GREMLIN Database
YAAJ - Uncharacterized transporter YaaJ
UniProt: P30143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11555
Length: 476 (436)
Sequences: 3765 (2325)
Seq/√Len: 111.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_V315_A4.9241.00
115_L437_I4.1561.00
219_S313_A3.5991.00
133_M426_A3.5301.00
108_A434_V3.2791.00
227_I230_L3.2601.00
312_T316_M3.1521.00
118_E135_R3.0331.00
107_F438_A3.0271.00
137_L429_L2.9671.00
37_F100_F2.8571.00
235_W239_E2.7461.00
234_I238_F2.7271.00
204_M362_S2.7141.00
221_V225_M2.6791.00
31_R435_H2.6191.00
24_A428_L2.5521.00
229_Q232_H2.5191.00
203_L207_F2.4881.00
371_A389_L2.4421.00
150_L374_N2.4121.00
236_S240_S2.3911.00
145_L149_F2.3731.00
186_A394_F2.3431.00
6_S10_S2.2761.00
213_I217_L2.2551.00
173_S353_T2.2161.00
116_Y433_V2.2041.00
26_C101_I2.1991.00
133_M143_G2.1631.00
24_A424_L2.1581.00
7_F11_V2.1421.00
134_A377_F2.1131.00
134_A140_R2.0931.00
199_G202_R2.0891.00
243_G246_E2.0731.00
9_N414_I2.0601.00
31_R432_P2.0441.00
76_N306_D2.0391.00
232_H235_W2.0371.00
5_F414_I1.9921.00
190_L394_F1.9621.00
291_H440_D1.9511.00
233_V319_L1.9501.00
92_V237_I1.9021.00
183_I187_V1.8781.00
42_Q45_K1.8701.00
387_W390_R1.8651.00
304_F308_L1.8371.00
5_F410_Q1.8211.00
27_W431_S1.8121.00
291_H444_Q1.8101.00
188_F357_I1.7941.00
421_I425_T1.7881.00
406_P410_Q1.7771.00
224_V227_I1.7741.00
186_A398_I1.7701.00
41_R45_K1.7481.00
144_V378_L1.7471.00
293_A437_I1.7411.00
120_D124_Q1.7211.00
260_I264_F1.7021.00
233_V316_M1.6961.00
84_I92_V1.6961.00
207_F358_L1.6961.00
179_L398_I1.6861.00
372_E390_R1.6721.00
261_T265_Q1.6641.00
330_L338_K1.6541.00
4_F8_I1.6531.00
29_T36_Q1.6521.00
62_Q201_A1.6501.00
290_P294_A1.6451.00
251_A254_Y1.6421.00
42_Q441_Y1.6251.00
149_F418_C1.6251.00
78_A332_G1.6011.00
235_W238_F1.5811.00
262_N265_Q1.5751.00
230_L233_V1.5701.00
432_P436_T1.5471.00
21_L268_M1.5381.00
33_G439_S1.5361.00
217_L221_V1.5301.00
38_R442_L1.5301.00
190_L194_T1.5151.00
65_C204_M1.5021.00
29_T34_F1.4871.00
146_F419_M1.4861.00
13_W417_A1.4831.00
375_L379_R1.4821.00
282_A299_Q1.4781.00
86_A262_N1.4761.00
437_I440_D1.4731.00
223_C320_L1.4661.00
193_I368_Y1.4621.00
379_R382_N1.4621.00
113_A283_A1.4351.00
103_M304_F1.4301.00
341_R349_A1.4241.00
391_I395_A1.4191.00
42_Q46_S1.4141.00
20_L428_L1.4131.00
134_A144_V1.4131.00
240_S244_W1.4111.00
248_A251_A1.4091.00
72_V310_I1.4061.00
115_L433_V1.4041.00
225_M343_L1.4031.00
219_S317_L1.4011.00
223_C230_L1.3841.00
225_M228_G1.3731.00
177_P180_V1.3701.00
62_Q205_Q1.3681.00
387_W391_I1.3651.00
32_T35_V1.3601.00
74_S356_V1.3581.00
182_G401_T1.3541.00
223_C316_M1.3541.00
96_W312_T1.3501.00
167_A181_T1.3491.00
60_S289_P1.3441.00
180_V184_I1.3431.00
144_V148_V1.3381.00
33_G442_L1.3361.00
146_F279_P1.3361.00
