GREMLIN Database
LHR - Probable ATP-dependent helicase lhr
UniProt: P30015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11548
Length: 1538 (1424)
Sequences: 618 (363)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
844_L853_I7.3501.00
20_R24_L6.8491.00
992_A1000_L5.4611.00
1350_Y1357_A5.4041.00
286_L315_L5.3021.00
401_A431_R5.2491.00
1223_Q1264_A5.0891.00
685_L701_L4.9751.00
129_G148_P4.9551.00
497_R501_D4.8401.00
1158_S1162_P4.6941.00
45_E234_T4.6521.00
483_Y497_R4.5660.99
847_R852_E4.5120.99
496_P499_V4.5070.99
483_Y500_F4.4120.99
204_L208_A4.3170.99
85_T172_G4.1340.99
468_T482_W3.9590.98
1476_V1510_N3.9410.98
1200_H1208_S3.8890.98
536_P939_E3.8730.98
1242_S1258_L3.8170.98
1104_Y1389_V3.7440.98
507_L523_L3.7300.98
1272_T1326_S3.6970.98
660_N663_A3.6920.98
1049_L1054_V3.6420.97
971_L991_L3.6000.97
787_A823_V3.5950.97
1276_W1279_L3.5820.97
222_D225_A3.5810.97
684_H854_Q3.4850.96
1262_L1271_I3.4670.96
598_Q608_T3.4650.96
478_Q481_E3.4620.96
434_R668_L3.4370.96
40_V47_A3.4000.96
955_D1046_E3.3830.96
290_L316_Y3.3570.96
1028_F1043_L3.2800.95
587_I594_S3.2700.95
956_L971_L3.1980.94
303_G588_I3.1580.94
143_L161_M3.1450.94
472_A532_L3.0580.93
669_I679_V3.0540.93
289_V378_C3.0410.92
191_A492_W3.0060.92
253_A660_N3.0000.92
287_D319_R2.9850.92
997_A1008_L2.9640.91
950_P1000_L2.9420.91
925_E1087_R2.9370.91
950_P992_A2.9060.91
444_E651_T2.9060.91
296_I394_V2.8790.90
981_F997_A2.8510.90
286_L351_I2.8430.90
629_A705_Y2.8350.89
50_I220_A2.8250.89
1197_V1279_L2.7910.89
476_A533_T2.7610.88
1142_V1165_V2.7550.88
975_L991_L2.7160.87
633_E847_R2.6690.86
201_D208_A2.6610.86
1147_A1201_L2.6100.85
471_A477_L2.6070.85
523_L533_T2.5960.85
89_L173_V2.5690.84
1496_L1499_E2.5610.84
759_P849_N2.5530.84
945_L980_I2.5520.84
925_E930_A2.5330.83
762_L845_M2.5320.83
477_L482_W2.5300.83
685_L705_Y2.5250.83
757_F762_L2.5200.83
143_L169_T2.5100.83
1224_Q1228_A2.4840.82
942_F980_I2.4800.82
253_A663_A2.4620.81
980_I993_C2.4540.81
46_H228_G2.4500.81
243_H423_V2.4250.80
701_L755_F2.4240.80
218_R453_N2.4130.80
284_G288_E2.4050.80
195_L489_A2.3890.79
428_F439_S2.3840.79
370_A375_E2.3670.79
445_C634_M2.3670.79
1043_L1062_R2.3600.78
472_A477_L2.3330.77
1143_I1182_V2.3220.77
217_V379_V2.3180.77
472_A534_A2.3180.77
478_Q500_F2.2990.76
1201_L1204_Y2.2820.76
523_L532_L2.2800.76
86_S143_L2.2770.76
246_I428_F2.2750.76
413_I426_G2.2570.75
629_A840_A2.2550.75
863_P1283_T2.2530.75
926_L1080_V2.2480.75
589_T950_P2.2400.74
920_R924_E2.2380.74
161_M169_T2.2290.74
288_E429_F2.2040.73
643_A679_V2.2030.73
982_P989_E2.2010.73
378_C1083_R2.1970.73
187_S916_P2.1850.73
66_L150_I2.1790.72
1135_G1138_G2.1780.72
1509_V1514_V2.1760.72
202_A485_R2.1690.72
783_C827_T2.1640.72
41_A47_A2.1620.72
437_V1197_V2.1560.71
168_E171_R2.1530.71
141_S145_R2.1480.71
480_D497_R2.1400.71
