GREMLIN Database
THIC - Phosphomethylpyrimidine synthase
UniProt: P30136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11585
Length: 631 (596)
Sequences: 625 (156)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
613_M616_N5.7311.00
165_I207_V5.6180.99
267_V291_I5.0920.99
414_H449_E5.0780.99
49_I73_V4.9420.99
383_C390_L4.5570.98
511_K561_T4.4800.97
512_Q561_T4.4390.97
213_I389_S4.3740.97
207_V214_I4.0900.95
32_R81_G4.0310.95
377_R425_E3.7550.92
39_H103_A3.5190.90
377_R422_I3.4930.89
449_E453_H3.3950.88
146_R384_A3.2050.85
506_N568_E3.1480.83
31_K48_E3.1350.83
45_P164_F3.0470.81
107_T139_K3.0410.81
381_E426_Y3.0000.80
151_H427_D2.9200.78
440_M484_M2.8910.78
236_V514_L2.8490.76
117_Y121_R2.8440.76
238_A267_V2.7810.75
550_E563_R2.7790.75
479_G490_C2.7040.72
534_Q538_N2.6760.72
370_N374_Q2.6620.71
337_L370_N2.6580.71
121_R278_E2.6500.71
377_R426_Y2.5540.68
572_Q575_G2.5290.67
95_K136_L2.5040.66
384_A426_Y2.3930.62
306_I587_K2.3780.62
213_I431_M2.3450.61
597_V600_Y2.3150.60
38_T103_A2.3150.60
368_Q374_Q2.2950.59
540_M556_A2.2810.59
121_R124_D2.2760.58
115_S121_R2.2670.58
407_E414_H2.2520.57
238_A259_S2.2300.57
348_L402_Q2.2270.57
113_R119_K2.2170.56
110_L121_R2.2090.56
470_A477_T2.2060.56
444_R448_T2.2050.56
121_R131_R2.1940.55
233_L518_K2.1930.55
68_N542_K2.1890.55
512_Q516_T2.1810.55
205_D209_A2.1800.55
110_L115_S2.1430.54
306_I309_D2.1280.53
216_A223_S2.0980.52
516_T519_I2.0650.51
449_E452_E2.0630.51
110_L114_S2.0380.50
343_M407_E1.9910.48
184_Q532_G1.9860.48
110_L117_Y1.9630.47
414_H453_H1.9570.47
337_L411_A1.9540.47
233_L530_H1.9450.46
113_R121_R1.9420.46
95_K98_Q1.9210.45
124_D131_R1.9150.45
187_G192_A1.8940.44
37_G167_I1.8790.44
118_T121_R1.8710.44
440_M443_I1.8640.43
110_L119_K1.8530.43
181_L184_Q1.8490.43
450_E530_H1.8390.42
259_S264_A1.8250.42
338_L367_H1.8240.42
54_T68_N1.8200.42
32_R164_F1.8170.42
115_S119_K1.8070.41
311_T314_A1.7950.41
511_K560_F1.7910.41
146_R151_H1.7790.40
450_E455_H1.7660.40
121_R127_L1.7610.40
267_V287_S1.7560.40
296_I594_S1.7440.39
26_A261_R1.7290.39
151_H384_A1.7280.39
106_D152_Y1.7150.38
41_G103_A1.7140.38
35_I46_M1.7060.38
187_G190_F1.7050.38
146_R426_Y1.6650.36
173_R233_L1.6640.36
238_A287_S1.6590.36
115_S131_R1.6550.36
238_A264_A1.6470.36
113_R120_A1.6440.36
132_F281_E1.6420.36
610_M614_S1.6360.35
151_H155_Q1.6350.35
365_S374_Q1.6170.35
165_I227_I1.6160.35
38_T42_V1.6090.35
37_G163_E1.6060.34
187_G191_G1.6000.34
48_E72_P1.5950.34
359_M370_N1.5790.34
150_L484_M1.5670.33
131_R278_E1.5660.33
511_K515_I1.5630.33
479_G516_T1.5600.33
249_I279_T1.5590.33
416_L432_I1.5430.32
115_S120_A1.5340.32
554_N563_R1.5290.32
484_M488_F1.5270.32
