GREMLIN Database
FLGL - Flagellar hook-associated protein 3
UniProt: P29744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11545
Length: 317 (300)
Sequences: 5402 (4183)
Seq/√Len: 241.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_Q237_K4.8361.00
83_V121_L3.5751.00
111_A115_Q3.3441.00
90_A114_I3.2501.00
276_S280_D3.1831.00
89_N113_D3.1161.00
35_R42_D2.9051.00
29_Q286_T2.7941.00
285_A289_S2.7521.00
63_T265_S2.7151.00
103_S106_D2.6651.00
86_A121_L2.6431.00
86_A117_L2.6351.00
53_S275_M2.5201.00
129_D134_Y2.4971.00
116_G119_D2.4551.00
34_K279_V2.4501.00
89_N93_K2.4051.00
60_S268_A2.3911.00
275_M279_V2.3731.00
36_V45_A2.3551.00
19_S300_S2.3291.00
120_Q123_N2.3221.00
281_V286_T2.3201.00
73_V250_L2.2021.00
26_Y293_Q2.1921.00
115_Q212_K2.1421.00
66_R261_D2.1281.00
104_D108_A2.0981.00
77_E247_R2.0821.00
25_K29_Q2.0631.00
61_Q64_L2.0531.00
145_P148_E2.0361.00
90_A117_L1.9431.00
93_K113_D1.9141.00
53_S279_V1.9121.00
57_A92_E1.9081.00
28_E38_N1.9001.00
146_F149_E1.8771.00
237_K241_N1.8581.00
94_I233_N1.8461.00
98_S230_D1.8391.00
45_A278_L1.8191.00
82_Q85_T1.8091.00
108_A112_T1.7981.00
89_N92_E1.7491.00
246_V249_E1.7431.00
93_K110_L1.7281.00
110_L223_E1.7201.00
145_P149_E1.6971.00
83_V243_V1.6901.00
102_L106_D1.6861.00
87_I236_L1.6701.00
291_I294_Q1.6411.00
87_I243_V1.6221.00
49_A279_V1.6201.00
83_V86_A1.6091.00
100_G107_R1.5831.00
30_M286_T1.5781.00
87_I240_L1.5681.00
90_A236_L1.5411.00
14_R18_N1.5371.00
140_K143_T1.5181.00
70_T258_E1.5141.00
42_D45_A1.5031.00
59_N264_G1.5021.00
202_A206_S1.4971.00
79_V124_L1.4941.00
26_Y289_S1.4621.00
105_D108_A1.4611.00
110_L114_I1.4441.00
115_Q119_D1.4361.00
227_A231_K1.4321.00
97_A110_L1.4281.00
86_A124_L1.4131.00
115_Q118_R1.3881.00
91_Q95_V1.3881.00
106_D109_S1.3811.00
96_Y110_L1.3801.00
80_L243_V1.3751.00
88_Q91_Q1.3711.00
109_S112_T1.3501.00
100_G226_A1.3471.00
222_K228_A1.3461.00
82_Q124_L1.3361.00
205_D209_A1.3291.00
86_A120_Q1.3241.00
56_Q272_T1.3191.00
144_A147_S1.3191.00
36_V49_A1.3161.00
111_A114_I1.3081.00
268_A272_T1.2991.00
83_V124_L1.2721.00
84_T240_L1.2701.00
161_K169_S1.2701.00
36_V41_D1.2661.00
199_N202_A1.2551.00
28_E37_V1.2401.00
28_E32_T1.2371.00
112_T249_E1.2281.00
66_R257_L1.2261.00
70_T261_D1.2231.00
80_L83_V1.2171.00
95_V98_S1.1941.00
56_Q271_Q1.1891.00
26_Y286_T1.1871.00
143_T146_F1.1841.00
67_T261_D1.1801.00
22_E293_Q1.1771.00
105_D241_N1.1771.00