308_L400_V2.1360.71
763_L842_E2.1200.70
184_V187_S2.1180.70
722_H769_A2.1170.70
1010_E1013_P2.0710.68
275_G377_R2.0700.68
471_A836_Y2.0690.68
467_Q470_A2.0620.68
476_A534_A2.0610.68
640_H681_G2.0490.67
1480_K1484_L2.0420.67
235_V246_I2.0300.67
280_Y950_P2.0190.66
1484_L1506_L2.0180.66
1138_G1142_V2.0130.66
582_S597_I2.0110.66
68_R174_E2.0070.66
1185_S1328_L2.0010.65
468_T471_A1.9980.65
617_L950_P1.9960.65
1433_W1458_V1.9950.65
143_L148_P1.9830.65
86_S995_D1.9670.64
1143_I1199_L1.9660.64
975_L982_P1.9570.64
709_V1028_F1.9480.63
954_E957_A1.9460.63
139_E289_V1.9440.63
378_C836_Y1.9380.63
482_W1402_T1.9320.63
468_T477_L1.9310.63
159_Y986_S1.9300.63
468_T1402_T1.9280.62
471_A482_W1.9170.62
1143_I1161_L1.9130.62
252_V406_V1.9080.62
413_I508_S1.9050.61
439_S992_A1.9000.61
66_L1334_N1.8990.61
98_G159_Y1.8960.61
847_R850_G1.8950.61
584_V1139_V1.8950.61
1167_D1172_M1.8900.61
195_L486_V1.8840.61
508_S523_L1.8820.60
471_A500_F1.8750.60
560_P606_I1.8750.60
641_L651_T1.8670.60
1293_T1297_H1.8540.59
851_G1188_K1.8360.58
1451_R1468_A1.8320.58
582_S586_D1.8290.58
11_L14_V1.8230.58
129_G161_M1.8160.58
309_T1147_A1.8090.57
843_R847_R1.8080.57
1290_R1293_T1.7990.57
1509_V1519_M1.7980.57
1177_L1279_L1.7980.57
483_Y501_D1.7940.57
365_A369_Q1.7920.57
1423_A1491_A1.7860.56
33_V37_T1.7860.56
763_L1028_F1.7860.56
249_V284_G1.7850.56
286_L710_H1.7840.56
1139_V1165_V1.7840.56
46_H233_V1.7840.56
288_E427_L1.7800.56
73_G174_E1.7720.56
953_V991_L1.7710.56
184_V204_L1.7660.55
402_T438_D1.7640.55
437_V642_L1.7600.55
17_P402_T1.7570.55
681_G728_D1.7550.55
709_V840_A1.7550.55
72_E87_R1.7540.55
228_G233_V1.7520.55
922_V1083_R1.7520.55
361_K365_A1.7440.54
1238_A1318_T1.7390.54
482_W755_F1.7380.54
981_F1008_L1.7350.54
1297_H1300_R1.7300.54
21_D115_E1.7200.53
1062_R1075_W1.7200.53
281_I299_T1.7160.53
1099_V1352_I1.7140.53
936_K940_G1.7120.53
1231_A1327_L1.7090.53
309_T836_Y1.7080.53
937_G940_G1.7080.53
659_E663_A1.7040.53
1389_V1510_N1.6970.52
454_L910_P1.6930.52
70_F126_L1.6920.52
463_V548_T1.6810.52
86_S169_T1.6790.51
49_V297_V1.6770.51
942_F993_C1.6740.51
1092_A1384_M1.6710.51
474_M534_A1.6690.51
1009_P1013_P1.6570.51
1346_M1388_F1.6470.50
921_Q1091_A1.6440.50
132_T246_I1.6390.50
98_G288_E1.6370.50
437_V639_L1.6300.49
455_T1149_V1.6250.49
515_D817_G1.6210.49
14_V39_H1.6210.49
184_V1020_V1.6190.49
855_I1279_L1.6140.49
972_E975_L1.6120.48
437_V1144_E1.6120.48
512_P814_I1.6080.48
813_E816_Q1.6080.48
506_M707_R1.5910.48
66_L362_E1.5870.47
1352_I1486_P1.5850.47
1083_R1156_W1.5840.47
508_S742_I1.5790.47
304_L767_R1.5780.47
132_T244_P1.5710.47
1239_Q1243_Q1.5710.47
489_A1409_L1.5630.46
1183_I1198_A1.5590.46
126_L556_S1.5580.46
1286_S1290_R1.5570.46
439_S950_P1.5560.46
13_D853_I1.5520.46
993_C1003_A1.5470.46
922_V1087_R1.5470.46
47_A228_G1.5390.45
65_A1467_L1.5370.45
