GREMLIN Database
THIH - 2-iminoacetate synthase
UniProt: P30140 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11590
Length: 377 (302)
Sequences: 5530 (3133)
Seq/√Len: 180.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_R169_E4.8251.00
187_E203_F4.2551.00
164_E214_R4.1751.00
210_D249_H3.2271.00
107_E143_R3.1691.00
149_R176_D3.1171.00
39_R238_M3.0561.00
62_Q66_R3.0461.00
115_A151_Q2.9521.00
188_A235_D2.9271.00
88_D97_S2.9061.00
30_R41_D2.7251.00
64_L289_L2.7081.00
106_D109_D2.6551.00
138_M142_R2.6491.00
164_E168_A2.6331.00
107_E147_A2.6261.00
295_E316_N2.5811.00
110_I144_H2.5711.00
139_D169_E2.4031.00
164_E211_R2.3831.00
43_M234_V2.3241.00
111_A147_A2.2431.00
241_E290_L2.2261.00
39_R241_E2.2211.00
168_A172_Q2.1991.00
203_F207_E2.1481.00
207_E211_R2.0931.00
112_R115_A2.0311.00
233_R279_Q2.0141.00
45_L286_A1.9821.00
115_A119_E1.9791.00
257_V291_A1.9591.00
60_R289_L1.9531.00
62_Q312_P1.9191.00
147_A150_E1.9071.00
171_K215_A1.8951.00
182_Q239_V1.8801.00
114_S148_L1.8391.00
142_R146_P1.8351.00
43_M47_S1.8181.00
222_L243_L1.7871.00
147_A151_Q1.7861.00
66_R71_N1.7641.00
236_S279_Q1.7581.00
188_A238_M1.7391.00
296_L315_I1.7361.00
177_G219_K1.7281.00
143_R146_P1.7181.00
42_M290_L1.7061.00
185_Y235_D1.6921.00
38_T41_D1.6891.00
43_M237_Y1.6881.00
142_R173_L1.6551.00
62_Q65_T1.6551.00
111_A115_A1.6171.00
165_T168_A1.6161.00
171_K217_I1.6111.00
30_R35_S1.6041.00
109_D112_R1.5991.00
39_R234_V1.5971.00
145_L175_L1.5691.00
116_A119_E1.5671.00
54_L282_Q1.5551.00
204_W207_E1.5481.00
240_A287_F1.5371.00
141_F170_L1.5231.00
117_I122_F1.5171.00
39_R237_Y1.4931.00
111_A151_Q1.4851.00
39_R43_M1.4841.00
189_T192_R1.4771.00
47_S233_R1.4701.00
58_A313_L1.4641.00
163_A166_E1.4491.00
59_Q63_R1.4391.00
167_Y215_A1.4381.00
162_L170_L1.4271.00
37_L289_L1.4151.00
298_L310_V1.4141.00
63_R67_Q1.4141.00
29_E33_N1.4141.00
145_L160_Q1.3821.00
138_M166_E1.3751.00
210_D214_R1.3661.00
210_D246_L1.3551.00
201_D204_W1.3301.00
187_E191_A1.3261.00
42_M241_E1.3201.00
281_V310_V1.3111.00
28_V60_R1.3091.00
115_A152_F1.3071.00
236_S283_T1.2941.00
46_L286_A1.2931.00
47_S234_V1.2891.00
49_A282_Q1.2811.00
82_S129_T1.2681.00
141_F159_V1.2621.00
202_F206_L1.2581.00
226_I283_T1.2531.00
108_A112_R1.2451.00
169_E172_Q1.2301.00
42_M237_Y1.2221.00
241_E245_W1.2191.00
187_E202_F1.2161.00
112_R116_A1.2081.00
32_L63_R1.1971.00
187_E242_H1.1931.00
168_A171_K1.1911.00
111_A150_E1.1831.00
226_I280_L1.1761.00
