GREMLIN Database
MOAD - Molybdopterin synthase sulfur carrier subunit
UniProt: P30748 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11597
Length: 81 (80)
Sequences: 730 (467)
Seq/√Len: 52.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_N70_D4.0871.00
25_F34_H3.0401.00
31_L66_L3.0351.00
39_S42_W2.7511.00
3_K18_A2.6951.00
55_V64_H2.5351.00
6_F19_T2.4701.00
60_V64_H2.1511.00
14_V45_A2.1451.00
28_V53_A1.9811.00
26_P30_A1.9060.99
10_V45_A1.8300.99
28_V55_V1.7120.99
55_V60_V1.6760.99
32_R46_L1.5860.98
33_Q36_A1.5410.97
57_Q71_E1.5340.97
32_R74_F1.4770.97
66_L72_V1.3860.95
10_V51_L1.3850.95
27_T30_A1.3740.95
55_V66_L1.3010.93
6_F42_W1.2660.92
40_D44_L1.2630.92
30_A33_Q1.2510.92
13_L52_L1.2450.92
9_Q59_L1.2400.92
3_K20_E1.2020.90
2_I59_L1.1960.90
9_Q52_L1.1350.88
22_A34_H1.1140.87
4_V28_V1.0960.86
4_V74_F1.0280.82
10_V60_V1.0200.81
4_V72_V1.0160.81
45_A49_G0.9790.78
38_Q42_W0.9770.78
53_A62_F0.9690.78
53_A60_V0.9650.77
2_I72_V0.9590.77
9_Q13_L0.9410.76
5_L77_P0.9360.75
44_L47_E0.9130.73
34_H38_Q0.9130.73
8_A15_G0.9100.73
37_A43_A0.9000.72
6_F52_L0.8940.72
55_V70_D0.8810.71
67_T70_D0.8620.69
14_V74_F0.8580.69
22_A25_F0.8510.68
14_V59_L0.8400.67
29_E61_S0.8370.67
61_S72_V0.8290.66
11_R15_G0.8280.66
2_I8_A0.8190.65
14_V44_L0.8070.64
5_L55_V0.8030.64
36_A53_A0.8010.63
2_I69_G0.8000.63
10_V13_L0.8000.63
46_L59_L0.7970.63
6_F9_Q0.7930.63
14_V20_E0.7750.61
5_L57_Q0.7730.61
39_S44_L0.7670.60
11_R47_E0.7630.60
70_D78_V0.7570.59
14_V42_W0.7540.59
41_R44_L0.7540.59
40_D43_A0.7380.57
21_V34_H0.7320.56
9_Q42_W0.7170.55
31_L72_V0.7150.55
6_F16_T0.6960.53
19_T23_A0.6760.51
16_T33_Q0.6720.50
15_G46_L0.6680.50
2_I68_D0.6600.49
66_L70_D0.6570.49
19_T22_A0.6570.49
9_Q14_V0.6540.48
28_V62_F0.6490.48
3_K24_D0.6480.48
59_L78_V0.6330.46
8_A11_R0.6290.46
51_L74_F0.6260.45
41_R59_L0.6160.44
39_S47_E0.6130.44
37_A47_E0.6090.44
56_N69_G0.5950.42
9_Q45_A0.5940.42
5_L27_T0.5850.41
31_L34_H0.5760.40
69_G78_V0.5750.40
24_D33_Q0.5700.40
47_E50_K0.5660.39
13_L32_R0.5660.39
66_L69_G0.5650.39
46_L74_F0.5650.39
56_N68_D0.5650.39
8_A54_A0.5620.39
34_H66_L0.5560.38
33_Q51_L0.5540.38
56_N78_V0.5510.38
19_T34_H0.5390.37
20_E47_E0.5360.36
3_K72_V0.5260.35
10_V25_F0.5250.35
32_R62_F0.5190.35
32_R69_G0.5160.34
23_A31_L0.5150.34
33_Q48_D0.5110.34
3_K57_Q0.5090.34
37_A57_Q0.5070.33
2_I40_D0.5070.33
30_A48_D0.5070.33
19_T65_P0.5030.33
61_S77_P0.5000.33
6_F69_G0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fm0D 1 1 99.8 0.415 Contact Map
2k9xA 1 0.9877 99.8 0.43 Contact Map
1vjkA 1 0.963 99.8 0.442 Contact Map
4idiA 1 0.963 99.8 0.444 Contact Map
2qjlA 1 1 99.8 0.444 Contact Map
1wgkA 1 1 99.8 0.445 Contact Map
4hroA 1 0.9753 99.8 0.463 Contact Map
2g1eA 1 0.9877 99.8 0.469 Contact Map
1v8cA 3 0.963 99.8 0.47 Contact Map
2m19A 1 1 99.8 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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