1235_A1514_V1.5360.45
848_L855_I1.5330.45
285_I400_V1.5300.45
919_I1084_L1.5290.45
296_I316_Y1.5280.45
1186_G1267_W1.5260.45
793_R807_R1.5230.45
1151_L1156_W1.5230.45
224_A228_G1.5220.44
255_M277_I1.5220.44
1226_I1272_T1.5210.44
482_W707_R1.5120.44
369_Q1476_V1.5090.44
707_R733_A1.5090.44
922_V1084_L1.5080.44
230_D1075_W1.5070.44
471_A701_L1.5030.44
428_F1350_Y1.4990.43
794_T1236_W1.4970.43
377_R468_T1.4950.43
757_F1087_R1.4950.43
1069_N1134_E1.4930.43
1057_Q1105_A1.4890.43
517_S521_P1.4860.43
941_L956_L1.4860.43
1022_Y1060_Q1.4760.42
1293_T1300_R1.4760.42
1151_L1160_I1.4730.42
60_A1476_V1.4710.42
148_P161_M1.4690.42
1095_A1384_M1.4660.42
604_Q1273_S1.4640.42
47_A233_V1.4570.42
668_L705_Y1.4560.42
377_R482_W1.4550.42
304_L363_Q1.4550.42
760_E1302_G1.4540.41
1272_T1403_I1.4510.41
277_I588_I1.4500.41
684_H856_S1.4490.41
488_R971_L1.4470.41
144_T161_M1.4470.41
161_M1402_T1.4470.41
585_N740_A1.4440.41
919_I1472_K1.4440.41
1484_L1509_V1.4440.41
73_G1302_G1.4430.41
315_L351_I1.4420.41
378_C438_D1.4390.41
145_R848_L1.4320.41
66_L1147_A1.4240.40
863_P1138_G1.4240.40
378_C560_P1.4230.40
769_A971_L1.4220.40
707_R845_M1.4220.40
285_I435_D1.4190.40
592_A708_R1.4180.40
492_W1353_I1.4170.40
681_G684_H1.4160.40
43_R234_T1.4150.40
402_T731_V1.4130.40
1158_S1390_E1.4120.40
143_L422_G1.4090.40
981_F1010_E1.4080.39
1195_G1267_W1.4080.39
428_F443_V1.4070.39
1290_R1300_R1.4060.39
47_A903_N1.4030.39
280_Y992_A1.4020.39
66_L588_I1.4000.39
1156_W1199_L1.3980.39
402_T476_A1.3980.39
732_V877_E1.3980.39
548_T971_L1.3960.39
98_G429_F1.3950.39
1506_L1533_Q1.3900.39
506_M729_A1.3900.39
398_I840_A1.3890.39
879_M1377_M1.3890.39
1384_M1400_R1.3870.39
1112_Q1142_V1.3780.38
1135_G1167_D1.3750.38
1379_D1394_G1.3700.38
506_M1113_G1.3680.38
1274_D1324_R1.3640.38
917_Q920_R1.3640.38
482_W836_Y1.3630.38
91_I158_L1.3620.38
1050_G1053_I1.3620.38
450_R827_T1.3570.37
1156_W1369_S1.3560.37
716_A762_L1.3510.37
1234_G1262_L1.3500.37
1507_T1533_Q1.3470.37
556_S588_I1.3440.37
1199_L1279_L1.3430.37
184_V1210_T1.3430.37
195_L463_V1.3400.37
503_T508_S1.3370.36
523_L1271_I1.3350.36
1505_T1513_P1.3340.36
481_E1224_Q1.3340.36
309_T1142_V1.3330.36
361_K1218_N1.3330.36
597_I784_A1.3320.36
847_R1167_D1.3290.36
31_T420_V1.3280.36
1254_D1257_A1.3270.36
1037_L1070_L1.3230.36
685_L1156_W1.3230.36
163_T542_A1.3210.36
129_G506_M1.3200.36
643_A673_R1.3200.36
1227_V1270_V1.3200.36
245_Q427_L1.3180.36
1054_V1067_V1.3170.36
794_T797_H1.3170.36
668_L1092_A1.3160.36
1143_I1156_W1.3140.36
463_V1389_V1.3120.35
88_I511_Y1.3100.35
525_W923_E1.3090.35
555_Y594_S1.3090.35
616_R621_R1.3090.35
952_T1031_Y1.3090.35
184_V235_V1.3080.35
184_V499_V1.3060.35
132_T1377_M1.3050.35
471_A478_Q1.3020.35
1025_R1060_Q1.3010.35
881_Q884_A1.3010.35
161_M1266_V1.2990.35
1036_A1076_V1.2990.35
536_P940_G1.2990.35
