GREMLIN Database
PSUK - Pseudouridine kinase
UniProt: P30235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11646
Length: 313 (280)
Sequences: 22656 (17030)
Seq/√Len: 1017.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_N264_S3.1311.00
139_V162_F2.6821.00
73_L88_I2.6791.00
58_W82_Y2.5521.00
224_M230_Y2.4921.00
231_Y276_V2.4891.00
8_V135_A2.4341.00
265_C270_M2.3721.00
271_P274_E2.3691.00
229_V258_M2.2551.00
70_Q88_I2.1501.00
65_S90_P2.0931.00
50_L55_N2.0881.00
213_H232_S2.0821.00
188_R224_M2.0291.00
162_F263_A1.9831.00
52_L79_S1.9711.00
9_I47_A1.9521.00
265_C278_F1.9091.00
298_S301_N1.8981.00
257_A282_C1.8781.00
62_A124_Y1.8751.00
137_V160_P1.8731.00
160_P182_H1.8411.00
48_Q79_S1.8221.00
62_A89_V1.8061.00
206_A238_S1.7981.00
270_M274_E1.7761.00
185_K259_M1.7711.00
182_H218_N1.7681.00
77_N83_V1.7671.00
49_N260_A1.7481.00
268_D299_I1.7461.00
239_G273_A1.7381.00
209_A232_S1.7191.00
254_A287_L1.7191.00
74_T78_Q1.6911.00
229_V280_Q1.6881.00
230_Y240_W1.6851.00
283_S287_L1.6611.00
73_L77_N1.6571.00
137_V162_F1.6551.00
75_Q78_Q1.6531.00
183_T219_R1.6491.00
273_A277_R1.6481.00
262_L275_S1.6201.00
154_D180_Q1.6171.00
224_M240_W1.5971.00
231_Y239_G1.5951.00
289_C301_N1.5741.00
261_G282_C1.5551.00
7_V50_L1.5541.00
150_A154_D1.5541.00
221_V262_L1.5471.00
211_W215_H1.5411.00
219_R233_D1.5141.00
50_L264_S1.5111.00
244_I281_G1.5071.00
250_N291_Y1.5071.00
137_V263_A1.4931.00
246_T288_S1.4911.00
231_Y272_F1.4821.00
224_M227_D1.4781.00
13_A61_S1.4741.00
65_S70_Q1.4621.00
151_W154_D1.4601.00
70_Q74_T1.4561.00
164_D223_S1.4441.00
211_W214_Q1.4411.00
204_D207_K1.4241.00
241_S276_V1.4231.00
233_D237_E1.4101.00
197_I211_W1.3911.00
39_P72_L1.3891.00
181_I184_L1.3831.00
261_G278_F1.3821.00
160_P183_T1.3811.00
233_D236_G1.3701.00
92_E119_A1.3701.00
206_A210_A1.3661.00
37_F71_S1.3511.00
15_I71_S1.3481.00
213_H234_I1.3401.00
69_G94_T1.3371.00
65_S88_I1.3351.00
44_R76_T1.3351.00
17_V35_I1.3101.00
165_P186_P1.3091.00
153_L161_V1.2881.00
264_S268_D1.2871.00
73_L86_C1.2861.00
210_A214_Q1.2791.00
56_K82_Y1.2741.00
241_S280_Q1.2521.00
133_Q157_A1.2511.00
229_V276_V1.2471.00
244_I277_R1.2341.00
160_P218_N1.2321.00
150_A176_D1.2321.00
210_A232_S1.2281.00
75_Q79_S1.2261.00
132_I135_A1.2241.00
146_E149_L1.2231.00
262_L266_W1.2131.00
219_R262_L1.2121.00
39_P75_Q1.2111.00
219_R272_F1.2061.00
261_G279_A1.2061.00
155_N182_H1.2021.00
224_M228_G1.2001.00
89_V92_E1.1971.00
262_L279_A1.1921.00
185_K223_S1.1811.00
265_C275_S1.1811.00
219_R266_W1.1761.00
109_V112_N1.1751.00
223_S258_M1.1731.00
274_E277_R1.1711.00
70_Q73_L1.1701.00
71_S74_T1.1701.00
121_T124_Y1.1671.00
51_A81_V1.1661.00
46_I139_V1.1621.00
53_L261_G1.1611.00
17_V37_F1.1381.00
55_N267_V1.1331.00
175_R215_H1.1311.00
210_A238_S1.1301.00
197_I207_K1.1291.00
22_H103_N1.1241.00
50_L57_A1.1231.00
149_L153_L1.1171.00
74_T77_N1.1161.00
108_L111_I1.1141.00
191_A222_L1.1091.00
207_K210_A1.1061.00
285_M289_C1.1051.00
232_S238_S1.0981.00
248_V287_L1.0901.00
47_A57_A1.0891.00
285_M288_S1.0891.00
