70
364_Y	379_A	0.649	0.70
162_W	166_A	0.648	0.70
261_M	313_Y	0.648	0.70
393_M	416_H	0.647	0.70
92_G	124_E	0.647	0.70
111_P	114_A	0.647	0.70
601_L	607_N	0.646	0.69
507_N	511_L	0.644	0.69
284_C	298_I	0.643	0.69
632_R	637_S	0.643	0.69
288_L	292_G	0.642	0.69
87_V	129_V	0.641	0.69
193_T	306_E	0.640	0.69
201_D	273_L	0.640	0.69
122_F	147_L	0.639	0.69
38_V	71_E	0.639	0.69
125_G	153_F	0.637	0.68
85_R	169_N	0.637	0.68
202_S	314_D	0.636	0.68
228_I	272_S	0.636	0.68
608_G	619_K	0.634	0.68
393_M	499_I	0.634	0.68
416_H	486_G	0.634	0.68
46_I	60_I	0.633	0.68
201_D	499_I	0.633	0.68
554_L	585_A	0.633	0.68
109_A	142_S	0.632	0.68
221_K	296_D	0.631	0.68
178_V	247_I	0.631	0.68
541_A	545_V	0.631	0.68
468_I	472_Q	0.630	0.68
254_L	386_N	0.629	0.67
547_D	551_A	0.628	0.67
201_D	390_E	0.628	0.67
34_G	38_V	0.628	0.67
313_Y	499_I	0.627	0.67
122_F	126_D	0.627	0.67
207_D	497_S	0.627	0.67
417_M	532_A	0.627	0.67
209_D	229_A	0.626	0.67
186_G	278_V	0.625	0.67
598_R	611_Q	0.625	0.67
208_M	275_A	0.624	0.67
210_D	390_E	0.624	0.67
288_L	347_R	0.623	0.67
597_V	613_K	0.623	0.67
216_A	222_L	0.623	0.67
528_T	531_M	0.622	0.67
318_D	323_T	0.621	0.66
126_D	264_R	0.621	0.66
272_S	497_S	0.621	0.66
591_A	600_E	0.619	0.66
205_T	260_P	0.619	0.66
201_D	207_D	0.618	0.66
425_D	440_A	0.618	0.66
106_L	109_A	0.617	0.66
317_S	385_A	0.617	0.66
327_Q	334_A	0.616	0.66
324_G	327_Q	0.616	0.66
97_L	119_N	0.615	0.66
33_F	45_F	0.615	0.66
179_A	265_E	0.615	0.66
206_E	499_I	0.615	0.66
228_I	497_S	0.614	0.66
156_D	604_S	0.613	0.65
91_Q	124_E	0.612	0.65
227_A	281_V	0.612	0.65
205_T	310_K	0.611	0.65
214_A	343_I	0.611	0.65
614_G	624_I	0.611	0.65
386_N	489_L	0.610	0.65
439_D	442_E	0.610	0.65
253_Y	390_E	0.610	0.65
323_T	338_R	0.609	0.65
56_H	83_L	0.609	0.65
195_L	308_K	0.608	0.65
272_S	313_Y	0.607	0.65
535_R	542_E	0.607	0.65
207_D	272_S	0.606	0.65
361_R	539_R	0.606	0.65
170_L	473_S	0.606	0.65
169_N	534_R	0.605	0.64
186_G	233_A	0.604	0.64
442_E	445_T	0.603	0.64
219_D	223_Q	0.603	0.64
207_D	210_D	0.602	0.64
390_E	394_I	0.602	0.64
208_M	307_S	0.598	0.64
202_S	208_M	0.598	0.64
279_R	351_R	0.598	0.64
414_N	500_R	0.598	0.64
404_L	514_V	0.597	0.63
452_L	464_L	0.596	0.63
195_L	285_R	0.595	0.63
129_V	166_A	0.595	0.63
207_D	313_Y	0.594	0.63
55_M	80_E	0.594	0.63
196_D	333_I	0.594	0.63
341_A	388_I	0.593	0.63
227_A	548_W	0.593	0.63
521_T	524_Q	0.593	0.63
235_I	505_M	0.592	0.63
87_V	163_V	0.591	0.63
231_P	499_I	0.591	0.63
178_V	241_L	0.591	0.63
29_T	32_G	0.589	0.62
205_T	267_S	0.589	0.62
277_E	307_S	0.588	0.62
575_G	587_A	0.588	0.62
198_V	316_V	0.587	0.62
46_I	75_P	0.587	0.62
