GREMLIN Database
RNT - Ribonuclease T
UniProt: P30014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11547
Length: 215 (200)
Sequences: 407 (200)
Seq/√Len: 14.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_D69_N4.3041.00
158_A197_I4.1831.00
72_P76_A4.0801.00
24_V36_L3.7891.00
54_P192_V3.7660.99
30_N33_T3.6350.99
39_I129_M3.4500.99
30_N34_D3.2090.98
43_T55_D2.9920.97
45_K55_D2.9500.97
70_L75_L2.9250.97
107_I115_A2.7040.95
161_Q170_T2.7000.95
133_A141_N2.6240.94
126_H130_M2.5350.93
149_F156_G2.4790.92
21_V44_L2.4420.92
70_L82_P2.4390.92
189_R192_V2.2590.88
173_M192_V2.2310.87
96_L100_F2.1740.86
168_C175_F2.1540.85
39_I99_I2.0820.83
65_F68_A1.9860.80
123_N148_T1.9170.78
59_H184_L1.9050.77
44_L55_D1.8650.76
33_T69_N1.8530.75
159_L196_E1.7630.72
156_G198_V1.7490.71
158_A201_W1.7440.71
147_A152_A1.7220.70
104_R140_R1.6600.67
107_I110_S1.6140.64
17_F116_I1.6070.64
18_Y119_A1.5620.62
18_Y106_G1.5410.61
74_A157_L1.5030.59
30_N69_N1.4970.58
29_F77_F1.4940.58
76_A86_D1.4700.57
52_L198_V1.4380.55
119_A147_A1.4170.54
176_D179_Q1.3830.52
24_V129_M1.3760.52
63_E91_S1.3740.52
168_C173_M1.3680.51
18_Y147_A1.3530.51
58_L99_I1.3320.50
168_C205_G1.3250.49
174_D189_R1.2960.48
41_A62_V1.2640.46
77_F157_L1.2530.45
31_A127_S1.2430.45
45_K106_G1.2410.45
96_L129_M1.2380.44
93_Y97_H1.2220.44
157_L197_I1.2090.43
33_T71_Q1.2010.42
100_F133_A1.2000.42
46_M52_L1.1900.42
47_D53_M1.1870.42
103_V129_M1.1780.41
41_A114_R1.1750.41
43_T187_T1.1700.41
175_F205_G1.1680.41
122_A148_T1.1640.40
102_V106_G1.1590.40
73_E76_A1.1530.40
117_M147_A1.1480.40
99_I187_T1.1370.39
140_R145_P1.1350.39
126_H148_T1.1300.39
113_N147_A1.1280.39
173_M189_R1.1190.38
39_I62_V1.1100.38
75_L78_N1.0910.37
55_D106_G1.0870.36
51_W202_K1.0760.36
29_F139_K1.0640.35
75_L83_N1.0560.35
61_H74_A1.0540.35
123_N127_S1.0520.35
103_V115_A1.0520.35
41_A79_G1.0490.35
29_F71_Q1.0480.35
27_A77_F1.0460.34
72_P77_F1.0410.34
184_L188_E1.0360.34
13_R19_P1.0340.34
187_T202_K1.0290.34
86_D175_F1.0290.34
165_S197_I1.0230.33
74_A77_F1.0080.33
45_K110_S0.9860.32
62_V95_A0.9810.31
99_I103_V0.9740.31
84_D88_G0.9590.30
37_L80_I0.9540.30
104_R145_P0.9480.30
72_P172_G0.9370.29
74_A190_T0.9330.29
152_A175_F0.9250.29
133_A161_Q0.9160.28
155_A167_A0.9160.28
41_A104_R0.9090.28
66_V134_E0.9090.28
42_I54_P0.9060.28
130_M145_P0.9050.28
116_I152_A0.9030.28
21_V187_T0.9010.28
129_M166_K0.8940.27
130_M153_A0.8900.27
153_A177_S0.8870.27
14_F19_P0.8830.27
175_F207_W0.8780.27
90_V95_A0.8780.27
168_C206_G0.8730.26
114_R140_R0.8650.26
24_V66_V0.8610.26
15_R19_P0.8570.26
149_F153_A0.8560.26
96_L102_V0.8550.26
15_R20_V0.8530.26
119_A184_L0.8470.25
18_Y107_I0.8410.25
127_S130_M0.8290.25
148_T179_Q0.8290.25
61_H78_N0.8280.25
18_Y117_M0.8240.24
30_N71_Q0.8220.24
63_E84_D0.8200.24
27_A36_L0.8150.24
130_M141_N0.8150.24
90_V98_E0.8010.24
129_M133_A0.8000.24
196_E200_R0.7940.23
32_K134_E0.7940.23
62_V158_A0.7900.23
78_N175_F0.7890.23
51_W153_A0.7870.23
43_T53_M0.7870.23
54_P131_A0.7860.23
84_D175_F0.7850.23
40_A111_G0.7830.23
43_T58_L0.7820.23
10_L20_V0.7800.23
204_L207_W0.7690.22
108_K134_E0.7690.22
45_K53_M0.7670.22
29_F152_A0.7670.22
82_P172_G0.7650.22
17_F113_N0.7600.22
61_H82_P0.7590.22
18_Y100_F0.7570.22
13_R20_V0.7540.22
113_N165_S0.7520.22
86_D147_A0.7500.22
