EPTA - ECOLI - GREMLIN Contacts

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EPTA - Phosphoethanolamine transferase EptA

UniProt:	P30845	Sequences: MLKRLLKRPSLNLLAWLLLAAFYISICLNIAFFKQVLQALPLDSLHNVLVFLSMPVVAFSVINIVLTLSSFLWLNRPLACLFILVGAAAQYFIMTYGIVIDRSMIANIIDTTPAESYALMTPQMLLTLGFSGVLAALIACWIKIKPATSRLRSVLFRGANILVSVLLILLVAALFYKDYASLFRNNKELVKSLSPSNSIVASWSWYSHQRLANLPLVRIGEDAHRNPLMQNEKRKNLTILIVGETSRAENFSLNGYPRETNPRLAKDNVVYFPNTASCGTATAVSVPCMFSDMPREHYKEELAQHQEGVLDIIQRAGINVLWNDNDGGCKGACDRVPHQNVTALNLPDQCINGECYDEVLFHGLEEYINNLQGDGVIVLHTIGSHGPTYYNRYPPQFRKFTPTCDTNEIQTCTKEQLVNTYDNTLVYVDYIVDKAINLLKEHQDKFTTSLVYLSDHGESLGENGIYLHGLPYAIAPDSQKQVPMLLWLSEDYQKRYQVDQNCLQKQAQTQHYSQDNLFSTLLGLTGVETKYYQAADDILQTCRRVSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11613
Length:	547 (487)
Sequences:	5854 (4946)
Seq/√Len:	224.1

ECOLI - EPTA EPTB EPTC YHBX OPGE YEJM YJGX OPGB YIDJ
BACSU - LTAS2 YQGS LTAS1 YVGJ
HALSA - Q9HQ44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
263_R	433_D	6.391	1.00
273_P	509_T	5.795	1.00
523_G	537_D	5.015	1.00
314_Q	342_T	4.947	1.00
263_R	266_K	4.253	1.00
369_N	442_H	4.145	1.00
365_E	438_L	3.870	1.00
259_E	265_A	3.701	1.00
433_D	437_N	3.580	1.00
319_N	373_G	3.489	1.00
241_I	452_Y	3.390	1.00
239_I	450_L	3.222	1.00
238_T	313_I	3.191	1.00
437_N	440_K	3.091	1.00
243_G	246_S	3.065	1.00
237_L	448_T	2.970	1.00
275_T	512_Y	2.848	1.00
238_T	525_T	2.688	1.00
252_S	261_N	2.678	1.00
139_A	143_K	2.665	1.00
44_S	48_V	2.656	1.00
291_S	308_G	2.655	1.00
236_N	447_T	2.645	1.00
313_I	525_T	2.629	1.00
237_L	375_G	2.581	1.00
346_L	349_Q	2.470	1.00
436_I	450_L	2.455	1.00
261_N	265_A	2.393	1.00
440_K	445_K	2.386	1.00
364_L	379_L	2.343	1.00
363_G	366_E	2.216	1.00
240_L	376_V	2.188	1.00
439_L	450_L	2.155	1.00
254_N	271_Y	2.154	1.00
488_L	491_D	2.111	1.00
289_M	453_L	2.103	1.00
434_K	437_N	2.085	1.00
437_N	441_E	2.078	1.00
239_I	448_T	2.062	1.00
268_N	440_K	2.039	1.00
208_H	211_L	2.034	1.00
282_T	380_H	2.031	1.00
241_I	432_V	2.030	1.00
262_P	429_D	2.026	1.00
449_S	486_L	2.011	1.00
361_F	365_E	1.968	1.00
445_K	487_W	1.968	1.00
236_N	449_S	1.956	1.00
384_S	424_T	1.937	1.00
358_E	434_K	1.932	1.00
357_D	361_F	1.886	1.00
234_R	447_T	1.852	1.00
240_L	451_V	1.849	1.00
48_V	51_F	1.799	1.00
116_S	119_L	1.793	1.00
453_L	514_Q	1.780	1.00
