GREMLIN Database
BAES - Signal transduction histidine-protein kinase BaeS
UniProt: P30847 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11617
Length: 467 (440)
Sequences: 47900 (41989)
Seq/√Len: 2001.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
391_A452_S4.1411.00
392_D396_G3.8101.00
385_T456_E3.7031.00
431_L435_E3.6261.00
313_V349_G3.5211.00
442_I454_T3.3431.00
263_L281_L3.2081.00
389_T452_S3.1941.00
402_L445_H2.9611.00
338_Q376_Q2.9341.00
369_T393_S2.8621.00
387_R456_E2.8421.00
338_Q374_S2.8151.00
378_S389_T2.8141.00
389_T454_T2.7961.00
349_G437_H2.6971.00
387_R454_T2.6491.00
312_P348_F2.6361.00
380_G387_R2.6351.00
374_S393_S2.6271.00
381_Q459_L2.6141.00
340_S378_S2.6001.00
376_Q391_A2.5921.00
260_R286_G2.5811.00
443_A453_I2.5721.00
446_S449_G2.5581.00
430_C441_I2.5291.00
357_L434_V2.5291.00
398_S401_Q2.5131.00
444_A454_T2.4761.00
267_Q282_Q2.4741.00
406_F441_I2.4241.00
444_A452_S2.4201.00
267_Q279_A2.3941.00
378_S391_A2.3631.00
380_G389_T2.3371.00
312_P346_T2.3261.00
314_D317_P2.2641.00
397_V405_L2.2621.00
434_V439_G2.2571.00
402_L443_A2.2091.00
336_K374_S2.2001.00
401_Q404_K2.1821.00
271_R274_T2.1801.00
440_R456_E2.1791.00
445_H451_V2.1731.00
321_V355_M2.1561.00
340_S376_Q2.1461.00
218_D221_G2.1421.00
311_A351_R2.0951.00
434_V455_V2.0861.00
349_G354_L1.9921.00
326_F359_N1.9731.00
260_R285_V1.9641.00
357_L433_I1.9531.00
404_K407_E1.8991.00
230_L234_L1.8731.00
310_K348_F1.8531.00
289_T293_D1.8361.00
260_R289_T1.8351.00
399_D402_L1.8331.00
330_F366_L1.8301.00
243_D247_D1.8261.00
442_I456_E1.8251.00
216_S221_G1.8141.00
220_L224_A1.8121.00
369_T373_G1.8081.00
202_K207_D1.8011.00
382_R387_R1.7981.00
29_W33_I1.7961.00
401_Q410_Y1.7891.00
357_L430_C1.7781.00
435_E440_R1.7591.00
397_V401_Q1.7421.00
363_E367_R1.7221.00
433_I437_H1.7141.00
373_G393_S1.7041.00
358_F388_L1.6811.00
404_K410_Y1.6651.00
231_A234_L1.6591.00
316_I320_E1.6301.00
241_R245_M1.6261.00
264_E282_Q1.6201.00
397_V451_V1.6101.00
239_Q243_D1.5811.00
263_L282_Q1.5791.00
197_V222_K1.5711.00
360_N430_C1.5421.00
144_I147_P1.5361.00
217_E221_G1.5301.00
350_D353_R1.5251.00
376_Q393_S1.5161.00
369_T375_L1.5011.00
259_L285_V1.4871.00
267_Q275_P1.4841.00
388_L455_V1.4811.00
401_Q412_T1.4751.00
357_L455_V1.4691.00
282_Q286_G1.4651.00
262_E277_T1.4551.00
392_D450_G1.4521.00
238_Q241_R1.4451.00
321_V351_R1.4301.00
406_F443_A1.4291.00
266_I278_V1.4181.00
434_V441_I1.4071.00
402_L406_F1.4011.00
197_V201_H1.3911.00
445_H448_F1.3881.00
353_R356_Q1.3831.00
269_G274_T1.3691.00
353_R436_A1.3491.00
251_E356_Q1.3461.00
316_I379_A1.3411.00
259_L281_L1.3371.00
224_A228_N1.3351.00
314_D346_T1.3311.00
407_E410_Y1.3301.00
386_V459_L1.3231.00
325_A355_M1.3221.00
351_R355_M1.3181.00
398_S447_P1.3151.00
260_R282_Q1.3101.00
231_A235_E1.3091.00
368_Y411_R1.2901.00
