GREMLIN Database
DCUP - Uroporphyrinogen decarboxylase
UniProt: P29680 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11543
Length: 354 (332)
Sequences: 3899 (2545)
Seq/√Len: 139.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R19_D5.0341.00
11_R16_Q4.0151.00
183_D229_K3.6841.00
190_T233_G3.4401.00
179_H221_Q3.4381.00
307_E310_T3.3921.00
45_D48_S3.3031.00
220_Q258_A3.2951.00
305_E347_R3.2311.00
105_C108_D3.1691.00
179_H226_Y2.9841.00
13_L266_A2.7941.00
174_D177_A2.7771.00
57_C130_T2.6831.00
308_V341_F2.6081.00
132_R202_Q2.5151.00
8_R20_V2.5081.00
257_E281_R2.4801.00
277_D280_R2.3961.00
309_A344_A2.3871.00
88_G100_T2.3531.00
310_T314_G2.3411.00
334_P337_H2.3091.00
9_Y203_A2.3081.00
194_N237_E2.3001.00
197_I204_V2.2981.00
65_R138_E2.2631.00
38_A41_A2.2631.00
187_K229_K2.2511.00
301_P340_V2.2331.00
228_H232_D2.2121.00
195_A198_K2.1951.00
309_A313_A2.1741.00
340_V344_A2.1711.00
156_V170_M2.1141.00
305_E344_A2.0951.00
190_T229_K2.0831.00
106_K174_D2.0771.00
125_M195_A2.0721.00
305_E340_V2.0531.00
186_A190_T2.0171.00
300_P303_R1.9921.00
274_D314_G1.9791.00
145_S189_V1.9751.00
194_N233_G1.9691.00
302_A306_E1.9291.00
15_R320_G1.9201.00
109_V177_A1.9161.00
276_A314_G1.9031.00
179_H222_F1.8721.00
25_M341_F1.8711.00
235_L265_D1.8541.00
301_P337_H1.8491.00
259_M267_L1.8231.00
110_D180_A1.8041.00
323_F345_V1.8001.00
7_D11_R1.7691.00
220_Q261_E1.7591.00
308_V344_A1.7291.00
186_A230_I1.7161.00
108_D111_K1.6801.00
122_G126_N1.6651.00
339_G343_E1.6641.00
11_R19_D1.6621.00
180_A184_K1.6221.00
219_Y227_M1.6061.00
170_M177_A1.5981.00
104_T166_V1.5971.00
126_N129_R1.5661.00
304_I340_V1.5461.00
12_A287_A1.5371.00
190_T230_I1.5321.00
130_T134_E1.4831.00
15_R287_A1.4821.00
25_M338_A1.4771.00
276_A280_R1.4761.00
106_K177_A1.4421.00
183_D187_K1.3971.00
344_A347_R1.3961.00
167_I178_L1.3941.00
304_I337_H1.3741.00
130_T133_R1.3731.00
183_D226_Y1.3561.00
11_R18_V1.3461.00
343_E347_R1.3421.00
48_S52_N1.3361.00
106_K180_A1.3351.00
54_E130_T1.3261.00
287_A320_G1.3151.00
277_D281_R1.3081.00
224_L261_E1.3041.00
66_R339_G1.3031.00
224_L228_H1.2991.00
12_A22_P1.2981.00
340_V343_E1.2961.00
231_V264_C1.2911.00
74_L131_I1.2851.00
215_T218_D1.2841.00
194_N198_K1.2811.00
49_L59_V1.2741.00
127_A131_I1.2711.00
67_Y339_G1.2641.00
175_P221_Q1.2641.00
67_Y335_P1.2471.00
337_H340_V1.2451.00
301_P305_E1.2411.00
299_A303_R1.2381.00
305_E309_A1.2321.00
303_R306_E1.2291.00
106_K110_D1.2251.00
129_R199_A1.2171.00
57_C131_I1.1991.00
194_N236_R1.1981.00
116_D119_D1.1971.00
191_L194_N1.1911.00
129_R133_R1.1891.00
8_R18_V1.1891.00
62_Q66_R1.1791.00
292_M323_F1.1721.00
274_D277_D1.1711.00
21_T312_L1.1711.00