29_N	33_F	1.773	1.00
438_L	441_E	1.735	1.00
385_H	455_D	1.733	1.00
246_S	425_L	1.730	1.00
365_E	442_H	1.720	1.00
399_K	426_V	1.696	1.00
243_G	452_Y	1.681	1.00
394_P	427_Y	1.679	1.00
426_V	430_Y	1.676	1.00
400_F	403_T	1.668	1.00
324_D	327_G	1.654	1.00
89_A	99_V	1.643	1.00
263_R	429_D	1.637	1.00
238_T	449_S	1.632	1.00
252_S	259_E	1.631	1.00
321_L	324_D	1.626	1.00
312_I	522_L	1.621	1.00
438_L	442_H	1.618	1.00
329_C	332_A	1.617	1.00
243_G	428_V	1.608	1.00
445_K	450_L	1.598	1.00
361_F	381_T	1.595	1.00
237_L	446_F	1.570	1.00
430_Y	433_D	1.568	1.00
451_V	486_L	1.567	1.00
430_Y	434_K	1.553	1.00
141_W	145_K	1.543	1.00
218_R	222_D	1.537	1.00
246_S	428_V	1.526	1.00
242_V	453_L	1.509	1.00
47_N	51_F	1.502	1.00
329_C	333_C	1.500	1.00
242_V	286_V	1.496	1.00
264_L	432_V	1.494	1.00
365_E	369_N	1.491	1.00
115_E	118_A	1.483	1.00
250_N	422_D	1.483	1.00
358_E	427_Y	1.462	1.00
252_S	265_A	1.459	1.00
477_D	481_Q	1.447	1.00
248_A	481_Q	1.445	1.00
398_R	401_T	1.435	1.00
292_D	519_S	1.435	1.00
361_F	435_A	1.423	1.00
477_D	480_K	1.413	1.00
275_T	484_M	1.403	1.00
269_V	487_W	1.402	1.00
360_L	379_L	1.401	1.00
185_N	188_E	1.400	1.00
369_N	438_L	1.398	1.00
220_G	223_A	1.393	1.00
384_S	425_L	1.375	1.00
454_S	482_V	1.369	1.00
435_A	450_L	1.360	1.00
137_L	141_W	1.356	1.00
198_S	201_A	1.354	1.00
266_K	433_D	1.352	1.00
431_I	434_K	1.352	1.00
269_V	273_P	1.344	1.00
258_R	422_D	1.339	1.00
368_I	439_L	1.337	1.00
310_L	341_V	1.332	1.00
198_S	202_S	1.331	1.00
261_N	264_L	1.328	1.00
434_K	438_L	1.326	1.00
298_Y	301_E	1.322	1.00
246_S	261_N	1.321	1.00
290_F	376_V	1.318	1.00
321_L	375_G	1.312	1.00
363_G	367_Y	1.307	1.00
215_P	218_R	1.299	1.00
291_S	335_R	1.298	1.00
362_H	434_K	1.292	1.00
246_S	251_F	1.291	1.00
322_W	326_D	1.290	1.00
240_L	289_M	1.283	1.00
484_M	517_L	1.281	1.00
322_W	336_V	1.280	1.00
323_N	367_Y	1.280	1.00
263_R	436_I	1.273	1.00
29_N	32_F	1.271	1.00
193_L	197_N	1.264	1.00
242_V	378_V	1.261	1.00
295_R	298_Y	1.260	1.00
211_L	216_L	1.257	1.00
218_R	221_E	1.256	1.00
44_S	47_N	1.252	1.00
192_S	196_S	1.251	1.00
260_T	264_L	1.251	1.00
243_G	432_V	1.241	1.00
375_G	444_D	1.240	1.00
240_L	378_V	1.239	1.00
212_A	215_P	1.238	1.00
118_A	122_P	1.231	1.00
488_L	492_Y	1.226	1.00
250_N	425_L	1.224	1.00
170_L	174_L	1.217	1.00
436_I	440_K	1.216	1.00
309_V	521_L	1.212	1.00
