GREMLIN Database
SDHM - L-serine dehydratase 2
UniProt: P30744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11623
Length: 455 (449)
Sequences: 1755 (992)
Seq/√Len: 46.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_A313_A4.5391.00
189_S356_E4.1591.00
373_M424_V4.1451.00
264_I404_V4.0001.00
220_I298_A3.9381.00
197_L202_K3.6331.00
265_N405_N3.5611.00
426_E430_E3.5511.00
128_R142_T3.4881.00
314_R356_E3.2021.00
71_A86_F3.1971.00
180_H184_T3.1061.00
197_L205_L3.0671.00
300_Y311_S3.0411.00
355_A360_A3.0031.00
44_R112_C2.9891.00
182_Q363_A2.9391.00
194_K197_L2.8421.00
355_A407_A2.8211.00
180_H191_L2.7901.00
201_S204_E2.7261.00
325_L425_I2.7171.00
326_Y348_S2.7141.00
91_N109_V2.7021.00
122_L144_Y2.6741.00
337_V341_G2.6561.00
193_M206_E2.5901.00
244_R248_V2.5701.00
209_L316_L2.5411.00
94_G108_P2.5031.00
67_I90_V2.4871.00
347_C372_A2.4791.00
34_I102_Q2.4771.00
241_A245_R2.4701.00
179_K183_E2.3381.00
95_R104_E2.2761.00
326_Y345_V2.2531.00
108_P111_Q2.2431.00
44_R132_L2.2311.00
210_A309_A2.2271.00
74_L77_T2.2121.00
130_T140_S2.1821.00
206_E313_A2.1491.00
10_I211_N2.1241.00
71_A90_V2.1111.00
227_E245_R2.1111.00
189_S314_R2.1001.00
4_V320_S2.0921.00
9_K24_K2.0781.00
130_T137_V2.0781.00
181_C362_P2.0731.00
48_D116_H2.0320.99
202_K206_E2.0100.99
322_I352_A1.9770.99
133_A136_K1.9770.99
4_V209_L1.9460.99
120_L126_G1.9380.99
233_K387_Q1.9020.99
49_V66_I1.8840.99
229_V235_R1.8800.99
28_Q151_I1.8800.99
48_D130_T1.8650.99
27_K31_D1.8640.99
67_I113_M1.8550.99
356_E365_V1.8400.99
8_F319_A1.8380.99
32_D139_Y1.8110.99
9_K76_D1.7990.99
309_A313_A1.7950.99
206_E210_A1.7900.99
206_E309_A1.7850.99
45_V98_L1.7760.99
5_F208_H1.7550.98
43_T133_A1.7270.98
89_D93_H1.7260.98
362_P365_V1.7130.98
200_H204_E1.7110.98
419_V451_I1.6920.98
186_L191_L1.6790.98
38_L41_D1.6700.98
190_G194_K1.6620.98
169_Y194_K1.6620.98
326_Y373_M1.6600.98
347_C376_N1.6490.98
203_E207_Q1.6490.98
307_V311_S1.6400.98
434_D439_Y1.6340.98
334_G397_A1.6300.97
177_L191_L1.5910.97
360_A411_L1.5860.97
137_V140_S1.5720.97
345_V399_A1.5660.97
63_D115_F1.5640.97
141_Q153_D1.5620.97
421_L425_I1.5510.97
200_H208_H1.5420.96
426_E429_Y1.5410.96
81_D222_R1.5360.96
176_D179_K1.5350.96
217_R298_A1.5210.96
361_S364_Q1.5170.96
181_C191_L1.5060.96
33_L131_A1.5060.96
5_F205_L1.5040.96
430_E433_K1.5040.96
192_M324_S1.5030.96
40_K103_H1.5020.96
172_S328_M1.4980.96
267_F303_F1.4920.96
310_N314_R1.4890.96
367_I413_R1.4880.96
32_D141_Q1.4870.96
169_Y184_T1.4860.96
201_S205_L1.4810.96
256_D408_R1.4780.95
237_P416_E1.4770.95
122_L157_F1.4740.95
318_V356_E1.4730.95
193_M205_L1.4500.95
348_S373_M1.4490.95
43_T134_G1.4380.95
39_L103_H1.4350.95
218_G222_R1.4270.94
308_N311_S1.4240.94
206_E310_N1.4130.94
193_M202_K1.4100.94
67_I71_A1.4030.94
73_N86_F1.3970.94
217_R220_I1.3890.94
331_S341_G1.3850.94
