GREMLIN Database
THIG - Thiazole synthase
UniProt: P30139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11589
Length: 256 (250)
Sequences: 1803 (702)
Seq/√Len: 44.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_A145_C5.2731.00
83_H122_Q4.9481.00
92_N125_V3.8971.00
79_I118_T3.6541.00
14_F37_L3.3901.00
222_L225_E3.3581.00
130_C137_C3.0361.00
164_R192_Q2.9571.00
212_D215_N2.8991.00
3_R6_D2.8761.00
114_K117_E2.6681.00
15_T207_I2.6581.00
117_E121_Q2.5811.00
186_V235_P2.5811.00
7_K64_T2.5331.00
9_F37_L2.5071.00
109_P136_L2.4361.00
222_L229_L2.4271.00
111_E114_K2.4071.00
179_V200_A2.4051.00
228_L232_Q2.3381.00
228_L231_R2.2531.00
96_L116_A2.2231.00
24_Q28_E2.2061.00
218_K229_L2.1841.00
152_G193_A2.1711.00
127_L147_A2.1271.00
158_N236_G2.1181.00
113_L136_L2.0180.99
125_V146_A2.0100.99
215_N229_L2.0060.99
141_E175_T1.9790.99
189_H192_Q1.9690.99
120_V143_V1.9520.99
161_L193_A1.9110.99
13_L224_V1.9080.99
218_K222_L1.8770.99
3_R8_T1.8510.99
118_T122_Q1.7660.98
215_N222_L1.7540.98
15_T35_S1.7200.98
221_R225_E1.6960.98
75_A111_E1.6750.97
14_F179_V1.6550.97
218_K225_E1.6230.97
168_E172_Q1.6130.97
171_I198_A1.6130.97
168_E240_Y1.5910.97
75_A79_I1.5880.96
229_L232_Q1.5440.96
10_D36_Q1.5400.96
159_Q165_A1.5340.96
211_D234_G1.5330.96
116_A143_V1.5180.95
186_V230_A1.4730.95
141_E174_A1.4530.94
5_A125_V1.4500.94
110_I136_L1.4260.94
75_A118_T1.4230.94
131_G166_M1.4180.93
85_A94_L1.4050.93
159_Q238_R1.3860.93
32_A214_V1.3820.93
215_N232_Q1.3620.92
189_H238_R1.3470.92
9_F64_T1.3330.91
209_V236_G1.3270.91
121_Q142_E1.3160.91
27_V31_R1.3120.90
30_I38_V1.2970.90
116_A120_V1.2950.90
21_A25_L1.2900.90
248_L251_F1.2890.90
132_A166_M1.2850.89
127_L146_A1.2630.89
76_E118_T1.2590.88
205_T209_V1.2590.88
13_L207_I1.2540.88
139_R142_E1.2490.88
141_E176_V1.2430.88
187_P230_A1.2400.88
132_A163_T1.2210.87
4_I14_F1.1950.86
26_M38_V1.1920.86
59_I62_G1.1840.85
188_S195_E1.1710.85
138_K141_E1.1570.84
34_G225_E1.1550.84
28_E31_R1.1530.84
114_K118_T1.1530.84
32_A218_K1.1460.83
14_F202_L1.1430.83
117_E139_R1.1350.83
109_P130_C1.1320.82
110_I117_E1.1220.82
100_P135_V1.1200.82
76_E83_H1.1140.81
215_N218_K1.1100.81
37_L64_T1.1080.81
4_I179_V1.1080.81
22_S25_L1.0980.80
5_A93_W1.0900.80
80_F83_H1.0840.80
108_D154_P1.0820.79
218_K221_R1.0800.79
128_P145_C1.0670.79
72_A81_A1.0650.78
203_V207_I1.0620.78
120_V145_C1.0570.78
75_A98_I1.0530.78
178_V198_A1.0510.77
215_N233_S1.0460.77
25_L214_V1.0380.77
170_I178_V1.0220.75
174_A178_V1.0110.75
104_W132_A1.0100.75
34_G221_R1.0060.74
167_L198_A1.0030.74
239_S243_H1.0030.74
74_T77_E1.0020.74
110_I139_R1.0000.74
136_L139_R0.9980.74
204_N208_A0.9950.73
153_A189_H0.9950.73
171_I178_V0.9940.73
