GREMLIN Database
THIF - Sulfur carrier protein ThiS adenylyltransferase
UniProt: P30138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11587
Length: 251 (221)
Sequences: 8867 (5841)
Seq/√Len: 392.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_T99_Q3.5101.00
54_T101_T3.3181.00
88_Q92_T3.3091.00
81_R89_Q3.1691.00
30_Q56_V3.1351.00
82_P104_Q3.0891.00
60_D106_R3.0071.00
30_Q54_T2.9821.00
56_V119_A2.9681.00
74_F86_V2.5501.00
204_E207_K2.5321.00
44_A91_L2.4431.00
169_C172_C2.3661.00
43_A123_L2.3541.00
123_L205_A2.3311.00
33_I44_A2.3091.00
77_E93_Q2.2971.00
78_D81_R2.2311.00
88_Q102_A2.2011.00
32_L119_A2.1981.00
76_T96_P2.1651.00
73_L87_S2.1511.00
85_Q104_Q2.1261.00
121_V205_A2.1041.00
149_A197_M2.0461.00
149_A201_Q2.0411.00
122_V139_C2.0271.00
56_V103_L1.9921.00
29_S209_L1.9171.00
113_K141_A1.9141.00
85_Q102_A1.9041.00
75_T93_Q1.8131.00
84_S102_A1.7621.00
117_A142_L1.7291.00
24_Q28_D1.7251.00
84_S104_Q1.6721.00
36_L57_L1.6651.00
156_G197_M1.6631.00
10_S14_L1.6591.00
126_T131_T1.6351.00
138_A142_L1.6171.00
113_K142_L1.5881.00
18_I22_G1.5831.00
18_I210_S1.5621.00
75_T90_R1.5561.00
41_T73_L1.5501.00
62_D82_P1.5411.00
56_V101_T1.5241.00
46_Y195_G1.5191.00
32_L58_A1.5121.00
13_I20_L1.4971.00
107_L112_L1.4891.00
48_A91_L1.4781.00
26_L206_I1.4681.00
81_R85_Q1.4661.00
82_P85_Q1.4571.00
137_A171_R1.4281.00
9_Y95_N1.4201.00
42_P45_L1.4181.00
44_A57_L1.3831.00
78_D90_R1.3781.00
31_V121_V1.3731.00
90_R93_Q1.3611.00
160_V208_L1.3361.00
8_R76_T1.3251.00
48_A98_I1.3021.00
43_A125_C1.2981.00
30_Q119_A1.2961.00
105_Q111_A1.2931.00
75_T78_D1.2861.00
222_F227_S1.2691.00
137_A141_A1.2641.00
12_Q23_Q1.2451.00
192_P203_L1.2041.00
20_L24_Q1.1951.00
36_L87_S1.1941.00
25_K29_S1.1871.00
158_L200_L1.1841.00
91_L98_I1.1821.00
108_T111_A1.1781.00
67_N83_K1.1721.00
88_Q100_L1.1391.00
91_L100_L1.1331.00
136_N140_V1.1261.00
200_L229_W1.1221.00
34_I135_I1.1161.00
45_L72_I1.1141.00
45_L49_G1.1011.00
113_K138_A1.0981.00
198_G202_A1.0951.00
151_A194_V1.0931.00
112_L138_A1.0841.00
27_L97_D1.0761.00
95_N98_I1.0661.00
222_F229_W1.0641.00
136_N146_L1.0611.00
223_D226_S1.0611.00
81_R86_V1.0611.00
92_T98_I1.0571.00
135_I146_L1.0571.00
85_Q88_Q1.0541.00
171_R174_W1.0481.00
32_L56_V1.0441.00
74_F78_D1.0341.00
195_G199_T1.0281.00
126_T135_I1.0251.00
183_N186_T1.0111.00
63_V74_F0.9921.00
196_V222_F0.9921.00
78_D89_Q0.9921.00
50_A206_I0.9831.00
30_Q101_T0.9781.00
