GREMLIN Database
YCGB - Uncharacterized protein YcgB
UniProt: P29013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11516
Length: 510 (461)
Sequences: 683 (323)
Seq/√Len: 15.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
442_I457_L6.3221.00
392_K396_D6.2521.00
179_L478_V5.6961.00
42_D132_K5.1911.00
394_M425_I4.8011.00
354_E358_Y4.5141.00
157_I261_I4.3421.00
363_I371_T4.2371.00
114_T311_F3.9701.00
45_P101_N3.9291.00
175_S480_R3.7861.00
342_F372_L3.7501.00
367_D370_E3.5660.99
462_H466_P3.4440.99
35_V38_L3.2660.99
358_Y419_E3.2110.99
40_R370_E3.1030.98
57_M81_T3.0600.98
247_M262_L3.0570.98
373_H377_R3.0500.98
419_E424_E3.0220.98
175_S477_H2.9840.98
456_T489_E2.9090.97
38_L296_H2.8510.97
347_R396_D2.8200.97
346_K350_Q2.8110.97
164_Y168_E2.7790.97
285_W289_W2.7420.96
459_Y490_Q2.6430.95
31_E34_R2.5380.94
341_M345_I2.4830.94
366_S371_T2.4720.93
39_Y296_H2.4480.93
356_D363_I2.4210.93
319_V336_A2.4190.93
281_M345_I2.4080.92
35_V297_L2.4060.92
34_R38_L2.3940.92
153_A264_I2.3860.92
369_L373_H2.3710.92
40_R373_H2.3630.92
393_V396_D2.3540.92
379_F388_F2.3450.91
171_R480_R2.2910.90
445_W458_R2.2800.90
358_Y393_V2.2450.89
341_M393_V2.1380.87
371_T388_F2.0910.86
168_E171_R2.0720.85
336_A340_A2.0490.84
435_L439_E2.0410.84
288_F346_K2.0380.84
458_R489_E2.0380.84
35_V293_I1.9890.83
103_C128_N1.9730.82
332_I388_F1.9530.81
168_E173_L1.9510.81
279_Q438_L1.9450.81
157_I264_I1.9440.81
345_I348_I1.9390.81
129_S285_W1.9350.81
82_E86_K1.8880.79
87_H90_Q1.8810.79
311_F315_H1.8160.76
112_T261_I1.8000.76
114_T294_L1.7960.75
207_E211_S1.7880.75
342_F345_I1.7850.75
492_N495_G1.7500.73
107_L285_W1.7210.72
172_L258_Q1.7180.72
473_E476_K1.7020.71
457_L478_V1.6460.69
363_I388_F1.6100.67
129_S376_M1.6050.67
208_Y214_N1.6040.67
88_G248_E1.5870.66
243_L478_V1.5770.65
320_F328_W1.5760.65
29_L125_Y1.5630.65
27_V30_A1.5620.64
40_R369_L1.5570.64
218_R221_P1.5530.64
44_Y143_A1.5530.64
29_L120_M1.5450.64
156_Y260_E1.5450.64
306_R459_Y1.5300.63
35_V303_V1.5010.61
297_L464_R1.4970.61
244_L265_V1.4770.60
303_V307_F1.4560.59
385_I396_D1.4560.59
103_C246_F1.4520.59
40_R357_K1.4500.59
129_S289_W1.4480.58
443_Q460_I1.4400.58
172_L176_C1.4390.58
35_V296_H1.4130.56
403_L425_I1.4070.56
77_K474_V1.4010.56
255_E450_R1.3820.55
168_E258_Q1.3660.54
99_N275_Q1.3580.53
193_I200_A1.3450.53
168_E478_V1.3400.52
396_D399_F1.3380.52
336_A397_F1.3360.52
160_C260_E1.3340.52
244_L262_L1.3260.52
340_A397_F1.3220.51
346_K369_L1.3020.50
344_D348_I1.3020.50
119_V315_H1.3010.50
454_S487_M1.2890.50
269_S276_K1.2890.50
31_E302_K1.2890.50
19_D142_D1.2880.49
313_H410_Y1.2860.49
25_L107_L1.2790.49
33_D43_T1.2700.48
317_N386_S1.2670.48
68_N74_F1.2580.48
213_V216_L1.2440.47
356_D367_D1.2390.47
91_G314_S1.2370.47
352_P355_E1.2360.47
119_V314_S1.2330.46
158_T474_V1.2330.46
88_G259_R1.2330.46
291_Y315_H1.2240.46
30_A498_E1.2230.46
315_H402_V1.2210.46
