GREMLIN Database
NADC - Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt: P30011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11546
Length: 297 (263)
Sequences: 5709 (3322)
Seq/√Len: 204.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_R140_E3.6221.00
239_E242_Q3.1021.00
268_R272_E3.0061.00
66_G290_L2.8521.00
156_L163_L2.7651.00
223_D249_R2.7171.00
56_S111_S2.5581.00
135_V172_G2.5481.00
195_S198_Q2.5411.00
93_D96_D2.5131.00
87_T108_E2.4801.00
216_V222_L2.4781.00
28_A80_Q2.4001.00
262_V270_F2.3111.00
57_H108_E2.2871.00
197_R201_E2.1821.00
92_V102_Q2.1641.00
91_H106_E2.1501.00
250_T256_L2.1171.00
197_R224_E2.0841.00
245_E248_K2.0421.00
86_V109_G2.0301.00
69_C169_C2.0261.00
223_D227_K2.0091.00
68_F92_V2.0051.00
217_E221_E1.9781.00
55_R108_E1.9261.00
104_L292_L1.8981.00
114_L294_M1.8871.00
65_N99_N1.8011.00
78_F121_A1.7991.00
81_L117_G1.7911.00
242_Q245_E1.7741.00
243_M258_V1.7371.00
137_H264_D1.7371.00
167_V172_G1.7201.00
269_E272_E1.6711.00
198_Q201_E1.6611.00
165_Y169_C1.6301.00
150_L277_F1.6231.00
36_G180_S1.6141.00
83_G113_V1.5991.00
142_L149_L1.5811.00
57_H106_E1.5781.00
197_R227_K1.5611.00
142_L147_T1.5551.00
74_V105_F1.5451.00
222_L225_A1.5441.00
127_T156_L1.5421.00
68_F98_I1.5421.00
140_E143_E1.5321.00
74_V121_A1.5161.00
65_N100_A1.5151.00
138_Y264_D1.4911.00
200_V214_V1.4901.00
134_K287_V1.4901.00
26_A29_Q1.4761.00
68_F71_K1.4761.00
198_Q202_K1.4691.00
255_L277_F1.4611.00
60_V292_L1.4481.00
127_T163_L1.4461.00
243_M270_F1.4301.00
266_T269_E1.4281.00
138_Y280_V1.4221.00
110_P113_V1.4151.00
138_Y267_L1.4051.00
76_E80_Q1.4021.00
134_K264_D1.3741.00
141_L264_D1.3661.00
53_N110_P1.3621.00
60_V74_V1.3591.00
92_V96_D1.3511.00
149_L267_L1.3471.00
152_T160_R1.3441.00
213_E232_I1.3431.00
141_L268_R1.3361.00
233_I246_A1.3271.00
69_C132_A1.3241.00
222_L250_T1.3201.00
222_L226_L1.3131.00
37_G180_S1.3091.00
99_N102_Q1.3081.00
148_Q173_A1.3031.00
68_F104_L1.3001.00
109_G114_L1.2981.00
72_R94_D1.2951.00
46_T185_I1.2871.00
75_E79_I1.2861.00
97_V140_E1.2721.00
67_V97_V1.2691.00
126_Q289_A1.2591.00
183_F207_H1.2551.00
58_A294_M1.2441.00
59_T106_E1.2431.00
211_P231_D1.2401.00
35_L116_T1.2311.00
255_L276_D1.2301.00
97_V136_R1.2181.00
232_I255_L1.2181.00
220_E223_D1.2171.00
187_E295_R1.2161.00
223_D226_L1.2091.00
63_R293_S1.2091.00
144_G268_R1.2081.00
30_A124_F1.1971.00
76_E79_I1.1931.00
225_A228_A1.1921.00
201_E205_W1.1911.00
64_E288_Q1.1681.00
240_T270_F1.1671.00
257_E277_F1.1661.00
45_I210_A1.1501.00
86_V113_V1.1481.00
135_V139_V1.1401.00
44_D47_A1.1271.00
92_V98_I1.1261.00
43_N46_T1.1191.00
60_V125_V1.1081.00
73_W165_Y1.1051.00
78_F117_G1.0911.00
103_S106_E1.0871.00
144_G272_E1.0811.00
59_T103_S1.0771.00
67_V136_R1.0691.00
77_V117_G1.0651.00
209_D232_I1.0551.00
77_V120_T1.0431.00
271_A278_I1.0381.00
219_L246_A1.0361.00
51_P54_S1.0361.00
213_E234_M1.0321.00