140_A161_V1.0861.00
146_E150_A1.0841.00
139_V263_A1.0821.00
67_F70_Q1.0761.00
244_I280_Q1.0721.00
191_A208_V1.0711.00
248_V251_V1.0651.00
183_T262_L1.0621.00
22_H34_K1.0531.00
183_T266_W1.0521.00
48_Q52_L1.0461.00
244_I284_S1.0401.00
265_C268_D1.0361.00
13_A72_L1.0341.00
58_W131_F1.0311.00
138_I159_V1.0301.00
246_T287_L1.0291.00
219_R231_Y1.0261.00
209_A222_L1.0191.00
188_R227_D1.0111.00
51_A80_G1.0081.00
49_N257_A1.0071.00
147_E151_W1.0051.00
139_V259_M1.0031.00
107_M111_I1.0021.00
155_N180_Q1.0011.00
243_P280_Q0.9991.00
55_N268_D0.9981.00
122_A151_W0.9961.00
9_I43_G0.9931.00
58_W135_A0.9911.00
280_Q283_S0.9811.00
20_Y36_K0.9791.00
147_E150_A0.9791.00
66_D94_T0.9771.00
65_S91_G0.9771.00
17_V96_S0.9761.00
18_A38_T0.9731.00
185_K262_L0.9721.00
50_L260_A0.9711.00
257_A286_A0.9691.00
262_L272_F0.9671.00
163_V181_I0.9651.00
58_W85_K0.9601.00
275_S279_A0.9561.00
218_N234_I0.9491.00
13_A59_L0.9481.00
10_I138_I0.9481.00
63_V73_L0.9451.00
64_G94_T0.9411.00
71_S75_Q0.9411.00
63_V69_G0.9361.00
264_S299_I0.9331.00
234_I237_E0.9311.00
13_A44_R0.9261.00
277_R281_G0.9231.00
17_V68_Y0.9231.00
39_P71_S0.9221.00
187_N190_E0.9211.00
195_S208_V0.9201.00
135_A159_V0.9191.00
207_K211_W0.9171.00
51_A56_K0.9131.00
8_V60_L0.9131.00
89_V119_A0.9111.00
150_A153_L0.9041.00
19_G98_L0.9031.00
227_D240_W0.8971.00
209_A220_L0.8921.00
186_P191_A0.8901.00
237_E273_A0.8901.00
270_M278_F0.8871.00
73_L83_V0.8861.00
53_L282_C0.8851.00
264_S278_F0.8831.00
247_N288_S0.8831.00
188_R192_E0.8821.00
63_V86_C0.8771.00
266_W275_S0.8701.00
228_G243_P0.8651.00
144_I149_L0.8621.00
248_V288_S0.8601.00
87_L124_Y0.8581.00
63_V88_I0.8571.00
83_V86_C0.8491.00
62_A87_L0.8481.00
23_E26_N0.8461.00
249_I290_E0.8431.00
106_E109_V0.8431.00
72_L94_T0.8331.00
271_P275_S0.8301.00
126_A151_W0.8221.00
44_R293_N0.8191.00
257_A261_G0.8181.00
164_D185_K0.8131.00
46_I259_M0.8021.00
128_H131_F0.7971.00
178_L181_I0.7961.00
258_M280_Q0.7951.00
7_V267_V0.7891.00
132_I159_V0.7851.00
14_N95_S0.7841.00
257_A283_S0.7831.00
261_G265_C0.7771.00
120_I124_Y0.7741.00
8_V58_W0.7701.00
213_H233_D0.7701.00
280_Q284_S0.7681.00
176_D179_N0.7671.00
51_A57_A0.7651.00
210_A213_H0.7651.00
241_S273_A0.7651.00
162_F185_K0.7641.00
16_D40_G0.7641.00
145_S149_L0.7621.00
100_L108_L0.7611.00
206_A240_W0.7571.00
241_S277_R0.7541.00
137_V267_V0.7521.00
283_S286_A0.7491.00
148_A152_I0.7491.00
73_L87_L0.7491.00
233_D272_F0.7471.00
164_D186_P0.7461.00
8_V131_F0.7451.00
7_V137_V0.7421.00
144_I147_E0.7401.00
142_C163_V0.7381.00
15_I37_F0.7381.00
278_F302_V0.7361.00
131_F135_A0.7311.00
124_Y127_Q0.7251.00
221_V231_Y0.7241.00
149_L152_I0.7221.00
47_A59_L0.7191.00
15_I68_Y0.7191.00
53_L278_F0.7161.00
209_A213_H0.7131.00
33_G110_A0.7081.00
281_G285_M0.7061.00
58_W84_D0.7051.00
66_D69_G0.7031.00
99_S252_T0.6991.00
53_L264_S0.6941.00
48_Q293_N0.6901.00
258_M276_V0.6891.00
108_L112_N0.6881.00
239_G276_V0.6861.00
117_S120_I0.6851.00
209_A238_S0.6821.00
278_F299_I0.6801.00
162_F183_T0.6791.00