353_R433_I1.2891.00
327_R331_A1.2821.00
323_G339_F1.2791.00
182_T186_A1.2751.00
140_V144_I1.2751.00
258_V284_E1.2731.00
432_N435_E1.2721.00
445_H449_G1.2661.00
320_E339_F1.2651.00
258_V262_E1.2631.00
200_T203_L1.2621.00
142_A145_A1.2611.00
263_L285_V1.2501.00
235_E239_Q1.2341.00
318_L322_A1.2261.00
203_L231_A1.2151.00
385_T440_R1.2081.00
406_F453_I1.1971.00
244_F248_I1.1891.00
30_A34_S1.1841.00
202_K210_T1.1831.00
247_D408_R1.1831.00
207_D210_T1.1801.00
137_G140_V1.1761.00
221_G224_A1.1751.00
443_A451_V1.1691.00
341_L379_A1.1661.00
406_F431_L1.1631.00
439_G457_L1.1601.00
220_L223_L1.1521.00
405_L443_A1.1501.00
165_Q169_L1.1451.00
391_A446_S1.1351.00
144_I149_E1.1311.00
266_I274_T1.1261.00
211_R232_S1.1241.00
236_K240_M1.1021.00
83_R87_H1.1011.00
142_A147_P1.1001.00
322_A326_F1.0981.00
399_D445_H1.0961.00
238_Q242_R1.0891.00
142_A149_E1.0891.00
279_A283_A1.0881.00
271_R275_P1.0861.00
262_E280_S1.0821.00
322_A359_N1.0811.00
61_Q65_H1.0781.00
365_S375_L1.0781.00
36_E40_I1.0761.00
143_V148_V1.0731.00
411_R420_S1.0701.00
263_L278_V1.0661.00
308_Y350_D1.0631.00
161_K165_Q1.0611.00
79_F83_R1.0561.00
263_L267_Q1.0541.00
290_K352_D1.0491.00
194_K197_V1.0461.00
227_F230_L1.0451.00
329_R332_S1.0421.00
145_A148_V1.0401.00
313_V318_L1.0391.00
360_N363_E1.0371.00
143_V147_P1.0351.00
187_R191_A1.0341.00
216_S224_A1.0331.00
138_A141_G1.0321.00
28_H32_R1.0241.00
319_L379_A1.0151.00
200_T226_D1.0131.00
316_I341_L1.0101.00
258_V261_G1.0091.00
200_T227_F1.0021.00
146_S149_E1.0011.00
322_A355_M1.0001.00
77_F80_Q0.9991.00
253_R293_D0.9971.00
32_R164_R0.9941.00
261_G265_A0.9941.00
310_K437_H0.9941.00
50_R53_L0.9921.00
293_D297_Q0.9881.00
139_E142_A0.9841.00
294_D353_R0.9821.00
201_H222_K0.9761.00
392_D451_V0.9751.00
44_K48_E0.9751.00
108_W111_D0.9701.00
142_A146_S0.9701.00
276_E280_S0.9691.00
342_P380_G0.9681.00
397_V402_L0.9641.00
145_A149_E0.9601.00
228_N231_A0.9591.00
11_K218_D0.9581.00
354_L437_H0.9581.00
275_P279_A0.9561.00
361_L453_I0.9541.00
260_R264_E0.9531.00
199_G212_V0.9511.00
186_A190_L0.9491.00
164_R168_W0.9471.00
270_V274_T0.9431.00
9_T187_R0.9421.00
200_T204_A0.9371.00
221_G225_Q0.9331.00
397_V443_A0.9311.00
284_E287_T0.9301.00
197_V226_D0.9221.00
85_F89_N0.9221.00
211_R228_N0.9201.00
358_F362_L0.9201.00
143_V146_S0.9201.00
229_Q233_T0.9201.00
179_A183_F0.9201.00
425_L429_I0.9191.00
78_V82_L0.9181.00
408_R432_N0.9171.00
88_D91_E0.9141.00
434_V457_L0.9111.00
140_V145_A0.9111.00
75_D79_F0.9101.00
317_P321_V0.9101.00
243_D408_R0.9081.00
48_E52_Q0.9071.00
361_L441_I0.9061.00
359_N363_E0.9051.00
197_V200_T0.9051.00
86_E90_S0.9031.00
213_T228_N0.9021.00
33_I36_E0.9021.00
326_F362_L0.9001.00
141_G145_A0.8981.00
405_L453_I0.8981.00
33_I37_R0.8981.00
382_R385_T0.8971.00
318_L349_G0.8961.00
137_G142_A0.8911.00