394_M399_F1.2110.45
61_S320_F1.2070.45
363_I367_D1.2020.45
83_R87_H1.1960.44
45_P319_V1.1950.44
129_S373_H1.1910.44
68_N268_V1.1870.44
262_L380_K1.1770.43
391_P395_R1.1720.43
120_M399_F1.1710.43
285_W376_M1.1700.43
292_T295_N1.1690.43
39_Y289_W1.1680.43
23_D50_V1.1660.43
136_L380_K1.1630.43
281_M342_F1.1580.42
126_G187_Y1.1550.42
53_S316_T1.1440.41
70_P154_R1.1420.41
371_T375_A1.1410.41
245_Y248_E1.1370.41
236_P285_W1.1350.41
19_D434_N1.1310.41
83_R276_K1.1300.41
48_I119_V1.1300.41
192_K293_I1.1270.41
80_E287_T1.1210.40
233_R388_F1.1210.40
77_K490_Q1.1190.40
340_A343_Q1.1180.40
426_R430_S1.1040.39
233_R237_S1.1040.39
29_L33_D1.1030.39
248_E259_R1.1020.39
226_E229_V1.0950.39
341_M426_R1.0940.39
47_Q73_S1.0930.39
344_D347_R1.0920.39
51_I116_Q1.0860.38
252_P316_T1.0800.38
353_T356_D1.0800.38
44_Y103_C1.0790.38
373_H376_M1.0760.38
173_L244_L1.0710.38
233_R357_K1.0710.38
176_C380_K1.0700.37
107_L289_W1.0670.37
258_Q463_N1.0660.37
34_R37_K1.0660.37
138_R357_K1.0580.37
369_L372_L1.0570.37
119_V380_K1.0550.37
198_E201_R1.0530.37
251_A254_L1.0510.36
54_E186_R1.0470.36
68_N328_W1.0450.36
358_Y463_N1.0440.36
136_L452_D1.0370.36
225_E229_V1.0370.36
215_M287_T1.0360.36
77_K158_T1.0330.36
176_C235_Y1.0300.35
46_H128_N1.0280.35
223_R444_I1.0270.35
306_R331_G1.0260.35
96_I279_Q1.0240.35
351_S358_Y1.0240.35
247_M481_L1.0180.35
240_Q313_H1.0160.35
82_E340_A1.0150.35
278_T311_F1.0140.35
172_L411_L1.0130.35
244_L266_R1.0110.34
362_D388_F1.0090.34
25_L478_V1.0040.34
332_I358_Y1.0040.34
133_N430_S1.0040.34
131_F275_Q1.0040.34
88_G319_V1.0030.34
199_K498_E0.9920.33
489_E496_S0.9810.33
288_F368_W0.9780.33
204_S444_I0.9740.33
143_A146_I0.9710.32
65_M76_K0.9700.32
126_G344_D0.9660.32
40_R113_I0.9660.32
61_S269_S0.9650.32
302_K427_N0.9630.32
23_D362_D0.9560.32
91_G119_V0.9510.31
281_M384_F0.9500.31
77_K276_K0.9430.31
56_M271_Y0.9430.31
28_Y32_I0.9400.31
154_R386_S0.9390.31
366_S370_E0.9390.31
186_R189_R0.9380.31
99_N131_F0.9360.31
39_Y261_I0.9350.31
54_E297_L0.9320.31
19_D191_Q0.9310.30
52_T341_M0.9270.30
356_D359_W0.9260.30
33_D293_I0.9220.30
117_A307_F0.9200.30
47_Q59_A0.9200.30
196_Q220_L0.9190.30
386_S393_V0.9170.30
68_N478_V0.9130.30
159_E228_T0.9130.30
19_D459_Y0.9120.30
35_V393_V0.9090.29
388_F494_D0.9090.29
91_G120_M0.9080.29
294_L303_V0.9050.29
337_L498_E0.9010.29
261_I438_L0.9000.29
317_N397_F0.8970.29
71_H75_G0.8970.29
332_I403_L0.8940.29
228_T446_N0.8920.29
113_I303_V0.8890.29
117_A436_S0.8890.29
274_P290_H0.8890.29
56_M60_Y0.8890.29
80_E279_Q0.8870.28
46_H105_A0.8860.28
70_P471_R0.8850.28
183_G347_R0.8840.28
206_E309_L0.8830.28
319_V403_L0.8810.28
105_A285_W0.8780.28
472_K478_V0.8780.28
109_E442_I0.8760.28
99_N278_T0.8760.28
67_I476_K0.8750.28
213_V253_L0.8740.28
133_N438_L0.8730.28
374_F434_N0.8730.28
399_F488_L0.8700.28
196_Q351_S0.8680.28
269_S400_F0.8680.28
363_I366_S0.8670.28
51_I331_G0.8660.27