14_V42_A1.2970.35
480_D530_G1.2970.35
489_A508_S1.2940.35
178_I253_A1.2930.35
220_A237_N1.2870.34
296_I919_I1.2850.34
1377_M1399_E1.2850.34
1185_S1198_A1.2850.34
465_A1058_L1.2800.34
985_I1065_G1.2740.34
432_T1113_G1.2740.34
114_D1010_E1.2730.34
633_E679_V1.2730.34
244_P443_V1.2700.34
1465_L1488_V1.2660.34
1398_A1402_T1.2650.34
970_Y991_L1.2640.33
126_L1300_R1.2630.33
468_T755_F1.2610.33
643_A1223_Q1.2610.33
1045_H1241_I1.2590.33
244_P428_F1.2580.33
1059_Q1069_N1.2550.33
26_A114_D1.2550.33
686_V856_S1.2530.33
150_I425_K1.2490.33
1061_L1388_F1.2430.33
304_L875_V1.2420.33
1256_S1260_E1.2360.32
439_S501_D1.2310.32
1344_E1382_R1.2280.32
499_V503_T1.2270.32
952_T1268_Q1.2260.32
1290_R1297_H1.2250.32
132_T708_R1.2250.32
351_I363_Q1.2230.32
730_S1509_V1.2220.32
444_E641_L1.2190.32
91_I642_L1.2170.32
742_I1394_G1.2160.32
482_W717_I1.2150.32
283_T315_L1.2140.32
1298_R1303_R1.2130.31
739_V808_A1.2110.31
633_E705_Y1.2090.31
504_L525_W1.2080.31
47_A181_V1.2070.31
937_G1023_P1.2060.31
363_Q602_R1.2040.31
511_Y709_V1.2030.31
994_M1012_L1.2030.31
467_Q1286_S1.2030.31
705_Y844_L1.2020.31
1056_E1059_Q1.2020.31
911_G1071_Q1.2010.31
764_Q768_E1.2010.31
684_H1203_E1.1990.31
716_A918_V1.1990.31
402_T439_S1.1990.31
1226_I1258_L1.1980.31
985_I990_R1.1970.31
124_V1468_A1.1960.31
594_S796_G1.1950.31
1013_P1016_Y1.1950.31
145_R439_S1.1920.31
978_K1156_W1.1910.31
707_R1402_T1.1900.31
1107_L1111_R1.1870.30
218_R630_E1.1860.30
1106_R1350_Y1.1840.30
434_R717_I1.1830.30
876_A1477_W1.1810.30
924_E1160_I1.1800.30
679_V1167_D1.1780.30
984_M989_E1.1780.30
198_E489_A1.1770.30
184_V1467_L1.1760.30
244_P569_R1.1720.30
60_A428_F1.1710.30
297_V378_C1.1680.30
293_R523_L1.1660.30
1141_R1144_E1.1650.30
1239_Q1255_L1.1640.30
1343_A1364_P1.1640.30
110_K114_D1.1630.30
284_G429_F1.1620.30
909_D917_Q1.1620.30
362_E1474_M1.1590.29
468_T836_Y1.1590.29
975_L980_I1.1580.29
69_L808_A1.1570.29
1008_L1013_P1.1570.29
29_Q1241_I1.1560.29
196_S777_A1.1560.29
994_M1003_A1.1560.29
575_D595_W1.1540.29
231_R256_D1.1530.29
589_T617_L1.1500.29
762_L1510_N1.1480.29
710_H1200_H1.1450.29
584_V588_I1.1440.29
497_R500_F1.1440.29
1222_L1261_A1.1430.29
807_R1138_G1.1420.29
1040_A1055_E1.1420.29
944_L948_L1.1410.29
422_G685_L1.1380.29
1042_Q1167_D1.1380.29
1112_Q1116_P1.1370.29
136_P139_E1.1370.29
92_S105_L1.1340.28
121_E124_V1.1340.28
62_F108_P1.1320.28
13_D642_L1.1310.28
1032_L1038_V1.1310.28
104_N108_P1.1270.28
245_Q1012_L1.1260.28
290_L319_R1.1240.28
757_F770_V1.1230.28
1484_L1488_V1.1230.28
62_F104_N1.1210.28
536_P540_L1.1190.28
1338_R1405_R1.1190.28
50_I217_V1.1170.28
1070_L1111_R1.1140.28
703_S853_I1.1140.28
757_F845_M1.1130.28
246_I909_D1.1130.28
132_T1066_L1.1120.28
304_L401_A1.1110.28
220_A235_V1.1110.28
917_Q972_E1.1110.28
478_Q483_Y1.1100.28
89_L223_V1.1090.28
304_L431_R1.1090.28
