MENC - ECOLI - GREMLIN Contacts

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MENC - o-succinylbenzoate synthase

UniProt:	P29208	Sequences: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELTDTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRDRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSTLPVVEVDALERLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11532
Length:	320 (296)
Sequences:	9224 (5842)
Seq/√Len:	339.5

ECOLI - MENC GUDD GUDX AEEP RHMD RSPA DGOD
BACSU - AEEP YITF GUDD MENC
HALSA - Q9HP25 Q9HS20 Q9HQN7
SULSO - GAD ARAD Q97YL9 Q97VG1 Q97YR3 Q97UK8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
203_A	230_R	3.759	1.00
103_N	310_V	3.630	1.00
39_R	94_L	3.264	1.00
35_R	40_E	2.931	1.00
167_T	170_K	2.914	1.00
33_C	40_E	2.906	1.00
195_T	198_D	2.903	1.00
122_A	152_A	2.844	1.00
54_E	65_A	2.775	1.00
175_A	189_L	2.555	1.00
200_R	204_R	2.509	1.00
88_S	243_E	2.502	1.00
175_A	206_T	2.428	1.00
201_A	204_R	2.417	1.00
172_Q	205_E	2.415	1.00
176_K	179_N	2.406	1.00
239_T	248_Q	2.394	1.00
118_I	152_A	2.249	1.00
179_N	207_G	2.244	1.00
224_V	257_L	2.187	1.00
39_R	98_L	2.183	1.00
147_N	184_D	2.164	1.00
157_H	187_A	2.159	1.00
201_A	205_E	2.141	1.00
221_F	225_A	2.121	1.00
113_D	116_D	2.115	1.00
143_G	177_Y	2.076	1.00
307_T	312_E	2.068	1.00
200_R	226_E	2.040	1.00
197_D	226_E	2.021	1.00
114_P	118_I	1.986	1.00
225_A	255_L	1.973	1.00
148_L	151_E	1.893	1.00
105_R	128_K	1.890	1.00
177_Y	183_R	1.848	1.00
168_P	201_A	1.844	1.00
144_M	147_N	1.796	1.00
222_A	226_E	1.791	1.00
88_S	92_A	1.790	1.00
174_F	178_V	1.778	1.00
193_C	202_F	1.773	1.00
147_N	151_E	1.744	1.00
130_A	156_L	1.740	1.00
168_P	202_F	1.727	1.00
179_N	208_I	1.717	1.00
244_K	247_E	1.709	1.00
34_L	91_L	1.684	1.00
18_V	23_R	1.684	1.00
138_E	141_R	1.666	1.00
116_D	119_L	1.653	1.00
58_E	61_S	1.639	1.00
279_A	313_V	1.630	1.00
95_T	99_P	1.623	1.00
179_N	183_R	1.604	1.00
246_R	250_Q	1.593	1.00
39_R	97_T	1.586	1.00
147_N	183_R	1.550	1.00
141_R	144_M	1.545	1.00
143_G	184_D	1.539	1.00
33_C	42_W	1.538	1.00
160_L	186_I	1.533	1.00
159_R	187_A	1.531	1.00
133_K	163_N	1.530	1.00
55_T	58_E	1.502	1.00
45_I	86_G	1.497	1.00
153_I	158_L	1.494	1.00
245_V	277_I	1.493	1.00
119_L	123_D	1.486	1.00
222_A	225_A	1.483	1.00
224_V	251_A	1.479	1.00
211_A	231_A	1.471	1.00
32_V	86_G	1.468	1.00
250_Q	253_H	1.459	1.00
146_V	184_D	1.448	1.00
103_N	312_E	1.439	1.00
92_A	243_E	1.406	1.00
247_E	253_H	1.401	1.00
172_Q	202_F	1.397	1.00
112_G	116_D	1.393	1.00
223_F	229_V	1.388	1.00
54_E	58_E	1.382	1.00
193_C	198_D	1.379	1.00
121_L	153_I	1.359	1.00
143_G	147_N	1.356	1.00
93_E	97_T	1.349	1.00
135_G	142_D	1.347	1.00
119_L	122_A	1.346	1.00
211_A	233_V	1.345	1.00
132_V	149_L	1.338	1.00
57_E	98_L	1.329	1.00
253_H	282_T	1.325	1.00
37_G	98_L	1.322	1.00
118_I	151_E	1.300	1.00
89_C	273_Q	1.294	1.00
176_K	207_G	1.282	1.00