384_K459_L0.8881.00
368_Y395_P0.8881.00
325_A359_N0.8861.00
308_Y353_R0.8831.00
290_K294_D0.8821.00
165_Q168_W0.8811.00
280_S284_E0.8801.00
315_L388_L0.8771.00
184_L188_G0.8771.00
192_P196_L0.8761.00
322_A325_A0.8761.00
361_L430_C0.8751.00
296_H299_S0.8711.00
107_F110_V0.8691.00
362_L377_I0.8691.00
358_F390_F0.8681.00
180_L184_L0.8661.00
323_G327_R0.8631.00
335_L369_T0.8621.00
272_K275_P0.8611.00
245_M248_I0.8611.00
251_E360_N0.8591.00
237_N240_M0.8581.00
370_D373_G0.8571.00
199_G210_T0.8541.00
196_L200_T0.8491.00
88_D92_D0.8491.00
132_P136_N0.8411.00
281_L285_V0.8391.00
382_R456_E0.8381.00
239_Q242_R0.8351.00
355_M359_N0.8351.00
357_L437_H0.8341.00
76_R79_F0.8341.00
203_L230_L0.8341.00
59_G63_A0.8301.00
285_V289_T0.8301.00
283_A321_V0.8291.00
329_R363_E0.8291.00
252_L288_L0.8281.00
361_L455_V0.8281.00
257_A261_G0.8281.00
226_D229_Q0.8221.00
326_F363_E0.8211.00
137_G141_G0.8211.00
55_S59_G0.8191.00
322_A362_L0.8181.00
319_L358_F0.8181.00
43_I46_G0.8181.00
45_H48_E0.8171.00
214_P225_Q0.8121.00
200_T223_L0.8121.00
183_F187_R0.8061.00
265_A269_G0.8051.00
61_Q64_Q0.8041.00
83_R88_D0.8041.00
320_E324_G0.8031.00
397_V403_Q0.7991.00
47_N51_L0.7981.00
276_E279_A0.7951.00
153_R157_I0.7951.00
62_Y66_G0.7941.00
250_H254_T0.7941.00
103_W110_V0.7921.00
138_A142_A0.7911.00
78_V81_I0.7911.00
430_C434_V0.7891.00
83_R86_E0.7871.00
396_G451_V0.7861.00
189_L192_P0.7861.00
377_I390_F0.7861.00
298_L428_A0.7861.00
352_D355_M0.7841.00
336_K339_F0.7811.00
63_A66_G0.7781.00
19_T23_L0.7721.00
42_Y46_G0.7711.00
51_L54_L0.7691.00
132_P142_A0.7681.00
201_H226_D0.7651.00
51_L55_S0.7631.00
204_A229_Q0.7631.00
251_E255_P0.7631.00
356_Q433_I0.7621.00
250_H360_N0.7611.00
142_A148_V0.7591.00
160_D164_R0.7591.00
86_E89_N0.7591.00
40_I44_K0.7581.00
385_T458_P0.7581.00
325_A329_R0.7581.00
132_P135_V0.7571.00
141_G144_I0.7561.00
106_Q109_V0.7521.00
431_L440_R0.7511.00
432_N436_A0.7511.00
315_L386_V0.7461.00
342_P345_I0.7461.00
233_T236_K0.7451.00
38_G42_Y0.7451.00
87_H90_S0.7451.00
82_L86_E0.7431.00
399_D403_Q0.7431.00
230_L233_T0.7431.00
402_L444_A0.7431.00
32_R36_E0.7421.00
198_D202_K0.7391.00
194_K198_D0.7391.00
136_N140_V0.7381.00
310_K438_N0.7381.00
395_P420_S0.7361.00
223_L227_F0.7341.00
144_I148_V0.7331.00
253_R289_T0.7321.00
79_F86_E0.7321.00
245_M249_S0.7321.00
324_G327_R0.7321.00
140_V147_P0.7301.00
310_K349_G0.7271.00
254_T258_V0.7261.00
309_Q350_D0.7251.00
274_T277_T0.7251.00
211_R231_A0.7251.00
42_Y45_H0.7241.00
210_T213_T0.7241.00
201_H205_A0.7211.00
439_G455_V0.7191.00
297_Q356_Q0.7191.00
356_Q359_N0.7181.00
279_A282_Q0.7181.00
340_S380_G0.7181.00
319_L377_I0.7181.00
286_G289_T0.7181.00
256_L292_V0.7151.00
44_K47_N0.7141.00
222_K225_Q0.7121.00
25_I29_W0.7101.00
39_F42_Y0.7091.00
212_V224_A0.7091.00
321_V325_A0.7061.00
367_R420_S0.7051.00
