GREMLIN Database
MENC - o-succinylbenzoate synthase
UniProt: P29208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11532
Length: 320 (296)
Sequences: 9224 (5842)
Seq/√Len: 339.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_A230_R3.7591.00
103_N310_V3.6301.00
39_R94_L3.2641.00
35_R40_E2.9311.00
167_T170_K2.9141.00
33_C40_E2.9061.00
195_T198_D2.9031.00
122_A152_A2.8441.00
54_E65_A2.7751.00
175_A189_L2.5551.00
200_R204_R2.5091.00
88_S243_E2.5021.00
175_A206_T2.4281.00
201_A204_R2.4171.00
172_Q205_E2.4151.00
176_K179_N2.4061.00
239_T248_Q2.3941.00
118_I152_A2.2491.00
179_N207_G2.2441.00
224_V257_L2.1871.00
39_R98_L2.1831.00
147_N184_D2.1641.00
157_H187_A2.1591.00
201_A205_E2.1411.00
221_F225_A2.1211.00
113_D116_D2.1151.00
143_G177_Y2.0761.00
307_T312_E2.0681.00
200_R226_E2.0401.00
197_D226_E2.0211.00
114_P118_I1.9861.00
225_A255_L1.9731.00
148_L151_E1.8931.00
105_R128_K1.8901.00
177_Y183_R1.8481.00
168_P201_A1.8441.00
144_M147_N1.7961.00
222_A226_E1.7911.00
88_S92_A1.7901.00
174_F178_V1.7781.00
193_C202_F1.7731.00
147_N151_E1.7441.00
130_A156_L1.7401.00
168_P202_F1.7271.00
179_N208_I1.7171.00
244_K247_E1.7091.00
34_L91_L1.6841.00
18_V23_R1.6841.00
138_E141_R1.6661.00
116_D119_L1.6531.00
58_E61_S1.6391.00
279_A313_V1.6301.00
95_T99_P1.6231.00
179_N183_R1.6041.00
246_R250_Q1.5931.00
39_R97_T1.5861.00
147_N183_R1.5501.00
141_R144_M1.5451.00
143_G184_D1.5391.00
33_C42_W1.5381.00
160_L186_I1.5331.00
159_R187_A1.5311.00
133_K163_N1.5301.00
55_T58_E1.5021.00
45_I86_G1.4971.00
153_I158_L1.4941.00
245_V277_I1.4931.00
119_L123_D1.4861.00
222_A225_A1.4831.00
224_V251_A1.4791.00
211_A231_A1.4711.00
32_V86_G1.4681.00
250_Q253_H1.4591.00
146_V184_D1.4481.00
103_N312_E1.4391.00
92_A243_E1.4061.00
247_E253_H1.4011.00
172_Q202_F1.3971.00
112_G116_D1.3931.00
223_F229_V1.3881.00
54_E58_E1.3821.00
193_C198_D1.3791.00
121_L153_I1.3591.00
143_G147_N1.3561.00
93_E97_T1.3491.00
135_G142_D1.3471.00
119_L122_A1.3461.00
211_A233_V1.3451.00
132_V149_L1.3381.00
57_E98_L1.3291.00
253_H282_T1.3251.00
37_G98_L1.3221.00
118_I151_E1.3001.00
89_C273_Q1.2941.00
176_K207_G1.2821.00
221_F251_A1.2601.00
224_V255_L1.2501.00
236_P245_V1.2461.00
107_A110_C1.2341.00
118_I122_A1.2281.00
247_E250_Q1.2201.00
173_Q177_Y1.2171.00
150_L158_L1.2151.00
176_K205_E1.2131.00
62_V66_W1.2071.00
150_L185_R1.1991.00
251_A254_A1.1961.00
239_T245_V1.1951.00
251_A255_L1.1911.00
234_I245_V1.1911.00
148_L152_A1.1851.00
203_A227_E1.1821.00
191_E233_V1.1751.00
198_D201_A1.1701.00
54_E61_S1.1681.00
302_R316_L1.1631.00
31_Y42_W1.1631.00
66_W84_A1.1611.00
129_V159_R1.1601.00
197_D222_A1.1531.00
31_Y269_L1.1511.00
153_I156_L1.1501.00
57_E95_T1.1501.00
115_D119_L1.1491.00
54_E62_V1.1491.00
150_L155_D1.1471.00
172_Q201_A1.1411.00
246_R280_W1.1401.00
118_I153_I1.1371.00
105_R310_V1.1321.00
173_Q176_K1.1291.00
166_W174_F1.1281.00
212_W223_F1.1251.00
166_W189_L1.1241.00
232_V252_A1.1211.00
162_A189_L1.1111.00
224_V232_V1.1081.00
144_M148_L1.1051.00
146_V160_L1.1031.00
168_P198_D1.0971.00
63_L67_V1.0861.00
16_G23_R1.0851.00
120_K123_D1.0841.00
146_V178_V1.0751.00
140_V144_M1.0741.00
143_G183_R1.0731.00
221_F255_L1.0581.00
121_L130_A1.0561.00