150_L384_A1.5150.31
117_Y120_A1.5120.31
223_S389_S1.5100.31
181_L185_H1.5020.31
33_I46_M1.4980.31
108_E140_R1.4950.31
185_H442_M1.4950.31
117_Y131_R1.4940.31
185_H538_N1.4940.31
51_L71_I1.4620.30
163_E167_I1.4600.30
401_I534_Q1.4550.30
66_E542_K1.4550.30
542_K546_E1.4510.30
508_E512_Q1.4410.29
38_T41_G1.4320.29
53_P67_E1.4260.29
118_T124_D1.4210.29
181_L538_N1.4000.28
441_Q450_E1.3970.28
185_H534_Q1.3940.28
614_S618_R1.3910.28
22_L514_L1.3900.28
101_I223_S1.3890.28
184_Q538_N1.3860.28
101_I106_D1.3680.27
127_L131_R1.3610.27
515_I568_E1.3560.27
22_L25_T1.3520.27
26_A81_G1.3490.26
173_R511_K1.3330.26
116_D119_K1.3280.26
593_I597_V1.3270.26
357_S593_I1.3260.26
72_P171_M1.3240.26
567_D576_K1.3220.26
587_K596_E1.3120.25
113_R117_Y1.3080.25
233_L441_Q1.3050.25
512_Q560_F1.3030.25
30_S47_R1.3000.25
121_R130_L1.2990.25
482_A517_Y1.2980.25
42_V79_P1.2940.25
113_R118_T1.2920.25
110_L113_R1.2880.25
51_L70_A1.2830.25
330_F379_I1.2810.25
339_R411_A1.2810.25
561_T565_Y1.2790.25
392_L416_L1.2790.25
308_E361_K1.2750.24
595_Q599_D1.2730.24
566_H582_S1.2670.24
115_S278_E1.2630.24
141_A160_P1.2600.24
390_L426_Y1.2540.24
337_L340_Y1.2530.24
185_H507_K1.2310.23
213_I430_V1.2300.23
567_D582_S1.2290.23
110_L118_T1.2220.23
114_S121_R1.2180.23
115_S124_D1.2160.23
146_R427_D1.2150.23
117_Y278_E1.2120.23
117_Y124_D1.2030.23
141_A428_V1.2000.22
115_S118_T1.1980.22
376_F416_L1.1970.22
476_F512_Q1.1930.22
307_A361_K1.1900.22
291_I594_S1.1890.22
615_E619_A1.1880.22
110_L278_E1.1880.22
400_S466_T1.1810.22
110_L120_A1.1770.22
540_M555_L1.1740.22
148_T425_E1.1720.22
556_A564_A1.1710.22
39_H42_V1.1700.22
51_L69_E1.1690.22
287_S291_I1.1670.22
345_A595_Q1.1670.22
216_A389_S1.1670.22
80_Y87_I1.1640.22
339_R370_N1.1630.22
68_N278_E1.1630.22
151_H428_V1.1630.22
336_V390_L1.1570.21
284_L401_I1.1490.21
256_L514_L1.1470.21
514_L556_A1.1440.21
376_F392_L1.1440.21
319_L379_I1.1410.21
414_H455_H1.1400.21
101_I221_P1.1370.21
194_L209_A1.1360.21
440_M447_M1.1350.21
36_T43_R1.1340.21
227_I248_S1.1320.21
45_P574_S1.1300.21
33_I173_R1.1300.21
117_Y127_L1.1240.21
315_F450_E1.1220.21
593_I601_A1.1210.21
438_V450_E1.1190.20
336_V383_C1.1100.20
449_E455_H1.1090.20
567_D571_P1.1090.20
384_A390_L1.1070.20
443_I466_T1.1050.20
511_K564_A1.1050.20
112_V138_P1.1010.20
512_Q565_Y1.1010.20
155_Q384_A1.1000.20
147_V151_H1.1000.20
127_L130_L1.0970.20
37_G160_P1.0970.20
45_P122_L1.0890.20
236_V256_L1.0880.20
158_I375_H1.0790.20
567_D578_A1.0780.20
441_Q484_M1.0700.19
155_Q381_E1.0680.19
147_V427_D1.0650.19
477_T516_T1.0610.19
190_F444_R1.0600.19
550_E554_N1.0600.19
248_S251_E1.0600.19
114_S117_Y1.0580.19
207_V320_L1.0500.19
165_I214_I1.0490.19