241_E244_R1.0311.00
131_V163_L1.0301.00
60_V105_F1.0281.00
61_I295_R1.0231.00
128_L166_A1.0221.00
247_V251_N1.0201.00
145_T271_A1.0181.00
36_G178_G1.0061.00
202_K205_W1.0061.00
145_T268_R0.9961.00
65_N97_V0.9951.00
86_V107_L0.9951.00
68_F125_V0.9921.00
147_T172_G0.9911.00
69_C165_Y0.9851.00
94_D169_C0.9791.00
211_P232_I0.9781.00
139_V173_A0.9721.00
72_R75_E0.9651.00
183_F203_A0.9651.00
81_L113_V0.9600.99
60_V121_A0.9590.99
141_L267_L0.9510.99
145_T272_E0.9470.99
134_K137_H0.9450.99
258_V275_V0.9440.99
87_T90_W0.9430.99
267_L280_V0.9400.99
134_K138_Y0.9370.99
88_I105_F0.9320.99
215_E219_L0.9310.99
139_V144_G0.9310.99
240_T269_E0.9310.99
251_N254_A0.9300.99
43_N47_A0.9230.99
190_I194_G0.9210.99
72_R165_Y0.9200.99
111_S192_A0.9190.99
27_V80_Q0.9180.99
61_I293_S0.9180.99
191_I217_E0.9180.99
26_A162_A0.9140.99
222_L233_I0.8990.99
266_T270_F0.8960.99
262_V266_T0.8960.99
73_W162_A0.8910.99
224_E227_K0.8880.99
267_L278_I0.8870.99
85_D110_P0.8870.99
55_R110_P0.8850.99
215_E218_N0.8820.99
62_T66_G0.8760.99
98_I104_L0.8740.99
193_S202_K0.8690.99
174_N182_A0.8650.99
258_V273_T0.8620.99
229_G253_K0.8540.99
130_G287_V0.8510.99
215_E220_E0.8500.99
224_E228_A0.8450.99
75_E90_W0.8440.99
71_K75_E0.8380.99
52_E112_R0.8370.99
222_L246_A0.8270.98
218_N221_E0.8230.98
86_V110_P0.8190.98
78_F86_V0.8160.98
200_V228_A0.8150.98
71_K90_W0.8150.98
147_T278_I0.8140.98
235_L246_A0.8120.98
244_R272_E0.8120.98
244_R248_K0.8100.98
230_A254_A0.8080.98
258_V270_F0.7980.98
91_H103_S0.7980.98
163_L287_V0.7970.98
48_K112_R0.7970.98
243_M247_V0.7950.98
117_G121_A0.7930.98
250_T254_A0.7880.98
217_E295_R0.7820.98
56_S114_L0.7820.98
245_E249_R0.7810.98
204_S212_V0.7740.98
280_V283_L0.7720.98
128_L162_A0.7710.98
139_V172_G0.7710.98
73_W128_L0.7690.98
85_D113_V0.7680.98
145_T278_I0.7680.98
78_F88_I0.7630.97
264_D282_A0.7600.97
142_L271_A0.7590.97
178_G181_D0.7580.97
66_G129_S0.7560.97
281_G284_T0.7460.97
60_V122_L0.7410.97
201_E228_A0.7400.97
46_T184_L0.7390.97
204_S231_D0.7390.97
137_H140_E0.7380.97
216_V246_A0.7370.97
26_A30_A0.7360.97
74_V88_I0.7320.97
60_V294_M0.7310.97
246_A249_R0.7310.97
119_R152_T0.7300.97
27_V124_F0.7280.97
128_L163_L0.7260.97
90_W96_D0.7250.97
31_L81_L0.7250.97
94_D165_Y0.7250.97
28_A32_R0.7240.96
223_D245_E0.7240.96
197_R228_A0.7240.96
139_V143_E0.7240.96
124_F162_A0.7230.96
151_D174_N0.7220.96
33_E160_R0.7200.96
213_E257_E0.7180.96
286_H289_A0.7120.96
211_P255_L0.7100.96
263_T266_T0.7100.96
215_E221_E0.7090.96
27_V77_V0.7070.96
27_V76_E0.7060.96
54_S111_S0.7050.96
45_I183_F0.7030.96
232_I277_F0.7030.96
238_F242_Q0.7020.96
247_V273_T0.7010.96
68_F129_S0.7000.96
281_G285_K0.6960.96
185_I203_A0.6960.96
127_T131_V0.6950.96
77_V121_A0.6940.96
71_K94_D0.6930.95
45_I48_K0.6920.95
238_F246_A0.6880.95
168_L179_L0.6880.95
66_G98_I0.6850.95
240_T273_T0.6840.95
62_T98_I0.6810.95
