GREMLIN Database
HYI - Hydroxypyruvate isomerase
UniProt: P30147 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11584
Length: 258 (221)
Sequences: 15613 (11018)
Seq/√Len: 741.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_K201_G3.0981.00
88_A132_M3.0291.00
22_E52_N2.8611.00
46_K50_A2.7611.00
220_N223_Y2.6921.00
123_V167_D2.6141.00
31_G236_W2.5541.00
207_D215_G2.5361.00
92_R136_E2.4731.00
47_H51_S2.3941.00
194_T227_V2.3871.00
139_L201_G2.2891.00
92_R132_M2.2571.00
139_L174_K2.1741.00
141_L201_G2.1311.00
16_D19_A2.0921.00
18_L48_V2.0791.00
131_N170_C2.0391.00
95_R136_E2.0201.00
162_L195_Q2.0131.00
163_K167_D1.9811.00
119_H163_K1.9381.00
84_R128_Y1.8811.00
101_K141_L1.8131.00
48_V52_N1.7971.00
22_E26_Q1.7601.00
81_E85_D1.7541.00
227_V230_N1.7501.00
194_T230_N1.7441.00
132_M135_K1.7001.00
49_L56_H1.6991.00
48_V51_S1.6811.00
119_H167_D1.6801.00
162_L166_D1.6791.00
91_I136_E1.6511.00
43_E96_A1.6421.00
130_A173_L1.6131.00
41_D44_E1.6041.00
25_A52_N1.5661.00
141_L176_Q1.5641.00
188_E191_N1.5431.00
79_R82_E1.5391.00
120_A167_D1.5231.00
191_N195_Q1.5101.00
117_Q120_A1.5061.00
89_A92_R1.5041.00
203_L228_I1.4991.00
134_M172_N1.4991.00
94_A99_N1.4841.00
132_M136_E1.4731.00
123_V127_R1.4661.00
85_D89_A1.4621.00
222_D226_K1.4601.00
131_N135_K1.4541.00
42_I96_A1.4481.00
120_A124_E1.4481.00
39_D96_A1.4401.00
21_F52_N1.4191.00
207_D217_G1.4171.00
226_K230_N1.4151.00
44_E47_H1.4011.00
80_E125_N1.3991.00
91_I133_L1.3901.00
190_T223_Y1.3871.00
88_A128_Y1.3651.00
18_L51_S1.3541.00
124_E127_R1.3521.00
23_K26_Q1.3481.00
179_I224_L1.3361.00
121_T124_E1.3211.00
227_V231_S1.3021.00
101_K139_L1.2821.00
47_H50_A1.2711.00
44_E48_V1.2661.00
174_K199_K1.2601.00
157_G160_Q1.2581.00
22_E48_V1.2521.00
85_D88_A1.2461.00
197_A231_S1.2401.00
134_M170_C1.2341.00
210_H213_E1.2341.00
19_A22_E1.2261.00
130_A168_V1.2241.00
137_D172_N1.2191.00
123_V168_V1.2181.00
166_D199_K1.1981.00
159_R195_Q1.1981.00
84_R88_A1.1761.00
192_T196_W1.1741.00
88_A92_R1.1731.00
190_T194_T1.1731.00
25_A53_K1.1591.00
43_E47_H1.1561.00
91_I138_I1.1541.00
161_A175_I1.1421.00
144_P182_M1.1401.00
156_T160_Q1.1381.00
91_I132_M1.1381.00
177_Y182_M1.1371.00
127_R169_G1.1311.00
162_L196_W1.1141.00
81_E128_Y1.1121.00
128_Y131_N1.1091.00
134_M171_C1.1071.00
46_K96_A1.1011.00
127_R168_V1.0931.00
76_I79_R1.0891.00
162_L199_K1.0771.00
223_Y227_V1.0731.00
87_V129_A1.0671.00
119_H123_V1.0671.00