150_L476_F1.0390.19
80_Y376_F1.0370.19
110_L131_R1.0340.19
150_L490_C1.0340.19
118_T490_C1.0340.19
561_T587_K1.0320.18
72_P172_G1.0300.18
234_V516_T1.0290.18
561_T564_A1.0280.18
117_Y130_L1.0240.18
68_N534_Q1.0230.18
414_H452_E1.0230.18
165_I484_M1.0120.18
259_S442_M1.0110.18
447_M472_G1.0090.18
37_G42_V1.0090.18
234_V524_A1.0080.18
193_H209_A1.0080.18
43_R140_R1.0050.18
198_I207_V0.9990.18
296_I337_L0.9950.18
612_D624_I0.9900.18
384_A427_D0.9900.18
119_K124_D0.9880.18
338_L593_I0.9880.18
516_T565_Y0.9870.18
213_I284_L0.9870.18
214_I469_I0.9820.17
124_D127_L0.9810.17
22_L236_V0.9740.17
377_R384_A0.9740.17
68_N538_N0.9730.17
306_I511_K0.9720.17
209_A508_E0.9720.17
514_L572_Q0.9660.17
383_C426_Y0.9650.17
198_I519_I0.9630.17
171_M479_G0.9630.17
174_E197_N0.9600.17
53_P315_F0.9600.17
118_T278_E0.9590.17
349_T400_S0.9570.17
54_T66_E0.9570.17
407_E455_H0.9560.17
23_E507_K0.9550.17
599_D610_M0.9550.17
287_S377_R0.9520.17
114_S119_K0.9520.17
31_K50_Q0.9490.17
608_M611_A0.9480.17
574_S577_V0.9470.17
120_A278_E0.9460.17
115_S127_L0.9450.17
442_M490_C0.9430.17
594_S614_S0.9430.17
77_S430_V0.9400.17
378_E381_E0.9400.17
450_E453_H0.9390.17
367_H617_F0.9370.16
26_A32_R0.9360.16
576_K582_S0.9350.16
256_L516_T0.9350.16
160_P163_E0.9350.16
165_I511_K0.9340.16
150_L214_I0.9340.16
89_V250_E0.9320.16
89_V173_R0.9310.16
71_I535_I0.9300.16
165_I234_V0.9300.16
188_M442_M0.9290.16
124_D130_L0.9290.16
118_T131_R0.9260.16
151_H426_Y0.9260.16
275_Y511_K0.9250.16
184_Q534_Q0.9250.16
213_I557_L0.9250.16
209_A456_E0.9250.16
101_I104_R0.9220.16
34_Y45_P0.9190.16
175_R213_I0.9190.16
146_R390_L0.9150.16
389_S479_G0.9140.16
466_T612_D0.9110.16
453_H490_C0.9090.16
174_E519_I0.9080.16
101_I152_Y0.9070.16
376_F432_I0.9050.16
51_L540_M0.9010.16
130_L279_T0.9000.16
512_Q515_I0.8980.16
456_E568_E0.8970.16
130_L278_E0.8970.16
209_A450_E0.8960.16
110_L138_P0.8950.16
338_L364_L0.8950.16
118_T125_D0.8940.16
110_L124_D0.8930.16
142_K381_E0.8920.16
89_V490_C0.8880.16
256_L490_C0.8860.15
163_E309_D0.8840.15
311_T316_R0.8830.15
571_P582_S0.8820.15
617_F624_I0.8820.15
400_S594_S0.8810.15
106_D427_D0.8790.15
614_S620_R0.8780.15
184_Q442_M0.8760.15
102_D107_T0.8740.15
22_L257_V0.8720.15
112_V119_K0.8690.15
141_A427_D0.8680.15
194_L619_A0.8670.15
146_R428_V0.8670.15
284_L389_S0.8670.15
346_K599_D0.8660.15
511_K587_K0.8650.15
29_N620_R0.8650.15
420_T424_W0.8640.15
601_A605_T0.8630.15
370_N411_A0.8600.15
617_F623_E0.8590.15
114_S131_R0.8570.15
344_T582_S0.8560.15
426_Y514_L0.8560.15
264_A267_V0.8550.15
46_M389_S0.8500.15
116_D120_A0.8490.15
616_N620_R0.8480.15
23_E257_V0.8460.15
119_K278_E0.8460.15
571_P576_K0.8450.15
621_G625_Y0.8440.15
