GREMLIN Database
PEPT - Peptidase T
UniProt: P29745 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11549
Length: 408 (348)
Sequences: 29015 (20643)
Seq/√Len: 1106.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T166_R3.2841.00
216_K272_R3.0221.00
39_K43_E2.8341.00
10_N37_L2.7701.00
216_K274_D2.7151.00
128_L384_F2.6611.00
63_P164_D2.5951.00
222_V231_M2.5891.00
237_L309_C2.5161.00
72_A164_D2.4111.00
214_N274_D2.3931.00
217_I241_I2.3841.00
295_M299_K2.3721.00
291_K295_M2.3691.00
218_V312_E2.3251.00
218_V310_Y2.3101.00
218_V272_R2.2951.00
342_D399_R2.2831.00
41_Q44_E2.2811.00
338_Q403_L2.2751.00
154_V398_V2.2591.00
342_D403_L2.2351.00
37_L41_Q2.1271.00
216_K312_E2.1041.00
238_A261_Y2.0981.00
214_N276_H2.0981.00
72_A166_R2.0921.00
262_H274_D2.0901.00
238_A273_A2.0791.00
292_R296_E2.0511.00
14_L37_L1.9731.00
45_M153_A1.9611.00
154_V158_K1.9511.00
260_F276_H1.9431.00
214_N314_V1.9261.00
240_R243_A1.9171.00
116_M382_H1.9051.00
238_A275_M1.9041.00
61_T164_D1.8811.00
42_L60_A1.8761.00
337_Q341_R1.8731.00
117_F125_G1.8681.00
343_C399_R1.8511.00
239_A242_H1.8501.00
32_W36_H1.8451.00
74_G189_A1.8351.00
216_K314_V1.8291.00
41_Q45_M1.7831.00
336_A400_I1.7411.00
40_E44_E1.7231.00
180_K184_V1.7181.00
33_K36_H1.6791.00
7_R41_Q1.6671.00
241_I298_A1.6621.00
299_K303_K1.6441.00
36_H40_E1.6381.00
239_A243_A1.6171.00
232_V237_L1.6071.00
293_K296_E1.5881.00
37_L40_E1.5881.00
220_N232_V1.5821.00
127_T388_E1.5731.00
236_S246_P1.5581.00
399_R402_E1.5581.00
288_E292_R1.5561.00
234_A273_A1.5471.00
4_L394_V1.5431.00
10_N13_S1.5411.00
334_D337_Q1.5261.00
203_L207_N1.5201.00
35_L79_V1.5161.00
66_V162_H1.5001.00
47_L62_L1.4891.00
9_L13_S1.4861.00
74_G168_A1.4831.00
341_R346_E1.4681.00
10_N33_K1.4681.00
153_A157_Q1.4681.00
286_Q289_A1.4631.00
38_L79_V1.4631.00
221_N271_E1.4581.00
6_E10_N1.4551.00
147_E393_A1.4451.00
263_L273_A1.4451.00
289_A293_K1.4421.00
39_K51_T1.4331.00
32_W56_G1.4311.00
244_E297_I1.4281.00
40_E43_E1.4241.00
227_A230_V1.4221.00
203_L206_E1.4081.00
244_E300_K1.4061.00
39_K58_L1.4021.00
291_K315_I1.3901.00
254_T290_R1.3731.00
48_I63_P1.3601.00
10_N14_L1.3451.00
337_Q349_L1.3411.00
217_I238_A1.3401.00
392_K395_Q1.3291.00
41_Q153_A1.3281.00
13_S124_L1.3201.00
74_G192_A1.3201.00
7_R150_T1.3191.00
240_R304_G1.3141.00
213_V277_Y1.3141.00
399_R403_L1.2991.00
335_I403_L1.2991.00
302_G311_I1.2971.00
214_N316_E1.2881.00
75_F148_I1.2821.00
181_H184_V1.2811.00
117_F122_Q1.2791.00
181_H185_D1.2791.00
143_A390_M1.2751.00
143_A385_V1.2621.00
215_I275_M1.2621.00
77_S141_D1.2541.00
16_T34_L1.2441.00
124_L387_L1.2411.00
339_A403_L1.2381.00
65_N162_H1.2381.00
292_R295_M1.2381.00
343_C395_Q1.2341.00
296_E300_K1.2231.00
62_L156_Q1.2181.00
6_E9_L1.2101.00
36_H39_K1.2011.00