440_D444_Q1.3351.00
31_R431_S1.3351.00
166_V185_L1.3261.00
40_I44_G1.3251.00
384_K388_C1.3151.00
231_P235_W1.3010.99
216_V220_L1.2930.99
236_S319_L1.2910.99
5_F407_L1.2900.99
133_M142_M1.2890.99
161_V412_A1.2820.99
8_I414_I1.2730.99
59_T62_Q1.2700.99
224_V228_G1.2690.99
202_R205_Q1.2670.99
435_H439_S1.2620.99
15_S19_Y1.2610.99
411_L415_I1.2580.99
27_W31_R1.2570.99
275_M420_A1.2570.99
284_A369_I1.2530.99
233_V320_L1.2510.99
77_L333_I1.2470.99
64_L305_I1.2450.99
179_L183_I1.2430.99
177_P181_T1.2420.99
223_C227_I1.2390.99
100_F308_L1.2300.99
188_F361_F1.2270.99
220_L224_V1.2260.99
228_G231_P1.2160.99
140_R143_G1.2040.99
443_R447_L1.2030.99
34_F37_F1.1940.99
249_G253_G1.1850.99
36_Q104_A1.1790.99
106_S110_C1.1770.99
61_F65_C1.1730.99
364_I397_V1.1700.99
321_A343_L1.1660.99
281_A370_Y1.1620.99
176_F181_T1.1590.99
203_L365_V1.1590.99
20_L421_I1.1580.99
163_A401_T1.1540.99
138_G141_W1.1430.99
221_V344_M1.1400.99
27_W435_H1.1390.99
182_G398_I1.1370.99
398_I402_L1.1360.99
8_I11_V1.1340.99
226_N320_L1.1340.99
120_D126_R1.1320.98
110_C299_Q1.1310.98
141_W145_L1.1310.98
202_R206_G1.1300.98
240_S243_G1.1270.98
433_V436_T1.1260.98
119_R125_F1.1230.98
78_A165_A1.1220.98
40_I304_F1.1190.98
151_L154_Y1.1130.98
136_G430_L1.1130.98
189_T361_F1.1120.98
151_L375_L1.1030.98
321_A339_A1.1000.98
250_G254_Y1.1000.98
239_E245_Q1.0980.98
132_Y426_A1.0970.98
301_I305_I1.0950.98
236_S239_E1.0930.98
111_S296_G1.0920.98
318_I336_I1.0830.98
314_S336_I1.0830.98
39_Y442_L1.0710.98
379_R385_A1.0620.98
28_F108_A1.0610.98
137_L141_W1.0530.98
216_V313_A1.0500.98
318_I335_L1.0490.98
39_Y297_I1.0480.98
111_S293_A1.0450.97
98_A264_F1.0440.97
103_M308_L1.0380.97
230_L234_I1.0330.97
70_A366_A1.0330.97
7_F10_S1.0300.97
344_M347_W1.0300.97
158_F367_N1.0230.97
222_I343_L1.0210.97
351_F355_V1.0190.97
350_E354_L1.0140.97
81_A336_I1.0130.97
107_F293_A1.0120.97
338_K342_V1.0070.97
85_T335_L1.0070.97
107_F111_S1.0070.97
47_L298_V1.0060.97
180_V183_I1.0040.97
227_I231_P0.9980.97
315_A319_L0.9970.97
341_R345_G0.9960.97
195_R199_G0.9960.97
226_N229_Q0.9950.97
207_F362_S0.9930.97
66_T197_L0.9930.97
334_Q338_K0.9910.96
171_S178_P0.9840.96
164_N409_W0.9780.96
81_A318_I0.9740.96
118_E134_A0.9740.96
375_L385_A0.9740.96
323_N338_K0.9740.96
338_K341_R0.9730.96
62_Q202_R0.9700.96
420_A424_L0.9690.96
96_W234_I0.9690.96
80_V311_C0.9690.96
60_S298_V0.9630.96
19_Y23_G0.9620.96
43_F301_I0.9600.96
246_E249_G0.9580.96
84_I318_I0.9580.96
43_F300_M0.9560.96
22_F98_A0.9550.96
187_V191_L0.9550.96
210_L214_I0.9540.96
247_A250_G0.9540.96
222_I340_M0.9530.96
126_R373_N0.9510.96
272_E277_S0.9500.96
395_A399_G0.9500.96
248_A252_A0.9480.95
22_F268_M0.9450.95
198_H202_R0.9360.95
439_S443_R0.9330.95
4_F7_F0.9330.95
140_R144_V0.9310.95
382_N385_A0.9250.95