89_L246_S0.9860.73
136_L140_L0.9850.73
12_H228_L0.9830.73
98_I250_G0.9790.72
184_I220_F0.9770.72
9_F93_W0.9760.72
190_A224_V0.9760.72
15_T29_A0.9710.72
4_I127_L0.9700.72
15_T30_I0.9660.71
31_R62_G0.9600.71
152_G161_L0.9590.71
31_R63_V0.9590.71
53_A56_E0.9330.69
194_L228_L0.9180.67
165_A168_E0.9120.67
14_F116_A0.8980.66
163_T166_M0.8980.66
9_F127_L0.8970.65
83_H118_T0.8940.65
85_A88_A0.8900.65
76_E114_K0.8890.65
87_E90_G0.8880.65
162_E165_A0.8720.63
153_A162_E0.8620.62
170_I174_A0.8610.62
186_V189_H0.8570.62
141_E148_V0.8560.62
172_Q241_F0.8530.62
20_F208_A0.8480.61
244_A249_T0.8420.61
5_A147_A0.8390.60
191_A226_A0.8390.60
134_P170_I0.8370.60
135_V139_R0.8360.60
159_Q162_E0.8300.59
7_K127_L0.8260.59
20_F38_V0.8230.59
148_V176_V0.8230.59
157_S241_F0.8180.58
142_E170_I0.8130.58
3_R7_K0.8080.57
184_I224_V0.8080.57
104_W169_I0.8030.57
73_K102_A0.8030.57
161_L184_I0.7990.56
6_D230_A0.7980.56
99_H250_G0.7970.56
30_I63_V0.7930.56
110_I113_L0.7930.56
120_V126_V0.7920.56
134_P174_A0.7920.56
222_L226_A0.7910.56
20_F204_N0.7850.55
202_L213_P0.7840.55
80_F89_L0.7840.55
70_S158_N0.7840.55
43_K250_G0.7810.55
26_M29_A0.7790.55
7_K93_W0.7780.54
138_K173_Q0.7660.53
28_E214_V0.7650.53
179_V203_V0.7650.53
113_L134_P0.7630.53
194_L227_G0.7600.53
66_L127_L0.7540.52
19_K26_M0.7530.52
81_A99_H0.7500.52
100_P104_W0.7500.52
30_I162_E0.7470.52
46_D49_Q0.7460.51
75_A114_K0.7410.51
104_W166_M0.7350.50
189_H235_P0.7340.50
158_N209_V0.7290.50
108_D139_R0.7270.50
99_H245_T0.7170.49
101_D173_Q0.7140.48
137_C170_I0.7090.48
244_A248_L0.7090.48
40_L65_L0.7080.48
180_V204_N0.7060.48
6_D125_V0.7030.47
15_T38_V0.7020.47
225_E229_L0.7000.47
109_P159_Q0.6990.47
26_M30_I0.6970.47
164_R196_M0.6970.47
93_W127_L0.6950.46
187_P235_P0.6930.46
55_L74_T0.6900.46
215_N230_A0.6860.46
52_D56_E0.6840.45
201_V224_V0.6840.45
113_L117_E0.6830.45
184_I189_H0.6800.45
23_S57_P0.6780.45
66_L96_L0.6760.45
187_P220_F0.6720.44
152_G209_V0.6690.44
184_I192_Q0.6680.44
27_V60_A0.6650.44
20_F29_A0.6640.44
73_K130_C0.6630.43
153_A205_T0.6620.43
159_Q184_I0.6600.43
169_I240_Y0.6590.43
11_S221_R0.6540.43
57_P145_C0.6540.43
15_T20_F0.6530.42
158_N235_P0.6520.42
103_R241_F0.6510.42
93_W128_P0.6460.42
30_I54_I0.6410.41
79_I83_H0.6390.41
2_L199_D0.6380.41
15_T63_V0.6380.41
65_L91_T0.6360.41
152_G167_L0.6340.41
70_S236_G0.6320.41
9_F36_Q0.6320.41
45_V55_L0.6310.40
29_A217_A0.6260.40
79_I122_Q0.6250.40
35_S196_M0.6230.40
82_A91_T0.6230.40
72_A96_L0.6220.40
43_K81_A0.6210.39
168_E210_A0.6190.39
154_P159_Q0.6180.39
86_R92_N0.6160.39
139_R143_V0.6160.39
36_Q62_G0.6110.39
78_A98_I0.6110.39
76_E89_L0.6110.39
70_S251_F0.6110.39
112_T171_I0.6090.38
37_L93_W0.6080.38
100_P132_A0.6070.38
