GREMLIN Database
YBIC - Uncharacterized oxidoreductase YbiC
UniProt: P30178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11581
Length: 361 (332)
Sequences: 2105 (1560)
Seq/√Len: 85.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_E326_Q3.9991.00
128_A166_C3.7621.00
72_K86_D3.5881.00
85_G93_A3.4751.00
299_K314_E3.3921.00
206_L220_M3.1631.00
66_Q86_D2.9651.00
208_D212_V2.8431.00
155_G301_S2.6771.00
106_H134_A2.6681.00
200_P215_T2.6411.00
99_A130_Q2.5521.00
13_H35_D2.5021.00
98_M131_C2.4711.00
332_A336_Q2.4421.00
114_A251_S2.4221.00
216_N219_V2.3961.00
20_F53_I2.3931.00
200_P217_P2.3891.00
132_A168_V2.2451.00
46_D323_R2.2091.00
78_G108_H2.2081.00
79_A108_H2.1991.00
76_E104_K2.1861.00
69_H86_D2.1491.00
278_N281_L2.0901.00
308_P318_N2.0881.00
321_R325_K2.0871.00
302_P309_I2.0651.00
167_V242_M2.0561.00
12_L50_I2.0331.00
21_R27_E2.0281.00
103_E107_Q2.0231.00
121_I124_I2.0151.00
41_N46_D1.9831.00
171_R292_E1.9711.00
100_L103_E1.9451.00
323_R329_P1.9331.00
320_R324_Q1.9211.00
42_L323_R1.9101.00
203_P215_T1.8811.00
17_Q31_K1.8461.00
151_A227_S1.8101.00
179_L238_A1.7971.00
209_V222_E1.7751.00
175_F321_R1.7731.00
17_Q21_R1.7571.00
102_I134_A1.7471.00
129_E133_A1.7251.00
34_A38_I1.7211.00
14_S18_A1.7101.00
94_A274_T1.7011.00
74_V84_D1.6801.00
186_I205_C1.6781.00
135_G288_N1.6681.00
195_W218_A1.6681.00
101_G111_A1.6671.00
208_D219_V1.6551.00
52_M189_G1.6311.00
305_D308_P1.6021.00
78_G104_K1.5961.00
121_I140_H1.5891.00
101_G276_I1.5761.00
162_T183_T1.5711.00
131_C276_I1.5591.00
168_V178_L1.5561.00
9_A42_L1.5501.00
151_A207_I1.5421.00
106_H136_F1.5291.00
81_V111_A1.5271.00
136_F279_P1.5241.00
81_V113_V1.5201.00
201_V205_C1.4920.99
84_D117_N1.4910.99
304_D308_P1.4730.99
150_V184_S1.4720.99
207_I227_S1.4710.99
335_W339_C1.4700.99
138_S168_V1.4670.99
138_S276_I1.4620.99
33_V89_F1.4420.99
66_Q69_H1.4360.99
165_F243_C1.4280.99
201_V220_M1.4200.99
17_Q27_E1.4130.99
98_M130_Q1.4130.99
299_K308_P1.4080.99
15_F342_A1.4000.99
43_A320_R1.3930.99
336_Q340_D1.3890.99
187_A190_K1.3730.99
6_R329_P1.3540.99
101_G113_V1.3520.99
110_I275_I1.3450.99
98_M276_I1.3420.99
245_I291_T1.3380.99
112_A275_I1.3360.99
95_H130_Q1.3290.99
81_V100_L1.3170.99
100_L104_K1.3070.99
253_G271_C1.3050.99
69_H88_A1.2990.99
139_I275_I1.2930.98
48_H120_H1.2910.98
194_A201_V1.2720.98
32_L95_H1.2660.98
29_E92_V1.2640.98
73_T83_L1.2640.98
118_S272_M1.2500.98
111_A276_I1.2490.98
19_V57_V1.2490.98
102_I136_F1.2440.98
87_R117_N1.2370.98
214_T220_M1.2340.98
25_S89_F1.2310.98
157_D301_S1.2240.98
16_I53_I1.2210.98
42_L324_Q1.2190.98
254_K269_L1.2140.98
279_P284_A1.2060.98
27_E31_K1.2040.98
36_H91_Q1.2020.98