238_T	376_V	1.202	1.00
197_N	201_A	1.198	1.00
384_S	428_V	1.190	1.00
476_P	479_Q	1.189	1.00
242_V	289_M	1.189	1.00
176_Y	183_F	1.186	1.00
341_V	378_V	1.184	1.00
319_N	342_T	1.182	1.00
400_F	404_C	1.180	1.00
57_V	61_V	1.179	1.00
398_R	402_P	1.179	1.00
522_L	527_V	1.178	1.00
196_S	201_A	1.173	1.00
157_R	160_N	1.172	1.00
431_I	435_A	1.158	1.00
323_N	377_I	1.158	1.00
236_N	374_D	1.157	1.00
531_Y	534_A	1.155	1.00
318_I	374_D	1.151	1.00
324_D	332_A	1.137	1.00
80_C	84_L	1.133	1.00
136_A	140_C	1.131	1.00
270_V	508_Q	1.129	1.00
453_L	482_V	1.128	1.00
333_C	337_P	1.118	1.00
247_R	457_G	1.117	1.00
313_I	522_L	1.116	1.00
115_E	119_L	1.116	1.00
383_G	427_Y	1.115	1.00
307_E	315_R	1.110	1.00
256_Y	422_D	1.108	1.00
127_T	130_F	1.106	1.00
164_S	168_I	1.104	1.00
317_G	374_D	1.101	1.00
449_S	488_L	1.098	1.00
114_A	118_A	1.095	1.00
115_E	124_M	1.093	1.00
115_E	123_Q	1.093	1.00
129_G	133_V	1.091	1.00
113_P	119_L	1.089	1.00
398_R	403_T	1.088	1.00
331_G	334_D	1.080	1.00
359_V	362_H	1.078	1.00
289_M	517_L	1.077	1.00
235_K	316_A	1.076	1.00
395_P	398_R	1.075	1.00
519_S	535_A	1.075	1.00
154_V	157_R	1.072	1.00
195_P	201_A	1.072	1.00
272_F	484_M	1.070	1.00
319_N	343_A	1.069	1.00
436_I	452_Y	1.068	1.00
354_E	382_I	1.064	1.00
282_T	385_H	1.063	1.00
125_L	129_G	1.063	1.00
421_Y	425_L	1.058	1.00
260_T	265_A	1.057	1.00
21_A	29_N	1.057	1.00
366_E	369_N	1.056	1.00
397_F	430_Y	1.054	1.00
246_S	264_L	1.053	1.00
45_L	48_V	1.052	1.00
244_E	455_D	1.051	1.00
209_Q	212_A	1.048	1.00
241_I	361_F	1.048	1.00
379_L	435_A	1.046	1.00
238_T	451_V	1.044	1.00
238_T	318_I	1.041	1.00
451_V	521_L	1.040	1.00
248_A	254_N	1.038	1.00
221_E	224_H	1.038	1.00
126_L	130_F	1.037	1.00
364_L	368_I	1.035	1.00
449_S	521_L	1.032	1.00
195_P	198_S	1.032	1.00
299_K	302_L	1.031	1.00
197_N	202_S	1.026	1.00
246_S	250_N	1.023	1.00
75_N	78_L	1.020	1.00
219_I	223_A	1.019	1.00
54_M	66_L	1.006	1.00
341_V	344_L	1.006	1.00
357_D	360_L	1.004	1.00
219_I	224_H	1.002	1.00
186_N	189_L	1.000	1.00
217_V	220_G	1.000	1.00
394_P	397_F	0.999	1.00
278_C	288_C	0.996	1.00
113_P	117_Y	0.996	1.00
453_L	517_L	0.992	1.00
133_V	137_L	0.991	1.00
274_N	511_H	0.990	1.00
196_S	200_V	0.988	1.00
356_Y	359_V	0.987	1.00
217_V	221_E	0.987	1.00
139_A	142_I	0.984	1.00
218_R	224_H	0.983	1.00
208_H	212_A	0.982	1.00
