GREMLIN Database
YABI - Inner membrane protein YabI
UniProt: P30149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11571
Length: 254 (195)
Sequences: 4703 (3371)
Seq/√Len: 241.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_W137_V3.4201.00
55_S58_H3.2601.00
64_I149_L3.0801.00
114_L146_I2.9441.00
191_G195_C2.8661.00
49_I160_I2.6251.00
108_H111_F2.5901.00
68_L145_I2.5491.00
60_W153_P2.5051.00
193_W197_R2.4941.00
25_F73_I2.4601.00
192_G196_W2.3981.00
179_W183_A2.3761.00
63_G152_P2.3471.00
94_N97_L2.3281.00
110_M139_K2.2821.00
72_W141_I2.2611.00
102_E106_H2.1821.00
194_L198_L2.1501.00
136_P139_K2.0631.00
190_V194_L1.9431.00
56_F60_W1.9301.00
56_F157_L1.9121.00
62_A66_G1.9071.00
60_W156_F1.8911.00
12_S16_S1.8831.00
181_L185_A1.8781.00
96_A100_K1.7831.00
42_M156_F1.7601.00
83_K102_E1.7231.00
157_L161_L1.7191.00
99_D103_H1.7001.00
25_F69_M1.6971.00
17_L58_H1.6941.00
192_G195_C1.6911.00
79_W134_D1.6831.00
110_M143_P1.6631.00
45_L59_A1.6261.00
95_K99_D1.6191.00
189_W193_W1.6141.00
56_F156_F1.6091.00
137_V141_I1.5741.00
86_H95_K1.5621.00
68_L148_C1.5511.00
21_V65_I1.5121.00
90_F93_K1.5111.00
17_L55_S1.4721.00
20_V63_G1.4221.00
27_E38_G1.4131.00
59_A156_F1.4061.00
24_A66_G1.3941.00
118_F150_L1.3871.00
138_A142_T1.3791.00
60_W157_L1.3751.00
80_R84_P1.3441.00
33_G74_S1.3001.00
194_L197_R1.2991.00
15_Y19_A1.2961.00
76_W80_R1.2951.00
68_L144_N1.2801.00
21_V62_A1.2591.00
49_I56_F1.2451.00
111_F115_V1.2361.00
6_E10_T1.2351.00
57_W157_L1.2331.00
57_W61_L1.2171.00
116_G126_V1.2151.00
68_L141_I1.2061.00
29_L36_L1.1911.00
50_G164_A1.1841.00
195_C199_W1.1801.00
197_R200_R1.1791.00
61_L65_I1.1751.00
178_K182_L1.1751.00
195_C198_L1.1741.00
76_W137_V1.1711.00
190_V193_W1.1391.00
88_W93_K1.1351.00
67_C148_C1.1131.00
21_V66_G1.1111.00
65_I69_M1.1011.00
198_L202_G1.0981.00
58_H62_A1.0931.00
197_R201_S1.0861.00
15_Y18_M1.0821.00
186_V190_V1.0811.00
50_G160_I1.0671.00
17_L62_A1.0651.00
42_M46_G1.0581.00
169_P172_M1.0451.00
71_D137_V1.0441.00
166_I169_P1.0431.00
99_D102_E1.0431.00
105_L130_A1.0371.00
26_L33_G1.0311.00
88_W91_L1.0251.00
78_G132_M1.0251.00
42_M63_G1.0221.00
141_I145_I1.0181.00
64_I152_P1.0171.00
71_D117_R1.0091.00
10_T13_T1.0021.00
20_V59_A0.9941.00
191_G194_L0.9931.00
71_D144_N0.9891.00
72_W76_W0.9841.00
199_W202_G0.9791.00
74_S124_P0.9791.00
138_A141_I0.9751.00
144_N148_C0.9681.00
198_L201_S0.9641.00
114_L150_L0.9641.00
165_A168_I0.9481.00
39_T123_R0.9271.00
102_E133_L0.9221.00
74_S128_M0.9211.00
185_A188_L0.9191.00
46_G159_G0.9141.00
89_S92_K0.9061.00
76_W79_W0.9061.00
64_I68_L0.9031.00
196_W199_W0.9001.00
165_A169_P0.8981.00
58_H61_L0.8881.00
167_D171_G0.8810.99
188_L192_G0.8750.99
54_L59_A0.8750.99
49_I156_F0.8750.99
36_L124_P0.8700.99
127_P144_N0.8700.99
47_A166_I0.8430.99
57_W60_W0.8420.99
60_W64_I0.8380.99
169_P173_Q0.8380.99
67_C117_R0.8360.99
97_L100_K0.8350.99
24_A63_G0.8240.99
187_F191_G0.8240.99
153_P157_L0.8140.99
150_L153_P0.8100.99
177_F180_L0.8060.99
186_V189_W0.8020.99
93_K125_L0.8020.99
77_L81_F0.7990.99
179_W182_L0.7970.99
89_S95_K0.7950.99
81_F84_P0.7950.99
88_W95_K0.7940.99
142_T146_I0.7890.99
13_T16_S0.7820.99
26_L34_L0.7790.99
12_S15_Y0.7780.99
91_L98_L0.7750.99