221_F	251_A	1.260	1.00
224_V	255_L	1.250	1.00
236_P	245_V	1.246	1.00
107_A	110_C	1.234	1.00
118_I	122_A	1.228	1.00
247_E	250_Q	1.220	1.00
173_Q	177_Y	1.217	1.00
150_L	158_L	1.215	1.00
176_K	205_E	1.213	1.00
62_V	66_W	1.207	1.00
150_L	185_R	1.199	1.00
251_A	254_A	1.196	1.00
239_T	245_V	1.195	1.00
251_A	255_L	1.191	1.00
234_I	245_V	1.191	1.00
148_L	152_A	1.185	1.00
203_A	227_E	1.182	1.00
191_E	233_V	1.175	1.00
198_D	201_A	1.170	1.00
54_E	61_S	1.168	1.00
302_R	316_L	1.163	1.00
31_Y	42_W	1.163	1.00
66_W	84_A	1.161	1.00
129_V	159_R	1.160	1.00
197_D	222_A	1.153	1.00
31_Y	269_L	1.151	1.00
153_I	156_L	1.150	1.00
57_E	95_T	1.150	1.00
115_D	119_L	1.149	1.00
54_E	62_V	1.149	1.00
150_L	155_D	1.147	1.00
172_Q	201_A	1.141	1.00
246_R	280_W	1.140	1.00
118_I	153_I	1.137	1.00
105_R	310_V	1.132	1.00
173_Q	176_K	1.129	1.00
166_W	174_F	1.128	1.00
212_W	223_F	1.125	1.00
166_W	189_L	1.124	1.00
232_V	252_A	1.121	1.00
162_A	189_L	1.111	1.00
224_V	232_V	1.108	1.00
144_M	148_L	1.105	1.00
146_V	160_L	1.103	1.00
168_P	198_D	1.097	1.00
63_L	67_V	1.086	1.00
16_G	23_R	1.085	1.00
120_K	123_D	1.084	1.00
146_V	178_V	1.075	1.00
140_V	144_M	1.074	1.00
143_G	183_R	1.073	1.00
221_F	255_L	1.058	1.00
121_L	130_A	1.056	1.00
114_P	148_L	1.055	1.00
249_V	281_L	1.051	1.00
179_N	206_T	1.049	1.00
229_V	232_V	1.033	1.00
217_R	220_D	1.024	1.00
139_A	174_F	1.018	1.00
60_Q	64_L	1.018	1.00
212_W	229_V	1.017	1.00
186_I	208_I	1.016	1.00
57_E	99_P	1.015	1.00
35_R	42_W	1.009	1.00
42_W	269_L	1.008	1.00
61_S	65_A	1.000	1.00
149_L	153_I	0.988	1.00
170_K	173_Q	0.985	1.00
108_P	124_M	0.980	1.00
62_V	65_A	0.973	1.00
134_V	162_A	0.967	1.00
193_C	199_S	0.967	1.00
114_P	144_M	0.962	1.00
94_L	98_L	0.955	1.00
64_L	67_V	0.954	1.00
162_A	166_W	0.952	1.00
119_L	152_A	0.949	1.00
106_A	109_L	0.946	1.00
48_L	52_S	0.943	1.00
41_G	90_A	0.941	1.00
306_S	311_V	0.938	1.00
227_E	257_L	0.931	1.00
132_V	146_V	0.928	1.00
199_S	212_W	0.919	1.00
202_F	210_I	0.918	1.00
140_V	177_Y	0.916	1.00
60_Q	247_E	0.915	1.00
43_G	86_G	0.913	1.00
312_E	315_A	0.912	1.00
35_R	38_E	0.912	1.00
106_A	110_C	0.911	1.00
159_R	188_F	0.906	1.00
47_P	51_F	0.904	1.00
99_P	102_A	0.903	1.00
168_P	172_Q	0.903	1.00
233_V	262_S	0.902	1.00
115_D	118_I	0.895	1.00
69_N	75_C	0.895	1.00
168_P	193_C	0.891	1.00
216_L	223_F	0.885	1.00
59_A	95_T	0.884	1.00
236_P	274_L	0.880	1.00
129_V	157_H	0.880	1.00
134_V	166_W	0.880	1.00
234_I	259_A	0.874	1.00
201_A	227_E	0.873	1.00
95_T	98_L	0.873	1.00
108_P	127_E	0.871	1.00
48_L	51_F	0.870	1.00
96_D	99_P	0.869	1.00
142_D	166_W	0.866	1.00
118_I	148_L	0.861	1.00
171_G	202_F	0.860	1.00
213_D	235_K	0.855	1.00
200_R	228_G	0.855	1.00
103_N	308_L	0.854	1.00
121_L	149_L	0.849	1.00
111_N	117_L	0.846	1.00
216_L	220_D	0.838	1.00
58_E	62_V	0.835	1.00
51_F	54_E	0.835	1.00
139_A	143_G	0.835	1.00
263_S	266_E	0.827	1.00
192_P	210_I	0.821	1.00