247_G271_C1.2010.98
105_A111_A1.2010.98
77_A281_L1.1960.97
112_A273_T1.1850.97
206_L214_T1.1850.97
73_T81_V1.1760.97
218_A222_E1.1660.97
319_T323_R1.1630.97
296_E300_A1.1510.97
84_D116_H1.1410.97
57_V341_A1.1370.97
201_V206_L1.1320.96
177_L241_A1.1270.96
47_S190_K1.1260.96
81_V101_G1.1230.96
65_L119_H1.1220.96
331_D334_S1.1180.96
285_P288_N1.1150.96
169_F242_M1.1060.96
60_W67_I1.1050.96
18_A21_R1.0980.96
172_K289_A1.0950.96
81_V104_K1.0890.96
295_A299_K1.0880.96
105_A136_F1.0850.95
310_L316_E1.0800.95
16_I20_F1.0800.95
80_A282_F1.0760.95
82_T116_H1.0760.95
23_M57_V1.0740.95
310_L318_N1.0710.95
336_Q339_C1.0690.95
128_A140_H1.0680.95
310_L315_W1.0640.95
195_W217_P1.0630.95
318_N322_E1.0610.95
142_V272_M1.0600.95
74_V82_T1.0580.95
112_A277_I1.0560.95
20_F33_V1.0540.95
330_L335_W1.0480.95
188_F221_Q1.0430.94
117_N269_L1.0390.94
112_A282_F1.0350.94
102_I105_A1.0340.94
173_D292_E1.0310.94
106_H278_N1.0300.94
102_I106_H1.0280.94
102_I131_C1.0180.94
144_V149_M1.0150.94
125_G128_A1.0110.93
71_A86_D1.0050.93
12_L328_I1.0030.93
58_R62_Q0.9960.93
165_F239_L0.9960.93
9_A38_I0.9940.93
8_D11_T0.9930.93
194_A199_V0.9900.93
141_F243_C0.9900.93
181_Y238_A0.9860.93
304_D307_K0.9850.93
98_M138_S0.9840.92
13_H31_K0.9830.92
160_F240_A0.9750.92
29_E70_H0.9670.92
140_H274_T0.9650.92
191_T282_F0.9630.92
172_K292_E0.9530.91
128_A168_V0.9490.91
96_E99_A0.9450.91
120_H189_G0.9440.91
16_I34_A0.9380.91
97_A113_V0.9340.90
77_A278_N0.9320.90
26_E68_N0.9320.90
16_I50_I0.9310.90
159_R301_S0.9300.90
152_P237_Y0.9260.90
315_W319_T0.9260.90
292_E295_A0.9230.90
129_E178_L0.9160.90
319_T322_E0.9150.89
172_K288_N0.9140.89
200_P216_N0.9140.89
30_A34_A0.9140.89
153_F237_Y0.9070.89
177_L295_A0.9040.89
149_M188_F0.9040.89
23_M61_S0.9040.89
31_K35_D0.9040.89
26_E29_E0.9020.89
12_L330_L0.8980.89
15_F19_V0.8930.88
85_G115_L0.8900.88
150_V183_T0.8900.88
35_D126_Y0.8870.88
191_T220_M0.8840.88
121_I272_M0.8820.88
212_V304_D0.8790.88
214_T219_V0.8750.87
70_H96_E0.8740.87
50_I334_S0.8730.87
99_A103_E0.8690.87
39_A320_R0.8680.87
9_A324_Q0.8670.87
302_P308_P0.8640.87
279_P283_G0.8610.86
204_G229_L0.8600.86
73_T96_E0.8600.86
115_L272_M0.8590.86
241_A294_F0.8590.86
173_D296_E0.8580.86
129_E320_R0.8540.86
244_E248_G0.8470.86
73_T100_L0.8460.85
13_H17_Q0.8380.85
186_I190_K0.8340.85
321_R324_Q0.8310.84
159_R297_W0.8270.84
258_Q297_W0.8220.84
292_E296_E0.8190.84
10_Q14_S0.8170.83
203_P213_P0.8160.83
181_Y239_L0.8120.83
72_K84_D0.8030.82
160_F241_A0.8020.82
183_T231_F0.8010.82
71_A83_L0.8010.82
83_L113_V0.8000.82
105_A276_I0.7980.82
295_A311_L0.7980.82
104_K111_A0.7940.82
43_A129_E0.7920.81
237_Y311_L0.7900.81
