GREMLIN Database
METN - Methionine import ATP-binding protein MetN
UniProt: P30750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11621
Length: 343 (268)
Sequences: 22611 (15825)
Seq/√Len: 966.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_N23_N4.3381.00
32_Q210_C4.2211.00
19_Q22_N3.9021.00
205_K226_S3.5841.00
4_L7_I3.2651.00
5_S61_S3.1531.00
9_K50_C3.1451.00
3_K27_H2.9751.00
35_G208_C2.9081.00
8_T59_E2.6841.00
186_I192_L2.6681.00
29_P32_Q2.5581.00
34_Y212_A2.5541.00
48_I163_L2.5401.00
48_I197_I2.5131.00
7_I57_P2.4151.00
83_Q160_K2.3711.00
96_S139_S2.3541.00
10_V19_Q2.3181.00
22_N218_E2.2331.00
9_K58_T2.1691.00
97_R105_L2.1651.00
8_T23_N2.1331.00
224_T227_E2.1051.00
223_D227_E2.0971.00
49_R54_L2.0851.00
28_V34_Y2.0831.00
136_S140_N2.0711.00
100_F104_A1.9991.00
3_K63_L1.9961.00
4_L26_L1.9841.00
35_G204_V1.9621.00
9_K55_E1.9431.00
210_C221_E1.9201.00
6_N25_S1.9081.00
184_K206_R1.8991.00
8_T19_Q1.8871.00
113_P116_E1.8221.00
26_L212_A1.7541.00
212_A219_L1.7441.00
97_R101_G1.7411.00
99_V141_L1.7181.00
10_V58_T1.7151.00
227_E231_H1.7031.00
210_C222_Q1.6651.00
100_F134_H1.6441.00
198_T204_V1.6211.00
50_C57_P1.5981.00
5_S63_L1.5951.00
100_F135_D1.5881.00
98_T101_G1.5581.00
8_T22_N1.4841.00
49_R55_E1.4661.00
120_R123_E1.4581.00
116_E120_R1.4581.00
97_R102_N1.4541.00
30_A160_K1.4451.00
138_P149_V1.4431.00
196_L208_C1.3981.00
133_K136_S1.3911.00
180_L206_R1.3771.00
4_L51_V1.3751.00
101_G104_A1.3671.00
122_T134_H1.3661.00
102_N138_P1.3511.00
32_Q209_D1.3461.00
102_N153_R1.3441.00
128_V152_A1.3371.00
116_E119_R1.3361.00
52_N163_L1.3331.00
231_H234_T1.3191.00
11_F20_A1.3181.00
158_N192_L1.2891.00
85_G154_A1.2781.00
126_S131_G1.2581.00
85_G159_P1.2411.00
5_S25_S1.2291.00
227_E230_S1.2251.00
42_A214_I1.2161.00
223_D228_V1.2091.00
213_V232_P1.2031.00
280_A284_S1.1971.00
124_L156_A1.1951.00
208_C211_V1.1891.00
137_Y140_N1.1881.00
120_R158_N1.1821.00
123_E127_L1.1821.00
125_L134_H1.1801.00
124_L152_A1.1451.00
141_L149_V1.1351.00
171_L179_I1.1261.00
254_Q258_Q1.1251.00
21_L50_C1.1221.00
11_F46_T1.1211.00
65_D160_K1.1151.00
229_F232_P1.1131.00
94_L97_R1.1111.00
213_V228_V1.1031.00
226_S230_S1.1031.00
51_V195_L1.0951.00
52_N86_M1.0851.00
270_R273_F1.0831.00
28_V193_T1.0831.00
34_Y210_C1.0801.00
282_L286_T1.0801.00
215_S220_I1.0781.00
212_A222_Q1.0741.00
238_Q242_Q1.0721.00
183_L194_I1.0671.00
273_F276_Q1.0621.00
39_A42_A1.0581.00
237_A241_I1.0511.00
104_A121_V1.0401.00
50_C62_V1.0391.00
6_N59_E1.0371.00
122_T130_L1.0291.00
95_S139_S1.0261.00
21_L24_V1.0241.00
98_T102_N1.0201.00
277_S281_P1.0151.00
4_L62_V1.0141.00
9_K46_T1.0121.00
115_D119_R1.0091.00
114_K117_V1.0061.00
124_L127_L1.0051.00
243_S246_H1.0041.00
122_T126_S1.0021.00
54_L88_F0.9991.00
271_L274_T0.9981.00
287_A291_N0.9951.00
276_Q280_A0.9941.00
31_G193_T0.9911.00
264_D268_M0.9911.00
87_I154_A0.9881.00
279_D282_L0.9831.00
286_T290_F0.9791.00