168_R334_Q0.9230.95
270_S306_D0.9220.95
129_P279_P0.9170.95
142_M426_A0.9140.95
150_L419_M0.9130.94
310_I313_A0.9100.94
399_G403_L0.9080.94
165_A356_V0.9080.94
438_A442_L0.9070.94
154_Y277_S0.9070.94
273_A303_I0.9070.94
133_M141_W0.9050.94
232_H236_S0.9050.94
433_V437_I0.9040.94
444_Q448_G0.9020.94
110_C302_G0.9010.94
410_Q414_I0.8960.94
42_Q445_R0.8940.94
152_I415_I0.8920.94
103_M300_M0.8920.94
223_C233_V0.8900.94
245_Q251_A0.8870.94
84_I319_L0.8860.94
221_V224_V0.8850.94
32_T435_H0.8840.93
125_F286_A0.8830.93
158_F275_M0.8830.93
39_Y42_Q0.8790.93
189_T364_I0.8780.93
86_A252_A0.8770.93
386_I390_R0.8770.93
247_A251_A0.8740.93
320_L343_L0.8700.93
89_P236_S0.8690.93
20_L24_A0.8680.93
279_P283_A0.8660.93
392_C395_A0.8660.93
290_P441_Y0.8650.93
429_L432_P0.8650.93
44_G301_I0.8630.93
214_I355_V0.8580.92
229_Q320_L0.8560.92
17_M417_A0.8550.92
192_A203_L0.8530.92
428_L431_S0.8520.92
57_G286_A0.8510.92
84_I315_A0.8500.92
18_I22_F0.8500.92
328_M331_E0.8490.92
68_L72_V0.8470.92
78_A81_A0.8450.92
46_S298_V0.8410.92
71_R106_S0.8400.92
12_L16_V0.8370.91
93_F97_V0.8370.91
31_R34_F0.8370.91
114_Q117_K0.8360.91
304_F309_V0.8310.91
58_L201_A0.8310.91
77_L352_V0.8300.91
431_S435_H0.8280.91
348_G352_V0.8270.91
25_G102_G0.8270.91
35_V438_A0.8260.91
169_A337_Q0.8240.91
218_T355_V0.8240.91
93_F242_F0.8220.91
299_Q302_G0.8210.91
234_I316_M0.8190.91
108_A435_H0.8190.91
172_F334_Q0.8170.90
82_L262_N0.8150.90
182_G402_L0.8150.90
200_V369_I0.8140.90
170_L357_I0.8140.90
129_P132_Y0.8090.90
313_A317_L0.8090.90
236_S324_G0.8090.90
208_V211_M0.8090.90
174_F350_E0.8070.90
28_F427_I0.8040.90
168_R171_S0.8040.90
29_T37_F0.8020.90
163_A364_I0.8010.90
160_G403_L0.8000.90
228_G232_H0.7990.89
127_G283_A0.7980.89
108_A111_S0.7970.89
165_A333_I0.7930.89
154_Y389_L0.7920.89
189_T397_V0.7910.89
43_F297_I0.7890.89
118_E126_R0.7870.89
308_L312_T0.7840.89
346_S349_A0.7790.88
84_I324_G0.7790.88
85_T331_E0.7770.88
434_V438_A0.7730.88
142_M145_L0.7730.88
23_G428_L0.7720.88
149_F422_T0.7720.88
158_F416_M0.7720.88
282_A302_G0.7720.88
298_V302_G0.7690.88
76_N270_S0.7690.88
64_L298_V0.7680.88
289_P294_A0.7680.88
170_L181_T0.7670.87
294_A441_Y0.7660.87
270_S307_T0.7590.87
222_I317_L0.7560.87
396_T399_G0.7540.87
432_P439_S0.7530.87
106_S278_T0.7530.87
171_S181_T0.7530.87
6_S410_Q0.7490.86
237_I315_A0.7430.86
240_S259_A0.7420.86
32_T438_A0.7420.86
208_V212_A0.7410.86
47_L301_I0.7410.86
197_L369_I0.7320.85
65_C205_Q0.7320.85
218_T344_M0.7300.85
350_E353_T0.7280.85
4_F11_V0.7270.85
244_W247_A0.7270.85
25_G101_I0.7250.84
159_S412_A0.7230.84
206_G210_L0.7230.84
373_N376_F0.7200.84
385_A388_C0.7170.84
72_V212_A0.7170.84
71_R299_Q0.7170.84
238_F319_L0.7150.84
244_W254_Y0.7150.84
35_V39_Y0.7140.83
46_S441_Y0.7120.83