393_Y	423_N	0.981	1.00
112_T	119_L	0.980	1.00
220_G	224_H	0.978	1.00
155_L	159_A	0.978	1.00
172_A	176_Y	0.977	1.00
460_L	463_N	0.977	1.00
310_L	320_V	0.975	1.00
167_L	170_L	0.975	1.00
262_P	265_A	0.974	1.00
358_E	430_Y	0.973	1.00
194_S	198_S	0.971	1.00
321_L	377_I	0.969	1.00
263_R	430_Y	0.967	1.00
185_N	189_L	0.966	1.00
236_N	318_I	0.966	1.00
313_I	376_V	0.965	1.00
242_V	380_H	0.964	1.00
272_F	276_A	0.963	1.00
135_A	139_A	0.961	1.00
406_T	419_N	0.961	1.00
474_I	479_Q	0.961	1.00
263_R	437_N	0.960	1.00
240_L	453_L	0.960	1.00
30_I	34_K	0.959	1.00
138_I	142_I	0.955	1.00
174_L	179_Y	0.954	1.00
269_V	485_L	0.954	1.00
208_H	216_L	0.952	1.00
156_F	159_A	0.951	1.00
239_I	375_G	0.949	1.00
316_A	527_V	0.947	1.00
368_I	377_I	0.945	1.00
50_V	53_S	0.943	1.00
142_I	145_K	0.943	1.00
282_T	286_V	0.943	1.00
193_L	198_S	0.942	1.00
199_I	203_W	0.942	1.00
399_K	402_P	0.933	1.00
383_G	424_T	0.932	1.00
241_I	450_L	0.930	1.00
243_G	361_F	0.929	1.00
328_G	333_C	0.928	1.00
364_L	377_I	0.926	1.00
332_A	335_R	0.925	1.00
402_P	406_T	0.923	1.00
180_A	183_F	0.923	1.00
30_I	33_F	0.919	0.99
142_I	146_P	0.915	0.99
132_G	136_A	0.913	0.99
114_A	117_Y	0.910	0.99
259_E	262_P	0.909	0.99
381_T	431_I	0.908	0.99
153_S	156_F	0.906	0.99
112_T	115_E	0.906	0.99
166_L	169_L	0.906	0.99
227_P	230_Q	0.905	0.99
50_V	54_M	0.902	0.99
362_H	438_L	0.902	0.99
332_A	336_V	0.902	0.99
35_Q	38_Q	0.895	0.99
171_V	175_F	0.895	0.99
403_T	406_T	0.891	0.99
299_K	303_A	0.889	0.99
159_A	162_L	0.888	0.99
532_Y	537_D	0.887	0.99
295_R	301_E	0.887	0.99
235_K	374_D	0.884	0.99
178_D	182_L	0.882	0.99
239_I	368_I	0.881	0.99
276_A	481_Q	0.880	0.99
256_Y	260_T	0.878	0.99
274_N	481_Q	0.874	0.99
179_Y	182_L	0.874	0.99
160_N	171_V	0.873	0.99
400_F	405_D	0.873	0.99
202_S	205_W	0.871	0.99
104_M	107_N	0.863	0.99
112_T	116_S	0.862	0.99
94_M	127_T	0.859	0.99
282_T	455_D	0.857	0.99
400_F	426_V	0.857	0.99
170_L	173_A	0.857	0.99
64_I	67_T	0.856	0.99
423_N	426_V	0.856	0.99
432_V	436_I	0.854	0.99
381_T	428_V	0.849	0.99
244_E	385_H	0.847	0.99
258_R	262_P	0.847	0.99
326_D	382_I	0.846	0.99
362_H	365_E	0.845	0.99
54_M	59_F	0.845	0.99
222_D	225_R	0.841	0.99
137_L	140_C	0.838	0.99
25_S	28_L	0.838	0.99
321_L	325_N	0.837	0.99
159_A	170_L	0.837	0.99
246_S	452_Y	0.836	0.99
140_C	144_I	0.834	0.99
121_T	124_M	0.832	0.99