124_D135_I0.9771.00
121_V208_L0.9731.00
61_D83_K0.9651.00
78_D86_V0.9541.00
49_G94_L0.9541.00
138_A141_A0.9541.00
133_Q175_P0.9541.00
147_I208_L0.9501.00
128_N131_T0.9471.00
48_A55_L0.9471.00
19_A22_G0.9361.00
61_D67_N0.9331.00
183_N187_A0.9321.00
121_V147_I0.9321.00
169_C173_L0.9101.00
63_V86_V0.9021.00
32_L116_V0.9011.00
116_V119_A0.8981.00
45_L90_R0.8911.00
34_I58_A0.8901.00
220_R229_W0.8791.00
12_Q69_Q0.8731.00
25_K211_G0.8721.00
21_D25_K0.8711.00
44_A87_S0.8701.00
162_T165_W0.8661.00
109_G137_A0.8651.00
170_Y173_L0.8591.00
41_T45_L0.8561.00
182_R187_A0.8541.00
101_T118_R0.8531.00
133_Q137_A0.8531.00
89_Q93_Q0.8531.00
196_V200_L0.8511.00
123_L201_Q0.8461.00
139_C146_L0.8441.00
134_E138_A0.8361.00
114_D117_A0.8321.00
60_D104_Q0.8261.00
15_L154_F0.8251.00
121_V209_L0.8211.00
34_I107_L0.8171.00
124_D132_R0.8151.00
112_L134_E0.8071.00
147_I205_A0.8071.00
168_G172_C0.8041.00
42_P195_G0.8001.00
203_L224_G0.7991.00
105_Q114_D0.7991.00
136_N169_C0.7981.00
220_R227_S0.7901.00
118_R144_T0.7881.00
39_L201_Q0.7821.00
31_V205_A0.7781.00
45_L94_L0.7781.00
41_T74_F0.7731.00
120_D144_T0.7691.00
89_Q92_T0.7651.00
151_A189_V0.7631.00
182_R186_T0.7611.00
36_L84_S0.7611.00
133_Q171_R0.7601.00
158_L197_M0.7541.00
23_Q27_L0.7541.00
73_L91_L0.7531.00
189_V194_V0.7511.00
116_V138_A0.7481.00
122_V135_I0.7481.00
169_C174_W0.7471.00
171_R175_P0.7431.00
68_L79_I0.7421.00
168_G217_G0.7371.00
36_L44_A0.7351.00
193_V224_G0.7351.00
92_T99_Q0.7321.00
44_A55_L0.7311.00
55_L91_L0.7271.00
203_L222_F0.7271.00
170_Y174_W0.7241.00
136_N172_C0.7241.00
86_V89_Q0.7221.00
46_Y72_I0.7221.00
31_V52_V0.7221.00
38_G194_V0.7221.00
46_Y202_A0.7201.00
122_V144_T0.7171.00
65_L79_I0.7161.00
154_F225_K0.7071.00
7_M13_I0.7071.00
46_Y199_T0.7061.00
208_L215_P0.7041.00
24_Q27_L0.7031.00
160_V204_E0.7021.00
177_N180_P0.6971.00
58_A115_A0.6951.00
107_L111_A0.6921.00
7_M10_S0.6921.00
113_K117_A0.6890.99
109_G134_E0.6880.99
58_A107_L0.6850.99
12_Q50_A0.6820.99
12_Q15_L0.6810.99
25_K210_S0.6810.99
147_I160_V0.6790.99
162_T166_E0.6750.99
26_L53_G0.6740.99
65_L76_T0.6710.99
224_G227_S0.6700.99
9_Y98_I0.6660.99
116_V142_L0.6650.99
25_K28_D0.6650.99
30_Q118_R0.6640.99
124_D148_T0.6610.99
84_S100_L0.6610.99
22_G210_S0.6560.99
43_A201_Q0.6560.99
49_G69_Q0.6540.99
162_T167_Q0.6520.99
63_V73_L0.6480.99
85_Q89_Q0.6460.99
221_L230_R0.6450.99
55_L98_I0.6440.99
132_R150_S0.6430.99