526_E	529_V	0.587	0.62
212_L	388_I	0.587	0.62
253_Y	313_Y	0.586	0.62
469_R	535_R	0.586	0.62
246_K	531_M	0.586	0.62
174_A	244_A	0.585	0.62
555_K	630_E	0.585	0.62
597_V	612_I	0.584	0.62
390_E	393_M	0.584	0.62
201_D	414_N	0.583	0.62
152_T	160_P	0.583	0.62
253_Y	499_I	0.582	0.61
153_F	264_R	0.582	0.61
630_E	637_S	0.580	0.61
593_F	624_I	0.580	0.61
333_I	336_Q	0.580	0.61
186_G	281_V	0.580	0.61
554_L	640_A	0.580	0.61
309_A	337_V	0.579	0.61
159_V	163_V	0.579	0.61
266_L	499_I	0.579	0.61
194_A	306_E	0.578	0.61
158_F	257_F	0.578	0.61
513_A	523_P	0.578	0.61
231_P	414_N	0.577	0.61
423_N	564_F	0.577	0.61
177_G	180_T	0.576	0.61
222_L	342_Q	0.576	0.61
439_D	445_T	0.575	0.61
35_F	45_F	0.575	0.61
375_L	378_V	0.575	0.61
530_Q	533_E	0.574	0.60
494_T	501_K	0.574	0.60
136_P	143_F	0.573	0.60
229_A	235_I	0.573	0.60
552_R	555_K	0.573	0.60
441_E	444_L	0.573	0.60
438_V	444_L	0.573	0.60
210_D	499_I	0.573	0.60
122_F	150_Y	0.572	0.60
507_N	510_L	0.572	0.60
470_R	543_R	0.571	0.60
243_K	246_K	0.571	0.60
331_E	335_E	0.571	0.60
151_I	166_A	0.571	0.60
43_S	571_I	0.570	0.60
202_S	205_T	0.569	0.60
372_G	549_L	0.568	0.60
299_E	303_A	0.567	0.59
449_F	468_I	0.567	0.59
198_V	333_I	0.566	0.59
360_D	387_R	0.565	0.59
207_D	273_L	0.565	0.59
258_N	268_D	0.564	0.59
290_A	342_Q	0.564	0.59
370_E	375_L	0.564	0.59
557_K	628_I	0.564	0.59
337_V	341_A	0.564	0.59
174_A	179_A	0.564	0.59
590_P	639_I	0.563	0.59
547_D	586_I	0.562	0.59
22_A	64_I	0.562	0.59
229_A	499_I	0.561	0.59
89_K	634_E	0.559	0.58
56_H	101_P	0.559	0.58
566_A	638_I	0.559	0.58
274_R	279_R	0.558	0.58
265_E	269_D	0.558	0.58
323_T	326_W	0.557	0.58
201_D	497_S	0.557	0.58
352_H	454_R	0.555	0.58
564_F	626_V	0.555	0.58
276_N	309_A	0.553	0.58
241_L	267_S	0.553	0.58
85_R	129_V	0.553	0.58
360_D	382_R	0.553	0.58
176_D	179_A	0.553	0.58
356_L	394_I	0.553	0.58
251_T	260_P	0.552	0.57
356_L	391_E	0.552	0.57
350_W	354_H	0.552	0.57
199_T	275_A	0.552	0.57
426_A	605_Q	0.551	0.57
199_T	310_K	0.551	0.57
196_D	332_A	0.550	0.57
594_L	609_T	0.550	0.57
206_E	256_G	0.550	0.57
19_T	598_R	0.549	0.57
207_D	393_M	0.549	0.57
243_K	632_R	0.548	0.57
204_S	380_E	0.548	0.57
599_D	602_V	0.547	0.57
329_E	332_A	0.547	0.57
88_G	128_A	0.546	0.57
21_R	77_E	0.546	0.57
441_E	445_T	0.545	0.56
506_I	510_L	0.545	0.56
610_V	617_V	0.545	0.56
185_E	280_P	0.545	0.56
247_I	338_R	0.545	0.56
178_V	240_K	0.545	0.56
158_F	162_W	0.544	0.56
75_P	82_F	0.544	0.56
183_L	187_L	0.544	0.56
282_L	300_F	0.544	0.56
316_V	341_A	0.544	0.56
83_L	106_L	0.543	0.56
228_I	499_I	0.541	0.56
202_S	389_V	0.540	0.56
426_A	429_A	0.540	0.56
39_D	187_L	0.540	0.56
