GREMLIN Database
MOAE - Molybdopterin synthase catalytic subunit
UniProt: P30749 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11598
Length: 150 (133)
Sequences: 2719 (1735)
Seq/√Len: 150.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_S112_Q2.9531.00
62_A65_E2.9271.00
49_A87_E2.8171.00
51_T87_E2.6361.00
108_F111_G2.5471.00
12_P93_E2.4601.00
109_E112_Q2.3241.00
14_S17_E2.2011.00
67_V79_V2.1161.00
32_V111_G2.0651.00
38_V88_L2.0411.00
117_Y121_R1.9711.00
64_A68_D1.9491.00
63_L81_V1.9151.00
51_T127_R1.8831.00
69_E121_R1.8311.00
22_L98_G1.8141.00
105_S109_E1.7951.00
67_V81_V1.7811.00
46_S131_P1.7751.00
16_G20_P1.7741.00
18_E82_I1.7711.00
49_A129_A1.7561.00
18_E80_T1.7451.00
32_V108_F1.7431.00
95_V118_L1.6631.00
8_V85_I1.6061.00
28_D77_G1.5471.00
95_V115_M1.4831.00
73_R113_F1.4611.00
19_Y33_T1.4541.00
101_S107_A1.4411.00
70_A114_I1.4331.00
97_V115_M1.4281.00
32_V107_A1.3691.00
66_I114_I1.3581.00
79_V99_V1.3441.00
62_A121_R1.3341.00
68_D72_N1.3131.00
74_W113_F1.3131.00
69_E117_Y1.2881.00
74_W110_A1.2761.00
42_N47_V1.2721.00
106_S109_E1.2721.00
117_Y120_T1.2701.00
70_A113_F1.2651.00
52_L94_I1.2611.00
65_E69_E1.2531.00
88_L92_D1.2471.00
15_V19_Y1.2201.00
99_V110_A1.2141.00
69_E72_N1.2001.00
10_P85_I1.1881.00
57_G60_E1.1791.00
79_V114_I1.1761.00
17_E21_W1.1641.00
28_D100_T1.1591.00
13_F82_I1.1351.00
18_E96_F1.1321.00
76_L110_A1.1110.99
56_P60_E1.1090.99
75_P106_S1.0910.99
52_L124_F1.0650.99
69_E73_R1.0600.99
13_F96_F1.0220.99
10_P56_P1.0200.99
60_E64_A1.0180.99
108_F112_Q1.0180.99
67_V71_R1.0170.99
45_D132_E1.0150.99
26_D91_G1.0150.99
35_T96_F1.0080.99
81_V114_I1.0060.99
51_T129_A1.0050.99
88_L94_I0.9980.99
19_Y98_G0.9930.99
108_F115_M0.9850.99
99_V108_F0.9490.98
19_Y35_T0.9300.98
77_G102_A0.9240.98
15_V93_E0.9230.98
113_F117_Y0.9110.98
31_V100_T0.9090.98
62_A122_A0.9050.98
27_E40_N0.9000.98
28_D78_R0.8980.97
61_K65_E0.8940.97
74_W109_E0.8830.97
130_T135_R0.8780.97
38_V50_L0.8730.97
81_V118_L0.8670.97
18_E21_W0.8650.97
54_H85_I0.8650.97
87_E129_A0.8600.97
80_T98_G0.8500.97
45_D134_D0.8480.96
111_G115_M0.8480.96
14_S20_P0.8390.96
20_P24_E0.8360.96
30_A99_V0.8310.96
68_D71_R0.8280.96
60_E63_L0.8230.96
22_L80_T0.8200.96
70_A74_W0.8150.96
89_W92_D0.8130.96
97_V116_D0.8010.95
61_K64_A0.7900.95
62_A123_P0.7870.95
129_A134_D0.7810.94
7_V82_I0.7800.94
39_R103_H0.7570.93
107_A111_G0.7540.93
71_R78_R0.7480.93
38_V94_I0.7400.93
113_F116_D0.7370.93
45_D135_R0.7370.93
31_V37_K0.7290.92
71_R79_V0.7180.92
71_R74_W0.7170.91
32_V35_T0.7160.91
112_Q116_D0.7150.91
40_N46_S0.7150.91
49_A89_W0.7130.91
27_E77_G0.7120.91
48_N131_P0.7030.91
62_A117_Y0.7030.91
9_G13_F0.7020.91
26_D40_N0.7020.91
71_R76_L0.7000.91
45_D130_T0.7000.91
101_S106_S0.6990.90
21_W80_T0.6890.90
65_E68_D0.6830.89
8_V54_H0.6830.89
22_L78_R0.6810.89
6_I67_V0.6770.89
70_A76_L0.6710.89
59_T122_A0.6710.89
94_I118_L0.6680.88
37_K95_V0.6660.88
90_P117_Y0.6590.88
33_T98_G0.6560.87
84_R88_L0.6560.87
27_E41_H0.6530.87
22_L100_T0.6520.87
63_L66_I0.6510.87
7_V18_E0.6500.87
112_Q115_M0.6480.87
38_V59_T0.6470.87
66_I121_R0.6430.86
55_Y58_M0.6420.86
7_V60_E0.6390.86
71_R75_P0.6380.86
25_R28_D0.6340.86
25_R78_R0.6280.85
99_V111_G0.6260.85
53_E58_M0.6260.85
59_T124_F0.6230.85
43_L135_R0.6160.84
93_E96_F0.6080.83
15_V35_T0.6080.83
41_H47_V0.6070.83
63_L122_A0.6060.83
33_T96_F0.5990.82
17_E20_P0.5930.82
66_I116_D0.5890.81
66_I117_Y0.5840.81
54_H59_T0.5820.80
35_T93_E0.5820.80
53_E127_R0.5800.80
56_P85_I0.5730.79
99_V114_I0.5700.79
42_N130_T0.5690.79
65_E121_R0.5690.79
80_T100_T0.5660.79
30_A107_A0.5610.78
8_V63_L0.5440.76
75_P102_A0.5430.76
57_G114_I0.5400.75
42_N137_V0.5360.75
81_V97_V0.5320.74
111_G137_V0.5300.74
80_T96_F0.5280.74
40_N47_V0.5240.73
43_L46_S0.5220.73
82_I85_I0.5220.73
28_D37_K0.5210.73
20_P48_N0.5210.73
7_V80_T0.5190.72
24_E37_K0.5180.72
25_R77_G0.5150.72
41_H102_A0.5100.71
9_G17_E0.5080.71
48_N129_A0.5080.71
55_Y128_E0.5070.71
8_V60_E0.5070.71
135_R138_E0.5050.70
130_T133_G0.5040.70
21_W82_I0.5020.70
50_L137_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fm0E 2 0.9467 100 0.071 Contact Map
2q5wE 2 0.9067 100 0.129 Contact Map
2omdA 2 0.9267 100 0.131 Contact Map
2wp4A 2 0.8467 100 0.133 Contact Map
4ap8A 2 0.8733 100 0.185 Contact Map
3rpfA 2 0.94 100 0.208 Contact Map
2xexA 1 0.4533 29.7 0.938 Contact Map
4kiyV 1 0.4267 26.8 0.939 Contact Map
2dy1A 1 0.4667 20.5 0.942 Contact Map
4usiA 3 0.6267 15.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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