311_S357_L1.3810.93
142_T154_E1.3810.93
376_N379_L1.3810.93
429_Y433_K1.3620.93
119_N124_E1.3500.93
213_W312_L1.3450.93
108_P112_C1.3430.92
172_S176_D1.3380.92
10_I215_V1.3360.92
180_H183_E1.3320.92
390_V418_R1.3240.92
300_Y307_V1.3210.92
222_R274_E1.3190.92
27_K74_L1.3100.92
171_Y192_M1.3050.91
178_Q362_P1.2950.91
66_I127_M1.2840.91
67_I109_V1.2840.91
224_I266_M1.2810.91
132_L137_V1.2790.91
398_I405_N1.2770.90
211_N215_V1.2680.90
95_R106_E1.2640.90
413_R417_P1.2510.90
88_Q92_T1.2510.90
245_R248_V1.2470.89
26_G129_I1.2420.89
187_S190_G1.2410.89
322_I353_G1.2370.89
73_N82_S1.2330.89
292_I334_G1.2300.89
200_H205_L1.2280.89
46_V130_T1.2270.89
97_M104_E1.2220.88
221_E225_S1.2200.88
34_I99_A1.2140.88
367_I417_P1.2120.88
246_M412_R1.2060.88
401_V405_N1.2050.88
426_E450_K1.2040.88
42_V138_V1.1860.87
202_K205_L1.1770.86
265_N398_I1.1690.86
208_H212_V1.1660.86
173_S176_D1.1630.86
214_E218_G1.1560.85
366_C417_P1.1500.85
64_I84_P1.1420.85
86_F90_V1.1410.85
122_L154_E1.1390.85
184_T191_L1.1360.84
345_V348_S1.1360.84
310_N313_A1.1230.84
170_P180_H1.1220.84
292_I379_L1.1220.84
58_K63_D1.1160.83
50_Y126_G1.1050.83
367_I415_S1.1030.83
46_V114_N1.1020.83
58_K115_F1.1010.82
99_A102_Q1.0930.82
42_V131_A1.0860.82
437_A444_R1.0770.81
36_R139_Y1.0760.81
267_F302_K1.0750.81
219_G281_V1.0750.81
126_G129_I1.0700.81
186_L194_K1.0680.80
334_G343_V1.0530.80
261_V401_V1.0450.79
292_I400_A1.0450.79
197_L201_S1.0440.79
133_A138_V1.0420.79
331_S337_V1.0410.79
5_F212_V1.0410.79
96_L107_F1.0380.79
190_G314_R1.0370.78
262_D408_R1.0310.78
82_S86_F1.0220.77
298_A302_K1.0170.77
28_Q156_H1.0140.77
217_R221_E1.0080.76
360_A364_Q1.0020.76
39_L98_L1.0020.76
427_T447_L1.0020.76
423_K452_V1.0010.76
384_V419_V1.0000.76
187_S356_E0.9980.76
226_T241_A0.9960.76
94_G109_V0.9920.75
345_V372_A0.9920.75
175_A179_K0.9920.75
10_I212_V0.9920.75
76_D211_N0.9840.75
127_M451_I0.9810.75
264_I401_V0.9790.74
347_C399_A0.9780.74
54_S62_T0.9760.74
170_P195_N0.9740.74
31_D99_A0.9690.74
153_D157_F0.9680.74
250_Q412_R0.9650.73
341_G405_N0.9640.73
326_Y353_G0.9640.73
269_L397_A0.9620.73
318_V322_I0.9610.73
427_T434_D0.9580.73
68_M83_I0.9500.72
79_D82_S0.9480.72
24_K76_D0.9460.72
198_A205_L0.9360.71
171_Y321_A0.9360.71
214_E309_A0.9330.71
324_S372_A0.9320.71
30_T99_A0.9270.70
55_L444_R0.9240.70
301_D312_L0.9240.70
2_I6_D0.9230.70
247_L263_W0.9230.70
109_V113_M0.9230.70
41_D133_A0.9140.69
47_V129_I0.9120.69
55_L345_V0.9110.69
210_A310_N0.9100.69
262_D412_R0.9080.69
331_S432_G0.9050.68
251_D254_T0.9050.68
170_P173_S0.9050.68
263_W303_F0.9030.68
46_V132_L0.9000.68
97_M102_Q0.9000.68
20_V24_K0.8990.68
213_W217_R0.8930.67
188_L318_V0.8930.67
265_N397_A0.8920.67
40_K102_Q0.8920.67
38_L42_V0.8920.67
62_T168_P0.8920.67
153_D156_H0.8900.67
116_H119_N0.8890.67
193_M197_L0.8870.67
86_F89_D0.8850.67
128_R140_S0.8850.67