275_A	313_V	0.820	1.00
292_L	295_M	0.819	1.00
279_A	314_D	0.818	1.00
275_A	311_V	0.817	1.00
89_C	242_L	0.816	1.00
91_L	95_T	0.814	1.00
196_R	223_F	0.813	1.00
196_R	228_G	0.811	1.00
128_K	308_L	0.799	1.00
141_R	145_V	0.799	1.00
307_T	310_V	0.797	1.00
291_T	294_L	0.797	1.00
305_G	312_E	0.796	1.00
197_D	200_R	0.795	1.00
63_L	66_W	0.792	1.00
235_K	263_S	0.791	1.00
242_L	273_Q	0.789	1.00
258_T	285_T	0.785	1.00
278_A	287_P	0.782	1.00
169_L	173_Q	0.780	1.00
47_P	54_E	0.771	1.00
34_L	51_F	0.769	1.00
41_G	93_E	0.769	1.00
191_E	213_D	0.769	1.00
118_I	121_L	0.763	1.00
112_G	120_K	0.762	1.00
60_Q	246_R	0.759	1.00
191_E	215_S	0.756	1.00
196_R	226_E	0.756	1.00
203_A	210_I	0.751	1.00
36_E	98_L	0.747	1.00
130_A	153_I	0.746	1.00
246_R	281_L	0.746	1.00
96_D	101_A	0.744	0.99
187_A	209_A	0.744	0.99
277_I	280_W	0.740	0.99
172_Q	176_K	0.739	0.99
232_V	257_L	0.735	0.99
242_L	246_R	0.730	0.99
51_F	62_V	0.726	0.99
206_T	210_I	0.722	0.99
199_S	202_F	0.718	0.99
197_D	225_A	0.716	0.99
268_S	300_V	0.716	0.99
121_L	152_A	0.715	0.99
102_A	276_R	0.711	0.99
105_R	157_H	0.711	0.99
122_A	153_I	0.711	0.99
150_L	184_D	0.706	0.99
298_Q	302_R	0.706	0.99
36_E	39_R	0.706	0.99
260_V	286_I	0.705	0.99
117_L	145_V	0.701	0.99
293_D	296_Q	0.701	0.99
116_D	120_K	0.699	0.99
175_A	208_I	0.698	0.99
252_A	259_A	0.694	0.99
196_R	222_A	0.692	0.99
172_Q	206_T	0.691	0.99
110_C	124_M	0.690	0.99
89_C	237_T	0.689	0.99
272_T	276_R	0.687	0.99
47_P	66_W	0.686	0.99
290_D	294_L	0.686	0.99
134_V	160_L	0.685	0.99
204_R	227_E	0.684	0.99
176_K	183_R	0.684	0.99
164_R	215_S	0.679	0.99
143_G	178_V	0.678	0.99
266_E	270_G	0.676	0.99
252_A	257_L	0.675	0.99
47_P	59_A	0.670	0.99
32_V	87_V	0.667	0.99
150_L	154_P	0.666	0.99
147_N	177_Y	0.663	0.99
15_A	120_K	0.662	0.99
160_L	178_V	0.660	0.99
171_G	193_C	0.659	0.99
196_R	199_S	0.656	0.99
155_D	185_R	0.653	0.99
146_V	186_I	0.653	0.99
112_G	117_L	0.652	0.99
199_S	210_I	0.648	0.99
51_F	55_T	0.646	0.99
242_L	277_I	0.644	0.99
36_E	56_W	0.642	0.99
292_L	296_Q	0.639	0.98
59_A	63_L	0.639	0.98
172_Q	175_A	0.639	0.98
52_S	55_T	0.638	0.98
206_T	230_R	0.637	0.98
80_M	84_A	0.635	0.98
50_G	54_E	0.631	0.98
30_L	60_Q	0.631	0.98
272_T	275_A	0.629	0.98
114_P	117_L	0.629	0.98
50_G	65_A	0.629	0.98
45_I	82_S	0.628	0.98
120_K	124_M	0.626	0.98
143_G	174_F	0.620	0.98
262_S	266_E	0.616	0.98
107_A	159_R	0.616	0.98
47_P	52_S	0.611	0.98
249_V	259_A	0.608	0.98
237_T	264_S	0.608	0.98
203_A	228_G	0.607	0.98
128_K	310_V	0.606	0.98
103_N	307_T	0.606	0.98
89_C	269_L	0.605	0.98
139_A	177_Y	0.605	0.98
171_G	175_A	0.604	0.98
304_P	311_V	0.603	0.98
244_K	248_Q	0.599	0.98
85_F	89_C	0.598	0.98
191_E	214_E	0.597	0.98
46_S	266_E	0.596	0.98
174_F	177_Y	0.596	0.98
20_R	165_A	0.595	0.98
106_A	311_V	0.595	0.98
59_A	62_V	0.595	0.98
298_Q	301_R	0.595	0.98
262_S	265_I	0.595	0.98
133_K	161_D	0.592	0.98