114_P148_L1.0551.00
249_V281_L1.0511.00
179_N206_T1.0491.00
229_V232_V1.0331.00
217_R220_D1.0241.00
139_A174_F1.0181.00
60_Q64_L1.0181.00
212_W229_V1.0171.00
186_I208_I1.0161.00
57_E99_P1.0151.00
35_R42_W1.0091.00
42_W269_L1.0081.00
61_S65_A1.0001.00
149_L153_I0.9881.00
170_K173_Q0.9851.00
108_P124_M0.9801.00
62_V65_A0.9731.00
134_V162_A0.9671.00
193_C199_S0.9671.00
114_P144_M0.9621.00
94_L98_L0.9551.00
64_L67_V0.9541.00
162_A166_W0.9521.00
119_L152_A0.9491.00
106_A109_L0.9461.00
48_L52_S0.9431.00
41_G90_A0.9411.00
306_S311_V0.9381.00
227_E257_L0.9311.00
132_V146_V0.9281.00
199_S212_W0.9191.00
202_F210_I0.9181.00
140_V177_Y0.9161.00
60_Q247_E0.9151.00
43_G86_G0.9131.00
312_E315_A0.9121.00
35_R38_E0.9121.00
106_A110_C0.9111.00
159_R188_F0.9061.00
47_P51_F0.9041.00
99_P102_A0.9031.00
168_P172_Q0.9031.00
233_V262_S0.9021.00
115_D118_I0.8951.00
69_N75_C0.8951.00
168_P193_C0.8911.00
216_L223_F0.8851.00
59_A95_T0.8841.00
236_P274_L0.8801.00
129_V157_H0.8801.00
134_V166_W0.8801.00
234_I259_A0.8741.00
201_A227_E0.8731.00
95_T98_L0.8731.00
108_P127_E0.8711.00
48_L51_F0.8701.00
96_D99_P0.8691.00
142_D166_W0.8661.00
118_I148_L0.8611.00
171_G202_F0.8601.00
213_D235_K0.8551.00
200_R228_G0.8551.00
103_N308_L0.8541.00
121_L149_L0.8491.00
111_N117_L0.8461.00
216_L220_D0.8381.00
58_E62_V0.8351.00
51_F54_E0.8351.00
139_A143_G0.8351.00
263_S266_E0.8271.00
192_P210_I0.8211.00
275_A313_V0.8201.00
292_L295_M0.8191.00
279_A314_D0.8181.00
275_A311_V0.8171.00
89_C242_L0.8161.00
91_L95_T0.8141.00
196_R223_F0.8131.00
196_R228_G0.8111.00
128_K308_L0.7991.00
141_R145_V0.7991.00
307_T310_V0.7971.00
291_T294_L0.7971.00
305_G312_E0.7961.00
197_D200_R0.7951.00
63_L66_W0.7921.00
235_K263_S0.7911.00
242_L273_Q0.7891.00
258_T285_T0.7851.00
278_A287_P0.7821.00
169_L173_Q0.7801.00
47_P54_E0.7711.00
34_L51_F0.7691.00
41_G93_E0.7691.00
191_E213_D0.7691.00
118_I121_L0.7631.00
112_G120_K0.7621.00
60_Q246_R0.7591.00
191_E215_S0.7561.00
196_R226_E0.7561.00
203_A210_I0.7511.00
36_E98_L0.7471.00
130_A153_I0.7461.00
246_R281_L0.7461.00
96_D101_A0.7440.99
187_A209_A0.7440.99
277_I280_W0.7400.99
172_Q176_K0.7390.99
232_V257_L0.7350.99
242_L246_R0.7300.99
51_F62_V0.7260.99
206_T210_I0.7220.99
199_S202_F0.7180.99
197_D225_A0.7160.99
268_S300_V0.7160.99
121_L152_A0.7150.99
102_A276_R0.7110.99
105_R157_H0.7110.99
122_A153_I0.7110.99
150_L184_D0.7060.99
298_Q302_R0.7060.99
36_E39_R0.7060.99
260_V286_I0.7050.99
117_L145_V0.7010.99
293_D296_Q0.7010.99
116_D120_K0.6990.99
175_A208_I0.6980.99
252_A259_A0.6940.99
196_R222_A0.6920.99
172_Q206_T0.6910.99
110_C124_M0.6900.99
89_C237_T0.6890.99
272_T276_R0.6870.99
47_P66_W0.6860.99
290_D294_L0.6860.99
134_V160_L0.6850.99
204_R227_E0.6840.99
176_K183_R0.6840.99
164_R215_S0.6790.99
143_G178_V0.6780.99
266_E270_G0.6760.99
252_A257_L0.6750.99
47_P59_A0.6700.99
32_V87_V0.6670.99
150_L154_P0.6660.99
147_N177_Y0.6630.99
15_A120_K0.6620.99
160_L178_V0.6600.99
171_G193_C0.6590.99
196_R199_S0.6560.99
155_D185_R0.6530.99
146_V186_I0.6530.99
112_G117_L0.6520.99
199_S210_I0.6480.99
51_F55_T0.6460.99
242_L277_I0.6440.99
36_E56_W0.6420.99
292_L296_Q0.6390.98
59_A63_L0.6390.98
172_Q175_A0.6390.98
