GREMLIN Database
MOAA - Cyclic pyranopterin monophosphate synthase
UniProt: P30745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11595
Length: 329 (274)
Sequences: 11012 (8312)
Seq/√Len: 502.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_F103_Y4.1391.00
149_D184_R3.6501.00
53_R86_A3.5501.00
57_R86_A2.6901.00
110_A154_A2.6211.00
48_T51_E2.6031.00
128_D142_N2.5841.00
57_R90_N2.4901.00
81_T111_S2.4901.00
270_K282_N2.4491.00
107_R150_A2.4061.00
51_E287_L2.3811.00
25_N101_N2.3761.00
150_A153_E2.3031.00
131_Q173_Q2.2841.00
16_L59_F2.1611.00
54_R58_A2.1091.00
110_A114_D2.1081.00
163_T177_F2.0791.00
88_R118_T2.0651.00
173_Q176_T2.0321.00
125_D136_T2.0111.00
56_T87_V1.9821.00
108_D111_S1.9581.00
270_K285_D1.9561.00
133_H139_D1.9011.00
141_F180_W1.8471.00
49_V82_D1.8241.00
106_E146_A1.8081.00
141_F145_M1.8081.00
23_V46_F1.7861.00
161_V181_I1.7851.00
149_D152_F1.7661.00
65_E94_R1.7651.00
111_S114_D1.7641.00
86_A89_E1.7631.00
127_L173_Q1.7611.00
256_F274_C1.7151.00
52_I83_I1.6891.00
146_A149_D1.6881.00
69_L87_V1.6781.00
30_Y125_D1.6771.00
167_R212_V1.6601.00
129_A142_N1.6591.00
79_D82_D1.6541.00
142_N146_A1.6431.00
82_D85_A1.6281.00
282_N285_D1.6261.00
49_V53_R1.6211.00
175_D219_R1.6191.00
150_A154_A1.6171.00
102_G122_V1.6001.00
25_N104_R1.5981.00
128_D173_Q1.5811.00
179_N183_H1.5691.00
285_D288_E1.5691.00
127_L131_Q1.5571.00
60_A90_N1.5481.00
51_E54_R1.5421.00
143_Q146_A1.5411.00
266_S272_H1.5361.00
75_S98_V1.5241.00
176_T179_N1.5211.00
49_V79_D1.5191.00
149_D153_E1.4981.00
126_S131_Q1.4971.00
86_A90_N1.4941.00
85_A89_E1.4881.00
122_V148_I1.4771.00
29_T134_A1.4711.00
266_S270_K1.4691.00
152_F185_P1.4501.00
180_W184_R1.4471.00
179_N220_R1.4131.00
53_R57_R1.4091.00
122_V147_G1.3871.00
107_R153_E1.3841.00
168_D171_H1.3591.00
88_R96_I1.3581.00
81_T108_D1.3561.00
109_V113_R1.3441.00
132_F144_V1.3371.00
129_A139_D1.3281.00
289_D293_Q1.3181.00
144_V147_G1.3101.00
53_R82_D1.3071.00
290_D293_Q1.3001.00
20_I69_L1.2931.00
120_I151_A1.2861.00
14_Y65_E1.2761.00
214_R218_L1.2761.00
85_A111_S1.2741.00
209_S212_V1.2661.00
145_M149_D1.2631.00
46_F77_R1.2601.00
67_V87_V1.2531.00
133_H140_K1.2141.00
87_V96_I1.2141.00
145_M180_W1.2081.00
132_F140_K1.2041.00
131_Q172_H1.2021.00
75_S104_R1.1991.00
134_A168_D1.1991.00
99_T121_N1.1891.00
152_F184_R1.1871.00
215_D218_L1.1831.00
257_C260_C1.1791.00
61_R297_E1.1691.00
152_F186_I1.1621.00
163_T188_L1.1611.00
69_L96_I1.1541.00
47_L51_E1.1521.00
77_R83_I1.1501.00
291_T295_A1.1451.00
18_L52_I1.1451.00
58_A62_L1.1451.00
292_Q295_A1.1211.00
215_D219_R1.1191.00
131_Q134_A1.1151.00
135_I166_M1.1011.00
128_D176_T1.1001.00
107_R154_A1.0951.00
82_D86_A1.0941.00
145_M184_R1.0921.00
211_Q215_D1.0901.00
84_I117_L1.0901.00
111_S115_A1.0821.00
69_L84_I1.0771.00
20_I80_F1.0751.00
146_A150_A1.0721.00
161_V186_I1.0721.00
113_R154_A1.0601.00
49_V86_A1.0511.00
110_A150_A1.0491.00
127_L180_W1.0341.00
289_D294_Q1.0301.00
59_F67_V1.0241.00