216_G220_Q1.1660.99
275_I315_F1.1630.99
187_K190_T1.1630.99
92_E95_E1.1430.99
220_Q224_L1.1410.99
186_A229_K1.1390.99
107_A110_D1.1380.99
61_L65_R1.1350.99
9_Y246_T1.1350.99
12_A18_V1.1290.99
298_Y332_D1.1210.99
169_K173_A1.1180.99
294_P326_G1.1170.99
187_K191_L1.1070.99
51_K83_D1.1050.99
21_T321_H1.1040.99
228_H261_E1.0940.99
32_Y67_Y1.0900.99
296_M307_E1.0890.99
216_G258_A1.0850.99
296_M304_I1.0770.99
52_N55_L1.0650.99
302_A305_E1.0640.99
194_N234_L1.0610.99
292_M341_F1.0560.99
336_E339_G1.0520.99
117_P125_M1.0480.99
110_D184_K1.0420.99
90_Y100_T1.0400.99
189_V230_I1.0390.99
9_Y13_L1.0300.99
17_P319_E1.0260.99
329_I333_V1.0240.99
330_H333_V1.0200.99
23_V342_V1.0140.99
68_P139_V1.0100.99
20_V346_H1.0030.98
206_I230_I1.0010.98
177_A180_A0.9910.98
282_V288_L0.9900.98
14_L243_V0.9850.98
224_L258_A0.9830.98
261_E285_K0.9800.98
179_H183_D0.9780.98
152_A181_L0.9750.98
311_I323_F0.9750.98
224_L262_T0.9750.98
68_P346_H0.9690.98
37_K41_A0.9670.98
305_E343_E0.9660.98
76_S80_T0.9510.98
233_G236_R0.9490.98
232_D236_R0.9480.98
13_L322_V0.9480.98
263_G286_V0.9470.98
323_F341_F0.9450.98
260_A282_V0.9400.98
227_M247_L0.9390.98
205_M268_G0.9380.98
256_L278_A0.9310.97
171_M178_L0.9230.97
228_H263_G0.9210.97
279_R288_L0.9200.97
64_L139_V0.9190.97
301_P304_I0.9130.97
119_D122_G0.9130.97
329_I338_A0.9090.97
313_A316_G0.9070.97
54_E57_C0.9050.97
53_A57_C0.9040.97
297_L333_V0.9040.97
198_K237_E0.9020.97
311_I321_H0.9020.97
306_E310_T0.8990.97
182_L226_Y0.8920.97
47_M51_K0.8880.97
107_A111_K0.8770.96
229_K233_G0.8760.96
206_I231_V0.8750.96
170_M174_D0.8720.96
8_R11_R0.8700.96
166_V169_K0.8640.96
49_L55_L0.8640.96
301_P336_E0.8630.96
57_C134_E0.8570.96
178_L182_L0.8560.96
257_E285_K0.8540.96
305_E308_V0.8540.96
69_L342_V0.8510.96
308_V312_L0.8500.96
247_L264_C0.8490.96
21_T323_F0.8490.96
190_T194_N0.8470.96
206_I227_M0.8440.95
126_N130_T0.8420.95
145_S193_L0.8410.95
104_T108_D0.8340.95
197_I243_V0.8280.95
151_L189_V0.8280.95
56_A127_A0.8270.95
10_L14_L0.8250.95
88_G101_S0.8200.95
231_V245_V0.8150.95
171_M218_D0.8130.94
43_A55_L0.8130.94
176_Q183_D0.8120.94
193_L234_L0.8070.94
232_D235_L0.8050.94
153_T167_I0.8050.94
87_L155_M0.8040.94
279_R316_G0.8040.94
335_P339_G0.8030.94
18_V21_T0.8020.94
172_Y218_D0.7990.94
266_A322_V0.7970.94
197_I237_E0.7960.94
38_A42_Q0.7950.94
273_T278_A0.7940.94
43_A49_L0.7900.94
58_E65_R0.7830.93
278_A288_L0.7810.93
258_A261_E0.7800.93
187_K233_G0.7790.93
109_V181_L0.7780.93
336_E340_V0.7770.93
137_G140_P0.7750.93
57_C61_L0.7690.93
143_G196_Q0.7690.93
301_P344_A0.7670.93
303_R307_E0.7670.93
109_V170_M0.7670.93
232_D263_G0.7660.93
247_L262_T0.7650.93
300_P337_H0.7630.92