196_H337_A0.7890.81
237_Y241_A0.7880.81
174_N296_E0.7880.81
9_A328_I0.7870.81
85_G118_S0.7860.81
291_T295_A0.7850.81
114_A273_T0.7830.81
169_F287_C0.7800.80
98_M102_I0.7790.80
48_H189_G0.7790.80
167_V243_C0.7780.80
93_A115_L0.7740.80
131_C138_S0.7700.80
309_I314_E0.7680.79
80_A281_L0.7670.79
94_A121_I0.7630.79
100_L113_V0.7630.79
83_L97_A0.7630.79
329_P332_A0.7600.79
144_V161_G0.7600.79
171_R295_A0.7580.79
7_F335_W0.7470.78
99_A134_A0.7470.78
207_I229_L0.7460.77
183_T240_A0.7460.77
25_S33_V0.7460.77
82_T114_A0.7430.77
311_L314_E0.7420.77
71_A93_A0.7420.77
11_T14_S0.7410.77
141_F273_T0.7360.76
9_A13_H0.7340.76
87_R269_L0.7330.76
174_N299_K0.7330.76
43_A123_R0.7330.76
155_G237_Y0.7320.76
51_G192_R0.7310.76
170_P176_P0.7310.76
101_G131_C0.7280.76
204_G215_T0.7260.75
52_M120_H0.7220.75
150_V227_S0.7210.75
286_D289_A0.7160.74
156_R210_N0.7160.74
140_H272_M0.7120.74
150_V230_T0.7110.74
39_A126_Y0.7100.74
302_P306_D0.7100.74
75_K107_Q0.7080.74
135_G285_P0.7080.74
314_E317_V0.7070.74
314_E318_N0.7060.73
280_E284_A0.7040.73
139_I167_V0.7030.73
71_A96_E0.7030.73
56_Y122_G0.7000.73
50_I330_L0.7000.73
202_P205_C0.6990.73
83_L96_E0.6970.73
8_D328_I0.6930.72
23_M60_W0.6920.72
83_L100_L0.6920.72
32_L92_V0.6920.72
52_M192_R0.6910.72
185_A233_E0.6900.72
15_F338_I0.6900.72
150_V240_A0.6880.72
77_A108_H0.6830.71
44_G313_G0.6800.71
41_N323_R0.6800.71
162_T204_G0.6780.70
283_G290_Q0.6720.70
121_I316_E0.6720.70
334_S337_A0.6700.70
206_L221_Q0.6680.69
160_F294_F0.6680.69
35_D95_H0.6670.69
318_N321_R0.6650.69
187_A194_A0.6650.69
209_V219_V0.6630.69
137_V246_L0.6630.69
171_R176_P0.6610.68
95_H99_A0.6530.68
17_Q34_A0.6520.67
167_V246_L0.6520.67
193_V197_K0.6510.67
115_L274_T0.6500.67
47_S120_H0.6490.67
169_F245_I0.6470.67
191_T201_V0.6460.67
28_Q70_H0.6450.67
185_A205_C0.6440.66
56_Y120_H0.6440.66
128_A132_A0.6430.66
195_W221_Q0.6430.66
257_H297_W0.6420.66
76_E108_H0.6420.66
54_P337_A0.6390.66
98_M101_G0.6390.66
303_H306_D0.6340.65
70_H86_D0.6340.65
198_G218_A0.6340.65
28_Q31_K0.6330.65
36_H123_R0.6330.65
191_T228_L0.6310.65
136_F276_I0.6290.65
104_K108_H0.6270.64
18_A22_Q0.6260.64
250_L277_I0.6260.64
33_V92_V0.6260.64
144_V162_T0.6240.64
19_V53_I0.6240.64
12_L38_I0.6230.64
183_T237_Y0.6190.63
37_L53_I0.6150.63
52_M188_F0.6120.63
209_V325_K0.6120.63
40_A122_G0.6100.62
177_L312_P0.6090.62
319_T329_P0.6080.62
133_A175_F0.6080.62
152_P301_S0.6060.62
201_V215_T0.6040.62
188_F206_L0.6040.62
299_K311_L0.6030.61
255_T293_A0.6020.61
118_S121_I0.6010.61
243_C270_N0.6000.61
137_V277_I0.6000.61
13_H324_Q0.5990.61
63_G217_P0.5990.61
246_L273_T0.5970.61
29_E68_N0.5950.60
33_V91_Q0.5950.60