206_I210_S0.6410.99
50_A191_G0.6410.99
42_P46_Y0.6400.99
43_A198_G0.6370.99
205_A209_L0.6360.99
157_Q160_V0.6290.99
212_I225_K0.6270.99
76_T79_I0.6250.99
128_N132_R0.6230.99
111_A115_A0.6230.99
78_D93_Q0.6170.99
194_V199_T0.6170.99
44_A73_L0.6160.99
190_V203_L0.6140.99
7_M65_L0.6130.99
53_G95_N0.6130.99
42_P72_I0.6090.99
8_R97_D0.6080.99
126_T132_R0.6010.99
212_I215_P0.5980.99
26_L52_V0.5980.99
170_Y175_P0.5970.99
29_S52_V0.5960.99
47_L55_L0.5950.99
37_G40_G0.5950.99
67_N70_R0.5930.98
29_S120_D0.5930.98
171_R176_D0.5910.98
192_P206_I0.5900.98
10_S13_I0.5900.98
175_P178_Q0.5890.98
21_D24_Q0.5890.98
48_A100_L0.5860.98
62_D104_Q0.5840.98
177_N181_E0.5840.98
140_V172_C0.5830.98
61_D66_S0.5820.98
67_N71_Q0.5800.98
145_P208_L0.5780.98
13_I23_Q0.5780.98
124_D127_D0.5770.98
178_Q181_E0.5770.98
103_L119_A0.5740.98
41_T63_V0.5730.98
73_L90_R0.5690.98
33_I47_L0.5650.98
57_L100_L0.5640.98
15_L18_I0.5640.98
57_L87_S0.5630.98
59_D84_S0.5610.98
31_V123_L0.5580.98
52_V209_L0.5570.98
131_T134_E0.5560.98
64_H67_N0.5540.98
70_R83_K0.5540.98
61_D127_D0.5540.98
90_R94_L0.5530.98
67_N127_D0.5520.98
176_D179_E0.5520.98
116_V122_V0.5500.98
36_L74_F0.5480.97
116_V139_C0.5460.97
38_G69_Q0.5460.97
147_I201_Q0.5430.97
148_T159_M0.5420.97
42_P198_G0.5410.97
200_L203_L0.5400.97
83_K127_D0.5390.97
189_V193_V0.5390.97
42_P199_T0.5370.97
116_V144_T0.5350.97
153_G193_V0.5340.97
156_G190_V0.5330.97
140_V161_L0.5320.97
171_R177_N0.5310.97
107_L116_V0.5220.97
115_A119_A0.5210.97
61_D70_R0.5200.97
192_P199_T0.5180.96
33_I40_G0.5170.96
214_T226_S0.5150.96
199_T203_L0.5150.96
210_S215_P0.5130.96
173_L177_N0.5100.96
18_I23_Q0.5100.96
207_K213_E0.5090.96
159_M163_P0.5070.96
37_G71_Q0.5060.96
119_A144_T0.5060.96
154_F212_I0.5050.96
39_L194_V0.5050.96
62_D65_L0.5040.96
30_Q120_D0.5030.96
55_L100_L0.5030.96
221_L224_G0.5010.96
172_C175_P0.5010.96
35_G40_G0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zud1 2 0.9562 100 0.146 Contact Map
1jw9B 2 0.9442 100 0.178 Contact Map
1tt5B 1 0.9841 100 0.214 Contact Map
4gslA 2 0.9841 100 0.22 Contact Map
3h5nA 3 0.9562 100 0.23 Contact Map
2nvuB 1 0.9841 100 0.231 Contact Map
3h8vA 2 0.8287 100 0.232 Contact Map
1y8qA 1 0.9124 100 0.249 Contact Map
3ruiA 2 0.9841 100 0.254 Contact Map
1y8qB 1 0.9402 100 0.276 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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