348_L542_K0.8440.15
451_L456_E0.8430.15
381_E384_A0.8410.15
116_D121_R0.8400.15
600_Y605_T0.8400.15
32_R66_E0.8330.14
441_Q448_T0.8320.14
164_F546_E0.8300.14
71_I151_H0.8300.14
145_R155_Q0.8280.14
81_G164_F0.8280.14
27_F508_E0.8260.14
154_R563_R0.8250.14
610_M613_M0.8240.14
89_V167_I0.8240.14
87_I378_E0.8200.14
27_F261_R0.8160.14
364_L367_H0.8160.14
106_D223_S0.8120.14
576_K579_H0.8100.14
124_D278_E0.8100.14
223_S378_E0.8100.14
146_R383_C0.8090.14
308_E385_A0.8090.14
139_K514_L0.8080.14
124_D249_I0.8070.14
160_P427_D0.8010.14
340_Y411_A0.7970.14
443_I447_M0.7930.14
22_L27_F0.7900.14
256_L390_L0.7900.14
43_R441_Q0.7900.14
68_N115_S0.7900.14
256_L260_T0.7890.14
420_T431_M0.7890.14
402_Q449_E0.7890.14
186_P442_M0.7870.14
238_A484_M0.7870.14
54_T70_A0.7860.14
19_I274_R0.7860.14
209_A455_H0.7850.14
506_N556_A0.7830.14
43_R85_I0.7820.14
45_P81_G0.7800.14
587_K605_T0.7790.14
32_R80_Y0.7770.13
248_S279_T0.7760.13
35_I383_C0.7740.13
80_Y85_I0.7730.13
101_I107_T0.7730.13
51_L556_A0.7730.13
336_V340_Y0.7690.13
359_M594_S0.7680.13
254_E507_K0.7680.13
425_E624_I0.7670.13
611_A614_S0.7670.13
35_I167_I0.7670.13
550_E572_Q0.7670.13
233_L511_K0.7660.13
340_Y370_N0.7660.13
421_K425_E0.7640.13
213_I260_T0.7590.13
81_G426_Y0.7590.13
518_K599_D0.7570.13
260_T425_E0.7570.13
187_G195_P0.7570.13
71_I359_M0.7570.13
146_R425_E0.7560.13
392_L432_I0.7550.13
367_H593_I0.7520.13
250_E561_T0.7520.13
377_R390_L0.7500.13
42_V164_F0.7490.13
68_N110_L0.7490.13
191_G451_L0.7480.13
323_A385_A0.7470.13
368_Q452_E0.7460.13
567_D579_H0.7450.13
128_D278_E0.7440.13
594_S600_Y0.7430.13
213_I449_E0.7430.13
96_L556_A0.7390.13
383_C479_G0.7380.13
80_Y416_L0.7380.13
476_F490_C0.7370.13
518_K610_M0.7370.13
158_I469_I0.7350.13
246_T256_L0.7350.13
613_M617_F0.7340.13
73_V536_R0.7330.13
486_G569_T0.7320.13
154_R556_A0.7310.13
120_A124_D0.7310.13
340_Y430_V0.7300.13
304_N309_D0.7300.13
88_N91_Q0.7290.13
261_R416_L0.7290.13
251_E259_S0.7280.13
570_L574_S0.7240.13
570_L582_S0.7230.13
119_K507_K0.7230.13
172_G511_K0.7230.13
274_R575_G0.7220.13
315_F374_Q0.7210.13
608_M612_D0.7210.13
37_G41_G0.7200.13
566_H578_A0.7200.13
118_T260_T0.7170.13
22_L89_V0.7140.12
259_S565_Y0.7140.12
130_L134_G0.7130.12
597_V601_A0.7120.12
367_H625_Y0.7110.12
22_L256_L0.7110.12
122_L128_D0.7090.12
150_L274_R0.7090.12
209_A441_Q0.7080.12
188_M192_A0.7070.12
278_E542_K0.7070.12
466_T470_A0.7060.12
144_G160_P0.7060.12
605_T612_D0.7040.12
146_R377_R0.7020.12
374_Q426_Y0.7020.12
46_M163_E0.7000.12
348_L484_M0.7000.12
125_D128_D0.7000.12
374_Q383_C0.7000.12
194_L236_V0.7000.12
80_Y392_L0.6990.12
29_N188_M0.6990.12
571_P578_A0.6990.12
158_I346_K0.6990.12