173_A	177_K	0.831	0.99
60_S	63_N	0.830	0.99
259_E	426_V	0.828	0.99
318_I	525_T	0.828	0.99
322_W	380_H	0.827	0.99
491_D	494_K	0.824	0.99
246_S	384_S	0.821	0.99
218_R	223_A	0.821	0.99
245_T	454_S	0.818	0.99
161_I	165_V	0.816	0.99
131_S	135_A	0.815	0.99
214_L	217_V	0.807	0.99
361_F	428_V	0.806	0.99
432_V	450_L	0.804	0.99
446_F	490_E	0.800	0.99
210_R	213_N	0.800	0.99
49_L	53_S	0.799	0.99
237_L	449_S	0.798	0.99
24_I	31_A	0.798	0.99
29_N	34_K	0.796	0.99
201_A	204_S	0.792	0.99
341_V	376_V	0.791	0.98
174_L	178_D	0.791	0.98
240_L	309_V	0.790	0.98
113_P	123_Q	0.789	0.98
283_A	330_K	0.789	0.98
439_L	444_D	0.788	0.98
397_F	427_Y	0.788	0.98
176_Y	181_S	0.785	0.98
459_S	462_E	0.784	0.98
168_I	172_A	0.784	0.98
31_A	34_K	0.779	0.98
458_E	479_Q	0.779	0.98
240_L	517_L	0.778	0.98
278_C	513_S	0.778	0.98
243_G	384_S	0.777	0.98
443_Q	446_F	0.777	0.98
89_A	100_I	0.776	0.98
176_Y	179_Y	0.776	0.98
446_F	489_S	0.775	0.98
119_L	124_M	0.774	0.98
21_A	25_S	0.774	0.98
484_M	512_Y	0.773	0.98
261_N	429_D	0.771	0.98
29_N	38_Q	0.770	0.98
171_V	174_L	0.770	0.98
482_V	514_Q	0.768	0.98
179_Y	183_F	0.768	0.98
244_E	381_T	0.766	0.98
458_E	461_G	0.766	0.98
364_L	435_A	0.766	0.98
31_A	35_Q	0.765	0.98
400_F	406_T	0.765	0.98
51_F	59_F	0.764	0.98
260_T	422_D	0.764	0.98
252_S	260_T	0.763	0.98
33_F	36_V	0.762	0.98
297_H	301_E	0.762	0.98
419_N	423_N	0.758	0.98
385_H	456_H	0.757	0.98
226_N	229_M	0.757	0.98
245_T	456_H	0.756	0.98
341_V	345_N	0.756	0.98
60_S	66_L	0.754	0.98
300_E	303_A	0.753	0.98
321_L	367_Y	0.753	0.98
152_R	155_L	0.750	0.98
358_E	362_H	0.748	0.98
322_W	327_G	0.747	0.98
115_E	122_P	0.745	0.98
483_P	486_L	0.743	0.98
295_R	299_K	0.742	0.98
154_V	158_G	0.741	0.98
401_T	405_D	0.741	0.98
439_L	443_Q	0.740	0.98
88_A	100_I	0.738	0.98
249_E	478_S	0.737	0.98
163_V	166_L	0.736	0.98
54_M	58_A	0.736	0.98
178_D	181_S	0.735	0.98
67_T	70_S	0.732	0.98
286_V	324_D	0.731	0.97
321_L	343_A	0.730	0.97
268_N	271_Y	0.730	0.97
194_S	197_N	0.728	0.97
355_C	359_V	0.728	0.97
367_Y	370_N	0.727	0.97
35_Q	39_A	0.726	0.97
17_L	20_A	0.726	0.97
193_L	196_S	0.726	0.97
193_L	202_S	0.721	0.97
211_L	215_P	0.717	0.97
361_F	431_I	0.715	0.97
249_E	265_A	0.715	0.97
312_I	315_R	0.714	0.97
27_C	33_F	0.712	0.97
452_Y	485_L	0.706	0.97
115_E	120_M	0.706	0.97
29_N	36_V	0.706	0.97
119_L	122_P	0.706	0.97