298_Y333_V0.7630.92
226_Y229_K0.7610.92
25_M69_L0.7610.92
298_Y330_H0.7610.92
114_I187_K0.7590.92
117_P195_A0.7580.92
297_L325_L0.7490.92
65_R134_E0.7470.92
304_I308_V0.7430.91
186_A226_Y0.7430.91
299_A337_H0.7420.91
235_L245_V0.7410.91
54_E58_E0.7380.91
304_I344_A0.7360.91
188_S191_L0.7280.91
223_S227_M0.7270.90
103_V108_D0.7250.90
217_R220_Q0.7250.90
53_A126_N0.7230.90
253_G277_D0.7210.90
293_D296_M0.7210.90
142_I203_A0.7200.90
308_V340_V0.7180.90
260_A286_V0.7170.90
74_L127_A0.7160.90
279_R283_G0.7140.90
217_R221_Q0.7110.89
186_A233_G0.7110.89
12_A320_G0.7100.89
308_V347_R0.7100.89
61_L135_L0.7090.89
27_R30_G0.7070.89
74_L128_V0.7070.89
266_A287_A0.7050.89
249_T252_G0.7040.89
223_S226_Y0.7000.89
114_I184_K0.7000.89
267_L282_V0.6990.89
253_G273_T0.6970.89
150_T207_F0.6950.88
113_P184_K0.6930.88
193_L204_V0.6930.88
48_S55_L0.6930.88
39_T43_A0.6920.88
18_V319_E0.6900.88
269_L278_A0.6890.88
292_M307_E0.6860.88
211_G223_S0.6840.88
248_F327_H0.6830.88
109_V180_A0.6800.87
149_W153_T0.6790.87
39_T55_L0.6780.87
128_V199_A0.6770.87
309_A312_L0.6760.87
311_I315_F0.6750.87
125_M129_R0.6750.87
54_E126_N0.6740.87
135_L141_L0.6740.87
109_V184_K0.6740.87
64_L68_P0.6730.87
61_L134_E0.6730.87
125_M192_Y0.6720.87
254_Q281_R0.6720.87
304_I341_F0.6720.87
342_V346_H0.6670.86
6_N202_Q0.6660.86
204_V234_L0.6640.86
128_V201_A0.6630.86
163_A166_V0.6620.86
118_E125_M0.6610.86
225_Y229_K0.6560.85
145_S206_I0.6540.85
276_A310_T0.6540.85
164_F209_T0.6540.85
312_L345_V0.6540.85
237_E242_R0.6520.85
9_Y71_A0.6480.85
152_A178_L0.6440.84
266_A289_Q0.6410.84
33_L66_R0.6390.84
276_A317_H0.6390.84
308_V323_F0.6390.84
58_E62_Q0.6380.84
216_G255_W0.6360.84
227_M259_M0.6360.84
279_R319_E0.6350.84
292_M308_V0.6340.83
176_Q180_A0.6310.83
256_L273_T0.6300.83
283_G319_E0.6290.83
306_E309_A0.6290.83
90_Y98_R0.6270.83
310_T313_A0.6260.83
306_E313_A0.6250.83
39_T59_V0.6250.83
53_A130_T0.6240.82
209_T212_G0.6230.82
64_L69_L0.6230.82
156_V167_I0.6230.82
292_M311_I0.6210.82
87_L99_F0.6200.82
336_E343_E0.6180.82
66_R335_P0.6160.82
264_C267_L0.6140.81
82_P87_L0.6130.81
180_A183_D0.6120.81
270_D326_G0.6100.81
183_D186_A0.6070.81
209_T327_H0.6070.81
82_P155_M0.6060.81
46_F50_C0.6060.81
299_A304_I0.6050.80
165_T169_K0.6040.80
117_P191_L0.6020.80
216_G257_E0.5980.80
254_Q273_T0.5970.80
333_V338_A0.5960.79
37_K40_R0.5940.79
218_D221_Q0.5940.79
43_A48_S0.5940.79
114_I191_L0.5940.79
152_A185_L0.5930.79
193_L200_G0.5910.79
301_P343_E0.5900.79
315_F321_H0.5900.79
125_M199_A0.5900.79
289_Q324_N0.5880.79
34_P38_A0.5880.79
247_L259_M0.5870.78
175_P222_F0.5860.78
182_L186_A0.5860.78
214_L223_S0.5850.78
127_A130_T0.5830.78