422_I425_E0.6980.12
115_S130_L0.6960.12
257_V407_E0.6960.12
148_T155_Q0.6930.12
567_D580_F0.6930.12
384_A425_E0.6930.12
158_I248_S0.6900.12
35_I313_E0.6900.12
130_L538_N0.6860.12
320_L445_R0.6860.12
430_V450_E0.6860.12
77_S465_L0.6840.12
506_N601_A0.6830.12
566_H570_L0.6830.12
151_H160_P0.6820.12
117_Y122_L0.6790.12
111_T378_E0.6790.12
374_Q384_A0.6790.12
344_T567_D0.6780.12
560_F563_R0.6780.12
18_F514_L0.6770.12
374_Q532_G0.6750.12
389_S594_S0.6750.12
95_K323_A0.6740.12
566_H576_K0.6740.12
569_T582_S0.6730.12
106_D160_P0.6730.12
586_P593_I0.6730.12
599_D614_S0.6730.12
608_M619_A0.6710.12
564_A568_E0.6710.12
29_N207_V0.6710.12
184_Q187_G0.6700.12
113_R124_D0.6680.12
410_F449_E0.6660.12
348_L444_R0.6660.12
407_E452_E0.6660.12
315_F378_E0.6650.12
296_I340_Y0.6650.12
187_G487_W0.6640.12
309_D343_M0.6640.12
18_F575_G0.6640.12
395_G548_R0.6640.12
374_Q390_L0.6630.12
40_P43_R0.6630.12
105_G112_V0.6630.12
506_N511_K0.6630.12
102_D223_S0.6620.12
49_I536_R0.6620.12
167_I448_T0.6620.12
114_S278_E0.6610.12
455_H530_H0.6610.12
486_G515_I0.6600.12
42_V421_K0.6600.12
27_F90_Q0.6580.12
51_L76_T0.6580.12
622_G626_L0.6570.12
307_A338_L0.6570.12
71_I425_E0.6560.12
337_L490_C0.6560.12
160_P167_I0.6560.12
43_R421_K0.6550.12
259_S267_V0.6550.12
39_H43_R0.6520.11
337_L466_T0.6520.11
367_H621_G0.6520.11
209_A234_V0.6510.11
309_D518_K0.6510.11
296_I336_V0.6510.11
606_I624_I0.6500.11
110_L127_L0.6500.11
142_K346_K0.6490.11
231_N456_E0.6490.11
450_E538_N0.6480.11
440_M480_I0.6460.11
114_S120_A0.6460.11
164_F444_R0.6440.11
338_L361_K0.6440.11
566_H569_T0.6430.11
279_T546_E0.6400.11
71_I594_S0.6400.11
314_A611_A0.6390.11
246_T385_A0.6390.11
452_E455_H0.6390.11
274_R466_T0.6360.11
257_V376_F0.6360.11
278_E428_V0.6330.11
39_H107_T0.6330.11
66_E278_E0.6330.11
617_F625_Y0.6320.11
167_I507_K0.6310.11
48_E390_L0.6310.11
337_L415_T0.6310.11
306_I596_E0.6310.11
155_Q427_D0.6300.11
164_F368_Q0.6300.11
38_T120_A0.6290.11
337_L442_M0.6280.11
152_Y163_E0.6270.11
275_Y450_E0.6250.11
606_I613_M0.6240.11
361_K596_E0.6240.11
114_S118_T0.6230.11
160_P428_V0.6220.11
307_A365_S0.6220.11
396_L431_M0.6210.11
37_G106_D0.6210.11
35_I142_K0.6190.11
579_H582_S0.6190.11
411_A452_E0.6190.11
422_I426_Y0.6190.11
343_M411_A0.6170.11
444_R455_H0.6170.11
155_Q488_F0.6170.11
592_K596_E0.6160.11
43_R84_Q0.6150.11
165_I560_F0.6140.11
34_Y515_I0.6140.11
118_T130_L0.6140.11
151_H278_E0.6130.11
338_L579_H0.6120.11
207_V309_D0.6120.11
152_Y427_D0.6110.11
52_S515_I0.6110.11
569_T579_H0.6110.11
316_R375_H0.6100.11
23_E441_Q0.6070.11
519_I568_E0.6070.11
396_L465_L0.6060.11
163_E308_E0.6050.11
99_P103_A0.6040.11
207_V244_A0.6040.11
466_T477_T0.6040.11