209_D	499_I	0.539	0.56
201_D	475_A	0.538	0.56
451_K	468_I	0.538	0.56
260_P	292_G	0.537	0.55
202_S	207_D	0.535	0.55
29_T	43_S	0.535	0.55
181_E	241_L	0.535	0.55
234_W	270_L	0.535	0.55
192_L	195_L	0.535	0.55
214_A	227_A	0.535	0.55
89_K	102_D	0.534	0.55
583_N	640_A	0.534	0.55
212_L	344_C	0.534	0.55
403_V	511_L	0.533	0.55
194_A	349_E	0.533	0.55
519_T	522_R	0.533	0.55
588_F	639_I	0.533	0.55
207_D	500_R	0.532	0.55
231_P	416_H	0.532	0.55
165_L	464_L	0.532	0.55
235_I	475_A	0.532	0.55
77_E	103_H	0.531	0.55
198_V	214_A	0.531	0.55
200_I	210_D	0.531	0.55
78_L	81_P	0.530	0.54
201_D	272_S	0.530	0.54
252_N	310_K	0.529	0.54
315_Q	318_D	0.529	0.54
126_D	155_D	0.529	0.54
227_A	400_A	0.527	0.54
591_A	594_L	0.527	0.54
271_C	393_M	0.526	0.54
212_L	393_M	0.526	0.54
362_P	462_G	0.524	0.54
235_I	486_G	0.524	0.54
253_Y	497_S	0.524	0.54
74_E	78_L	0.524	0.54
405_R	481_P	0.524	0.54
228_I	253_Y	0.523	0.53
552_R	633_M	0.523	0.53
101_P	105_L	0.523	0.53
26_V	46_I	0.522	0.53
225_I	374_V	0.522	0.53
174_A	260_P	0.522	0.53
36_L	73_A	0.521	0.53
423_N	427_L	0.520	0.53
202_S	317_S	0.520	0.53
36_L	51_M	0.520	0.53
432_K	438_V	0.519	0.53
554_L	638_I	0.519	0.53
218_P	295_E	0.519	0.53
197_F	307_S	0.516	0.52
210_D	228_I	0.516	0.52
314_D	385_A	0.516	0.52
271_C	475_A	0.514	0.52
532_A	535_R	0.514	0.52
55_M	135_H	0.513	0.52
396_A	511_L	0.513	0.52
589_I	626_V	0.513	0.52
477_I	495_W	0.512	0.52
36_L	622_D	0.511	0.52
532_A	536_R	0.511	0.52
208_M	385_A	0.510	0.52
213_F	223_Q	0.510	0.52
597_V	615_E	0.509	0.52
90_V	124_E	0.509	0.52
488_G	554_L	0.508	0.51
390_E	416_H	0.508	0.51
45_F	72_S	0.508	0.51
73_A	168_H	0.507	0.51
215_K	218_P	0.506	0.51
317_S	322_N	0.506	0.51
400_A	511_L	0.506	0.51
231_P	475_A	0.506	0.51
168_H	636_R	0.505	0.51
169_N	172_K	0.504	0.51
82_F	106_L	0.504	0.51
229_A	496_T	0.503	0.51
344_C	392_A	0.503	0.51
261_M	500_R	0.503	0.51
474_F	539_R	0.503	0.51
511_L	515_I	0.503	0.51
228_I	313_Y	0.503	0.51
26_V	52_K	0.502	0.51
235_I	239_S	0.502	0.51
229_A	393_M	0.502	0.51
186_G	280_P	0.500	0.50
157_H	549_L	0.500	0.50
414_N	477_I	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vnuD	1	0.9581	100	0.137	Contact Map
4ifdJ	1	0.972	100	0.139	Contact Map
2id0A	1	0.9798	100	0.147	Contact Map
4ro1A	1	0.8152	100	0.163	Contact Map
4pmwA	1	0.9736	100	0.163	Contact Map
2r7dA	1	0.6894	100	0.414	Contact Map
3bzcA	1	0.7842	99.9	0.886	Contact Map
1go3E	1	0.2453	99.6	0.912	Contact Map
1e3pA	3	0.7034	99.5	0.915	Contact Map
4qjfA	1	0.2438	99.4	0.921	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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