7_I50_C0.9761.00
236_L240_F0.9731.00
278_V281_P0.9711.00
163_L195_L0.9621.00
161_V193_T0.9601.00
235_P238_Q0.9591.00
273_F277_S0.9581.00
225_V229_F0.9581.00
270_R274_T0.9571.00
255_E258_Q0.9561.00
114_K118_K0.9521.00
276_Q279_D0.9481.00
275_G279_D0.9431.00
13_Q18_I0.9401.00
106_P153_R0.9401.00
34_Y195_L0.9361.00
238_Q241_I0.9301.00
5_S27_H0.9231.00
104_A108_E0.9131.00
168_T179_I0.9131.00
219_L222_Q0.9111.00
119_R123_E0.9041.00
93_L102_N0.9041.00
181_E185_D0.9021.00
284_S288_R0.9001.00
180_L203_V0.8941.00
24_V47_L0.8931.00
269_L273_F0.8931.00
268_M272_E0.8881.00
267_P270_R0.8861.00
234_T237_A0.8831.00
277_S280_A0.8821.00
196_L207_I0.8811.00
202_D206_R0.8771.00
85_G89_Q0.8761.00
102_N106_P0.8761.00
95_S146_K0.8741.00
113_P117_V0.8731.00
131_G134_H0.8731.00
23_N59_E0.8701.00
261_P274_T0.8681.00
285_E288_R0.8631.00
279_D284_S0.8551.00
272_E275_G0.8521.00
53_L56_R0.8511.00
99_V102_N0.8511.00
45_S49_R0.8501.00
36_V47_L0.8501.00
258_Q261_P0.8491.00
96_S137_Y0.8441.00
283_L287_A0.8431.00
33_I194_I0.8411.00
220_I235_P0.8381.00
269_L272_E0.8381.00
279_D287_A0.8381.00
102_N105_L0.8351.00
249_I252_D0.8321.00
266_V269_L0.8301.00
263_T266_V0.8301.00
288_R291_N0.8291.00
233_K237_A0.8261.00
234_T238_Q0.8251.00
181_E184_K0.8241.00
127_L185_D0.8241.00
263_T267_P0.8201.00
272_E280_A0.8191.00
262_F266_V0.8181.00
121_V124_L0.8151.00
103_V107_L0.8151.00
176_T200_E0.8141.00
265_C269_L0.8141.00
103_V106_P0.8131.00
237_A240_F0.8111.00
274_T278_V0.8101.00
240_F244_T0.8101.00
280_A287_A0.8101.00
280_A283_L0.8081.00
275_G278_V0.8081.00
230_S234_T0.8021.00
269_L274_T0.8011.00
272_E276_Q0.8011.00
231_H235_P0.7991.00
118_K122_T0.7981.00
104_A118_K0.7971.00
274_T277_S0.7931.00
235_P239_K0.7911.00
278_V282_L0.7891.00
284_S287_A0.7881.00
286_T289_R0.7871.00
251_E254_Q0.7851.00
267_P273_F0.7811.00
88_F91_F0.7791.00
22_N217_G0.7731.00
100_F103_V0.7731.00
268_M271_L0.7701.00
261_P265_C0.7691.00
50_C58_T0.7671.00
264_D267_P0.7651.00
260_E263_T0.7611.00
229_F233_K0.7571.00
265_C268_M0.7501.00
100_F121_V0.7481.00
257_L260_E0.7471.00
33_I196_L0.7461.00
129_G178_S0.7441.00
166_E199_H0.7441.00
266_V270_R0.7401.00
34_Y222_Q0.7351.00
50_C55_E0.7341.00
7_I62_V0.7341.00
64_V82_R0.7321.00
24_V219_L0.7311.00
162_L192_L0.7271.00
243_S247_L0.7231.00
228_V232_P0.7231.00
287_A290_F0.7231.00
211_V225_V0.7221.00
239_K242_Q0.7221.00
117_V121_V0.7211.00
183_L207_I0.7201.00
36_V195_L0.7181.00
138_P146_K0.7171.00
261_P264_D0.7151.00
280_A286_T0.7141.00
109_L114_K0.7081.00
103_V156_A0.7051.00
109_L113_P0.7041.00
29_P210_C0.7031.00
247_L250_P0.7011.00
230_S233_K0.6961.00
30_A65_D0.6901.00
57_P62_V0.6871.00
129_G132_D0.6831.00
218_E222_Q0.6821.00
259_A263_T0.6811.00
262_F265_C0.6771.00
26_L47_L0.6771.00
10_V13_Q0.6751.00
205_K225_V0.6731.00
271_L278_V0.6721.00
86_M89_Q0.6691.00
82_R89_Q0.6671.00
11_F55_E0.6611.00
186_I194_I0.6531.00
256_R260_E0.6491.00