81_T85_A1.0231.00
216_E219_R1.0231.00
230_S233_P1.0191.00
212_V215_D1.0121.00
18_L265_V1.0111.00
75_S80_F1.0101.00
256_F260_C1.0101.00
45_G268_I1.0101.00
152_F159_V1.0091.00
175_D179_N0.9991.00
53_R89_E0.9971.00
121_N162_N0.9951.00
128_D131_Q0.9891.00
55_V265_V0.9881.00
179_N182_Q0.9871.00
58_A290_D0.9811.00
56_T90_N0.9801.00
294_Q297_E0.9701.00
109_V150_A0.9701.00
54_R293_Q0.9681.00
140_K143_Q0.9621.00
47_L52_I0.9571.00
128_D133_H0.9551.00
272_H282_N0.9531.00
81_T115_A0.9491.00
22_D267_S0.9481.00
66_K95_Q0.9461.00
83_I87_V0.9451.00
80_F84_I0.9431.00
109_V154_A0.9361.00
113_R156_F0.9351.00
126_S141_F0.9331.00
21_T46_F0.9301.00
56_T67_V0.9281.00
120_I156_F0.9231.00
106_E150_A0.9191.00
165_L174_L0.9171.00
218_L222_W0.9161.00
59_F64_T0.9121.00
147_G150_A0.9121.00
16_L263_L0.9021.00
257_C274_C0.9011.00
148_I159_V0.9001.00
181_I188_L0.8971.00
151_A159_V0.8971.00
287_L290_D0.8961.00
271_L294_Q0.8921.00
49_V83_I0.8911.00
158_K187_Q0.8891.00
148_I161_V0.8881.00
148_I186_I0.8851.00
143_Q147_G0.8841.00
54_R57_R0.8811.00
25_N103_Y0.8801.00
25_N73_E0.8751.00
66_K97_A0.8721.00
232_G235_Q0.8581.00
88_R116_G0.8551.00
229_R232_G0.8531.00
54_R287_L0.8501.00
32_L70_T0.8461.00
29_T135_I0.8431.00
84_I115_A0.8391.00
30_Y135_I0.8341.00
291_T294_Q0.8281.00
231_D234_A0.8251.00
18_L56_T0.8241.00
95_Q119_G0.8201.00
80_F98_V0.8151.00
105_L147_G0.8131.00
239_H242_Y0.8131.00
109_V147_G0.8131.00
105_L122_V0.8111.00
181_I186_I0.8101.00
105_L151_A0.8101.00
180_W183_H0.8091.00
161_V188_L0.8001.00
234_A237_F0.7941.00
123_S164_V0.7941.00
26_F140_K0.7941.00
19_S70_T0.7901.00
14_Y261_N0.7881.00
142_N145_M0.7821.00
95_Q118_T0.7821.00
53_R90_N0.7811.00
126_S136_T0.7801.00
132_F141_F0.7791.00
47_L55_V0.7781.00
79_D83_I0.7771.00
224_H238_C0.7771.00
151_A156_F0.7741.00
233_P236_V0.7681.00
122_V151_A0.7671.00
69_L83_I0.7641.00
16_L265_V0.7641.00
98_V117_L0.7631.00
68_R97_A0.7591.00
58_A61_R0.7581.00
187_Q245_E0.7581.00
132_F136_T0.7561.00
106_E147_G0.7551.00
75_S147_G0.7531.00
57_R61_R0.7531.00
256_F259_T0.7501.00
292_Q296_L0.7481.00
20_I83_I0.7461.00
177_F188_L0.7461.00
60_A94_R0.7401.00
20_I77_R0.7391.00
231_D236_V0.7391.00
113_R118_T0.7351.00
100_T122_V0.7351.00
124_V161_V0.7321.00
212_V216_E0.7301.00
81_T84_I0.7281.00
133_H136_T0.7241.00
147_G151_A0.7241.00
19_S264_R0.7241.00
49_V77_R0.7221.00
238_C241_D0.7191.00
98_V120_I0.7171.00
179_N223_I0.7131.00
232_G236_V0.7131.00
290_D295_A0.7111.00
19_S267_S0.7111.00
210_G214_R0.7071.00
152_F187_Q0.7021.00
217_L221_G0.7011.00
34_D137_G0.7011.00
133_H138_Q0.6991.00
50_D53_R0.6961.00
121_N160_K0.6941.00
84_I96_I0.6931.00
217_L220_R0.6931.00
52_I77_R0.6931.00
29_T137_G0.6921.00
233_P237_F0.6911.00
286_L289_D0.6891.00
126_S173_Q0.6871.00
30_Y136_T0.6871.00
177_F181_I0.6851.00
73_E101_N0.6811.00
113_R116_G0.6731.00
21_T77_R0.6721.00
106_E143_Q0.6691.00
52_I55_V0.6631.00
110_A113_R0.6561.00
17_R70_T0.6551.00
249_I252_Y0.6551.00
