YCHG - ECOLI - GREMLIN Contacts

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YCHG - Putative uncharacterized protein YchG

UniProt:	P30192	Sequences: MPLLNDLLDFSDHPLMPPPSAQLFAEHLPTEWIQHCLTLSAHATVRRRRLPGDMVIWMVVQNEPITDVVRRLNLSADGEAGMNLLARSAVTQARQRVGAAPVEWLFRQTAQDRGAERYLKDDWHGLQLFAIDGAQFRTPDKPELREYYGSANTSTKRQNAYPVMRLVALMNLGSHILLNAVTAPYRQSETVLAHSMLATIPDNSITLFDKLFYSEDLLLTLNQKGCNRHWLLPAWKNIASEMIELGNTASPGTIPKRLEHLRGALEVVFITKRPRPSRPRSVKISKTRYPVKHSAAPLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11611
Length:	299 (267)
Sequences:	470 (384)
Seq/√Len:	23.5

ECOLI - YCHG INSG
HALSA - O52023 Q9HI34 O54648 O51966 O51972

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
88_S	92_Q	5.548	1.00
89_A	92_Q	4.719	1.00
203_N	227_N	4.004	1.00
179_N	199_T	3.532	1.00
210_K	231_L	3.454	1.00
93_A	96_R	3.102	1.00
167_V	212_F	2.765	0.99
126_L	227_N	2.670	0.99
254_I	262_R	2.612	0.99
136_F	166_L	2.599	0.99
141_K	144_L	2.465	0.98
179_N	198_A	2.444	0.98
189_E	209_D	2.392	0.98
278_R	281_S	2.391	0.98
274_P	280_R	2.345	0.98
129_F	178_L	2.334	0.98
68_V	72_L	2.286	0.97
44_T	52_G	2.266	0.97
255_P	259_E	2.233	0.97
103_E	107_R	2.204	0.97
107_R	179_N	2.198	0.96
67_D	70_R	2.126	0.96
268_V	272_K	2.048	0.95
135_Q	165_R	2.042	0.95
72_L	229_H	1.989	0.94
286_K	289_Y	1.977	0.94
277_S	282_V	1.974	0.94
277_S	280_R	1.968	0.93
261_L	268_V	1.960	0.93
211_L	233_P	1.953	0.93
276_P	280_R	1.947	0.93
125_G	128_L	1.937	0.93
200_I	206_T	1.931	0.93
201_P	204_S	1.872	0.92
55_V	93_A	1.855	0.91
133_G	189_E	1.820	0.90
130_A	172_L	1.796	0.90
274_P	277_S	1.793	0.90
106_F	196_M	1.775	0.89
278_R	282_V	1.774	0.89
145_R	150_S	1.766	0.89
167_V	196_M	1.736	0.88
129_F	200_I	1.730	0.88
253_T	257_R	1.653	0.85
137_R	163_V	1.650	0.85
284_I	287_T	1.633	0.85
132_D	209_D	1.632	0.85
268_V	274_P	1.622	0.84
36_C	58_M	1.590	0.83
280_R	283_K	1.588	0.83
78_G	95_Q	1.580	0.83
52_G	97_V	1.576	0.83
258_L	268_V	1.571	0.82
149_G	193_A	1.567	0.82
205_I	229_H	1.551	0.81
248_T	251_P	1.545	0.81
98_G	175_H	1.534	0.81
60_V	139_P	1.521	0.80
262_R	268_V	1.484	0.78
58_M	105_L	1.470	0.78
165_R	188_S	1.460	0.77
164_M	182_T	1.453	0.77
264_A	268_V	1.449	0.77
268_V	271_T	1.431	0.76
279_P	283_K	1.391	0.74
86_A	89_A	1.387	0.74
208_F	221_L	1.387	0.74
89_A	205_I	1.381	0.73
35_H	108_Q	1.369	0.73
271_T	277_S	1.367	0.72
103_E	199_T	1.366	0.72
34_Q	53_D	1.347	0.71
140_D	162_P	1.341	0.71
58_M	184_P	1.331	0.70
141_K	249_A	1.330	0.70
128_L	236_K	1.313	0.69
76_A	196_M	1.306	0.69
113_R	176_I	1.295	0.68
123_W	126_L	1.286	0.68
169_L	200_I	1.277	0.67
256_K	259_E	1.261	0.66
59_V	90_V	1.250	0.65