42_V98_L0.8830.66
430_E450_K0.8820.66
222_R226_T0.8800.66
324_S328_M0.8800.66
94_G106_E0.8790.66
366_C415_S0.8770.66
168_P198_A0.8680.65
337_V432_G0.8640.65
311_S314_R0.8610.64
176_D183_E0.8590.64
141_Q155_E0.8560.64
39_L42_V0.8560.64
229_V233_K0.8530.64
66_I113_M0.8490.63
209_L320_S0.8460.63
39_L99_A0.8450.63
168_P195_N0.8440.63
299_Y303_F0.8440.63
180_H185_G0.8380.62
37_N40_K0.8310.62
345_V373_M0.8270.61
379_L398_I0.8200.61
64_I443_S0.8190.61
211_N214_E0.8170.60
208_H211_N0.8100.60
177_L321_A0.8070.59
62_T115_F0.8060.59
199_L205_L0.8030.59
292_I343_V0.7990.59
87_I91_N0.7920.58
9_K20_V0.7920.58
82_S89_D0.7920.58
224_I244_R0.7910.58
31_D34_I0.7910.58
71_A97_M0.7910.58
251_D259_A0.7860.57
334_G337_V0.7850.57
28_Q32_D0.7840.57
12_I68_M0.7840.57
48_D114_N0.7820.57
13_G17_S0.7800.57
89_D92_T0.7790.57
300_Y304_I0.7690.56
169_Y180_H0.7690.56
348_S424_V0.7620.55
189_S318_V0.7610.55
221_E298_A0.7610.55
81_D84_P0.7590.55
207_Q211_N0.7530.54
167_V199_L0.7450.53
227_E241_A0.7410.53
49_V113_M0.7400.53
301_D307_V0.7390.53
252_K255_T0.7370.53
150_F327_K0.7370.53
120_L142_T0.7360.52
187_S314_R0.7350.52
256_D264_I0.7320.52
331_S334_G0.7320.52
38_L138_V0.7320.52
56_T59_G0.7300.52
300_Y357_L0.7280.52
2_I328_M0.7260.52
409_M418_R0.7230.51
426_E433_K0.7220.51
190_G249_S0.7210.51
61_H443_S0.7200.51
257_P262_D0.7190.51
84_P87_I0.7180.51
66_I124_E0.7150.50
191_L361_S0.7140.50
366_C413_R0.7130.50
256_D259_A0.7100.50
215_V219_G0.7080.50
221_E244_R0.7070.50
78_V83_I0.7060.50
193_M313_A0.7060.50
193_M310_N0.7050.49
82_S85_S0.7030.49
48_D64_I0.7030.49
96_L105_V0.7000.49
45_V122_L0.6990.49
168_P199_L0.6980.49
306_E311_S0.6980.49
364_Q371_I0.6960.49
13_G18_H0.6940.48
265_N401_V0.6930.48
124_E144_Y0.6930.48
242_A246_M0.6900.48
258_M408_R0.6900.48
376_N398_I0.6890.48
293_I319_A0.6880.48
325_L329_N0.6870.48
355_A409_M0.6870.48
58_K61_H0.6860.48
120_L144_Y0.6860.48
87_I109_V0.6850.47
372_A409_M0.6850.47
169_Y195_N0.6840.47
64_I334_G0.6830.47
31_D35_A0.6820.47
385_A390_V0.6810.47
345_V424_V0.6810.47
63_D113_M0.6780.47
220_I301_D0.6780.47
50_Y116_H0.6750.46
192_M321_A0.6710.46
84_P88_Q0.6710.46
71_A89_D0.6700.46
427_T450_K0.6700.46
117_A436_N0.6690.46
345_V429_Y0.6660.46
226_T277_A0.6640.45
267_F329_N0.6630.45
356_E362_P0.6590.45
304_I311_S0.6580.45
153_D376_N0.6580.45
243_L267_F0.6580.45
318_V352_A0.6550.44
348_S376_N0.6550.44
186_L363_A0.6550.44
68_M84_P0.6550.44
88_Q91_N0.6550.44
341_G432_G0.6540.44
184_T194_K0.6530.44
252_K302_K0.6530.44
26_G66_I0.6520.44
221_E302_K0.6520.44
221_E224_I0.6520.44
194_K225_S0.6520.44
292_I397_A0.6500.44
317_L397_A0.6500.44
267_F357_L0.6490.44
364_Q411_L0.6480.44
320_S324_S0.6460.44
93_H106_E0.6430.43
301_D311_S0.6430.43
141_Q151_I0.6430.43
420_C424_V0.6430.43
186_L242_A0.6420.43
67_I86_F0.6410.43
45_V103_H0.6390.43