26_I	29_N	0.706	0.97
310_L	376_V	0.706	0.97
22_F	29_N	0.703	0.97
177_K	180_A	0.702	0.97
187_K	190_V	0.700	0.97
478_S	481_Q	0.700	0.97
175_F	183_F	0.698	0.97
167_L	171_V	0.697	0.97
114_A	119_L	0.696	0.97
458_E	464_G	0.695	0.97
326_D	380_H	0.695	0.97
314_Q	320_V	0.693	0.97
231_N	234_R	0.693	0.97
436_I	445_K	0.693	0.97
267_D	271_Y	0.691	0.96
192_S	197_N	0.691	0.96
366_E	438_L	0.691	0.96
292_D	518_F	0.690	0.96
113_P	116_S	0.687	0.96
239_I	435_A	0.687	0.96
490_E	493_Q	0.687	0.96
158_G	161_I	0.685	0.96
237_L	447_T	0.684	0.96
47_N	50_V	0.684	0.96
57_V	64_I	0.684	0.96
459_S	479_Q	0.684	0.96
116_S	120_M	0.682	0.96
120_M	123_Q	0.682	0.96
155_L	158_G	0.681	0.96
173_A	178_D	0.680	0.96
311_D	315_R	0.679	0.96
173_A	176_Y	0.678	0.96
518_F	522_L	0.678	0.96
518_F	533_Q	0.678	0.96
398_R	406_T	0.675	0.96
74_L	77_P	0.675	0.96
75_N	79_A	0.674	0.96
177_K	183_F	0.673	0.96
489_S	492_Y	0.672	0.96
27_C	30_I	0.672	0.96
46_H	49_L	0.671	0.96
73_W	77_P	0.671	0.96
62_I	66_L	0.670	0.96
153_S	157_R	0.670	0.96
204_S	207_S	0.668	0.96
237_L	374_D	0.664	0.96
248_A	271_Y	0.659	0.95
371_L	375_G	0.658	0.95
54_M	62_I	0.657	0.95
64_I	68_L	0.655	0.95
323_N	360_L	0.655	0.95
37_L	40_L	0.655	0.95
17_L	21_A	0.654	0.95
330_K	335_R	0.653	0.95
398_R	405_D	0.651	0.95
341_V	346_L	0.647	0.95
19_L	29_N	0.645	0.95
213_N	217_V	0.645	0.95
160_N	164_S	0.642	0.95
54_M	68_L	0.642	0.95
107_N	110_D	0.641	0.95
48_V	54_M	0.640	0.95
322_W	378_V	0.639	0.95
175_F	179_Y	0.639	0.95
131_S	143_K	0.639	0.95
244_E	384_S	0.638	0.95
23_Y	27_C	0.637	0.94
80_C	83_I	0.637	0.94
54_M	67_T	0.636	0.94
238_T	521_L	0.636	0.94
282_T	456_H	0.635	0.94
21_A	33_F	0.635	0.94
186_N	190_V	0.634	0.94
48_V	59_F	0.634	0.94
400_F	423_N	0.632	0.94
63_N	67_T	0.632	0.94
268_N	272_F	0.632	0.94
486_L	520_T	0.631	0.94
185_N	190_V	0.631	0.94
516_N	535_A	0.631	0.94
264_L	485_L	0.630	0.94
192_S	201_A	0.629	0.94
476_P	480_K	0.627	0.94
21_A	28_L	0.626	0.94
203_W	206_Y	0.626	0.94
117_Y	120_M	0.626	0.94
517_L	521_L	0.626	0.94
24_I	29_N	0.625	0.94
309_V	518_F	0.624	0.94
433_D	436_I	0.624	0.94
335_R	339_Q	0.623	0.94
112_T	117_Y	0.623	0.94
175_F	181_S	0.623	0.94
247_R	460_L	0.622	0.94
219_I	222_D	0.622	0.94
268_N	273_P	0.621	0.94
27_C	34_K	0.621	0.94
323_N	326_D	0.620	0.94
25_S	29_N	0.619	0.94
136_A	143_K	0.619	0.94
325_N	360_L	0.617	0.93