122_G125_M0.5830.78
170_M173_A0.5810.78
296_M299_A0.5810.78
235_L241_R0.5800.78
297_L304_I0.5800.78
176_Q221_Q0.5790.78
280_R306_E0.5780.77
128_V196_Q0.5760.77
218_D222_F0.5750.77
177_A181_L0.5740.77
98_R102_P0.5730.77
201_A204_V0.5730.77
208_D212_G0.5720.77
47_M50_C0.5710.77
219_Y224_L0.5710.77
194_N197_I0.5700.76
244_P265_D0.5690.76
259_M262_T0.5690.76
227_M231_V0.5680.76
233_G237_E0.5680.76
162_K165_T0.5660.76
295_S330_H0.5650.76
51_K123_Y0.5640.76
279_R317_H0.5630.76
295_S298_Y0.5630.76
23_V345_V0.5630.76
131_I134_E0.5630.76
172_Y296_M0.5610.75
207_F328_G0.5610.75
113_P120_E0.5610.75
168_K213_V0.5600.75
269_L275_I0.5580.75
56_A59_V0.5570.75
28_Q31_R0.5560.75
191_L195_A0.5540.74
96_G154_Y0.5530.74
73_I144_F0.5520.74
273_T277_D0.5500.74
190_T234_L0.5490.74
243_V265_D0.5470.73
181_L185_L0.5460.73
150_T154_Y0.5450.73
115_P188_S0.5450.73
278_A281_R0.5450.73
101_S111_K0.5450.73
244_P248_F0.5450.73
198_K235_L0.5450.73
72_A135_L0.5420.73
255_W259_M0.5410.73
165_T332_D0.5400.73
63_P78_I0.5390.72
81_V188_S0.5380.72
147_S223_S0.5370.72
151_L185_L0.5360.72
275_I291_N0.5360.72
67_Y70_D0.5360.72
14_L18_V0.5350.72
123_Y126_N0.5340.72
279_R314_G0.5340.72
16_Q19_D0.5320.71
27_R31_R0.5310.71
195_A199_A0.5310.71
251_G272_T0.5290.71
7_D202_Q0.5290.71
142_I246_T0.5290.71
284_N319_E0.5290.71
118_E129_R0.5280.71
167_I171_M0.5280.71
43_A52_N0.5270.71
216_G254_Q0.5270.71
249_T259_M0.5270.71
278_A282_V0.5260.71
132_R137_G0.5260.71
169_K332_D0.5240.70
170_M178_L0.5240.70
176_Q179_H0.5220.70
297_L341_F0.5210.70
173_A217_R0.5200.70
227_M230_I0.5200.70
309_A347_R0.5180.69
147_S208_D0.5170.69
58_E134_E0.5150.69
145_S151_L0.5140.69
173_A300_P0.5140.69
216_G274_D0.5140.69
231_V262_T0.5140.69
68_P339_G0.5120.69
191_L237_E0.5120.69
267_L288_L0.5120.69
236_R276_A0.5110.68
171_M222_F0.5090.68
106_K170_M0.5090.68
338_A341_F0.5090.68
221_Q225_Y0.5070.68
64_L346_H0.5060.68
168_K218_D0.5060.68
255_W258_A0.5050.67
33_L62_Q0.5050.67
24_W328_G0.5050.67
163_A330_H0.5050.67
21_T345_V0.5050.67
182_L222_F0.5040.67
252_G259_M0.5040.67
208_D219_Y0.5040.67
325_L328_G0.5030.67
275_I311_I0.5030.67
257_E261_E0.5030.67
60_T63_P0.5030.67
172_Y222_F0.5020.67
118_E195_A0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r3sA 2 0.9915 100 0.191 Contact Map
2infA 2 0.9718 100 0.194 Contact Map
4zr8A 2 0.9887 100 0.196 Contact Map
4wshA 2 0.9887 100 0.213 Contact Map
1j93A 2 0.9661 100 0.221 Contact Map
4exqA 2 0.9774 100 0.223 Contact Map
2ejaA 2 0.952 100 0.236 Contact Map
4ay7A 1 0.9209 100 0.28 Contact Map
1u1jA 1 0.8898 99.9 0.698 Contact Map
3rpdA 1 0.8588 99.9 0.708 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.