163_T181_I0.6531.00
124_V141_F0.6521.00
18_L55_V0.6511.00
70_T275_L0.6491.00
211_Q214_R0.6491.00
15_Y66_K0.6481.00
235_Q240_P0.6471.00
133_H141_F0.6451.00
77_R82_D0.6441.00
286_L291_T0.6411.00
159_V186_I0.6341.00
225_Q228_Q0.6341.00
129_A141_F0.6341.00
210_G250_M0.6321.00
50_D86_A0.6311.00
56_T69_L0.6301.00
114_D154_A0.6291.00
216_E220_R0.6281.00
264_R275_L0.6281.00
127_L176_T0.6271.00
68_R99_T0.6261.00
170_N173_Q0.6251.00
249_I253_E0.6251.00
175_D178_L0.6211.00
99_T162_N0.6211.00
85_A114_D0.6191.00
271_L291_T0.6171.00
285_D289_D0.6161.00
234_A238_C0.6141.00
107_R110_A0.6121.00
101_N104_R0.6111.00
54_R290_D0.6111.00
17_R262_R0.6101.00
97_A119_G0.6090.99
229_R233_P0.6070.99
122_V144_V0.6070.99
62_L297_E0.6050.99
213_L216_E0.6040.99
28_C31_C0.6020.99
246_I249_I0.6020.99
58_A297_E0.6010.99
191_I194_M0.5980.99
104_R107_R0.5970.99
87_V94_R0.5960.99
26_F132_F0.5960.99
24_C28_C0.5960.99
129_A133_H0.5930.99
167_R209_S0.5910.99
248_L253_E0.5870.99
33_P70_T0.5830.99
87_V90_N0.5830.99
290_D294_Q0.5830.99
244_G247_G0.5820.99
126_S132_F0.5800.99
162_N191_I0.5780.99
85_A115_A0.5780.99
119_G158_K0.5770.99
73_E76_L0.5770.99
293_Q296_L0.5770.99
124_V144_V0.5760.99
23_V44_K0.5740.99
232_G237_F0.5740.99
119_G160_K0.5720.99
203_F206_H0.5710.99
175_D220_R0.5690.99
99_T275_L0.5690.99
70_T99_T0.5680.99
224_H240_P0.5670.99
67_V96_I0.5670.99
213_L217_L0.5670.99
219_R222_W0.5660.99
99_T276_F0.5640.99
24_C31_C0.5630.99
228_Q231_D0.5620.99
105_L112_W0.5620.99
125_D164_V0.5610.99
239_H243_A0.5590.99
55_V59_F0.5590.99
77_R80_F0.5590.99
284_R289_D0.5560.99
106_E109_V0.5560.99
17_R275_L0.5550.99
247_G250_M0.5500.99
105_L109_V0.5500.99
214_R248_L0.5490.99
128_D172_H0.5490.99
178_L182_Q0.5490.99
284_R294_Q0.5460.99
265_V271_L0.5460.99
208_I213_L0.5400.99
47_L284_R0.5400.99
16_L64_T0.5380.99
231_D235_Q0.5380.99
178_L239_H0.5380.99
250_M254_K0.5380.99
213_L220_R0.5310.99
230_S234_A0.5310.99
273_L277_G0.5300.99
262_R275_L0.5300.99
61_R292_Q0.5300.99
293_Q297_E0.5300.99
214_R217_L0.5290.99
263_L291_T0.5290.99
58_A296_L0.5290.99
73_E102_G0.5270.99
96_I118_T0.5270.99
56_T60_A0.5270.99
178_L188_L0.5260.99
136_T139_D0.5250.99
25_N76_L0.5230.98
230_S236_V0.5220.98
51_E55_V0.5210.98
20_I52_I0.5200.98
206_H210_G0.5180.98
103_Y147_G0.5160.98
67_V94_R0.5150.98
156_F159_V0.5140.98
17_R264_R0.5140.98
219_R223_I0.5110.98
258_A274_C0.5090.98
58_A292_Q0.5090.98
70_T162_N0.5070.98
193_L199_G0.5050.98
126_S129_A0.5020.98
15_Y68_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tv8A 2 0.9574 100 0.298 Contact Map
4k36A 1 0.924 100 0.392 Contact Map
4m7tA 1 0.7143 100 0.48 Contact Map
4rtbA 2 0.8906 100 0.586 Contact Map
3c8fA 1 0.6748 100 0.586 Contact Map
2a5hA 4 0.8784 99.9 0.606 Contact Map
2yx0A 1 0.7538 99.9 0.609 Contact Map
3rfaA 1 0.7477 99.9 0.617 Contact Map
4wcxA 1 0.9119 99.9 0.618 Contact Map
2qgqA 1 0.7599 99.9 0.618 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.