1042_Q1219_R1.1070.28
524_V939_E1.1070.28
242_R892_S1.1060.27
556_S615_A1.1040.27
353_R370_A1.1020.27
651_T655_W1.1020.27
142_K643_A1.1000.27
921_Q1160_I1.0980.27
401_A451_L1.0960.27
812_L936_K1.0940.27
1114_V1142_V1.0940.27
66_L436_L1.0940.27
489_A1047_F1.0930.27
1075_W1184_W1.0930.27
86_S482_W1.0910.27
1388_F1403_I1.0860.27
1075_W1185_S1.0850.27
221_S1052_A1.0850.27
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708_R993_C0.5220.12
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514_G820_D0.5210.12
82_K1521_T0.5210.12
233_V990_R0.5210.12
871_L1160_I0.5210.12
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716_A1058_L0.5210.12
1441_A1444_A0.5210.12
501_D504_L0.5210.12
480_D1191_G0.5200.12
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26_A1013_P0.5130.12
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625_N925_E0.5110.12
117_R1018_H0.5110.12
86_S377_R0.5100.11
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705_Y916_P0.5100.11
636_G682_S0.5100.11
897_D949_G0.5100.11
1326_S1503_R0.5100.11
909_D1079_E0.5090.11
514_G940_G0.5090.11
281_I970_Y0.5090.11
733_A907_Q0.5090.11
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422_G845_M0.5080.11
132_T359_V0.5080.11
708_R1184_W0.5080.11
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884_A1185_S0.5070.11
912_E1235_A0.5070.11
187_S475_D0.5070.11
1480_K1485_A0.5070.11
303_G437_V0.5070.11
473_A501_D0.5060.11
863_P1225_A0.5060.11
951_M1152_P0.5060.11
588_I770_V0.5060.11
955_D1178_A0.5060.11
226_F750_P0.5060.11
288_E721_I0.5060.11
807_R1147_A0.5050.11
1357_A1370_M0.5050.11
438_D638_F0.5050.11
989_E1212_A0.5050.11
1083_R1375_R0.5040.11
1428_D1434_G0.5040.11
187_S1210_T0.5040.11
668_L1065_G0.5040.11
1010_E1104_Y0.5040.11
1069_N1139_V0.5040.11
493_K1097_R0.5030.11
246_I413_I0.5030.11
668_L1529_S0.5030.11
721_I754_I0.5030.11
310_A375_E0.5020.11
1350_Y1369_S0.5020.11
126_L248_I0.5020.11
754_I816_Q0.5020.11
1077_S1097_R0.5020.11
1163_A1372_T0.5020.11
226_F555_Y0.5020.11
482_W662_I0.5020.11
484_S500_F0.5020.11
647_F659_E0.5020.11
1198_A1353_I0.5020.11
1104_Y1530_S0.5010.11
681_G847_R0.5010.11
87_R1114_V0.5010.11
1028_F1413_A0.5010.11
361_K589_T0.5010.11
1023_P1026_D0.5010.11
1037_L1074_I0.5010.11
98_G937_G0.5000.11
1191_G1419_Y0.5000.11
640_H882_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2va8A 1 0.4129 100 0.908 Contact Map
2p6rA 1 0.4116 100 0.908 Contact Map
2zj8A 2 0.3895 100 0.91 Contact Map
4f92B 1 0.4493 100 0.913 Contact Map
4w7sA 2 0.2685 100 0.92 Contact Map
4d25A 1 0.251 100 0.921 Contact Map
5agaA 4 0.4389 100 0.921 Contact Map
3i5xA 1 0.3114 100 0.922 Contact Map
4c9bA 1 0.2432 100 0.923 Contact Map
3eiqA 1 0.2308 100 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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