391_E395_Q1.2001.00
75_F401_A1.1981.00
71_P190_R1.1931.00
204_E207_N1.1861.00
156_Q159_K1.1851.00
340_M396_V1.1821.00
388_E392_K1.1771.00
4_L150_T1.1741.00
334_D338_Q1.1731.00
217_I237_L1.1701.00
11_Y34_L1.1701.00
7_R37_L1.1591.00
335_I339_A1.1561.00
211_A287_F1.1531.00
232_V309_C1.1521.00
339_A399_R1.1491.00
235_L261_Y1.1481.00
235_L263_L1.1451.00
12_V131_T1.1381.00
18_S175_V1.1341.00
295_M313_L1.1331.00
339_A343_C1.1331.00
362_S368_C1.1291.00
49_N52_L1.1231.00
366_L369_P1.1221.00
296_E299_K1.1201.00
9_L124_L1.1201.00
252_E283_D1.1171.00
338_Q342_D1.1171.00
298_A311_I1.1131.00
158_K398_V1.1001.00
199_G378_Y1.0981.00
12_V134_K1.0971.00
7_R153_A1.0961.00
64_A164_D1.0911.00
289_A292_R1.0891.00
283_D286_Q1.0841.00
248_D293_K1.0831.00
244_E247_A1.0811.00
243_A247_A1.0811.00
14_L33_K1.0801.00
386_T389_G1.0791.00
5_L9_L1.0731.00
10_N41_Q1.0691.00
249_E252_E1.0611.00
87_G382_H1.0611.00
291_K317_D1.0601.00
4_L146_A1.0521.00
128_L386_T1.0521.00
330_P334_D1.0471.00
9_L387_L1.0441.00
85_C126_Q1.0431.00
244_E301_V1.0411.00
143_A197_G1.0401.00
33_K37_L1.0371.00
152_L167_V1.0361.00
72_A190_R1.0251.00
195_V397_I1.0241.00
297_I301_V1.0201.00
38_L145_I1.0191.00
297_I300_K1.0161.00
9_L122_Q1.0151.00
213_V291_K1.0121.00
336_A369_P1.0111.00
338_Q341_R1.0111.00
150_T153_A1.0101.00
127_T386_T1.0081.00
242_H275_M1.0061.00
158_K402_E1.0051.00
177_K181_H0.9981.00
43_E49_N0.9931.00
299_K302_G0.9911.00
35_L58_L0.9811.00
293_K297_I0.9801.00
117_F123_L0.9801.00
236_S242_H0.9751.00
42_L149_M0.9751.00
240_R244_E0.9701.00
47_L60_A0.9691.00
57_T171_P0.9691.00
240_R247_A0.9681.00
11_Y37_L0.9661.00
148_I167_V0.9661.00
151_A398_V0.9611.00
300_K304_G0.9591.00
267_K276_H0.9591.00
339_A342_D0.9581.00
39_K52_L0.9571.00
385_V390_M0.9541.00
180_K360_Q0.9531.00
266_M269_T0.9531.00
238_A242_H0.9511.00
262_H265_S0.9391.00
154_V395_Q0.9321.00
192_A366_L0.9311.00
395_Q399_R0.9301.00
341_R345_I0.9291.00
79_V169_F0.9291.00
35_L39_K0.9221.00
398_V402_E0.9211.00
214_N267_K0.9161.00
50_V53_S0.9151.00
71_P163_G0.9111.00
45_M156_Q0.9091.00
389_G392_K0.9081.00
242_H258_E0.9031.00
258_E277_Y0.9021.00
394_V398_V0.9021.00
79_V145_I0.8971.00
249_E253_M0.8931.00
77_S145_I0.8931.00
218_V271_E0.8911.00
235_L273_A0.8911.00
335_I338_Q0.8861.00
125_G128_L0.8861.00
236_S239_A0.8861.00
19_K172_D0.8861.00
367_P370_N0.8841.00
4_L390_M0.8821.00
166_R189_A0.8801.00
151_A397_I0.8801.00
335_I400_I0.8771.00
215_I298_A0.8761.00
331_H335_I0.8741.00
240_R246_P0.8661.00
64_A67_P0.8631.00
372_F375_G0.8631.00
41_Q149_M0.8621.00
333_L337_Q0.8591.00
331_H334_D0.8521.00
10_N40_E0.8521.00
75_F151_A0.8521.00
245_V294_M0.8511.00
155_L160_I0.8481.00
236_S247_A0.8451.00
13_S122_Q0.8421.00
209_N281_D0.8411.00
300_K303_K0.8401.00
191_W332_I0.8401.00