132_L136_K0.6390.43
129_I142_T0.6380.43
261_V398_I0.6380.43
142_T174_A0.6380.43
237_P414_T0.6370.43
258_M329_N0.6360.43
435_M440_R0.6360.43
264_I405_N0.6360.43
39_L102_Q0.6350.43
89_D137_V0.6340.42
63_D405_N0.6330.42
93_H104_E0.6320.42
204_E208_H0.6320.42
58_K423_K0.6310.42
367_I427_T0.6280.42
2_I205_L0.6270.42
173_S329_N0.6260.42
110_D114_N0.6250.42
329_N334_G0.6250.42
44_R111_Q0.6240.41
304_I358_L0.6230.41
152_V157_F0.6230.41
262_D376_N0.6230.41
46_V50_Y0.6230.41
13_G16_S0.6220.41
113_M279_G0.6220.41
80_I222_R0.6200.41
77_T215_V0.6190.41
14_P17_S0.6190.41
326_Y425_I0.6190.41
14_P18_H0.6180.41
201_S207_Q0.6180.41
24_K28_Q0.6180.41
337_V405_N0.6170.41
77_T80_I0.6150.41
224_I443_S0.6150.41
144_Y157_F0.6150.41
357_L362_P0.6140.41
304_I307_V0.6140.41
266_M269_L0.6140.41
7_I157_F0.6140.41
28_Q143_Y0.6130.40
326_Y424_V0.6120.40
237_P242_A0.6110.40
214_E237_P0.6100.40
418_R423_K0.6100.40
98_L105_V0.6100.40
45_V102_Q0.6090.40
73_N113_M0.6090.40
26_G47_V0.6070.40
208_H290_C0.6060.40
12_I83_I0.6050.40
201_S208_H0.6050.40
361_S414_T0.6040.40
252_K259_A0.6040.40
46_V140_S0.6030.39
133_A137_V0.6030.39
116_H355_A0.6020.39
26_G269_L0.6020.39
217_R302_K0.6010.39
315_Y357_L0.6010.39
193_M314_R0.6010.39
322_I355_A0.6010.39
103_H106_E0.6010.39
353_G365_V0.6000.39
122_L409_M0.6000.39
405_N437_A0.6000.39
167_V198_A0.5970.39
10_I281_V0.5970.39
427_T439_Y0.5950.39
265_N341_G0.5940.39
94_G110_D0.5940.39
13_G19_T0.5930.39
188_L356_E0.5930.39
337_V397_A0.5910.38
325_L409_M0.5900.38
266_M387_Q0.5890.38
95_R144_Y0.5880.38
9_K241_A0.5870.38
363_A416_E0.5860.38
326_Y352_A0.5850.38
10_I218_G0.5850.38
336_E346_A0.5840.38
256_D303_F0.5830.38
43_T186_L0.5830.38
233_K390_V0.5830.38
158_G161_D0.5820.37
35_A229_V0.5800.37
343_V346_A0.5800.37
257_P408_R0.5790.37
29_F131_A0.5780.37
68_M402_K0.5780.37
24_K259_A0.5780.37
243_L401_V0.5780.37
409_M425_I0.5770.37
50_Y373_M0.5760.37
256_D304_I0.5760.37
105_V112_C0.5760.37
85_S89_D0.5760.37
54_S63_D0.5760.37
300_Y354_L0.5750.37
43_T136_K0.5750.37
23_M336_E0.5740.37
261_V345_V0.5740.37
213_W301_D0.5730.37
2_I324_S0.5730.37
146_I242_A0.5730.37
169_Y191_L0.5720.37
83_I87_I0.5720.37
241_A244_R0.5720.37
420_C423_K0.5720.37
186_L190_G0.5720.37
287_N327_K0.5710.36
301_D308_N0.5710.36
92_T114_N0.5710.36
347_C379_L0.5710.36
92_T182_Q0.5700.36
192_M400_A0.5700.36
219_G272_N0.5670.36
434_D438_K0.5670.36
348_S408_R0.5660.36
124_E440_R0.5660.36
334_G432_G0.5660.36
175_A225_S0.5650.36
419_V427_T0.5650.36
31_D211_N0.5650.36
37_N139_Y0.5640.36
47_V67_I0.5630.36
91_N113_M0.5620.36
175_A180_H0.5610.36
181_C405_N0.5610.36
222_R279_G0.5600.35
87_I155_E0.5580.35
32_D36_R0.5580.35
78_V154_E0.5570.35
14_P19_T0.5570.35
300_Y347_C0.5560.35
35_A84_P0.5550.35
191_L197_L0.5550.35
24_K158_G0.5540.35
50_Y120_L0.5540.35
162_S166_E0.5540.35
30_T38_L0.5510.35