52_S55_T0.6380.98
206_T230_R0.6370.98
80_M84_A0.6350.98
50_G54_E0.6310.98
30_L60_Q0.6310.98
272_T275_A0.6290.98
114_P117_L0.6290.98
50_G65_A0.6290.98
45_I82_S0.6280.98
120_K124_M0.6260.98
143_G174_F0.6200.98
262_S266_E0.6160.98
107_A159_R0.6160.98
47_P52_S0.6110.98
249_V259_A0.6080.98
237_T264_S0.6080.98
203_A228_G0.6070.98
128_K310_V0.6060.98
103_N307_T0.6060.98
89_C269_L0.6050.98
139_A177_Y0.6050.98
171_G175_A0.6040.98
304_P311_V0.6030.98
244_K248_Q0.5990.98
85_F89_C0.5980.98
191_E214_E0.5970.98
46_S266_E0.5960.98
174_F177_Y0.5960.98
20_R165_A0.5950.98
106_A311_V0.5950.98
59_A62_V0.5950.98
298_Q301_R0.5950.98
262_S265_I0.5950.98
133_K161_D0.5920.98
250_Q254_A0.5920.98
236_P277_I0.5910.97
268_S298_Q0.5910.97
109_L133_K0.5900.97
98_L101_A0.5900.97
290_D293_D0.5880.97
177_Y184_D0.5870.97
88_S241_S0.5870.97
129_V187_A0.5860.97
92_A242_L0.5850.97
278_A284_D0.5840.97
188_F260_V0.5840.97
51_F63_L0.5800.97
209_A231_A0.5800.97
93_E102_A0.5800.97
53_Q62_V0.5800.97
54_E59_A0.5770.97
171_G189_L0.5760.97
97_T316_L0.5760.97
168_P195_T0.5750.97
91_L94_L0.5740.97
56_W94_L0.5740.97
117_L121_L0.5740.97
150_L156_L0.5720.97
149_L152_A0.5720.97
235_K262_S0.5720.97
19_L22_R0.5710.97
186_I189_L0.5700.97
290_D295_M0.5700.97
47_P63_L0.5700.97
47_P55_T0.5690.97
233_V260_V0.5690.97
50_G62_V0.5680.97
140_V173_Q0.5660.97
276_R280_W0.5650.97
104_Y109_L0.5650.97
56_W60_Q0.5640.97
297_A301_R0.5640.97
92_A246_R0.5630.97
136_L142_D0.5630.97
128_K156_L0.5620.97
291_T295_M0.5610.97
134_V142_D0.5600.97
142_D145_V0.5590.96
44_E269_L0.5570.96
82_S238_L0.5550.96
115_D148_L0.5550.96
164_R191_E0.5540.96
111_N120_K0.5540.96
92_A96_D0.5510.96
175_A210_I0.5510.96
81_P84_A0.5510.96
145_V149_L0.5500.96
188_F231_A0.5500.96
281_L284_D0.5500.96
143_G146_V0.5480.96
121_L124_M0.5470.96
100_Q317_E0.5460.96
95_T101_A0.5450.96
240_G244_K0.5440.96
121_L148_L0.5420.96
197_D201_A0.5390.96
114_P141_R0.5370.96
44_E267_S0.5370.96
173_Q185_R0.5370.96
118_I149_L0.5360.96
249_V253_H0.5300.95
290_D296_Q0.5290.95
140_V155_D0.5290.95
114_P121_L0.5270.95
262_S288_G0.5270.95
299_Q302_R0.5260.95
50_G55_T0.5260.95
232_V248_Q0.5260.95
51_F66_W0.5240.95
132_V145_V0.5230.95
13_M16_G0.5200.95
63_L88_S0.5190.95
21_D164_R0.5170.95
169_L172_Q0.5170.95
61_S64_L0.5170.95
60_Q63_L0.5160.95
13_M27_R0.5160.95
213_D233_V0.5160.95
177_Y185_R0.5160.95
139_A170_K0.5160.95
77_L80_M0.5140.94
40_E97_T0.5140.94
178_V184_D0.5130.94
170_K174_F0.5110.94
62_V91_L0.5110.94
258_T282_T0.5110.94
199_S228_G0.5100.94
243_E246_R0.5080.94
87_V91_L0.5080.94
29_G267_S0.5070.94
242_L245_V0.5070.94
46_S78_P0.5060.94
272_T304_P0.5030.94
135_G165_A0.5030.94
163_N191_E0.5010.94
301_R316_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5sA 2 0.9875 100 0.187 Contact Map
3u9iA 2 0.9531 100 0.191 Contact Map
3ik4A 2 0.9875 100 0.202 Contact Map
3dgbA 5 0.9688 100 0.216 Contact Map
1r6wA 2 0.9875 100 0.217 Contact Map
3i6eA 4 0.9281 100 0.218 Contact Map
3fcpA 5 0.9219 100 0.221 Contact Map
2pgeA 1 0.9344 100 0.223 Contact Map
1r0mA 2 0.9187 100 0.226 Contact Map
3qldA 2 0.975 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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