223_R231_E0.8650.27
19_D29_L0.8630.27
206_E419_E0.8630.27
112_T418_N0.8590.27
119_V277_Q0.8520.27
24_L147_V0.8510.27
89_Q279_Q0.8500.27
36_A165_G0.8500.27
343_Q386_S0.8470.27
486_V494_D0.8450.27
304_T398_R0.8440.27
246_F271_Y0.8420.26
106_Y116_Q0.8420.26
131_F279_Q0.8400.26
289_W376_M0.8400.26
157_I476_K0.8400.26
53_S458_R0.8350.26
45_P337_L0.8300.26
67_I342_F0.8280.26
229_V304_T0.8250.26
319_V391_P0.8220.26
63_V240_Q0.8220.26
73_S100_S0.8200.25
438_L490_Q0.8190.25
63_V68_N0.8180.25
168_E255_E0.8170.25
229_V478_V0.8150.25
356_D397_F0.8150.25
294_L308_M0.8130.25
322_P481_L0.8120.25
52_T495_G0.8110.25
199_K225_E0.8100.25
193_I226_E0.8080.25
209_L212_Q0.8020.25
353_T396_D0.7990.25
23_D26_D0.7990.25
233_R424_E0.7980.25
158_T428_R0.7980.25
48_I87_H0.7950.24
440_P467_L0.7940.24
94_Y275_Q0.7920.24
342_F436_S0.7880.24
51_I65_M0.7880.24
21_T434_N0.7870.24
215_M483_G0.7870.24
479_H490_Q0.7860.24
332_I399_F0.7860.24
80_E216_L0.7850.24
25_L61_S0.7830.24
37_K203_K0.7820.24
361_P365_G0.7770.24
209_L213_V0.7760.24
227_K243_L0.7750.24
455_L475_L0.7720.23
222_K225_E0.7700.23
44_Y74_F0.7690.23
367_D480_R0.7690.23
88_G428_R0.7670.23
349_C363_I0.7670.23
275_Q278_T0.7660.23
342_F419_E0.7660.23
194_S331_G0.7640.23
50_V394_M0.7630.23
74_F354_E0.7600.23
145_S413_I0.7590.23
195_L495_G0.7570.23
256_S478_V0.7550.23
247_M491_Q0.7550.23
442_I478_V0.7550.23
267_K379_F0.7540.23
314_S380_K0.7510.23
50_V362_D0.7450.22
229_V261_I0.7440.22
403_L464_R0.7440.22
346_K368_W0.7440.22
101_N222_K0.7420.22
133_N302_K0.7420.22
344_D395_R0.7410.22
276_K438_L0.7410.22
170_E174_D0.7400.22
45_P255_E0.7350.22
70_P434_N0.7340.22
465_A492_N0.7340.22
468_D471_R0.7330.22
211_S386_S0.7330.22
231_E316_T0.7320.22
320_F403_L0.7310.22
227_K309_L0.7310.22
35_V302_K0.7290.22
35_V39_Y0.7280.22
35_V112_T0.7280.22
63_V343_Q0.7260.22
132_K258_Q0.7250.22
373_H490_Q0.7230.22
493_E498_E0.7230.22
354_E357_K0.7190.21
430_S475_L0.7190.21
99_N279_Q0.7170.21
230_A351_S0.7170.21
28_Y117_A0.7150.21
192_K195_L0.7140.21
321_Q385_I0.7130.21
222_K230_A0.7090.21
171_R175_S0.7070.21
157_I311_F0.7070.21
223_R465_A0.7060.21
287_T340_A0.7050.21
252_P451_G0.7040.21
402_V413_I0.7030.21
457_L488_L0.7020.21
36_A43_T0.7010.21
197_E203_K0.7010.21
199_K224_E0.7010.21
222_K243_L0.7000.21
181_N439_E0.7000.21
351_S494_D0.7000.21
277_Q437_N0.6950.21
87_H319_V0.6950.21
262_L463_N0.6940.20
316_T474_V0.6940.20
250_N435_L0.6940.20
261_I412_E0.6930.20
357_K365_G0.6920.20
77_K83_R0.6900.20
207_E227_K0.6890.20
39_Y297_L0.6890.20
61_S358_Y0.6880.20
155_K158_T0.6870.20
328_W464_R0.6870.20
39_Y377_R0.6870.20
61_S485_D0.6860.20
74_F258_Q0.6860.20
279_Q435_L0.6860.20
428_R463_N0.6820.20
141_T275_Q0.6820.20
167_D496_S0.6780.20
247_M478_V0.6780.20
67_I386_S0.6770.20
37_K200_A0.6750.20
409_N412_E0.6740.20
94_Y131_F0.6740.20
77_K80_E0.6710.20
276_K435_L0.6700.20
232_A329_Y0.6680.20