250_Q	254_A	0.592	0.98
236_P	277_I	0.591	0.97
268_S	298_Q	0.591	0.97
109_L	133_K	0.590	0.97
98_L	101_A	0.590	0.97
290_D	293_D	0.588	0.97
177_Y	184_D	0.587	0.97
88_S	241_S	0.587	0.97
129_V	187_A	0.586	0.97
92_A	242_L	0.585	0.97
278_A	284_D	0.584	0.97
188_F	260_V	0.584	0.97
51_F	63_L	0.580	0.97
209_A	231_A	0.580	0.97
93_E	102_A	0.580	0.97
53_Q	62_V	0.580	0.97
54_E	59_A	0.577	0.97
171_G	189_L	0.576	0.97
97_T	316_L	0.576	0.97
168_P	195_T	0.575	0.97
91_L	94_L	0.574	0.97
56_W	94_L	0.574	0.97
117_L	121_L	0.574	0.97
150_L	156_L	0.572	0.97
149_L	152_A	0.572	0.97
235_K	262_S	0.572	0.97
19_L	22_R	0.571	0.97
186_I	189_L	0.570	0.97
290_D	295_M	0.570	0.97
47_P	63_L	0.570	0.97
47_P	55_T	0.569	0.97
233_V	260_V	0.569	0.97
50_G	62_V	0.568	0.97
140_V	173_Q	0.566	0.97
276_R	280_W	0.565	0.97
104_Y	109_L	0.565	0.97
56_W	60_Q	0.564	0.97
297_A	301_R	0.564	0.97
92_A	246_R	0.563	0.97
136_L	142_D	0.563	0.97
128_K	156_L	0.562	0.97
291_T	295_M	0.561	0.97
134_V	142_D	0.560	0.97
142_D	145_V	0.559	0.96
44_E	269_L	0.557	0.96
82_S	238_L	0.555	0.96
115_D	148_L	0.555	0.96
164_R	191_E	0.554	0.96
111_N	120_K	0.554	0.96
92_A	96_D	0.551	0.96
175_A	210_I	0.551	0.96
81_P	84_A	0.551	0.96
145_V	149_L	0.550	0.96
188_F	231_A	0.550	0.96
281_L	284_D	0.550	0.96
143_G	146_V	0.548	0.96
121_L	124_M	0.547	0.96
100_Q	317_E	0.546	0.96
95_T	101_A	0.545	0.96
240_G	244_K	0.544	0.96
121_L	148_L	0.542	0.96
197_D	201_A	0.539	0.96
114_P	141_R	0.537	0.96
44_E	267_S	0.537	0.96
173_Q	185_R	0.537	0.96
118_I	149_L	0.536	0.96
249_V	253_H	0.530	0.95
290_D	296_Q	0.529	0.95
140_V	155_D	0.529	0.95
114_P	121_L	0.527	0.95
262_S	288_G	0.527	0.95
299_Q	302_R	0.526	0.95
50_G	55_T	0.526	0.95
232_V	248_Q	0.526	0.95
51_F	66_W	0.524	0.95
132_V	145_V	0.523	0.95
13_M	16_G	0.520	0.95
63_L	88_S	0.519	0.95
21_D	164_R	0.517	0.95
169_L	172_Q	0.517	0.95
61_S	64_L	0.517	0.95
60_Q	63_L	0.516	0.95
13_M	27_R	0.516	0.95
213_D	233_V	0.516	0.95
177_Y	185_R	0.516	0.95
139_A	170_K	0.516	0.95
77_L	80_M	0.514	0.94
40_E	97_T	0.514	0.94
178_V	184_D	0.513	0.94
170_K	174_F	0.511	0.94
62_V	91_L	0.511	0.94
258_T	282_T	0.511	0.94
199_S	228_G	0.510	0.94
243_E	246_R	0.508	0.94
87_V	91_L	0.508	0.94
29_G	267_S	0.507	0.94
242_L	245_V	0.507	0.94
46_S	78_P	0.506	0.94
272_T	304_P	0.503	0.94
135_G	165_A	0.503	0.94
163_N	191_E	0.501	0.94
301_R	316_L	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3s5sA	2	0.9875	100	0.187	Contact Map
3u9iA	2	0.9531	100	0.191	Contact Map
3ik4A	2	0.9875	100	0.202	Contact Map
3dgbA	5	0.9688	100	0.216	Contact Map
1r6wA	2	0.9875	100	0.217	Contact Map
3i6eA	4	0.9281	100	0.218	Contact Map
3fcpA	5	0.9219	100	0.221	Contact Map
2pgeA	1	0.9344	100	0.223	Contact Map
1r0mA	2	0.9187	100	0.226	Contact Map
3qldA	2	0.975	100	0.227	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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