120_D373_N0.7120.83
179_L402_L0.7120.83
16_V19_Y0.7120.83
69_A303_I0.7100.83
141_W144_V0.7070.83
161_V409_W0.7020.82
77_L359_F0.7010.82
168_R172_F0.7010.82
234_I312_T0.7000.82
285_A289_P0.6980.82
174_F181_T0.6950.82
102_G105_T0.6940.82
218_T351_F0.6930.82
154_Y367_N0.6920.82
66_T366_A0.6900.81
110_C282_A0.6890.81
240_S245_Q0.6880.81
230_L316_M0.6870.81
158_F412_A0.6850.81
248_A254_Y0.6830.81
11_V15_S0.6810.81
70_A367_N0.6800.80
333_I356_V0.6800.80
237_I319_L0.6790.80
18_I268_M0.6790.80
37_F41_R0.6780.80
331_E334_Q0.6760.80
144_V147_A0.6740.80
197_L200_V0.6730.80
341_R346_S0.6730.80
82_L85_T0.6720.80
12_L420_A0.6700.79
169_A333_I0.6700.79
445_R448_G0.6700.79
226_N343_L0.6680.79
56_G286_A0.6680.79
270_S308_L0.6680.79
212_A310_I0.6670.79
158_F420_A0.6670.79
432_P435_H0.6660.79
243_G251_A0.6640.79
347_W350_E0.6610.79
188_F191_L0.6610.79
108_A438_A0.6610.79
352_V355_V0.6600.78
130_A374_N0.6580.78
211_M270_S0.6580.78
432_P437_I0.6570.78
384_K387_W0.6540.78
24_A28_F0.6520.78
17_M420_A0.6520.78
154_Y158_F0.6520.78
92_V96_W0.6500.77
32_T108_A0.6500.77
353_T357_I0.6490.77
225_M229_Q0.6480.77
113_A279_P0.6480.77
367_N416_M0.6470.77
244_W248_A0.6470.77
12_L421_I0.6460.77
216_V219_S0.6460.77
159_S367_N0.6440.77
382_N388_C0.6430.77
229_Q233_V0.6430.77
277_S367_N0.6430.77
34_F100_F0.6420.76
194_T387_W0.6420.76
57_G125_F0.6410.76
439_S442_L0.6410.76
64_L302_G0.6410.76
111_S434_V0.6400.76
337_Q341_R0.6400.76
74_S360_A0.6380.76
160_G163_A0.6380.76
47_L305_I0.6370.76
186_A190_L0.6370.76
214_I354_L0.6370.76
115_L436_T0.6370.76
28_F434_V0.6350.76
305_I309_V0.6350.76
239_E244_W0.6340.76
259_A262_N0.6330.75
220_L223_C0.6310.75
403_L408_M0.6300.75
317_L340_M0.6290.75
28_F431_S0.6290.75
70_A275_M0.6270.75
33_G41_R0.6260.75
322_G325_T0.6220.74
159_S393_T0.6220.74
275_M416_M0.6210.74
46_S294_A0.6200.74
316_M320_L0.6190.74
215_W219_S0.6170.74
107_F434_V0.6160.74
156_I392_C0.6150.73
40_I103_M0.6150.73
388_C391_I0.6140.73
78_A331_E0.6130.73
72_V305_I0.6120.73
55_P119_R0.6100.73
98_A268_M0.6100.73
178_P181_T0.6060.72
247_A259_A0.6060.72
239_E243_G0.6040.72
293_A434_V0.6030.72
60_S285_A0.6030.72
35_V104_A0.6020.72
291_H441_Y0.6010.72
429_L433_V0.6010.72
247_A254_Y0.6000.72
153_A416_M0.5980.71
15_S18_I0.5970.71
5_F9_N0.5970.71
82_L405_L0.5960.71
106_S117_K0.5940.71
97_V238_F0.5890.70
282_A295_Q0.5890.70
389_L393_T0.5880.70
171_S175_D0.5880.70
111_S438_A0.5850.70
166_V364_I0.5850.70
20_L425_T0.5850.70
227_I232_H0.5820.69
133_M139_M0.5820.69
133_M138_G0.5800.69
147_A378_L0.5800.69
17_M421_I0.5790.69
182_G186_A0.5770.69
74_S166_V0.5770.69
126_R376_F0.5750.68
99_A102_G0.5750.68
324_G339_A0.5730.68
99_A307_T0.5710.68
111_S437_I0.5710.68
251_A324_G0.5710.68
254_Y261_T0.5700.68
254_Y260_I0.5680.67