163_K166_D1.0651.00
133_L140_L1.0631.00
18_L44_E1.0611.00
228_I231_S1.0561.00
42_I93_Y1.0521.00
114_S117_Q1.0441.00
31_G57_T1.0431.00
29_F239_C1.0351.00
21_F48_V1.0341.00
21_F49_L1.0281.00
39_D43_E1.0211.00
33_E58_L1.0171.00
88_A135_K1.0151.00
31_G55_E1.0121.00
23_K27_C1.0041.00
181_H206_A0.9931.00
115_S160_Q0.9911.00
49_L54_L0.9771.00
131_N134_M0.9771.00
194_T231_S0.9761.00
180_Y206_A0.9761.00
100_K139_L0.9761.00
92_R96_A0.9701.00
33_E202_H0.9651.00
82_E85_D0.9571.00
101_K201_G0.9541.00
18_L22_E0.9511.00
130_A170_C0.9401.00
59_H94_A0.9391.00
34_F56_H0.9371.00
84_R125_N0.9321.00
178_D240_E0.9301.00
191_N194_T0.9241.00
205_I221_Y0.9221.00
124_E128_Y0.9121.00
88_A136_E0.9101.00
42_I46_K0.9061.00
193_M231_S0.9051.00
219_I224_L0.9051.00
116_E120_A0.9031.00
92_R95_R0.9021.00
25_A30_R0.9021.00
206_A242_K0.8931.00
127_R131_N0.8921.00
24_A32_V0.8851.00
116_E163_K0.8811.00
77_P81_E0.8791.00
190_T227_V0.8771.00
130_A172_N0.8651.00
221_Y225_F0.8611.00
49_L52_N0.8531.00
127_R170_C0.8531.00
42_I97_L0.8501.00
165_I199_K0.8471.00
158_T195_Q0.8431.00
15_Y23_K0.8431.00
175_I196_W0.8341.00
193_M227_V0.8341.00
24_A29_F0.8261.00
209_P218_E0.8151.00
40_Y44_E0.8141.00
57_T236_W0.8131.00
55_E100_K0.8121.00
115_S118_I0.8121.00
168_V173_L0.8091.00
126_L173_L0.8091.00
159_R163_K0.8081.00
119_H160_Q0.8081.00
94_A102_I0.8061.00
22_E51_S0.8031.00
183_Q218_E0.8001.00
193_M197_A0.7991.00
180_Y208_N0.7981.00
225_F229_E0.7911.00
139_L172_N0.7851.00
80_E124_E0.7821.00
155_L161_A0.7791.00
43_E46_K0.7771.00
223_Y226_K0.7731.00
56_H99_N0.7711.00
86_G89_A0.7571.00
95_R138_I0.7561.00
158_T187_G0.7541.00
74_A79_R0.7531.00
150_I153_F0.7521.00
183_Q219_I0.7521.00
30_R55_E0.7511.00
80_E121_T0.7481.00
93_Y97_L0.7481.00
60_N105_L0.7471.00
117_Q121_T0.7351.00
165_I175_I0.7311.00
95_R137_D0.7311.00
121_T125_N0.7291.00
176_Q202_H0.7261.00
72_G125_N0.7241.00
55_E236_W0.7101.00
78_G82_E0.7081.00
129_A140_L0.7071.00
193_M200_I0.7011.00
18_L52_N0.6961.00
179_I221_Y0.6961.00
90_A102_I0.6961.00
127_R167_D0.6931.00
169_G172_N0.6931.00
122_L164_L0.6871.00
205_I237_V0.6851.00
202_H238_G0.6801.00
225_F237_V0.6761.00
203_L237_V0.6751.00
62_P90_A0.6701.00
130_A140_L0.6691.00
203_L233_Y0.6671.00
125_N128_Y0.6641.00
128_Y132_M0.6611.00
160_Q163_K0.6591.00
143_E240_E0.6561.00
20_R24_A0.6561.00
177_Y193_M0.6551.00
46_K98_G0.6541.00
103_N176_Q0.6511.00
177_Y192_T0.6491.00
25_A54_L0.6481.00