124_F159_L0.6810.95
142_L267_L0.6810.95
151_D167_V0.6750.95
240_T266_T0.6710.95
222_L249_R0.6700.95
219_L223_D0.6670.94
142_L145_T0.6650.94
247_V250_T0.6620.94
195_S224_E0.6550.94
241_E269_E0.6550.94
44_D189_H0.6530.94
56_S192_A0.6520.94
225_A230_A0.6500.94
26_A124_F0.6440.93
48_K116_T0.6430.93
261_N280_V0.6420.93
225_A254_A0.6410.93
217_E293_S0.6380.93
226_L250_T0.6370.93
219_L249_R0.6370.93
226_L249_R0.6310.93
281_G286_H0.6300.93
64_E290_L0.6270.92
148_Q277_F0.6200.92
233_I250_T0.6190.92
243_M273_T0.6170.92
234_M243_M0.6120.92
70_G129_S0.6090.91
58_A107_L0.6080.91
27_V30_A0.6080.91
77_V124_F0.6060.91
139_V147_T0.6050.91
251_N256_L0.6010.91
134_K282_A0.6000.91
213_E231_D0.5960.90
182_A209_D0.5950.90
184_L187_E0.5910.90
159_L163_L0.5910.90
143_E268_R0.5900.90
139_V149_L0.5900.90
44_D48_K0.5860.90
107_L117_G0.5850.90
175_H213_E0.5850.90
204_S229_G0.5840.90
207_H210_A0.5840.90
125_V292_L0.5830.89
216_V233_I0.5820.89
48_K206_L0.5820.89
62_T65_N0.5810.89
212_V215_E0.5810.89
258_V262_V0.5810.89
216_V219_L0.5800.89
55_R87_T0.5790.89
90_W106_E0.5790.89
66_G133_S0.5790.89
72_R76_E0.5770.89
200_V225_A0.5770.89
269_E273_T0.5770.89
124_F157_P0.5760.89
150_L279_S0.5720.89
62_T104_L0.5710.88
221_E224_E0.5690.88
150_L232_I0.5680.88
150_L209_D0.5670.88
61_I103_S0.5650.88
187_E237_N0.5630.88
177_L180_S0.5610.88
71_K91_H0.5590.87
148_Q182_A0.5590.87
63_R295_R0.5590.87
163_L285_K0.5590.87
53_N112_R0.5580.87
241_E273_T0.5500.87
240_T243_M0.5480.86
29_Q159_L0.5470.86
37_G43_N0.5470.86
216_V221_E0.5450.86
50_L111_S0.5430.86
47_A50_L0.5420.86
149_L278_I0.5410.86
219_L245_E0.5410.86
74_V77_V0.5390.86
78_F107_L0.5390.86
262_V278_I0.5390.86
142_L172_G0.5350.85
134_K141_L0.5340.85
98_I290_L0.5320.85
187_E217_E0.5310.85
260_G266_T0.5300.85
138_Y262_V0.5290.84
35_L181_D0.5250.84
149_L280_V0.5250.84
126_Q151_D0.5240.84
258_V274_G0.5210.84
148_Q174_N0.5190.83
71_K88_I0.5180.83
222_L256_L0.5180.83
226_L254_A0.5160.83
139_V170_G0.5150.83
143_E271_A0.5110.82
159_L162_A0.5100.82
212_V216_V0.5090.82
26_A161_S0.5090.82
81_L116_T0.5090.82
119_R160_R0.5080.82
88_I107_L0.5080.82
60_V107_L0.5070.82
261_N286_H0.5060.82
200_V230_A0.5050.82
229_G254_A0.5050.82
49_L202_K0.5030.81
247_V274_G0.5020.81
233_I254_A0.5020.81
43_N48_K0.5020.81
150_L255_L0.5020.81
90_W93_D0.5010.81
146_N173_A0.5000.81
146_N276_D0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qapA 2 0.9562 100 0.194 Contact Map
3pajA 2 0.9798 100 0.197 Contact Map
3l0gA 3 0.9158 100 0.203 Contact Map
3gnnA 2 0.8956 100 0.222 Contact Map
3tqvA 2 0.9428 100 0.23 Contact Map
1qpoA 2 0.936 100 0.23 Contact Map
2b7nA 6 0.9057 100 0.231 Contact Map
3c2eA 5 0.8586 100 0.252 Contact Map
1o4uA 2 0.8754 100 0.259 Contact Map
2jbmA 5 0.9394 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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