244_E	357_D	0.616	0.93
376_V	521_L	0.614	0.93
56_V	60_S	0.614	0.93
173_A	182_L	0.612	0.93
24_I	28_L	0.611	0.93
340_N	345_N	0.609	0.93
28_L	33_F	0.608	0.93
76_R	134_L	0.607	0.93
427_Y	430_Y	0.606	0.93
51_F	55_P	0.605	0.93
421_Y	457_G	0.604	0.93
519_S	533_Q	0.603	0.93
272_F	275_T	0.603	0.93
322_W	325_N	0.602	0.93
44_S	51_F	0.602	0.93
76_R	79_A	0.599	0.92
138_I	141_W	0.597	0.92
241_I	435_A	0.597	0.92
288_C	514_Q	0.596	0.92
287_P	293_M	0.595	0.92
58_A	62_I	0.593	0.92
287_P	291_S	0.593	0.92
280_T	336_V	0.592	0.92
402_P	405_D	0.592	0.92
328_G	332_A	0.592	0.92
290_F	378_V	0.591	0.92
286_V	332_A	0.590	0.92
230_Q	233_K	0.589	0.92
247_R	421_Y	0.589	0.92
216_L	219_I	0.589	0.92
127_T	133_V	0.588	0.92
254_N	257_P	0.588	0.92
251_F	261_N	0.585	0.92
185_N	201_A	0.584	0.92
370_N	373_G	0.584	0.92
174_L	181_S	0.583	0.91
188_E	201_A	0.583	0.91
201_A	205_W	0.581	0.91
432_V	452_Y	0.581	0.91
324_D	380_H	0.580	0.91
162_L	166_L	0.580	0.91
48_V	52_L	0.579	0.91
324_D	381_T	0.577	0.91
202_S	206_Y	0.576	0.91
131_S	145_K	0.576	0.91
358_E	397_F	0.575	0.91
25_S	31_A	0.575	0.91
247_R	253_L	0.575	0.91
441_E	446_F	0.574	0.91
33_F	41_P	0.574	0.91
28_L	32_F	0.573	0.91
158_G	162_L	0.573	0.91
92_F	101_D	0.572	0.91
429_D	433_D	0.571	0.91
143_K	148_T	0.571	0.91
269_V	272_F	0.571	0.91
285_S	514_Q	0.571	0.91
136_A	139_A	0.570	0.91
251_F	254_N	0.570	0.91
18_L	22_F	0.570	0.91
320_V	342_T	0.570	0.91
55_P	62_I	0.568	0.90
163_V	174_L	0.568	0.90
452_Y	487_W	0.568	0.90
424_T	427_Y	0.567	0.90
245_T	455_D	0.566	0.90
195_P	202_S	0.565	0.90
368_I	371_L	0.565	0.90
241_I	381_T	0.564	0.90
163_V	167_L	0.564	0.90
360_L	431_I	0.563	0.90
269_V	276_A	0.562	0.90
103_S	107_N	0.561	0.90
34_K	38_Q	0.561	0.90
54_M	64_I	0.558	0.90
381_T	435_A	0.557	0.90
32_F	35_Q	0.556	0.89
307_E	310_L	0.556	0.89
55_P	59_F	0.556	0.89
140_C	143_K	0.555	0.89
127_T	131_S	0.553	0.89
81_L	154_V	0.553	0.89
463_N	478_S	0.551	0.89
313_I	318_I	0.551	0.89
325_N	382_I	0.550	0.89
271_Y	485_L	0.550	0.89
330_K	333_C	0.550	0.89
271_Y	275_T	0.549	0.89
273_P	508_Q	0.549	0.89
359_V	363_G	0.548	0.89
447_T	451_V	0.548	0.89
402_P	423_N	0.547	0.89
200_V	204_S	0.547	0.89
51_F	54_M	0.547	0.89
250_N	418_V	0.545	0.88
190_V	193_L	0.545	0.88
351_I	356_Y	0.544	0.88
415_E	418_V	0.544	0.88
366_E	370_N	0.544	0.88
144_I	148_T	0.543	0.88