302_K306_D1.1731.00
273_Q277_D1.1661.00
283_W287_I1.1621.00
112_T245_T1.1301.00
81_S85_T1.1281.00
290_Y294_Q1.1251.00
126_N137_A1.1251.00
61_Q92_E1.1241.00
94_I207_A1.1241.00
34_K281_V1.1091.00
287_I291_I1.1091.00
25_K28_E1.1011.00
197_E202_A1.0961.00
8_M24_M1.0961.00
95_V233_N1.0951.00
163_Q167_S1.0911.00
102_L110_L1.0851.00
11_Q14_R1.0811.00
122_L126_N1.0801.00
79_V128_T1.0781.00
26_Y281_V1.0741.00
118_R122_L1.0721.00
59_N268_A1.0711.00
84_T244_L1.0701.00
66_R264_G1.0681.00
61_Q65_A1.0661.00
231_K235_G1.0521.00
23_W27_G1.0461.00
63_T264_G1.0401.00
225_A228_A1.0371.00
226_A230_D1.0341.00
88_Q240_L1.0311.00
50_V53_S1.0301.00
118_R205_D1.0271.00
115_Q208_I1.0201.00
249_E253_Q1.0161.00
84_T243_V1.0141.00
18_N22_E1.0071.00
212_K215_V1.0011.00
175_T178_K0.9971.00
208_I211_L0.9971.00
19_S23_W0.9951.00
93_K96_Y0.9891.00
32_T37_V0.9881.00
7_M11_Q0.9871.00
287_I290_Y0.9851.00
238_N241_N0.9821.00
70_T74_S0.9821.00
88_Q92_E0.9781.00
49_A275_M0.9761.00
94_I229_L0.9761.00
90_A118_R0.9751.00
234_R238_N0.9741.00
262_S265_S0.9731.00
59_N63_T0.9651.00
125_A136_F0.9631.00
297_L301_Y0.9611.00
241_N245_T0.9581.00
9_Y13_M0.9551.00
16_I297_L0.9541.00
234_R237_K0.9491.00
114_I223_E0.9481.00
134_Y137_A0.9471.00
129_D132_G0.9441.00
81_S247_R0.9421.00
85_T88_Q0.9411.00
294_Q298_Q0.9391.00
117_L120_Q0.9371.00
60_S63_T0.9361.00
82_Q259_S0.9181.00
51_V106_D0.9171.00
53_S57_A0.9141.00
99_N102_L0.9131.00
134_Y145_P0.9131.00
223_E229_L0.9101.00
14_R269_L0.9091.00
301_Y311_S0.9011.00
84_T88_Q0.8961.00
98_S229_L0.8881.00
64_L68_F0.8820.99
89_N117_L0.8810.99
24_M27_G0.8770.99
210_A215_V0.8770.99
116_G253_Q0.8770.99
94_I98_S0.8680.99
74_S254_L0.8670.99
225_A229_L0.8660.99
153_Y156_G0.8580.99
20_Q297_L0.8540.99
139_Y156_G0.8500.99
4_S34_K0.8460.99
176_G180_F0.8440.99
69_A257_L0.8440.99
23_W26_Y0.8420.99
163_Q166_A0.8360.99
238_N242_N0.8340.99
13_M17_T0.8330.99
170_M174_H0.8310.99
19_S22_E0.8310.99
15_G32_T0.8300.99
206_S209_A0.8250.99
165_D168_R0.8230.99
164_V260_L0.8210.99
123_N127_T0.8200.99
137_A145_P0.8170.99
19_S293_Q0.8160.99
94_I236_L0.8150.99
294_Q306_D0.8150.99
245_T249_E0.8150.99
63_T67_T0.8130.99
208_I212_K0.8110.99
95_V237_K0.8070.99
13_M288_S0.8030.99
18_N21_A0.8010.99
144_A148_E0.7980.99
289_S292_M0.7960.99
97_A229_L0.7890.99
310_L315_L0.7870.99
70_T254_L0.7860.99
286_T289_S0.7860.99
62_Y264_G0.7850.99
91_Q233_N0.7820.99
164_V167_S0.7820.99