235_E238_Q0.7051.00
141_G147_P0.7041.00
199_G202_K0.7011.00
161_K164_R0.7001.00
262_E281_L0.7001.00
46_G50_R0.6991.00
344_S381_Q0.6981.00
399_D446_S0.6971.00
361_L434_V0.6971.00
49_Q52_Q0.6951.00
323_G337_L0.6951.00
330_F375_L0.6941.00
334_G372_G0.6941.00
40_I43_I0.6931.00
294_D356_Q0.6931.00
216_S220_L0.6931.00
398_S412_T0.6921.00
397_V445_H0.6921.00
162_Q166_T0.6911.00
240_M243_D0.6901.00
46_G49_Q0.6901.00
162_Q165_Q0.6891.00
280_S283_A0.6891.00
297_Q353_R0.6891.00
334_G371_S0.6891.00
328_E331_A0.6881.00
385_T459_L0.6871.00
267_Q278_V0.6851.00
136_N141_G0.6851.00
353_R357_L0.6841.00
43_I47_N0.6831.00
248_I295_L0.6831.00
313_V351_R0.6811.00
262_E284_E0.6751.00
369_T372_G0.6751.00
392_D395_P0.6751.00
347_V350_D0.6731.00
191_A195_R0.6711.00
223_L226_D0.6711.00
168_W172_A0.6701.00
192_P197_V0.6701.00
308_Y436_A0.6691.00
244_F251_E0.6671.00
232_S236_K0.6671.00
389_T444_A0.6661.00
296_H300_M0.6641.00
212_V228_N0.6631.00
407_E431_L0.6611.00
316_I343_D0.6571.00
83_R89_N0.6561.00
89_N93_K0.6561.00
222_K226_D0.6561.00
186_A189_L0.6521.00
141_G146_S0.6511.00
156_D159_F0.6511.00
219_E223_L0.6501.00
111_D115_K0.6501.00
193_V223_L0.6491.00
166_T169_L0.6481.00
242_R247_D0.6471.00
277_T281_L0.6471.00
287_T355_M0.6461.00
442_I455_V0.6461.00
391_A448_F0.6451.00
209_T235_E0.6441.00
411_R422_G0.6431.00
251_E429_I0.6421.00
188_G191_A0.6421.00
429_I433_I0.6411.00
331_A334_G0.6381.00
335_L366_L0.6371.00
288_L292_V0.6351.00
375_L390_F0.6351.00
345_I379_A0.6341.00
314_D344_S0.6341.00
224_A227_F0.6341.00
330_F337_L0.6331.00
330_F334_G0.6321.00
401_Q414_G0.6311.00
324_G328_E0.6291.00
41_D44_K0.6281.00
195_R198_D0.6281.00
157_I161_K0.6271.00
80_Q84_S0.6271.00
379_A386_V0.6271.00
91_E95_G0.6261.00
265_A270_V0.6261.00
379_A388_L0.6261.00
56_D60_E0.6241.00
246_A249_S0.6231.00
223_L228_N0.6211.00
326_F366_L0.6201.00
85_F88_D0.6191.00
237_N241_R0.6181.00
439_G458_P0.6171.00
34_S37_R0.6151.00
257_A260_R0.6151.00
116_V119_G0.6131.00
34_S38_G0.6131.00
315_L347_V0.6121.00
136_N139_E0.6121.00
41_D45_H0.6091.00
58_L62_Y0.6091.00
242_R302_D0.6081.00
90_S93_K0.6081.00
247_D251_E0.6081.00
9_T194_K0.6081.00
172_A176_L0.6061.00
52_Q56_D0.6051.00
126_P130_R0.6051.00
82_L85_F0.6041.00
214_P224_A0.6041.00
313_V348_F0.6041.00
323_G377_I0.6031.00
397_V453_I0.6031.00
320_E323_G0.6021.00
328_E332_S0.6021.00
134_L137_G0.6011.00
178_A182_T0.5991.00
74_N77_F0.5981.00
258_V280_S0.5971.00
45_H49_Q0.5971.00
323_G326_F0.5961.00
15_A19_T0.5951.00
402_L453_I0.5951.00
26_S30_A0.5941.00
317_P351_R0.5941.00
362_L375_L0.5941.00
402_L451_V0.5931.00
405_L428_A0.5911.00
284_E325_A0.5901.00
353_R437_H0.5901.00
367_R422_G0.5881.00
192_P200_T0.5881.00
333_R371_S0.5861.00
37_R40_I0.5861.00
365_S390_F0.5861.00
140_V143_V0.5841.00
210_T214_P0.5841.00
141_G148_V0.5841.00