273_P	276_A	0.543	0.88
356_Y	360_L	0.540	0.88
134_L	138_I	0.539	0.88
92_F	284_V	0.539	0.88
118_A	121_T	0.538	0.88
92_F	387_P	0.538	0.88
365_E	434_K	0.537	0.88
393_Y	398_R	0.536	0.88
56_V	68_L	0.536	0.88
393_Y	397_F	0.535	0.88
195_P	206_Y	0.535	0.88
46_H	53_S	0.535	0.88
176_Y	180_A	0.534	0.87
176_Y	182_L	0.533	0.87
336_V	341_V	0.532	0.87
103_S	106_A	0.532	0.87
331_G	336_V	0.531	0.87
243_G	326_D	0.531	0.87
68_L	441_E	0.530	0.87
37_L	41_P	0.529	0.87
292_D	306_Q	0.529	0.87
381_T	384_S	0.529	0.87
107_N	281_A	0.529	0.87
57_V	60_S	0.527	0.87
256_Y	262_P	0.527	0.87
231_N	235_K	0.527	0.87
173_A	181_S	0.527	0.87
442_H	445_K	0.526	0.87
17_L	28_L	0.526	0.87
320_V	376_V	0.526	0.87
461_G	464_G	0.525	0.87
48_V	62_I	0.524	0.87
318_I	449_S	0.524	0.87
325_N	353_G	0.523	0.86
261_N	425_L	0.523	0.86
113_P	120_M	0.523	0.86
55_P	66_L	0.522	0.86
458_E	462_E	0.521	0.86
168_I	171_V	0.521	0.86
143_K	146_P	0.520	0.86
332_A	344_L	0.519	0.86
253_L	271_Y	0.519	0.86
236_N	448_T	0.518	0.86
32_F	36_V	0.518	0.86
25_S	33_F	0.518	0.86
428_V	431_I	0.517	0.86
117_Y	121_T	0.517	0.86
308_G	339_Q	0.516	0.86
284_V	287_P	0.516	0.86
246_S	454_S	0.514	0.85
290_F	310_L	0.514	0.85
203_W	207_S	0.513	0.85
208_H	213_N	0.512	0.85
247_R	285_S	0.512	0.85
84_L	88_A	0.511	0.85
242_V	376_V	0.511	0.85
332_A	380_H	0.511	0.85
50_V	56_V	0.510	0.85
383_G	452_Y	0.509	0.85
221_E	225_R	0.508	0.85
294_P	298_Y	0.507	0.85
513_S	516_N	0.507	0.85
174_L	177_K	0.506	0.85
160_N	173_A	0.506	0.85
324_D	330_K	0.506	0.85
28_L	31_A	0.505	0.84
54_M	60_S	0.505	0.84
313_I	316_A	0.505	0.84
401_T	404_C	0.505	0.84
264_L	425_L	0.505	0.84
164_S	167_L	0.505	0.84
168_I	176_Y	0.504	0.84
340_N	346_L	0.503	0.84
175_F	182_L	0.502	0.84
160_N	163_V	0.502	0.84
199_I	202_S	0.501	0.84
253_L	256_Y	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4kavA	1	0.6051	100	0.484	Contact Map
4tn0A	1	0.5594	100	0.495	Contact Map
4uorA	3	0.5686	100	0.504	Contact Map
2w5qA	1	0.5759	100	0.504	Contact Map
2w8dA	1	0.5759	100	0.51	Contact Map
3lxqA	1	0.5612	100	0.514	Contact Map
4upkA	3	0.5356	100	0.519	Contact Map
2vqrA	3	0.5393	100	0.521	Contact Map
4uplA	2	0.5448	100	0.521	Contact Map
4uopA	2	0.5759	100	0.522	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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