164_E215_A1.1741.00
88_D196_K1.1741.00
240_A290_L1.1741.00
188_A192_R1.1721.00
54_L58_A1.1591.00
298_L315_I1.1521.00
139_D142_R1.1511.00
28_V31_A1.1501.00
65_T69_F1.1421.00
211_R214_R1.1341.00
188_A232_W1.1341.00
36_Q244_L1.1211.00
146_P173_L1.1201.00
84_L104_T1.1181.00
104_T132_H1.1151.00
277_E306_F1.1111.00
235_D238_M1.1021.00
44_A48_P1.1011.00
305_W308_D1.1011.00
263_R274_I1.0901.00
207_E210_D1.0881.00
64_L67_Q1.0821.00
46_L283_T1.0791.00
159_V178_V1.0761.00
168_A215_A1.0641.00
224_A239_V1.0601.00
37_L42_M1.0561.00
46_L233_R1.0541.00
55_E58_A1.0521.00
111_A152_F1.0511.00
127_L144_H1.0471.00
118_R153_S1.0461.00
36_Q248_Q1.0321.00
79_L125_L1.0321.00
60_R63_R1.0301.00
303_S309_R1.0260.99
232_W235_D1.0260.99
57_L282_Q1.0210.99
107_E111_A1.0150.99
107_E140_Y1.0120.99
83_N94_F1.0040.99
26_A29_E1.0030.99
180_V205_R0.9900.99
113_E116_A0.9880.99
202_F242_H0.9870.99
116_A120_M0.9770.99
182_Q202_F0.9760.99
206_L242_H0.9750.99
36_Q292_P0.9600.99
137_G140_Y0.9590.99
276_D279_Q0.9560.99
42_M286_A0.9550.99
88_D95_S0.9500.99
138_M169_E0.9500.99
81_L110_I0.9480.99
107_E144_H0.9460.99
60_R64_L0.9420.99
84_L102_R0.9410.99
169_E173_L0.9270.99
103_K109_D0.9250.99
83_N100_I0.9160.99
338_Q341_P0.9150.99
58_A285_C0.9130.99
29_E56_Q0.9040.99
264_P274_I0.8970.99
146_P172_Q0.8970.99
180_V208_T0.8960.99
48_P57_L0.8910.99
146_P150_E0.8860.99
178_V212_L0.8850.98
142_R172_Q0.8820.98
243_L291_A0.8780.98
213_G220_I0.8730.98
143_R147_A0.8690.98
233_R283_T0.8690.98
238_M241_E0.8680.98
299_S319_S0.8600.98
242_H245_W0.8550.98
87_N196_K0.8540.98
210_D245_W0.8520.98
118_R152_F0.8500.98
189_T229_S0.8440.98
281_V313_L0.8430.98
266_T270_E0.8410.98
237_Y241_E0.8370.98
126_L299_S0.8320.98
113_E125_L0.8310.98
77_V117_I0.8290.98
98_N134_A0.8280.98
69_F316_N0.8230.98
211_R215_A0.8200.98
156_Q177_G0.8190.98
58_A281_V0.8190.98
96_M101_K0.8180.97
68_R293_E0.8170.97
209_P220_I0.8140.97
182_Q185_Y0.8130.97
175_L217_I0.8070.97
104_T136_V0.8060.97
56_Q59_Q0.7970.97
81_L129_T0.7920.97
139_D143_R0.7910.97
189_T228_L0.7850.97
80_Y103_K0.7800.97
48_P60_R0.7800.97
182_Q242_H0.7790.97
108_A147_A0.7770.97
190_Y205_R0.7760.97
114_S152_F0.7710.96
54_L278_R0.7700.96
264_P268_G0.7670.96
69_F295_E0.7660.96
191_A200_Q0.7650.96
248_Q292_P0.7650.96
240_A291_A0.7630.96
48_P282_Q0.7620.96
240_A243_L0.7610.96
35_S41_D0.7610.96
31_A34_A0.7600.96
284_I310_V0.7570.96
46_L237_Y0.7550.96
158_E299_S0.7540.96