31_K568_E0.6040.11
68_N546_E0.6040.11
450_E484_M0.6040.11
79_P103_A0.6030.11
43_R103_A0.6010.11
341_V469_I0.6010.11
71_I532_G0.6000.11
296_I519_I0.6000.11
416_L426_Y0.6000.11
137_T164_F0.6000.11
476_F479_G0.6000.11
33_I540_M0.5990.11
445_R449_E0.5990.11
231_N472_G0.5980.11
128_D431_M0.5980.11
124_D129_E0.5980.11
45_P96_L0.5980.11
438_V447_M0.5980.11
304_N384_A0.5970.11
616_N619_A0.5970.11
278_E281_E0.5960.11
407_E449_E0.5960.11
384_A428_V0.5960.11
32_R384_A0.5950.11
238_A260_T0.5950.11
514_L574_S0.5940.11
113_R275_Y0.5930.11
332_I379_I0.5920.11
73_V384_A0.5920.11
178_S309_D0.5920.11
127_L278_E0.5910.11
620_R626_L0.5910.11
479_G512_Q0.5910.11
233_L614_S0.5900.11
614_S617_F0.5900.11
364_L579_H0.5900.11
68_N185_H0.5890.11
192_A213_I0.5880.11
248_S308_E0.5880.11
171_M304_N0.5880.11
319_L330_F0.5870.11
96_L223_S0.5870.11
185_H196_E0.5870.11
132_F152_Y0.5860.11
68_N121_R0.5860.11
385_A514_L0.5860.11
36_T72_P0.5860.11
566_H579_H0.5840.11
163_E306_I0.5840.11
338_L617_F0.5840.11
173_R177_R0.5820.10
383_C449_E0.5820.10
315_F514_L0.5820.10
248_S447_M0.5820.10
19_I514_L0.5810.10
81_G261_R0.5810.10
80_Y257_V0.5800.10
539_A548_R0.5800.10
370_N476_F0.5800.10
77_S396_L0.5790.10
46_M167_I0.5780.10
538_N614_S0.5780.10
238_A442_M0.5770.10
73_V136_L0.5770.10
348_L359_M0.5770.10
128_D133_S0.5770.10
31_K54_T0.5760.10
85_I94_A0.5750.10
194_L574_S0.5740.10
173_R260_T0.5740.10
512_Q587_K0.5740.10
19_I22_L0.5740.10
33_I72_P0.5730.10
35_I314_A0.5730.10
607_E611_A0.5730.10
420_T592_K0.5720.10
360_A590_S0.5710.10
37_G46_M0.5710.10
507_K538_N0.5690.10
440_M466_T0.5670.10
45_P223_S0.5670.10
120_A250_E0.5660.10
37_G152_Y0.5650.10
388_V414_H0.5650.10
32_R426_Y0.5650.10
395_G477_T0.5650.10
68_N249_I0.5630.10
264_A590_S0.5620.10
25_T249_I0.5620.10
158_I320_L0.5620.10
128_D131_R0.5610.10
279_T542_K0.5600.10
447_M450_E0.5600.10
123_A574_S0.5600.10
139_K314_A0.5600.10
68_N119_K0.5590.10
515_I519_I0.5590.10
27_F610_M0.5590.10
150_L154_R0.5570.10
184_Q526_L0.5570.10
309_D385_A0.5570.10
262_W357_S0.5560.10
207_V486_G0.5560.10
173_R538_N0.5560.10
110_L534_Q0.5550.10
115_S538_N0.5550.10
42_V442_M0.5540.10
148_T274_R0.5540.10
189_S192_A0.5540.10
428_V532_G0.5540.10
181_L507_K0.5530.10
447_M466_T0.5520.10
313_E445_R0.5520.10
338_L357_S0.5520.10
36_T41_G0.5510.10
466_T515_I0.5510.10
33_I85_I0.5510.10
379_I448_T0.5500.10
390_L438_V0.5500.10
323_A560_F0.5500.10
264_A442_M0.5500.10
54_T542_K0.5500.10
198_I233_L0.5490.10
587_K590_S0.5480.10
150_L383_C0.5470.10
150_L486_G0.5460.10
309_D370_N0.5450.10
450_E466_T0.5450.10
506_N515_I0.5440.10
150_L250_E0.5440.10
79_P84_Q0.5420.10
539_A546_E0.5420.10
400_S443_I0.5420.10
514_L565_Y0.5420.10