89_A93_Y0.6431.00
21_F54_L0.6421.00
144_P161_A0.6411.00
19_A23_K0.6391.00
155_L164_L0.6381.00
101_K202_H0.6381.00
60_N63_A0.6361.00
21_F32_V0.6341.00
102_I133_L0.6311.00
183_Q189_L0.6301.00
76_I80_E0.6291.00
33_E238_G0.6281.00
84_R129_A0.6191.00
182_M192_T0.6131.00
22_E25_A0.6111.00
21_F25_A0.6091.00
169_G199_K0.6091.00
232_D235_G0.6091.00
77_P121_T0.6081.00
84_R87_V0.6061.00
45_L48_V0.6031.00
198_D231_S0.6021.00
126_L164_L0.5941.00
197_A227_V0.5941.00
197_A200_I0.5941.00
123_V164_L0.5941.00
80_E84_R0.5941.00
94_A138_I0.5931.00
143_E181_H0.5911.00
59_H99_N0.5911.00
165_I169_G0.5911.00
100_K137_D0.5901.00
104_C140_L0.5861.00
133_L138_I0.5851.00
193_M196_W0.5831.00
78_G81_E0.5821.00
131_N172_N0.5771.00
228_I233_Y0.5741.00
194_T197_A0.5741.00
206_A241_Y0.5711.00
143_E204_Q0.5701.00
161_A165_I0.5701.00
205_I225_F0.5701.00
179_I205_I0.5691.00
193_M228_I0.5681.00
202_H236_W0.5681.00
178_D206_A0.5651.00
202_H233_Y0.5641.00
118_I121_T0.5621.00
21_F45_L0.5601.00
162_L165_I0.5591.00
122_L126_L0.5591.00
82_E86_G0.5561.00
119_H164_L0.5561.00
60_N103_N0.5551.00
150_I154_H0.5541.00
74_A83_F0.5531.00
144_P155_L0.5531.00
91_I102_I0.5501.00
57_T238_G0.5491.00
158_T191_N0.5471.00
61_L90_A0.5451.00
177_Y200_I0.5441.00
193_M224_L0.5411.00
158_T162_L0.5381.00
165_I173_L0.5371.00
84_R132_M0.5351.00
80_E128_Y0.5341.00
150_I156_T0.5341.00
72_G83_F0.5271.00
92_R135_K0.5261.00
20_R23_K0.5251.00
214_P217_G0.5251.00
120_A123_V0.5231.00
15_Y19_A0.5231.00
133_L136_E0.5221.00
126_L130_A0.5221.00
141_L174_K0.5181.00
50_A96_A0.5181.00
49_L53_K0.5181.00
204_Q238_G0.5151.00
221_Y224_L0.5141.00
105_L181_H0.5111.00
229_E232_D0.5091.00
77_P80_E0.5091.00
175_I200_I0.5081.00
168_V171_C0.5081.00
184_R208_N0.5081.00
83_F86_G0.5081.00
98_G138_I0.5061.00
183_Q208_N0.5051.00
50_A98_G0.5041.00
176_Q181_H0.5031.00
46_K49_L0.5031.00
192_T195_Q0.5021.00
164_L168_V0.5001.00
130_A134_M0.5001.00
72_G75_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k77A 1 1 100 0.144 Contact Map
3ngfA 1 0.9961 100 0.176 Contact Map
3kwsA 2 0.969 100 0.21 Contact Map
1i60A 1 0.9535 100 0.213 Contact Map
3qc0A 2 0.9612 100 0.219 Contact Map
2qulA 2 0.969 100 0.221 Contact Map
2hk0A 3 0.9612 100 0.226 Contact Map
3vylA 4 0.9651 100 0.228 Contact Map
2zvrA 2 0.9729 100 0.229 Contact Map
3wqoA 2 0.9651 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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