230_Y238_S0.6771.00
92_E116_I0.6671.00
105_G109_V0.6661.00
99_S109_V0.6651.00
53_L302_V0.6641.00
191_A212_F0.6631.00
285_M301_N0.6631.00
68_Y96_S0.6621.00
145_S148_A0.6571.00
25_L31_N0.6541.00
258_M283_S0.6511.00
75_Q293_N0.6511.00
233_D239_G0.6491.00
270_M275_S0.6461.00
61_S86_C0.6451.00
208_V212_F0.6451.00
155_N158_N0.6431.00
206_A232_S0.6431.00
40_G45_N0.6431.00
100_L110_A0.6411.00
258_M279_A0.6411.00
123_E126_A0.6391.00
19_G33_G0.6351.00
228_G240_W0.6341.00
85_K131_F0.6341.00
205_V208_V0.6271.00
205_V224_M0.6251.00
47_A81_V0.6241.00
162_F259_M0.6231.00
146_E153_L0.6211.00
37_F68_Y0.6201.00
140_A153_L0.6171.00
226_G245_K0.6161.00
67_F71_S0.6161.00
206_A230_Y0.6151.00
79_S298_S0.6151.00
34_K103_N0.6131.00
144_I148_A0.6131.00
179_N216_G0.6081.00
184_L220_L0.6081.00
197_I208_V0.6061.00
56_K136_K0.6051.00
20_Y103_N0.6051.00
19_G35_I0.6051.00
137_V183_T0.6041.00
42_V166_V0.6021.00
153_L180_Q0.6011.00
36_K290_E0.5991.00
260_A264_S0.5961.00
221_V258_M0.5951.00
136_K159_V0.5941.00
116_I124_Y0.5931.00
206_A209_A0.5911.00
252_T292_T0.5911.00
213_H217_L0.5861.00
276_V280_Q0.5851.00
120_I125_L0.5841.00
102_D106_E0.5831.00
161_V181_I0.5831.00
175_R179_N0.5821.00
20_Y290_E0.5811.00
42_V143_N0.5811.00
185_K221_V0.5811.00
53_L260_A0.5771.00
105_G111_I0.5761.00
233_D238_S0.5751.00
44_R59_L0.5721.00
269_G275_S0.5721.00
7_V55_N0.5691.00
102_D108_L0.5691.00
229_V241_S0.5661.00
179_N215_H0.5611.00
217_L220_L0.5611.00
50_L263_A0.5601.00
285_M302_V0.5601.00
95_S117_S0.5591.00
12_S143_N0.5591.00
197_I204_D0.5541.00
67_F74_T0.5541.00
122_A126_A0.5491.00
246_T284_S0.5491.00
46_I263_A0.5481.00
140_A149_L0.5471.00
164_D256_D0.5461.00
70_Q77_N0.5451.00
116_I119_A0.5421.00
76_T81_V0.5411.00
266_W269_G0.5401.00
12_S166_V0.5391.00
39_P293_N0.5391.00
150_A180_Q0.5381.00
192_E197_I0.5371.00
189_L193_T0.5371.00
225_G251_V0.5351.00
51_A79_S0.5351.00
56_K267_V0.5331.00
45_N292_T0.5321.00
46_I260_A0.5301.00
191_A205_V0.5301.00
241_S244_I0.5291.00
191_A232_S0.5281.00
9_I50_L0.5271.00
272_F276_V0.5271.00
223_S256_D0.5271.00
17_V98_L0.5231.00
282_C302_V0.5231.00
137_V266_W0.5211.00
176_D180_Q0.5211.00
272_F275_S0.5211.00
188_R225_G0.5201.00
97_Y111_I0.5201.00
136_K160_P0.5191.00
13_A76_T0.5191.00
9_I57_A0.5181.00
131_F134_R0.5171.00
274_E278_F0.5171.00
168_A171_C0.5161.00
216_G220_L0.5111.00
97_Y143_N0.5091.00
146_E151_W0.5081.00
182_H219_R0.5081.00
226_G248_V0.5061.00
16_D97_Y0.5031.00
106_E112_N0.5021.00
265_C269_G0.5011.00
106_E111_I0.5001.00
46_I50_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkdA 2 0.9681 100 0.184 Contact Map
3kzhA 2 0.9904 100 0.19 Contact Map
2fv7A 2 0.9649 100 0.194 Contact Map
1vm7A 2 0.9457 100 0.197 Contact Map
2rbcA 2 0.9585 100 0.198 Contact Map
4xdaA 2 0.9681 100 0.205 Contact Map
3ry7A 2 0.9521 100 0.209 Contact Map
2nwhA 2 0.9617 100 0.215 Contact Map
3vasA 1 0.9489 100 0.22 Contact Map
2qcvA 3 0.9585 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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