138_P279_T0.5410.10
565_Y569_T0.5400.10
118_T127_L0.5400.10
39_H514_L0.5390.10
106_D163_E0.5380.10
364_L586_P0.5380.10
236_V264_A0.5380.10
19_I23_E0.5360.10
377_R383_C0.5360.10
173_R267_V0.5350.10
578_A582_S0.5350.10
133_S619_A0.5350.10
95_K197_N0.5340.10
383_C514_L0.5340.10
343_M479_G0.5330.10
367_H609_G0.5320.10
442_M614_S0.5310.10
315_F530_H0.5310.10
344_T576_K0.5300.10
118_T249_I0.5300.10
374_Q594_S0.5300.10
569_T576_K0.5300.10
606_I616_N0.5300.10
615_E618_R0.5290.10
68_N279_T0.5290.10
95_K314_A0.5290.10
110_L130_L0.5280.10
205_D615_E0.5270.10
19_I572_Q0.5270.10
365_S592_K0.5270.10
498_P586_P0.5270.10
73_V284_L0.5270.10
27_F112_V0.5260.10
254_E411_A0.5250.10
370_N577_V0.5250.10
207_V484_M0.5250.10
181_L542_K0.5250.10
158_I260_T0.5250.10
342_P590_S0.5240.10
340_Y592_K0.5240.10
71_I555_L0.5230.10
25_T514_L0.5230.10
22_L250_E0.5220.10
374_Q575_G0.5220.10
401_I532_G0.5220.10
307_A427_D0.5220.10
617_F622_G0.5210.10
115_S532_G0.5210.10
81_G560_F0.5200.10
617_F621_G0.5200.10
25_T207_V0.5200.10
71_I198_I0.5190.10
264_A360_A0.5190.10
185_H542_K0.5180.10
602_A622_G0.5180.10
246_T516_T0.5180.10
582_S598_R0.5180.10
24_G384_A0.5180.10
213_I555_L0.5180.10
308_E592_K0.5170.10
261_R376_F0.5170.10
606_I614_S0.5160.10
240_I267_V0.5160.10
51_L381_E0.5160.10
364_L593_I0.5160.10
141_A146_R0.5150.10
213_I424_W0.5140.10
91_Q98_Q0.5140.10
36_T39_H0.5130.10
113_R116_D0.5130.10
35_I48_E0.5130.10
119_K127_L0.5120.10
443_I530_H0.5120.10
515_I561_T0.5120.10
233_L484_M0.5120.10
115_S122_L0.5120.10
38_T174_E0.5120.10
119_K122_L0.5120.10
390_L479_G0.5110.10
171_M377_R0.5110.10
337_L516_T0.5110.10
96_L101_I0.5090.10
341_V486_G0.5090.10
89_V479_G0.5080.10
367_H579_H0.5070.10
244_A593_I0.5070.10
163_E185_H0.5070.10
68_N613_M0.5060.09
311_T407_E0.5060.09
117_Y425_E0.5060.09
344_T566_H0.5060.09
368_Q507_K0.5050.09
29_N550_E0.5050.09
336_V595_Q0.5040.09
415_T571_P0.5040.09
296_I575_G0.5030.09
119_K131_R0.5030.09
103_A160_P0.5020.09
195_P506_N0.5020.09
146_R150_L0.5020.09
148_T407_E0.5020.09
484_M561_T0.5010.09
304_N508_E0.5010.09
304_N624_I0.5010.09
258_W262_W0.5000.09
160_P575_G0.5000.09
171_M197_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3epoA 2 0.832 100 0.21 Contact Map
4s28A 2 0.8067 100 0.289 Contact Map
3fysA 1 0.065 23.5 0.992 Contact Map
4k0mC 1 0.1426 20.3 0.992 Contact Map
3s4oA 1 0.2425 18.1 0.992 Contact Map
3hxiC 1 0.019 15.8 0.992 Contact Map
1qtwA 1 0.3724 14.2 0.992 Contact Map
1zr9A 1 0.0919 11.7 0.993 Contact Map
2l8eA 1 0.0602 11.4 0.993 Contact Map
4h3dA 2 0.3391 11 0.993 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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