231_F239_L0.5930.60
10_Q13_H0.5920.60
36_H126_Y0.5910.60
298_V309_I0.5900.60
143_S253_G0.5890.60
333_G337_A0.5860.59
41_N50_I0.5850.59
75_K104_K0.5850.59
74_V116_H0.5830.59
46_D329_P0.5790.58
192_R195_W0.5780.58
337_A340_D0.5780.58
86_D286_D0.5770.58
245_I287_C0.5760.58
171_R174_N0.5760.58
78_G107_Q0.5750.58
124_I272_M0.5740.58
76_E100_L0.5730.58
82_T281_L0.5730.58
192_R196_H0.5720.57
219_V222_E0.5720.57
66_Q88_A0.5710.57
29_E89_F0.5700.57
57_V61_S0.5670.57
43_A316_E0.5670.57
87_R268_I0.5660.57
102_I130_Q0.5650.56
15_F18_A0.5620.56
97_A115_L0.5610.56
163_N243_C0.5590.56
141_F150_V0.5530.55
103_E134_A0.5530.55
31_K68_N0.5520.55
310_L314_E0.5520.55
179_L242_M0.5520.55
103_E200_P0.5500.55
299_K309_I0.5500.55
289_A293_A0.5490.54
51_G196_H0.5490.54
46_D50_I0.5480.54
169_F177_L0.5480.54
185_A229_L0.5470.54
31_K212_V0.5470.54
157_D300_A0.5470.54
74_V104_K0.5460.54
88_A91_Q0.5460.54
36_H127_W0.5450.54
210_N325_K0.5440.54
242_M273_T0.5430.54
231_F272_M0.5410.53
7_F12_L0.5370.53
12_L338_I0.5360.53
128_A178_L0.5340.52
47_S142_V0.5340.52
36_H40_A0.5320.52
88_A93_A0.5310.52
118_S143_S0.5300.52
39_A43_A0.5300.52
47_S193_V0.5290.52
48_H232_A0.5290.52
79_A110_I0.5290.52
19_V23_M0.5280.52
48_H52_M0.5280.52
96_E100_L0.5280.52
241_A298_V0.5270.51
300_A318_N0.5260.51
298_V311_L0.5260.51
13_H38_I0.5260.51
76_E81_V0.5260.51
162_T271_C0.5250.51
123_R143_S0.5230.51
135_G172_K0.5220.51
53_I165_F0.5210.51
149_M185_A0.5200.50
147_I184_S0.5190.50
46_D328_I0.5180.50
7_F11_T0.5170.50
90_G127_W0.5170.50
85_G237_Y0.5160.50
18_A325_K0.5140.50
149_M184_S0.5130.50
174_N292_E0.5130.50
156_R304_D0.5120.49
132_A135_G0.5110.49
150_V160_F0.5100.49
94_A115_L0.5100.49
196_H334_S0.5090.49
128_A138_S0.5080.49
190_K194_A0.5080.49
120_H190_K0.5070.49
59_S119_H0.5070.49
260_T266_D0.5070.49
209_V214_T0.5070.49
147_I188_F0.5060.49
24_G105_A0.5060.49
28_Q96_E0.5060.49
197_K331_D0.5050.48
150_V162_T0.5050.48
76_E80_A0.5050.48
27_E70_H0.5050.48
40_A123_R0.5050.48
52_M196_H0.5040.48
105_A109_G0.5040.48
47_S52_M0.5040.48
132_A292_E0.5030.48
48_H190_K0.5020.48
258_Q293_A0.5010.48
153_F234_H0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g8yA 2 0.9945 100 0.079 Contact Map
1v9nA 2 0.9197 100 0.096 Contact Map
3i0pA 2 0.9557 100 0.096 Contact Map
1vbiA 2 0.9307 100 0.103 Contact Map
1z2iA 2 0.9474 100 0.104 Contact Map
2x06A 2 0.9446 100 0.105 Contact Map
3uoeA 2 0.9252 100 0.106 Contact Map
1wtjA 2 0.9252 100 0.109 Contact Map
4h8aA 2 0.9224 100 0.118 Contact Map
1nxuA 2 0.9169 100 0.12 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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