215_I241_I0.8381.00
34_L79_V0.8351.00
50_V61_T0.8351.00
16_T142_K0.8341.00
8_F129_I0.8311.00
281_D287_F0.8241.00
284_R288_E0.8151.00
152_L156_Q0.8151.00
329_H332_I0.8141.00
261_Y273_A0.8121.00
242_H261_Y0.8111.00
206_E351_P0.8091.00
7_R10_N0.8081.00
315_I318_S0.8081.00
123_L126_Q0.8071.00
47_L152_L0.8061.00
124_L127_T0.8051.00
388_E391_E0.8051.00
211_A291_K0.8041.00
243_A246_P0.8041.00
333_L369_P0.8031.00
194_T197_G0.7981.00
212_S278_I0.7981.00
125_G130_T0.7971.00
301_V304_G0.7951.00
390_M394_V0.7941.00
116_M125_G0.7931.00
285_K289_A0.7841.00
193_Y400_I0.7841.00
43_E51_T0.7821.00
288_E291_K0.7811.00
39_K49_N0.7811.00
18_S21_G0.7801.00
17_Q20_A0.7791.00
147_E397_I0.7751.00
17_Q83_P0.7741.00
117_F120_L0.7741.00
19_K175_V0.7681.00
296_E303_K0.7671.00
340_M343_C0.7621.00
183_D186_A0.7611.00
154_V394_V0.7581.00
336_A396_V0.7581.00
45_M149_M0.7541.00
65_N161_P0.7531.00
245_V256_G0.7461.00
220_N380_G0.7441.00
147_E394_V0.7441.00
36_H51_T0.7441.00
154_V157_Q0.7431.00
151_A394_V0.7431.00
21_G32_W0.7431.00
217_I275_M0.7411.00
279_I290_R0.7341.00
47_L156_Q0.7301.00
287_F291_K0.7271.00
62_L152_L0.7231.00
229_G249_E0.7221.00
158_K161_P0.7161.00
122_Q129_I0.7151.00
258_E275_M0.7131.00
35_L56_G0.7131.00
358_G368_C0.7121.00
371_L396_V0.7101.00
166_R188_D0.7101.00
208_F211_A0.7081.00
295_M315_I0.7071.00
147_E151_A0.7061.00
145_I169_F0.7061.00
7_R146_A0.7061.00
319_Y322_M0.7061.00
183_D187_F0.7041.00
73_I401_A0.7031.00
148_I195_V0.7011.00
147_E195_V0.7001.00
150_T394_V0.6991.00
38_L169_F0.6951.00
118_P122_Q0.6901.00
38_L149_M0.6901.00
116_M120_L0.6861.00
339_A400_I0.6861.00
192_A197_G0.6831.00
62_L167_V0.6821.00
365_G368_C0.6811.00
240_R301_V0.6801.00
81_T120_L0.6761.00
44_E153_A0.6751.00
222_V270_V0.6701.00
49_N63_P0.6701.00
153_A156_Q0.6661.00
374_G385_V0.6651.00
262_H276_H0.6641.00
84_D120_L0.6641.00
256_G279_I0.6641.00
192_A196_D0.6631.00
9_L129_I0.6621.00
396_V400_I0.6611.00
72_A163_G0.6591.00
241_I275_M0.6571.00
395_Q398_V0.6561.00
212_S267_K0.6541.00
67_P164_D0.6531.00
33_K40_E0.6521.00
58_L169_F0.6511.00
213_V294_M0.6491.00
172_D175_V0.6491.00
39_K50_V0.6481.00
287_F320_Y0.6481.00
11_Y145_I0.6481.00
119_V122_Q0.6471.00
7_R11_Y0.6451.00
215_I313_L0.6441.00
81_T132_D0.6441.00
339_A396_V0.6421.00
232_V308_D0.6401.00
217_I234_A0.6331.00
168_A182_F0.6321.00
343_C396_V0.6311.00
5_L391_E0.6311.00
77_S148_I0.6291.00
302_G310_Y0.6271.00
11_Y146_A0.6261.00
194_T370_N0.6261.00
192_A368_C0.6251.00
288_E317_D0.6251.00
66_V164_D0.6231.00
302_G309_C0.6221.00
217_I311_I0.6221.00
38_L58_L0.6221.00
59_M166_R0.6211.00
377_N382_H0.6211.00
260_F274_D0.6201.00
9_L12_V0.6131.00
130_T384_F0.6121.00
5_L124_L0.6121.00
73_I191_W0.6111.00
47_L50_V0.6111.00
7_R149_M0.6111.00
63_P67_P0.6101.00