93_A	162_P	1.240	0.65
250_S	265_L	1.222	0.64
43_A	52_G	1.218	0.63
218_L	230_W	1.207	0.63
274_P	278_R	1.201	0.62
197_L	217_L	1.193	0.62
161_Y	185_Y	1.192	0.62
58_M	65_I	1.187	0.61
26_E	33_I	1.179	0.61
126_L	205_I	1.176	0.61
264_A	267_V	1.169	0.60
56_I	102_V	1.157	0.59
105_L	149_G	1.153	0.59
171_N	174_S	1.153	0.59
190_T	211_L	1.145	0.58
67_D	71_R	1.129	0.57
254_I	261_L	1.121	0.57
32_W	36_C	1.115	0.56
285_S	290_P	1.111	0.56
143_E	192_L	1.111	0.56
262_R	267_V	1.104	0.56
26_E	30_T	1.098	0.55
153_T	156_K	1.084	0.54
142_P	166_L	1.078	0.54
76_A	179_N	1.078	0.54
263_G	267_V	1.074	0.54
37_L	56_I	1.069	0.53
56_I	126_L	1.067	0.53
210_K	286_K	1.061	0.53
55_V	145_R	1.061	0.53
36_C	93_A	1.060	0.53
128_L	248_T	1.050	0.52
188_S	191_V	1.050	0.52
56_I	169_L	1.045	0.51
143_E	165_R	1.041	0.51
144_L	162_P	1.037	0.51
210_K	233_P	1.033	0.51
46_R	50_L	1.031	0.50
102_V	244_E	1.030	0.50
248_T	259_E	1.023	0.50
50_L	89_A	1.023	0.50
208_F	230_W	1.021	0.50
121_D	174_S	1.019	0.50
45_V	231_L	1.016	0.49
27_H	32_W	1.016	0.49
172_L	207_L	1.011	0.49
105_L	180_A	1.011	0.49
279_P	282_V	1.006	0.49
50_L	90_V	1.003	0.49
151_A	163_V	1.002	0.48
25_A	34_Q	0.997	0.48
23_L	26_E	0.997	0.48
209_D	212_F	0.994	0.48
127_Q	171_N	0.990	0.48
88_S	211_L	0.985	0.47
263_G	268_V	0.979	0.47
183_A	192_L	0.979	0.47
35_H	154_S	0.979	0.47
133_G	209_D	0.972	0.46
92_Q	139_P	0.969	0.46
88_S	91_T	0.963	0.46
198_A	220_T	0.961	0.46
218_L	228_R	0.956	0.45
197_L	214_S	0.955	0.45
143_E	147_Y	0.954	0.45
209_D	231_L	0.954	0.45
106_F	110_A	0.954	0.45
264_A	270_I	0.954	0.45
168_A	177_L	0.949	0.45
103_E	207_L	0.932	0.44
26_E	29_P	0.927	0.43
36_C	112_D	0.922	0.43
32_W	171_N	0.919	0.43
93_A	125_G	0.918	0.43
142_P	244_E	0.916	0.42
101_P	105_L	0.910	0.42
197_L	221_L	0.909	0.42
97_V	102_V	0.908	0.42
101_P	168_A	0.908	0.42
92_Q	218_L	0.907	0.42
148_Y	172_L	0.902	0.42
210_K	232_L	0.897	0.41
84_L	150_S	0.895	0.41
25_A	33_I	0.895	0.41
288_R	292_K	0.894	0.41
170_M	231_L	0.892	0.41
133_G	167_V	0.892	0.41
23_L	30_T	0.889	0.41
107_R	110_A	0.889	0.41
263_G	269_F	0.887	0.40
254_I	275_R	0.883	0.40
142_P	259_E	0.880	0.40
52_G	96_R	0.879	0.40
166_L	192_L	0.879	0.40
190_T	217_L	0.871	0.39
25_A	60_V	0.868	0.39
160_A	219_L	0.861	0.39
188_S	207_L	0.858	0.39
30_T	44_T	0.853	0.38
63_E	71_R	0.848	0.38
243_I	246_G	0.844	0.38
55_V	161_Y	0.843	0.38
107_R	157_R	0.842	0.37
58_M	205_I	0.841	0.37
129_F	204_S	0.835	0.37
41_A	144_L	0.829	0.37
30_T	35_H	0.829	0.37
38_T	62_N	0.828	0.37
32_W	44_T	0.823	0.36
190_T	233_P	0.822	0.36
88_S	106_F	0.821	0.36
132_D	189_E	0.821	0.36
59_V	160_A	0.821	0.36
33_I	270_I	0.820	0.36