90_A204_L0.7820.99
260_L264_G0.7810.99
27_G290_Y0.7810.99
4_S7_M0.7800.99
153_Y157_A0.7790.99
137_A143_T0.7770.99
22_E289_S0.7770.99
120_Q256_E0.7710.99
29_Q281_V0.7690.99
17_T20_Q0.7660.99
77_E250_L0.7640.99
94_I232_T0.7590.98
63_T268_A0.7540.98
200_L204_L0.7530.98
84_T247_R0.7510.98
152_K155_G0.7500.98
16_I300_S0.7460.98
102_L107_R0.7450.98
122_L125_A0.7370.98
254_L258_E0.7340.98
96_Y102_L0.7340.98
98_S233_N0.7300.98
311_S314_Q0.7280.98
57_A60_S0.7260.98
231_K234_R0.7260.98
164_V170_M0.7240.98
73_V257_L0.7220.98
128_T132_G0.7220.98
22_E25_K0.7220.98
69_A172_I0.7200.98
144_A149_E0.7170.98
160_I165_D0.7160.98
198_T206_S0.7150.98
44_I48_Q0.7060.98
143_T147_S0.7060.98
224_T228_A0.7050.98
261_D265_S0.7050.98
35_R64_L0.7000.97
265_S268_A0.6990.97
93_K117_L0.6980.97
16_I301_Y0.6960.97
134_Y144_A0.6940.97
143_T148_E0.6940.97
266_D269_L0.6940.97
203_M206_S0.6940.97
267_R271_Q0.6930.97
258_E262_S0.6930.97
199_N203_M0.6920.97
205_D208_I0.6900.97
228_A232_T0.6900.97
56_Q275_M0.6890.97
168_R172_I0.6850.97
168_R171_V0.6830.97
310_L314_Q0.6810.97
37_V41_D0.6780.97
46_A50_V0.6720.97
169_S172_I0.6720.97
209_A213_T0.6700.97
174_H180_F0.6620.96
79_V136_F0.6610.96
26_Y29_Q0.6610.96
137_A140_K0.6610.96
90_A121_L0.6570.96
114_I118_R0.6540.96
111_A118_R0.6540.96
71_Q74_S0.6540.96
162_Q165_D0.6530.96
8_M27_G0.6520.96
206_S211_L0.6520.96
94_I114_I0.6500.96
10_Q14_R0.6490.96
19_S297_L0.6480.96
192_D197_E0.6450.96
276_S279_V0.6430.96
118_R121_L0.6430.96
168_R176_G0.6430.96
76_E79_V0.6420.96
299_A302_K0.6390.96
8_M12_N0.6380.96
52_L278_L0.6370.96
9_Y12_N0.6360.95
178_K182_S0.6340.95
88_Q95_V0.6290.95
171_V174_H0.6280.95
147_S154_V0.6280.95
21_A25_K0.6220.95
294_Q301_Y0.6220.95
304_F308_Q0.6220.95
206_S212_K0.6220.95
302_K314_Q0.6210.95
310_L313_F0.6210.95
140_K145_P0.6200.95
76_E174_H0.6190.95
201_F211_L0.6190.95
12_N304_F0.6180.95
117_L259_S0.6170.95
300_S303_A0.6170.95
221_D232_T0.6160.95
52_L56_Q0.6140.95
79_V83_V0.6110.94
163_Q169_S0.6110.94
79_V127_T0.6110.94
289_S293_Q0.6100.94
66_R260_L0.6080.94
285_A288_S0.6010.94
35_R45_A0.6000.94
177_D181_D0.6000.94
142_E146_F0.6000.94
112_T115_Q0.5980.94
291_I295_T0.5970.94
301_Y304_F0.5970.94
5_T275_M0.5970.94
223_E228_A0.5970.94
118_R221_D0.5960.94
24_M28_E0.5930.93
23_W294_Q0.5920.93
15_G28_E0.5910.93
266_D270_G0.5910.93
138_G145_P0.5910.93
210_A232_T0.5900.93
129_D133_R0.5880.93
113_D252_T0.5870.93