168_I171_G0.7710.99
16_S19_A0.7670.99
17_L54_L0.7660.99
166_I170_A0.7610.98
6_E9_I0.7570.98
27_E117_R0.7570.98
69_M73_I0.7560.98
84_P87_R0.7530.98
196_W200_R0.7520.98
11_Q16_S0.7510.98
38_G144_N0.7500.98
47_A50_G0.7500.98
24_A152_P0.7490.98
72_W144_N0.7440.98
112_T115_V0.7370.98
167_D170_A0.7340.98
101_T133_L0.7310.98
189_W192_G0.7310.98
85_L88_W0.7310.98
75_F131_G0.7250.98
181_L188_L0.7240.98
10_T14_V0.7200.98
113_I135_L0.7190.98
21_V69_M0.7170.98
172_M175_G0.7160.98
7_H11_Q0.7140.98
34_L74_S0.7040.97
23_V41_L0.7010.97
75_F137_V0.7010.97
28_S117_R0.7000.97
103_H107_Q0.7000.97
9_I16_S0.6970.97
71_D116_G0.6960.97
14_V18_M0.6820.97
20_V45_L0.6820.97
100_K103_H0.6800.97
111_F143_P0.6770.97
96_A99_D0.6770.97
8_F16_S0.6750.97
83_K86_H0.6710.97
199_W203_K0.6700.97
117_R144_N0.6670.97
134_D139_K0.6660.96
47_A162_A0.6650.96
191_G197_R0.6640.96
46_G156_F0.6600.96
16_S54_L0.6580.96
120_G124_P0.6560.96
27_E144_N0.6440.96
180_L183_A0.6380.96
24_A147_G0.6360.95
193_W196_W0.6320.95
9_I48_L0.6320.95
44_G47_A0.6280.95
27_E124_P0.6270.95
44_G48_L0.6250.95
42_M152_P0.6200.95
139_K143_P0.6160.95
119_V122_T0.6150.95
71_D113_I0.6150.95
28_S113_I0.6130.94
101_T122_T0.6080.94
154_F158_P0.6060.94
112_T126_V0.6050.94
11_Q19_A0.6020.94
27_E127_P0.6020.94
114_L118_F0.6000.94
46_G59_A0.6000.94
117_R123_R0.6000.94
123_R151_W0.5990.94
38_G120_G0.5990.94
142_T145_I0.5990.94
79_W82_K0.5980.94
24_A124_P0.5980.94
28_S71_D0.5980.94
185_A192_G0.5940.94
130_A135_L0.5940.94
85_L90_F0.5910.93
43_A162_A0.5890.93
24_A28_S0.5890.93
171_G175_G0.5870.93
63_G156_F0.5850.93
11_Q15_Y0.5840.93
89_S93_K0.5820.93
28_S112_T0.5810.93
178_K185_A0.5800.93
105_L126_V0.5790.93
168_I172_M0.5780.93
21_V25_F0.5780.93
191_G202_G0.5770.93
73_I76_W0.5770.93
158_P161_L0.5750.92
29_L34_L0.5720.92
35_I121_P0.5710.92
68_L149_L0.5690.92
61_L64_I0.5660.92
149_L153_P0.5630.92
186_V197_R0.5560.91
29_L66_G0.5510.91
71_D141_I0.5490.91
93_K97_L0.5480.90
39_T155_Y0.5460.90
29_L124_P0.5440.90
129_V135_L0.5430.90
136_P193_W0.5410.90
102_E134_D0.5410.90
72_W145_I0.5410.90
190_V197_R0.5370.90
104_A109_S0.5370.90
155_Y173_Q0.5360.90
154_F157_L0.5360.90
67_C124_P0.5340.89
183_A187_F0.5340.89
161_L164_A0.5330.89
167_D173_Q0.5300.89
28_S34_L0.5290.89
25_F29_L0.5280.89
45_L54_L0.5250.89
152_P156_F0.5240.88
93_K98_L0.5240.88
116_G130_A0.5240.88
28_S127_P0.5230.88
28_S74_S0.5220.88
36_L40_V0.5220.88
170_A173_Q0.5210.88
184_T196_W0.5200.88
28_S144_N0.5180.88
103_H106_H0.5180.88
145_I149_L0.5120.87
24_A36_L0.5120.87
113_I130_A0.5110.87
166_I173_Q0.5110.87
27_E123_R0.5100.87
190_V199_W0.5090.87
67_C71_D0.5090.87
194_L200_R0.5060.87
162_A166_I0.5020.86
178_K183_A0.5010.86
118_F147_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dx5A 3 0.6772 52.3 0.935 Contact Map
4k0jA 3 0.6063 29 0.943 Contact Map
3wdoA 1 0.9528 27 0.944 Contact Map
4m64A 1 0.7953 26.4 0.945 Contact Map
3ne5A 3 0.6496 23.5 0.946 Contact Map
3w9iA 3 0.6378 20.7 0.947 Contact Map
2m20A 2 0.2362 19.9 0.948 Contact Map
2kluA 1 0.2756 16.1 0.95 Contact Map
2kncA 1 0.2087 14.3 0.951 Contact Map
4pypA 1 0.7205 14.3 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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