266_E	270_I	0.814	0.36
65_I	69_V	0.813	0.36
132_D	231_L	0.809	0.35
51_P	180_A	0.809	0.35
210_K	214_S	0.809	0.35
267_V	270_I	0.805	0.35
24_F	211_L	0.803	0.35
102_V	200_I	0.803	0.35
165_R	177_L	0.800	0.35
161_Y	171_N	0.799	0.35
131_I	193_A	0.794	0.34
125_G	248_T	0.793	0.34
29_P	105_L	0.789	0.34
141_K	162_P	0.788	0.34
47_R	143_E	0.787	0.34
60_V	161_Y	0.784	0.34
29_P	33_I	0.783	0.34
37_L	40_S	0.781	0.34
272_K	280_R	0.779	0.33
278_R	285_S	0.779	0.33
182_T	275_R	0.772	0.33
126_L	289_Y	0.767	0.33
44_T	96_R	0.761	0.32
88_S	215_E	0.760	0.32
25_A	53_D	0.760	0.32
175_H	236_K	0.759	0.32
142_P	163_V	0.759	0.32
235_W	267_V	0.756	0.32
143_E	187_Q	0.755	0.32
43_A	177_L	0.751	0.32
250_S	254_I	0.751	0.32
167_V	189_E	0.740	0.31
157_R	177_L	0.733	0.31
261_L	264_A	0.733	0.31
50_L	55_V	0.729	0.30
197_L	212_F	0.729	0.30
66_T	70_R	0.727	0.30
228_R	231_L	0.727	0.30
154_S	158_Q	0.722	0.30
33_I	57_W	0.721	0.30
241_E	247_N	0.718	0.30
221_L	228_R	0.717	0.30
75_S	174_S	0.714	0.29
260_H	268_V	0.713	0.29
261_L	269_F	0.713	0.29
115_A	120_K	0.712	0.29
189_E	210_K	0.712	0.29
279_P	292_K	0.711	0.29
28_L	33_I	0.707	0.29
72_L	186_R	0.705	0.29
141_K	291_V	0.705	0.29
65_I	68_V	0.700	0.29
141_K	250_S	0.697	0.29
259_E	265_L	0.693	0.28
132_D	210_K	0.691	0.28
89_A	100_A	0.690	0.28
252_G	259_E	0.687	0.28
24_F	107_R	0.686	0.28
219_L	222_N	0.684	0.28
160_A	234_A	0.682	0.28
178_L	286_K	0.682	0.28
167_V	181_V	0.679	0.27
186_R	199_T	0.679	0.27
121_D	172_L	0.678	0.27
250_S	276_P	0.677	0.27
110_A	161_Y	0.675	0.27
87_R	149_G	0.674	0.27
53_D	222_N	0.672	0.27
183_A	195_S	0.672	0.27
248_T	255_P	0.671	0.27
211_L	232_L	0.671	0.27
182_T	192_L	0.668	0.27
55_V	214_S	0.666	0.27
61_Q	229_H	0.665	0.27
56_I	291_V	0.663	0.27
50_L	285_S	0.662	0.27
148_Y	182_T	0.661	0.26
139_P	199_T	0.661	0.26
25_A	30_T	0.658	0.26
86_A	232_L	0.655	0.26
120_K	124_H	0.652	0.26
90_V	207_L	0.649	0.26
33_I	254_I	0.648	0.26
255_P	267_V	0.647	0.26
52_G	101_P	0.647	0.26
88_S	169_L	0.646	0.26
143_E	152_N	0.644	0.26
127_Q	201_P	0.642	0.25
89_A	213_Y	0.641	0.25
244_E	247_N	0.640	0.25
166_L	182_T	0.639	0.25
33_I	37_L	0.638	0.25
57_W	218_L	0.636	0.25
153_T	182_T	0.636	0.25
60_V	227_N	0.635	0.25
123_W	247_N	0.634	0.25
119_L	186_R	0.633	0.25
251_P	257_R	0.633	0.25
82_M	219_L	0.633	0.25
42_H	58_M	0.632	0.25
128_L	244_E	0.631	0.25
60_V	123_W	0.630	0.25
97_V	192_L	0.628	0.25
282_V	288_R	0.628	0.25
161_Y	174_S	0.628	0.25
87_R	212_F	0.627	0.25
111_Q	222_N	0.627	0.25
189_E	212_F	0.616	0.24
52_G	68_V	0.612	0.24
116_E	212_F	0.612	0.24
127_Q	210_K	0.607	0.24
90_V	236_K	0.607	0.24