7_K36_Q0.6070.38
27_V61_A0.6060.38
56_E122_Q0.6060.38
108_D111_E0.6040.38
141_E170_I0.6040.38
94_L126_V0.6030.38
240_Y243_H0.6030.38
147_A179_V0.6000.38
13_L203_V0.5990.37
101_D138_K0.5990.37
167_L171_I0.5990.37
194_L224_V0.5990.37
141_E171_I0.5960.37
96_L145_C0.5960.37
141_E173_Q0.5950.37
5_A146_A0.5950.37
62_G76_E0.5940.37
125_V128_P0.5930.37
70_S99_H0.5930.37
40_L85_A0.5920.37
82_A109_P0.5910.37
112_T153_A0.5910.37
17_T202_L0.5900.37
153_A244_A0.5900.37
214_V221_R0.5890.37
101_D169_I0.5890.37
138_K175_T0.5890.37
106_L151_L0.5860.36
157_S184_I0.5850.36
104_W130_C0.5850.36
2_L30_I0.5850.36
126_V195_E0.5850.36
186_V191_A0.5840.36
81_A96_L0.5830.36
179_V199_D0.5830.36
43_K130_C0.5820.36
25_L28_E0.5800.36
90_G180_V0.5770.36
134_P141_E0.5760.35
70_S209_V0.5720.35
15_T217_A0.5710.35
76_E80_F0.5660.35
120_V142_E0.5610.34
191_A210_A0.5590.34
5_A9_F0.5590.34
74_T238_R0.5570.34
110_I170_I0.5570.34
58_L89_L0.5550.34
186_V192_Q0.5530.33
18_G41_A0.5530.33
69_T82_A0.5520.33
234_G237_S0.5510.33
121_Q225_E0.5500.33
43_K80_F0.5500.33
104_W163_T0.5500.33
172_Q179_V0.5490.33
167_L180_V0.5490.33
74_T229_L0.5490.33
41_A147_A0.5470.33
106_L154_P0.5470.33
33_S213_P0.5470.33
45_V53_A0.5460.33
85_A89_L0.5460.33
161_L192_Q0.5450.33
171_I174_A0.5440.33
24_Q27_V0.5440.33
170_I175_T0.5410.32
118_T121_Q0.5400.32
152_G180_V0.5400.32
148_V235_P0.5380.32
35_S38_V0.5380.32
43_K137_C0.5370.32
192_Q196_M0.5360.32
55_L89_L0.5350.32
2_L9_F0.5300.31
59_I63_V0.5300.31
12_H231_R0.5280.31
42_M89_L0.5280.31
166_M200_A0.5280.31
132_A164_R0.5260.31
13_L33_S0.5250.31
198_A230_A0.5240.31
43_K167_L0.5240.31
113_L116_A0.5230.31
81_A87_E0.5230.31
194_L231_R0.5220.31
193_A196_M0.5220.31
64_T93_W0.5210.31
81_A85_A0.5210.31
117_E142_E0.5210.31
96_L100_P0.5190.31
130_C143_V0.5170.30
111_E137_C0.5160.30
63_V87_E0.5160.30
216_M233_S0.5160.30
131_G163_T0.5150.30
131_G135_V0.5140.30
109_P134_P0.5130.30
114_K139_R0.5120.30
43_K77_E0.5120.30
18_G106_L0.5100.30
200_A215_N0.5090.30
184_I203_V0.5080.30
151_L190_A0.5080.30
82_A127_L0.5070.30
184_I190_A0.5060.30
55_L205_T0.5030.29
4_I9_F0.5030.29
220_F235_P0.5030.29
15_T33_S0.5000.29
58_L167_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wv2A 3 0.8906 100 0.533 Contact Map
2htmA 3 0.9219 100 0.535 Contact Map
1xm3A 4 0.9727 100 0.618 Contact Map
4n6fA 2 0.9219 100 0.717 Contact Map
1ep3A 2 0.9336 99.6 0.862 Contact Map
3o07A 3 0.7969 99.5 0.872 Contact Map
2h6rA 3 0.7539 99.4 0.876 Contact Map
1ypfA 3 0.875 99.3 0.88 Contact Map
1f76A 1 0.8398 99.3 0.881 Contact Map
4oqvA 1 0.9141 99.3 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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