27_D44_A0.7520.96
228_L272_A0.7490.96
185_Y238_M0.7490.96
77_V122_F0.7450.96
144_H147_A0.7420.96
95_S268_G0.7400.95
163_A204_W0.7400.95
213_G247_Q0.7380.95
163_A208_T0.7260.95
115_A118_R0.7250.95
311_I314_A0.7230.95
134_A137_G0.7210.95
206_L210_D0.7160.95
166_E169_E0.7160.95
161_P205_R0.7160.95
26_A44_A0.7130.94
101_K329_Y0.7130.94
81_L159_V0.7120.94
269_I272_A0.7100.94
264_P270_E0.7080.94
55_E59_Q0.7040.94
138_M170_L0.7040.94
264_P271_P0.7040.94
184_T189_T0.7030.94
203_F242_H0.7030.94
108_A111_A0.7020.94
29_E32_L0.7020.94
297_S319_S0.7010.94
167_Y178_V0.6990.94
87_N131_E0.6990.94
265_C268_G0.6990.94
87_N200_Q0.6990.94
310_V315_I0.6970.94
128_V158_E0.6960.94
241_E244_L0.6940.94
284_I315_I0.6940.94
138_M157_M0.6930.94
66_R70_G0.6930.94
158_E161_P0.6880.93
32_L60_R0.6860.93
28_V32_L0.6850.93
189_T193_H0.6840.93
37_L290_L0.6830.93
27_D30_R0.6820.93
136_V140_Y0.6820.93
34_A41_D0.6810.93
161_P180_V0.6800.93
126_L319_S0.6800.93
184_T235_D0.6780.93
159_V170_L0.6760.93
43_M233_R0.6730.93
81_L127_L0.6720.93
131_E161_P0.6710.93
126_L179_M0.6700.92
111_A114_S0.6700.92
237_Y286_A0.6680.92
28_V56_Q0.6680.92
185_Y188_A0.6650.92
285_C314_A0.6650.92
167_Y208_T0.6630.92
263_R327_G0.6610.92
167_Y217_I0.6610.92
333_H336_L0.6610.92
163_A211_R0.6610.92
141_F145_L0.6600.92
282_Q286_A0.6580.92
284_I314_A0.6560.92
118_R123_E0.6540.92
303_S306_F0.6490.91
40_D234_V0.6470.91
212_L217_I0.6470.91
65_T73_V0.6450.91
291_A294_I0.6440.91
206_L246_L0.6440.91
40_D44_A0.6410.91
226_I236_S0.6400.91
32_L67_Q0.6400.91
185_Y242_H0.6390.91
330_A333_H0.6370.90
243_L294_I0.6340.90
36_Q249_H0.6330.90
281_V309_R0.6320.90
34_A249_H0.6300.90
93_G265_C0.6280.90
283_T286_A0.6280.90
63_R66_R0.6270.90
145_L155_L0.6260.90
90_T193_H0.6260.90
112_R119_E0.6210.89
126_L297_S0.6210.89
305_W309_R0.6190.89
62_Q71_N0.6180.89
333_H337_E0.6170.89
28_V63_R0.6170.89
284_I296_L0.6160.89
275_M280_L0.6160.89
190_Y194_H0.6140.89
57_L64_L0.6120.89
233_R236_S0.6110.89
225_L228_L0.6100.89
30_R33_N0.6090.88
287_F291_A0.6070.88
158_E319_S0.6060.88
79_L114_S0.6060.88
75_F320_A0.6050.88
41_D44_A0.6050.88
209_P222_L0.6040.88
42_M240_A0.6030.88
261_R280_L0.6020.88
27_D60_R0.6000.88
44_A47_S0.6000.88
304_P307_R0.5990.88
93_G194_H0.5990.88
90_T192_R0.5980.88
141_F144_H0.5970.87
237_Y290_L0.5960.87
221_G297_S0.5940.87
90_T98_N0.5920.87
39_R42_M0.5900.87
142_R170_L0.5870.87
132_H161_P0.5870.87
209_P246_L0.5860.86
58_A62_Q0.5860.86
