GREMLIN Database
LEUD - 3-isopropylmalate dehydratase small subunit
UniProt: P30126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11575
Length: 201 (171)
Sequences: 5984 (3026)
Seq/√Len: 231.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_T145_D3.1351.00
125_S128_E2.8271.00
78_E104_P2.7721.00
76_A103_A2.6801.00
79_N82_C2.4701.00
93_L119_L2.4111.00
14_P58_N2.3401.00
151_Q169_R2.3041.00
150_A156_G2.2961.00
8_H72_S2.2441.00
52_E56_Q2.1761.00
147_D150_A2.1341.00
170_H174_N2.1231.00
167_F171_C2.0511.00
146_V160_Y1.9771.00
73_I100_V1.9021.00
114_S119_L1.8641.00
90_P107_A1.8561.00
152_E159_T1.8381.00
114_S121_P1.8241.00
24_A47_W1.7851.00
21_D24_A1.7111.00
131_E158_K1.6841.00
56_Q61_F1.6821.00
9_T143_H1.6471.00
10_G72_S1.6131.00
149_E173_M1.5621.00
115_F121_P1.5561.00
14_P68_Y1.5531.00
54_G64_N1.5331.00
19_N79_N1.5221.00
149_E169_R1.5131.00
57_P69_Q1.5061.00
42_H45_N1.5041.00
104_P129_V1.4971.00
64_N68_Y1.4901.00
115_F168_R1.4811.00
116_N178_S1.4801.00
145_D157_E1.4301.00
100_V146_V1.4281.00
41_A44_F1.3971.00
10_G73_I1.3901.00
151_Q166_A1.3771.00
45_N48_R1.3701.00
13_V71_A1.3641.00
18_A78_E1.3531.00
124_L129_V1.3451.00
165_D168_R1.3431.00
59_P63_L1.3101.00
29_Q46_D1.3041.00
30_F45_N1.2901.00
148_L156_G1.2861.00
11_L70_G1.2831.00
12_V15_L1.2691.00
31_L35_T1.2671.00
147_D157_E1.2601.00
129_V132_L1.2581.00
56_Q64_N1.2571.00
73_I102_I1.2441.00
111_Y168_R1.2431.00
169_R173_M1.2321.00
145_D154_K1.2121.00
18_A104_P1.2081.00
139_N142_I1.1991.00
176_L180_G1.1951.00
16_D20_V1.1931.00
150_A154_K1.1891.00
125_S143_H1.1761.00
18_A77_R1.1721.00
102_I160_Y1.1691.00
52_E58_N1.1641.00
16_D133_F1.1461.00
63_L66_P1.1391.00
43_L92_A1.1371.00
90_P119_L1.1351.00
168_R171_C1.1241.00
40_G46_D1.1101.00
152_E161_R1.1071.00
123_K163_T1.1061.00
33_K39_F1.0951.00
146_V158_K1.0911.00
102_I129_V1.0881.00
77_R133_F1.0851.00
125_S161_R1.0841.00
32_Q38_G1.0831.00
144_F160_Y1.0741.00
148_L158_K1.0731.00
94_T119_L1.0721.00
145_D159_T1.0491.00
28_K46_D1.0451.00
147_D155_A1.0451.00
94_T99_K1.0381.00
72_S98_F1.0321.00
144_F155_A1.0241.00
67_Q70_G1.0201.00
15_L130_D1.0161.00
66_P69_Q1.0151.00
8_H100_V1.0151.00
164_I169_R1.0121.00
164_I172_M1.0101.00
78_E126_D0.9911.00
126_D130_D0.9881.00
80_F110_F0.9791.00
110_F114_S0.9791.00
75_L130_D0.9681.00
64_N67_Q0.9641.00
129_V133_F0.9581.00
10_G71_A0.9531.00
135_L155_A0.9521.00
94_T117_N0.9491.00
75_L133_F0.9481.00
111_Y115_F0.9441.00
33_K40_G0.9391.00
111_Y123_K0.9351.00
153_V160_Y0.9341.00
88_H107_A0.9281.00
43_L96_Y0.9261.00
26_I92_A0.9181.00
149_E155_A0.9131.00
171_C178_S0.9061.00
53_K56_Q0.8990.99
174_N178_S0.8950.99
125_S159_T0.8940.99
58_N61_F0.8880.99
40_G44_F0.8880.99
72_S99_K0.8700.99
128_E131_E0.8700.99
19_N82_C0.8540.99
88_H91_W0.8500.99
45_N55_Q0.8370.99
77_R130_D0.8350.99
16_D77_R0.8280.99
115_F164_I0.8250.99
75_L102_I0.8220.99