126_G144_Y0.5500.35
158_G162_S0.5490.34
143_Y401_V0.5490.34
30_T98_L0.5480.34
335_A441_E0.5480.34
54_S66_I0.5470.34
171_Y324_S0.5470.34
47_V307_V0.5460.34
146_I379_L0.5440.34
98_L102_Q0.5440.34
236_V279_G0.5440.34
207_Q210_A0.5440.34
337_V429_Y0.5440.34
334_G384_V0.5430.34
258_M262_D0.5430.34
33_L42_V0.5420.34
43_T110_D0.5420.34
45_V96_L0.5420.34
345_V405_N0.5410.34
187_S191_L0.5410.34
26_G105_V0.5410.34
46_V112_C0.5390.34
143_Y402_K0.5390.34
41_D183_E0.5390.34
415_S440_R0.5380.33
376_N402_K0.5380.33
20_V292_I0.5380.33
111_Q175_A0.5380.33
124_E409_M0.5380.33
104_E159_Q0.5380.33
55_L399_A0.5370.33
47_V113_M0.5370.33
278_G336_E0.5360.33
319_A353_G0.5350.33
43_T106_E0.5350.33
336_E432_G0.5340.33
63_D265_N0.5330.33
264_I299_Y0.5330.33
292_I423_K0.5320.33
423_K430_E0.5320.33
304_I357_L0.5320.33
346_A432_G0.5310.33
297_L315_Y0.5310.33
30_T34_I0.5290.33
124_E348_S0.5290.33
11_G22_P0.5280.33
134_G204_E0.5270.33
365_V443_S0.5270.33
251_D255_T0.5260.32
263_W364_Q0.5260.32
194_K320_S0.5250.32
413_R416_E0.5250.32
15_S18_H0.5250.32
41_D185_G0.5250.32
76_D451_I0.5230.32
280_R295_A0.5220.32
163_A166_E0.5220.32
87_I90_V0.5220.32
117_A423_K0.5220.32
376_N399_A0.5220.32
28_Q153_D0.5220.32
102_Q129_I0.5210.32
320_S328_M0.5200.32
385_A452_V0.5200.32
71_A224_I0.5180.32
217_R309_A0.5180.32
371_I413_R0.5180.32
334_G345_V0.5180.32
373_M420_C0.5180.32
331_S336_E0.5170.32
113_M141_Q0.5170.32
186_L235_R0.5170.32
43_T103_H0.5160.32
293_I315_Y0.5150.31
88_Q203_E0.5150.31
11_G18_H0.5150.31
107_F112_C0.5150.31
194_K235_R0.5140.31
191_L419_V0.5140.31
281_V373_M0.5130.31
36_R104_E0.5130.31
353_G364_Q0.5130.31
399_A409_M0.5110.31
76_D222_R0.5100.31
423_K444_R0.5090.31
93_H105_V0.5090.31
35_A40_K0.5080.31
102_Q106_E0.5080.31
430_E445_G0.5070.31
162_S190_G0.5070.31
104_E111_Q0.5070.31
437_A440_R0.5070.31
312_L316_L0.5070.31
9_K401_V0.5070.31
438_K445_G0.5060.31
440_R450_K0.5060.31
56_T335_A0.5050.31
24_K153_D0.5040.31
337_V340_Q0.5040.31
413_R440_R0.5040.31
60_H335_A0.5030.30
20_V75_P0.5030.30
220_I426_E0.5030.30
55_L267_F0.5030.30
59_G62_T0.5020.30
374_E394_E0.5020.30
182_Q305_R0.5020.30
87_I113_M0.5020.30
73_N83_I0.5010.30
24_K74_L0.5010.30
73_N78_V0.5010.30
15_S21_G0.5010.30
319_A357_L0.5000.30
126_G142_T0.5000.30
115_F260_V0.5000.30
184_T190_G0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rqoA 2 0.9846 100 0.175 Contact Map
2iafA 1 0.3033 100 0.74 Contact Map
1ygyA 4 0.4396 99.5 0.918 Contact Map
2hp0A 2 0.5341 69 0.978 Contact Map
1szqA 2 0.5253 51.2 0.98 Contact Map
3tsoC 2 0.1121 23.4 0.983 Contact Map
4zacA 2 0.367 19.5 0.984 Contact Map
4d0gC 1 0.0989 18.5 0.984 Contact Map
1owfB 1 0.1978 16.3 0.984 Contact Map
4n1vA 2 0.1934 15.2 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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