126_H205_G0.7500.22
22_I205_G0.7480.22
29_F79_G0.7400.21
63_E141_N0.7310.21
71_Q168_C0.7280.21
9_G110_S0.7270.21
152_A202_K0.7270.21
94_E109_A0.7260.21
46_M157_L0.7260.21
116_I149_F0.7240.21
57_T165_S0.7230.21
10_L117_M0.7220.21
49_Q111_G0.7110.20
77_F168_C0.7070.20
34_D71_Q0.7060.20
168_C207_W0.7040.20
158_A165_S0.7020.20
82_P113_N0.6940.20
161_Q166_K0.6940.20
130_M133_A0.6930.20
57_T155_A0.6870.19
76_A203_R0.6830.19
51_W203_R0.6790.19
76_A179_Q0.6790.19
104_R141_N0.6760.19
22_I196_E0.6730.19
175_F189_R0.6720.19
27_A145_P0.6710.19
68_A116_I0.6670.19
100_F107_I0.6640.19
39_I94_E0.6620.19
11_C106_G0.6570.18
42_I96_L0.6560.18
10_L57_T0.6560.18
27_A70_L0.6560.18
71_Q76_A0.6540.18
10_L103_V0.6510.18
50_G167_A0.6510.18
148_T202_K0.6510.18
54_P83_N0.6500.18
33_T68_A0.6500.18
46_M156_G0.6470.18
17_F54_P0.6370.18
78_N166_K0.6360.18
196_E203_R0.6360.18
73_E145_P0.6350.18
130_M148_T0.6350.18
53_M189_R0.6300.17
113_N116_I0.6280.17
18_Y59_H0.6270.17
63_E88_G0.6260.17
74_A113_N0.6240.17
95_A129_M0.6240.17
176_D187_T0.6240.17
34_D68_A0.6230.17
202_K205_G0.6220.17
158_A166_K0.6210.17
72_P176_D0.6200.17
107_I136_A0.6180.17
167_A193_L0.6160.17
46_M53_M0.6160.17
27_A62_V0.6140.17
12_D137_S0.6100.17
10_L78_N0.6050.17
47_D133_A0.6040.17
93_Y165_S0.6010.17
61_H184_L0.5960.16
42_I133_A0.5950.16
11_C174_D0.5940.16
79_G104_R0.5920.16
97_H159_L0.5920.16
51_W126_H0.5920.16
31_A174_D0.5910.16
21_V122_A0.5890.16
102_V159_L0.5860.16
59_H119_A0.5850.16
84_D117_M0.5840.16
153_A203_R0.5830.16
52_L187_T0.5810.16
73_E83_N0.5810.16
91_S179_Q0.5810.16
104_R114_R0.5780.16
17_F137_S0.5710.16
71_Q206_G0.5700.16
173_M205_G0.5700.16
198_V204_L0.5650.16
91_S137_S0.5610.15
153_A156_G0.5610.15
30_N101_K0.5560.15
107_I113_N0.5560.15
102_V117_M0.5550.15
152_A156_G0.5540.15
179_Q182_S0.5530.15
79_G139_K0.5520.15
108_K197_I0.5520.15
115_A119_A0.5510.15
77_F99_I0.5480.15
62_V104_R0.5470.15
155_A178_T0.5430.15
47_D51_W0.5420.15
126_H202_K0.5420.15
156_G201_W0.5410.15
133_A170_T0.5410.15
162_T190_T0.5400.15
197_I201_W0.5380.15
148_T152_A0.5380.15
35_A61_H0.5360.15
101_K200_R0.5350.15
57_T184_L0.5350.15
90_V123_N0.5350.15
91_S169_Q0.5350.15
130_M134_E0.5350.15
101_K155_A0.5330.15
10_L184_L0.5320.15
96_L132_A0.5320.15
113_N155_A0.5300.15
18_Y159_L0.5300.15
141_N159_L0.5290.15
77_F204_L0.5280.15
138_L182_S0.5280.15
14_F20_V0.5280.15
157_L201_W0.5270.14
62_V90_V0.5240.14
42_I57_T0.5240.14
33_T65_F0.5210.14
56_T123_N0.5190.14
10_L141_N0.5180.14
58_L133_A0.5150.14
97_H138_L0.5140.14
13_R16_G0.5120.14
104_R108_K0.5120.14
116_I179_Q0.5120.14
88_G147_A0.5110.14
60_F98_E0.5110.14
67_G167_A0.5100.14
61_H84_D0.5070.14
59_H138_L0.5070.14
10_L17_F0.5070.14
123_N126_H0.5040.14
8_T11_C0.5020.14
114_R145_P0.5020.14
38_E78_N0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v9wA 3 0.9581 100 0.71 Contact Map
2f96A 2 0.9395 100 0.721 Contact Map
4qozB 1 0.9628 99.9 0.792 Contact Map
1zbuA 1 0.9628 99.9 0.793 Contact Map
2qxfA 1 0.8558 99.9 0.795 Contact Map
3cg7A 2 0.8977 99.9 0.797 Contact Map
4rg8A 1 0.8558 99.9 0.797 Contact Map
3mxmB 2 0.9023 99.9 0.799 Contact Map
2guiA 1 0.7767 99.9 0.8 Contact Map
1w0hA 1 0.8884 99.9 0.801 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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