329_H334_D0.6101.00
387_L391_E0.6071.00
76_I168_A0.6061.00
84_D131_T0.6061.00
213_V315_I0.6031.00
236_S240_R0.6021.00
48_I61_T0.5991.00
356_T370_N0.5991.00
160_I402_E0.5981.00
55_K181_H0.5981.00
179_A183_D0.5981.00
5_L129_I0.5951.00
68_G71_P0.5941.00
156_Q160_I0.5941.00
87_G381_K0.5941.00
237_L301_V0.5921.00
129_I387_L0.5911.00
327_V330_P0.5901.00
264_A272_R0.5881.00
14_L34_L0.5861.00
168_A192_A0.5861.00
337_Q348_E0.5851.00
236_S243_A0.5851.00
14_L125_G0.5851.00
15_D20_A0.5841.00
192_A361_L0.5841.00
17_Q128_L0.5831.00
194_T358_G0.5811.00
217_I309_C0.5811.00
298_A313_L0.5811.00
241_I297_I0.5811.00
124_L129_I0.5801.00
49_N61_T0.5801.00
64_A159_K0.5791.00
207_N356_T0.5791.00
8_F146_A0.5761.00
141_D144_G0.5761.00
205_F349_L0.5761.00
277_Y294_M0.5741.00
330_P367_P0.5741.00
262_H272_R0.5741.00
47_L167_V0.5721.00
7_R45_M0.5711.00
366_L370_N0.5681.00
373_T393_A0.5681.00
122_Q125_G0.5681.00
17_Q120_L0.5671.00
237_L240_R0.5661.00
281_D290_R0.5651.00
76_I170_T0.5621.00
174_E379_H0.5621.00
377_N380_G0.5601.00
8_F387_L0.5591.00
209_N321_N0.5551.00
260_F265_S0.5531.00
17_Q84_D0.5521.00
371_L375_G0.5501.00
84_D87_G0.5481.00
321_N327_V0.5471.00
208_F255_E0.5461.00
241_I301_V0.5451.00
332_I335_I0.5451.00
66_V161_P0.5441.00
42_L47_L0.5391.00
43_E48_I0.5391.00
116_M122_Q0.5381.00
123_L130_T0.5371.00
42_L152_L0.5371.00
337_Q347_P0.5361.00
391_E394_V0.5351.00
150_T154_V0.5351.00
239_A246_P0.5351.00
59_M168_A0.5351.00
292_R299_K0.5341.00
371_L374_G0.5331.00
222_V227_A0.5321.00
369_P372_F0.5321.00
370_N374_G0.5301.00
234_A270_V0.5301.00
146_A390_M0.5301.00
191_W367_P0.5291.00
172_D177_K0.5281.00
5_L387_L0.5271.00
337_Q346_E0.5261.00
254_T281_D0.5261.00
204_E350_K0.5261.00
233_N257_Y0.5251.00
213_V313_L0.5231.00
245_V258_E0.5231.00
11_Y38_L0.5231.00
360_Q363_F0.5221.00
232_V310_Y0.5211.00
217_I298_A0.5171.00
131_T134_K0.5171.00
298_A302_G0.5161.00
21_G172_D0.5151.00
177_K319_Y0.5151.00
375_G389_G0.5141.00
71_P162_H0.5121.00
204_E208_F0.5111.00
4_L8_F0.5101.00
215_I277_Y0.5101.00
285_K288_E0.5081.00
241_I245_V0.5071.00
168_A361_L0.5071.00
192_A195_V0.5071.00
35_L52_L0.5051.00
49_N60_A0.5031.00
279_I294_M0.5031.00
284_R363_F0.5031.00
53_S56_G0.5031.00
250_S253_M0.5021.00
57_T182_F0.5021.00
129_I134_K0.5011.00
312_E315_I0.5011.00
231_M234_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfoA 2 0.8897 100 0.306 Contact Map
3rzaA 2 0.8725 100 0.313 Contact Map
3gb0A 2 0.8775 100 0.315 Contact Map
3ifeA 2 0.9951 100 0.326 Contact Map
1fnoA 2 0.9191 100 0.329 Contact Map
1cg2A 4 0.8799 100 0.337 Contact Map
3iszA 2 0.8529 100 0.338 Contact Map
4pqaA 2 0.8627 100 0.339 Contact Map
4mmoA 2 0.8799 100 0.346 Contact Map
2qyvA 2 0.8676 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.