44_F47_W0.8200.99
30_F42_H0.8170.99
75_L136_V0.8140.99
131_E134_A0.8130.99
74_L98_F0.8110.99
44_F48_R0.8100.99
90_P114_S0.8040.99
130_D134_A0.8020.99
143_H161_R0.8010.99
154_K159_T0.7980.99
57_P62_V0.7960.99
170_H173_M0.7940.99
104_P126_D0.7860.99
75_L124_L0.7810.99
15_L131_E0.7800.99
52_E55_Q0.7790.98
53_K57_P0.7790.98
12_V136_V0.7760.98
37_T95_D0.7760.98
171_C174_N0.7690.98
143_H159_T0.7640.98
166_A170_H0.7620.98
104_P131_E0.7620.98
131_E160_Y0.7610.98
118_Q175_G0.7610.98
13_V98_F0.7580.98
76_A101_V0.7550.98
29_Q45_N0.7540.98
35_T38_G0.7540.98
12_V75_L0.7480.98
139_N143_H0.7460.98
170_H176_L0.7450.98
123_K161_R0.7390.98
10_G100_V0.7370.98
34_V38_G0.7360.98
142_I155_A0.7270.98
31_L88_H0.7230.98
57_P61_F0.7180.97
57_P60_D0.6960.97
120_L172_M0.6890.97
54_G57_P0.6870.97
148_L151_Q0.6730.96
91_W117_N0.6700.96
155_A158_K0.6700.96
28_K45_N0.6670.96
17_A20_V0.6650.96
177_D180_G0.6630.96
102_I124_L0.6610.96
36_R88_H0.6590.96
80_F93_L0.6530.96
151_Q164_I0.6520.96
137_K142_I0.6510.95
128_E132_L0.6510.95
40_G47_W0.6430.95
11_L143_H0.6320.95
166_A169_R0.6280.95
39_F42_H0.6270.94
150_A159_T0.6250.94
44_F49_F0.6230.94
40_G45_N0.6220.94
12_V133_F0.6170.94
56_Q60_D0.6140.94
39_F43_L0.6110.94
104_P130_D0.6110.94
35_T42_H0.6080.94
94_T101_V0.6060.93
33_K42_H0.6040.93
28_K32_Q0.6020.93
138_A141_G0.6000.93
137_K140_P0.5990.93
32_Q164_I0.5990.93
31_L34_V0.5960.93
111_Y121_P0.5900.93
14_P62_V0.5880.92
26_I32_Q0.5780.92
141_G148_L0.5760.92
112_G115_F0.5740.91
62_V65_F0.5730.91
49_F58_N0.5720.91
124_L153_V0.5720.91
28_K85_S0.5690.91
43_L48_R0.5680.91
21_D31_L0.5680.91
11_L141_G0.5650.91
135_L142_I0.5600.90
25_I44_F0.5590.90
162_F169_R0.5590.90
78_E127_A0.5580.90
59_P62_V0.5570.90
82_C93_L0.5530.90
39_F91_W0.5530.90
40_G94_T0.5520.90
128_E160_Y0.5520.90
60_D64_N0.5520.90
141_G146_V0.5480.90
102_I153_V0.5460.89
13_V62_V0.5450.89
60_D63_L0.5450.89
53_K58_N0.5420.89
39_F88_H0.5390.89
69_Q158_K0.5390.89
40_G49_F0.5380.89
36_R91_W0.5370.89
148_L169_R0.5370.89
32_Q35_T0.5350.88
115_F171_C0.5310.88
136_V150_A0.5260.88
33_K38_G0.5250.87
11_L71_A0.5230.87
152_E155_A0.5230.87
75_L132_L0.5190.87
176_L179_I0.5190.87
136_V151_Q0.5180.87
36_R117_N0.5180.87
40_G43_L0.5160.87
16_D74_L0.5120.86
28_K88_H0.5100.86
25_I28_K0.5070.86
24_A46_D0.5050.85
159_T162_F0.5010.85
33_K46_D0.5000.85
75_L148_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q3wA 1 0.9005 100 0.089 Contact Map
2hcuA 1 0.8557 100 0.113 Contact Map
3h5jA 1 0.8358 100 0.198 Contact Map
3vbaA 2 0.8159 100 0.307 Contact Map
2pkpA 2 0.806 100 0.317 Contact Map
1v7lA 6 0.796 100 0.322 Contact Map
1l5jA 1 0.9104 100 0.347 Contact Map
2b3yA 1 0.8905 100 0.391 Contact Map
1c96A 1 0.8955 100 0.392 Contact Map
1rduA 1 0.5771 21.9 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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