49_R86_M0.6491.00
267_P271_L0.6461.00
87_I164_C0.6451.00
241_I244_T0.6421.00
51_V163_L0.6401.00
161_V195_L0.6351.00
103_V125_L0.6341.00
47_L214_I0.6341.00
119_R122_T0.6321.00
102_N107_L0.6321.00
23_N218_E0.6321.00
84_I161_V0.6301.00
277_S284_S0.6291.00
225_V236_L0.6271.00
265_C270_R0.6271.00
87_I147_Q0.6261.00
126_S132_D0.6261.00
115_D118_K0.6251.00
117_V120_R0.6231.00
265_C273_F0.6231.00
263_T270_R0.6221.00
89_Q143_G0.6201.00
98_T135_D0.6141.00
104_A117_V0.6141.00
107_L156_A0.6121.00
260_E266_V0.6101.00
256_R259_A0.6101.00
263_T269_L0.6081.00
260_E264_D0.6061.00
99_V149_V0.6041.00
123_E126_S0.6041.00
159_P186_I0.6031.00
13_Q19_Q0.6031.00
271_L275_G0.6021.00
267_P274_T0.6001.00
261_P267_P0.6001.00
134_H137_Y0.5991.00
239_K243_S0.5981.00
112_T117_V0.5981.00
256_R261_P0.5981.00
100_F122_T0.5971.00
83_Q157_S0.5971.00
285_E289_R0.5931.00
266_V271_L0.5921.00
182_L185_D0.5891.00
274_T279_D0.5891.00
255_E259_A0.5881.00
242_Q247_L0.5871.00
53_L64_V0.5851.00
9_K21_L0.5841.00
205_K224_T0.5821.00
214_I219_L0.5791.00
250_P253_Y0.5791.00
187_N194_I0.5781.00
225_V228_V0.5761.00
21_L47_L0.5761.00
240_F243_S0.5741.00
241_I245_L0.5741.00
105_L108_E0.5731.00
37_I211_V0.5721.00
173_P177_R0.5711.00
280_A291_N0.5671.00
12_H19_Q0.5641.00
273_F278_V0.5621.00
272_E277_S0.5611.00
284_S291_N0.5611.00
65_D82_R0.5581.00
282_L285_E0.5571.00
94_L102_N0.5571.00
176_T203_V0.5571.00
242_Q246_H0.5561.00
28_V161_V0.5561.00
37_I213_V0.5551.00
262_F267_P0.5551.00
281_P285_E0.5531.00
263_T268_M0.5501.00
257_L261_P0.5501.00
267_P272_E0.5481.00
270_R280_A0.5481.00
92_N95_S0.5471.00
184_K207_I0.5471.00
48_I52_N0.5421.00
9_K12_H0.5391.00
232_P236_L0.5381.00
226_S229_F0.5371.00
274_T280_A0.5361.00
278_V284_S0.5351.00
2_I161_V0.5341.00
10_V22_N0.5331.00
204_V208_C0.5321.00
236_L239_K0.5321.00
2_I64_V0.5321.00
197_I200_E0.5311.00
252_D255_E0.5311.00
122_T132_D0.5301.00
24_V212_A0.5291.00
128_V178_S0.5281.00
35_G211_V0.5261.00
283_L286_T0.5251.00
130_L133_K0.5241.00
250_P254_Q0.5231.00
269_L277_S0.5231.00
54_L92_N0.5231.00
177_R181_E0.5201.00
263_T271_L0.5191.00
275_G280_A0.5181.00
268_M273_F0.5171.00
256_R263_T0.5161.00
151_I179_I0.5151.00
263_T273_F0.5141.00
251_E255_E0.5101.00
285_E291_N0.5101.00
33_I208_C0.5071.00
10_V59_E0.5051.00
26_L34_Y0.5051.00
249_I253_Y0.5041.00
28_V195_L0.5031.00
256_R262_F0.5011.00
91_F146_K0.5001.00
258_Q262_F0.5001.00
267_P275_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 1 100 0.184 Contact Map
4yerA 2 0.8251 100 0.226 Contact Map
4u00A 1 0.6968 100 0.255 Contact Map
4ymuJ 2 0.6968 100 0.255 Contact Map
2oljA 2 0.6968 100 0.256 Contact Map
4rvcA 4 0.688 100 0.257 Contact Map
1vplA 2 0.688 100 0.258 Contact Map
1b0uA 2 0.7143 100 0.26 Contact Map
1oxxK 1 0.965 100 0.263 Contact Map
4mkiB 2 0.8105 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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