335_L339_F0.5831.00
405_L410_Y0.5831.00
345_I386_V0.5831.00
192_P218_D0.5801.00
111_D114_N0.5801.00
357_L360_N0.5791.00
79_F82_L0.5791.00
234_L237_N0.5781.00
236_K239_Q0.5781.00
302_D408_R0.5781.00
204_A233_T0.5761.00
103_W106_Q0.5741.00
18_A21_I0.5731.00
84_S87_H0.5721.00
196_L227_F0.5721.00
264_E268_D0.5711.00
342_P379_A0.5711.00
52_Q55_S0.5701.00
196_L224_A0.5701.00
198_D201_H0.5691.00
110_V117_L0.5691.00
356_Q360_N0.5681.00
202_K206_G0.5671.00
387_R442_I0.5661.00
54_L57_A0.5651.00
450_G453_I0.5651.00
318_L354_L0.5651.00
47_N50_R0.5641.00
200_T230_L0.5641.00
252_L255_P0.5631.00
69_R72_R0.5601.00
282_Q285_V0.5601.00
326_F329_R0.5601.00
217_E220_L0.5601.00
193_V220_L0.5601.00
109_V114_N0.5591.00
218_D222_K0.5591.00
278_V282_Q0.5581.00
354_L457_L0.5561.00
160_D163_Q0.5551.00
109_V113_N0.5541.00
192_P216_S0.5541.00
233_T237_N0.5531.00
403_Q407_E0.5531.00
29_W32_R0.5531.00
265_A277_T0.5521.00
156_D160_D0.5521.00
192_P195_R0.5521.00
60_E64_Q0.5501.00
262_E266_I0.5501.00
273_F277_T0.5481.00
60_E63_A0.5471.00
37_R41_D0.5471.00
132_P137_G0.5451.00
225_Q229_Q0.5441.00
428_A432_N0.5431.00
108_W114_N0.5431.00
430_C433_I0.5411.00
406_F409_F0.5401.00
102_G106_Q0.5391.00
82_L87_H0.5391.00
11_K15_A0.5391.00
330_F335_L0.5381.00
54_L58_L0.5381.00
116_V120_P0.5381.00
89_N94_P0.5371.00
195_R199_G0.5371.00
17_F20_C0.5361.00
411_R421_G0.5351.00
286_G290_K0.5321.00
365_S369_T0.5321.00
316_I344_S0.5311.00
135_V139_E0.5311.00
376_Q379_A0.5301.00
262_E285_V0.5301.00
333_R369_T0.5291.00
317_P320_E0.5281.00
135_V138_A0.5281.00
57_A60_E0.5271.00
16_I182_T0.5271.00
294_D352_D0.5261.00
202_K205_A0.5261.00
216_S219_E0.5251.00
187_R194_K0.5241.00
381_Q386_V0.5241.00
104_R108_W0.5241.00
10_G14_L0.5231.00
81_I86_E0.5211.00
347_V386_V0.5211.00
82_L88_D0.5191.00
362_L366_L0.5191.00
259_L263_L0.5181.00
267_Q270_V0.5181.00
166_T170_I0.5161.00
277_T280_S0.5161.00
398_S402_L0.5151.00
68_W72_R0.5151.00
101_H104_R0.5131.00
49_Q53_L0.5131.00
251_E291_L0.5111.00
244_F249_S0.5111.00
370_D393_S0.5101.00
396_G450_G0.5091.00
330_F333_R0.5091.00
89_N92_D0.5081.00
92_D95_G0.5071.00
201_H204_A0.5061.00
127_D132_P0.5051.00
322_A329_R0.5041.00
336_K372_G0.5041.00
86_E92_D0.5011.00
251_E254_T0.5011.00
413_E421_G0.5011.00
208_F231_A0.5011.00
298_L408_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.5803 100 0.322 Contact Map
4bixA 2 0.4882 100 0.364 Contact Map
4ctiA 2 0.4882 100 0.402 Contact Map
4q20A 2 0.4904 100 0.445 Contact Map
4mpcA 2 0.6424 100 0.462 Contact Map
3jz3A 2 0.3405 100 0.466 Contact Map
2c2aA 2 0.4946 100 0.47 Contact Map
4e01A 3 0.6103 100 0.471 Contact Map
2q8gA 2 0.6531 100 0.471 Contact Map
2e0aA 2 0.6552 100 0.477 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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