278_R306_F0.5840.86
58_A309_R0.5820.86
184_T224_A0.5820.86
162_L166_E0.5810.86
65_T316_N0.5800.86
277_E303_S0.5790.86
156_Q176_D0.5790.86
277_E305_W0.5770.86
277_E309_R0.5760.86
248_Q293_E0.5750.85
279_Q283_T0.5750.85
303_S308_D0.5700.85
306_F310_V0.5690.85
233_R286_A0.5680.85
195_L200_Q0.5680.85
162_L165_T0.5660.85
128_V319_S0.5660.85
334_P339_F0.5660.85
262_L274_I0.5630.84
31_A60_R0.5630.84
55_E312_P0.5610.84
289_L292_P0.5610.84
126_L158_E0.5600.84
167_Y212_L0.5600.84
81_L144_H0.5600.84
209_P213_G0.5570.84
65_T70_G0.5560.83
244_L247_Q0.5560.83
55_E71_N0.5540.83
298_L307_R0.5530.83
221_G319_S0.5510.83
124_H156_Q0.5490.83
50_A282_Q0.5490.83
266_T271_P0.5490.83
106_D112_R0.5480.83
128_V161_P0.5480.83
247_Q294_I0.5460.82
76_Y181_Y0.5450.82
90_T269_I0.5440.82
88_D96_M0.5440.82
73_V311_I0.5430.82
128_V179_M0.5430.82
77_V320_A0.5390.82
192_R230_D0.5390.82
276_D280_L0.5390.82
59_Q62_Q0.5360.81
86_A133_Q0.5320.81
189_T235_D0.5310.81
107_E110_I0.5300.80
61_A285_C0.5300.80
120_M321_F0.5290.80
56_Q60_R0.5270.80
79_L110_I0.5270.80
81_L95_S0.5270.80
105_L113_E0.5270.80
261_R267_G0.5260.80
196_K200_Q0.5260.80
124_H297_S0.5250.80
128_V259_F0.5240.80
37_L41_D0.5240.80
140_Y144_H0.5230.80
78_P300_T0.5220.80
295_E317_N0.5210.79
55_E67_Q0.5210.79
245_W249_H0.5210.79
212_L220_I0.5200.79
158_E225_L0.5200.79
49_A54_L0.5190.79
82_S104_T0.5180.79
188_A191_A0.5170.79
57_L285_C0.5170.79
91_Y205_R0.5160.79
267_G270_E0.5160.79
128_V225_L0.5160.79
188_A234_V0.5150.79
237_Y244_L0.5150.79
30_R34_A0.5140.78
75_F318_V0.5130.78
311_I315_I0.5120.78
286_A290_L0.5110.78
28_V289_L0.5110.78
193_H229_S0.5110.78
118_R148_L0.5100.78
297_S317_N0.5090.78
183_E319_S0.5090.78
326_P329_Y0.5080.78
179_M212_L0.5070.78
88_D195_L0.5070.78
226_I275_M0.5060.77
140_Y143_R0.5050.77
278_R282_Q0.5050.77
332_N335_E0.5050.77
332_N336_L0.5040.77
145_L170_L0.5030.77
263_R267_G0.5030.77
221_G254_R0.5030.77
98_N102_R0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wcxA 1 0.9894 100 0.458 Contact Map
4r33A 2 0.9629 100 0.46 Contact Map
4rtbA 2 0.9629 100 0.47 Contact Map
3t7vA 1 0.878 100 0.47 Contact Map
3iixA 1 0.9045 100 0.493 Contact Map
1r30A 2 0.7984 100 0.515 Contact Map
4u0oB 1 0.679 100 0.72 Contact Map
1oltA 1 0.8833 99.8 0.811 Contact Map
2qgqA 1 0.679 99.7 0.822 Contact Map
4jc0A 1 0.8886 99.7 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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