75_L79_V0.5830.93
298_Q302_K0.5820.93
303_A306_D0.5820.93
177_D180_F0.5820.93
176_G183_I0.5810.93
207_A211_L0.5810.93
165_D169_S0.5790.93
50_V279_V0.5790.93
220_A223_E0.5780.93
80_L247_R0.5760.92
292_M295_T0.5750.92
162_Q172_I0.5750.92
174_H179_I0.5730.92
206_S210_A0.5730.92
290_Y297_L0.5720.92
170_M176_G0.5720.92
290_Y306_D0.5690.92
103_S109_S0.5680.92
202_A205_D0.5680.92
202_A211_L0.5670.92
50_V244_L0.5670.92
48_Q51_V0.5670.92
7_M10_Q0.5660.92
73_V253_Q0.5660.92
230_D234_R0.5660.92
229_L232_T0.5640.92
145_P155_G0.5640.92
113_D117_L0.5600.91
34_K280_D0.5580.91
203_M207_A0.5550.91
98_S102_L0.5520.91
14_R17_T0.5520.91
200_L203_M0.5520.91
202_A214_P0.5510.91
169_S173_G0.5510.91
201_F204_L0.5500.91
116_G256_E0.5500.91
201_F205_D0.5490.91
181_D184_T0.5490.91
142_E147_S0.5490.91
202_A210_A0.5470.90
168_R179_I0.5450.90
63_T261_D0.5430.90
30_M287_I0.5430.90
292_M296_A0.5420.90
47_S131_N0.5410.90
76_E250_L0.5400.90
161_K171_V0.5390.90
160_I169_S0.5390.90
85_T89_N0.5390.90
192_D202_A0.5390.90
207_A210_A0.5380.90
25_K41_D0.5350.89
83_V87_I0.5340.89
85_T262_S0.5340.89
46_A247_R0.5330.89
168_R173_G0.5320.89
242_N245_T0.5310.89
172_I176_G0.5310.89
9_Y288_S0.5300.89
146_F153_Y0.5290.89
83_V136_F0.5290.89
78_S82_Q0.5270.89
140_K156_G0.5270.89
60_S285_A0.5250.89
297_L300_S0.5240.88
174_H178_K0.5230.88
295_T310_L0.5220.88
304_F313_F0.5210.88
40_S73_V0.5200.88
302_K305_T0.5190.88
211_L214_P0.5180.88
232_T235_G0.5180.88
133_R143_T0.5180.88
201_F212_K0.5180.88
117_L121_L0.5160.88
174_H177_D0.5160.88
73_V254_L0.5150.88
306_D316_S0.5140.88
142_E145_P0.5130.87
176_G179_I0.5120.87
42_D64_L0.5120.87
60_S272_T0.5120.87
107_R229_L0.5110.87
168_R177_D0.5100.87
198_T202_A0.5100.87
47_S109_S0.5100.87
97_A107_R0.5090.87
121_L127_T0.5090.87
12_N15_G0.5090.87
46_A49_A0.5070.87
140_K146_F0.5040.86
67_T277_D0.5030.86
233_N237_K0.5020.86
98_S101_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ucuA 1 0.9811 100 0.312 Contact Map
2d4xA 1 0.6751 100 0.374 Contact Map
3pwxA 2 0.7003 100 0.388 Contact Map
3k8wA 1 0.7224 100 0.479 Contact Map
4nx9A 1 0.6498 100 0.591 Contact Map
3v47C 1 0.5804 99.9 0.63 Contact Map
4cfiA 1 0.5773 99.9 0.671 Contact Map
1io1A 1 0.6909 99.9 0.675 Contact Map
3k1iC 1 0.3785 99.3 0.789 Contact Map
1oryB 2 0.1199 96.9 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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