133_G	165_R	0.603	0.23
31_E	178_L	0.601	0.23
235_W	238_I	0.597	0.23
51_P	55_V	0.597	0.23
134_A	231_L	0.595	0.23
48_R	93_A	0.593	0.23
71_R	80_A	0.593	0.23
59_V	218_L	0.593	0.23
40_S	44_T	0.592	0.23
136_F	168_A	0.590	0.23
25_A	28_L	0.589	0.23
261_L	267_V	0.589	0.23
203_N	226_C	0.587	0.23
77_D	86_A	0.586	0.23
202_D	282_V	0.585	0.23
64_P	91_T	0.585	0.23
208_F	228_R	0.585	0.23
285_S	291_V	0.577	0.22
164_M	177_L	0.577	0.22
207_L	230_W	0.576	0.22
128_L	237_N	0.574	0.22
117_R	245_L	0.574	0.22
284_I	291_V	0.572	0.22
259_E	269_F	0.572	0.22
207_L	222_N	0.572	0.22
102_V	170_M	0.570	0.22
179_N	223_Q	0.566	0.22
69_V	73_N	0.565	0.22
175_H	184_P	0.564	0.22
61_Q	214_S	0.562	0.21
128_L	136_F	0.561	0.21
124_H	205_I	0.561	0.21
43_A	96_R	0.559	0.21
196_M	238_I	0.556	0.21
58_M	90_V	0.554	0.21
82_M	214_S	0.554	0.21
49_R	54_M	0.553	0.21
44_T	170_M	0.553	0.21
231_L	235_W	0.550	0.21
30_T	177_L	0.550	0.21
36_C	52_G	0.547	0.21
253_T	282_V	0.547	0.21
73_N	141_K	0.545	0.21
138_T	175_H	0.544	0.21
162_P	174_S	0.542	0.20
31_E	117_R	0.541	0.20
262_R	269_F	0.541	0.20
149_G	194_H	0.541	0.20
174_S	236_K	0.539	0.20
246_G	286_K	0.539	0.20
94_R	97_V	0.537	0.20
39_L	104_W	0.535	0.20
113_R	206_T	0.535	0.20
184_P	279_P	0.535	0.20
64_P	134_A	0.534	0.20
42_H	66_T	0.533	0.20
121_D	173_G	0.532	0.20
49_R	70_R	0.532	0.20
139_P	259_E	0.528	0.20
118_Y	202_D	0.527	0.20
151_A	185_Y	0.526	0.20
253_T	263_G	0.525	0.20
43_A	73_N	0.525	0.20
122_D	173_G	0.523	0.20
96_R	166_L	0.522	0.20
87_R	148_Y	0.521	0.20
170_M	207_L	0.519	0.19
71_R	192_L	0.518	0.19
188_S	220_T	0.517	0.19
83_N	111_Q	0.517	0.19
26_E	210_K	0.516	0.19
263_G	266_E	0.516	0.19
62_N	232_L	0.516	0.19
123_W	289_Y	0.514	0.19
240_S	243_I	0.513	0.19
130_A	163_V	0.512	0.19
130_A	231_L	0.512	0.19
164_M	196_M	0.512	0.19
255_P	261_L	0.511	0.19
53_D	173_G	0.511	0.19
251_P	259_E	0.511	0.19
282_V	285_S	0.510	0.19
46_R	92_Q	0.510	0.19
207_L	236_K	0.507	0.19
69_V	111_Q	0.507	0.19
240_S	246_G	0.505	0.19
169_L	196_M	0.504	0.19
151_A	212_F	0.502	0.19
134_A	216_D	0.502	0.19
123_W	239_A	0.501	0.19
91_T	141_K	0.500	0.19
221_L	240_S	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8094	99.1	0.843	Contact Map
1j5sA	3	0.9431	20.4	0.962	Contact Map
1bcoA	1	0.5217	11.4	0.966	Contact Map
2jp7A	1	0.1839	8.7	0.968	Contact Map
2x78A	2	0.5117	8	0.969	Contact Map
2nutA	1	0.903	4.1	0.973	Contact Map
2kycA	1	0.3378	3.7	0.973	Contact Map
3ulqB	1	0.0903	3.5	0.974	Contact Map
4u7bA	2	0.903	3.3	0.974	Contact Map
1rroA	1	0.3378	3	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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