74_S165_A0.5680.67
197_L201_A0.5680.67
43_F298_V0.5670.67
71_R282_A0.5670.67
425_T429_L0.5660.67
129_P280_N0.5640.67
395_A398_I0.5630.67
121_V383_P0.5630.67
132_Y423_N0.5630.67
160_G408_M0.5620.67
113_A278_T0.5610.66
336_I339_A0.5600.66
95_M307_T0.5600.66
214_I218_T0.5600.66
98_A348_G0.5590.66
170_L174_F0.5590.66
166_V360_A0.5590.66
76_N91_A0.5590.66
159_S389_L0.5570.66
40_I309_V0.5570.66
181_T184_I0.5570.66
122_N383_P0.5570.66
245_Q248_A0.5550.66
161_V408_M0.5550.66
244_W259_A0.5540.66
189_T193_I0.5530.65
183_I398_I0.5530.65
106_S302_G0.5510.65
130_A280_N0.5490.65
176_F180_V0.5480.65
33_G432_P0.5470.65
105_T278_T0.5470.65
295_Q303_I0.5460.64
364_I393_T0.5450.64
39_Y446_K0.5450.64
92_V312_T0.5450.64
105_T271_N0.5450.64
399_G402_L0.5440.64
269_F412_A0.5440.64
60_S295_Q0.5430.64
181_T185_L0.5430.64
136_G139_M0.5420.64
70_A363_S0.5420.64
96_W238_F0.5410.64
192_A361_F0.5410.64
375_L388_C0.5410.64
234_I237_I0.5400.64
278_T370_Y0.5400.64
35_V107_F0.5400.64
251_A259_A0.5390.63
323_N335_L0.5390.63
98_A254_Y0.5390.63
283_A390_R0.5380.63
271_N307_T0.5380.63
80_V270_S0.5370.63
441_Y445_R0.5360.63
108_A431_S0.5360.63
43_F47_L0.5340.63
58_L66_T0.5340.63
77_L336_I0.5330.63
193_I390_R0.5330.63
12_L414_I0.5320.62
216_V309_V0.5320.62
168_R332_G0.5320.62
269_F318_I0.5300.62
264_F268_M0.5290.62
110_C132_Y0.5270.62
394_F397_V0.5270.62
143_G149_F0.5240.61
167_A401_T0.5240.61
443_R446_K0.5230.61
142_M429_L0.5200.61
166_V357_I0.5200.61
160_G164_N0.5200.61
58_L284_A0.5190.61
35_V297_I0.5190.61
272_E279_P0.5180.60
218_T357_I0.5170.60
356_V360_A0.5160.60
168_R178_P0.5160.60
222_I321_A0.5160.60
261_T414_I0.5150.60
321_A324_G0.5140.60
173_S349_A0.5130.60
231_P234_I0.5120.59
86_A261_T0.5120.59
71_R278_T0.5120.59
64_L68_L0.5110.59
144_V377_F0.5100.59
82_L409_W0.5100.59
145_L148_V0.5100.59
96_W308_L0.5100.59
108_A427_I0.5090.59
12_L412_A0.5080.59
160_G396_T0.5080.59
436_T440_D0.5070.59
54_Q286_A0.5070.59
152_I157_I0.5070.59
71_R110_C0.5070.59
38_R41_R0.5070.59
78_A356_V0.5050.58
35_V40_I0.5040.58
199_G289_P0.5030.58
383_P387_W0.5030.58
212_A364_I0.5030.58
238_F320_L0.5030.58
160_G405_L0.5030.58
184_I187_V0.5020.58
243_G247_A0.5020.58
45_K48_K0.5020.58
416_M420_A0.5010.58
133_M422_T0.5000.58
109_E423_N0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7773 99.9 0.859 Contact Map
3giaA 1 0.8025 99.8 0.872 Contact Map
4djkA 2 0.7353 99.7 0.89 Contact Map
4wgvA 2 0.75 98.1 0.943 Contact Map
2xq2A 2 0.8571 98 0.945 Contact Map
3dh4A 3 0.8151 97.8 0.947 Contact Map
4us3A 1 0.7899 97.1 0.954 Contact Map
4xp4A 1 0.7983 96.4 0.958 Contact Map
2jlnA 1 0.7941 96 0.959 Contact Map
2a65A 2 0.8025 95.9 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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