448_D451_G0.6640.19
31_E57_M0.6640.19
289_W484_F0.6630.19
133_N373_H0.6620.19
458_R491_Q0.6610.19
346_K366_S0.6610.19
479_H495_G0.6600.19
87_H434_N0.6570.19
154_R268_V0.6570.19
275_Q279_Q0.6560.19
69_Y275_Q0.6550.19
220_L444_I0.6550.19
332_I351_S0.6540.19
110_E356_D0.6530.19
158_T463_N0.6520.19
196_Q425_I0.6480.19
104_I128_N0.6470.19
258_Q474_V0.6470.19
359_W365_G0.6470.19
231_E407_R0.6460.19
244_L251_A0.6460.19
52_T154_R0.6460.19
120_M486_V0.6450.19
77_K373_H0.6450.19
51_I382_E0.6440.19
105_A175_S0.6430.19
64_G71_H0.6420.19
276_K439_E0.6420.19
70_P151_I0.6410.19
226_E231_E0.6400.19
262_L474_V0.6400.19
434_N437_N0.6400.19
462_H491_Q0.6390.19
143_A318_V0.6390.19
207_E408_H0.6380.18
292_T369_L0.6380.18
24_L113_I0.6370.18
196_Q480_R0.6360.18
392_K429_L0.6350.18
208_Y213_V0.6350.18
153_A267_K0.6340.18
52_T112_T0.6330.18
100_S318_V0.6320.18
407_R428_R0.6310.18
153_A291_Y0.6310.18
349_C371_T0.6310.18
218_R244_L0.6290.18
128_N382_E0.6290.18
370_E373_H0.6290.18
19_D145_S0.6290.18
28_Y50_V0.6290.18
173_L265_V0.6280.18
37_K492_N0.6280.18
220_L261_I0.6270.18
50_V429_L0.6240.18
88_G110_E0.6230.18
276_K313_H0.6220.18
146_I271_Y0.6180.18
221_P248_E0.6160.18
85_Y98_I0.6150.18
52_T63_V0.6140.18
171_R471_R0.6140.18
177_H421_G0.6140.18
110_E150_L0.6140.18
385_I498_E0.6120.18
34_R179_L0.6120.18
413_I421_G0.6120.18
89_Q446_N0.6110.18
32_I113_I0.6110.18
114_T313_H0.6100.18
474_V478_V0.6100.18
304_T497_I0.6090.18
21_T164_Y0.6090.18
105_A374_F0.6060.17
487_M493_E0.6040.17
212_Q385_I0.6040.17
142_D145_S0.6030.17
125_Y285_W0.6030.17
190_P396_D0.6010.17
91_G380_K0.6010.17
211_S478_V0.6000.17
361_P367_D0.5980.17
357_K363_I0.5980.17
194_S243_L0.5980.17
142_D237_S0.5970.17
173_L410_Y0.5960.17
223_R233_R0.5960.17
198_E245_Y0.5950.17
363_I474_V0.5950.17
173_L186_R0.5950.17
291_Y339_F0.5940.17
145_S484_F0.5930.17
355_E360_F0.5930.17
358_Y407_R0.5930.17
350_Q366_S0.5930.17
419_E463_N0.5930.17
67_I154_R0.5920.17
129_S133_N0.5910.17
239_P389_L0.5910.17
73_S108_M0.5910.17
231_E234_R0.5900.17
207_E234_R0.5900.17
252_P450_R0.5870.17
27_V448_D0.5870.17
403_L407_R0.5860.17
84_L89_Q0.5840.17
211_S232_A0.5830.17
154_R328_W0.5830.17
26_D171_R0.5830.17
446_N489_E0.5820.17
362_D492_N0.5810.17
252_P356_D0.5790.17
48_I67_I0.5770.17
243_L370_E0.5760.16
67_I303_V0.5760.16
249_K264_I0.5760.16
65_M73_S0.5750.16
88_G91_G0.5750.16
19_D195_L0.5750.16
123_A242_N0.5740.16
244_L451_G0.5740.16
163_R166_V0.5730.16
309_L319_V0.5720.16
209_L379_F0.5720.16
26_D120_M0.5720.16
196_Q230_A0.5720.16
211_S487_M0.5710.16
110_E349_C0.5710.16
407_R425_I0.5710.16
232_A354_E0.5700.16
216_L448_D0.5680.16
42_D377_R0.5680.16
349_C366_S0.5680.16
31_E172_L0.5680.16
302_K362_D0.5680.16
98_I275_Q0.5670.16
48_I402_V0.5650.16
227_K493_E0.5640.16
77_K306_R0.5640.16
48_I78_F0.5640.16
142_D493_E0.5610.16
150_L277_Q0.5610.16
79_I145_S0.5610.16
349_C367_D0.5600.16
57_M279_Q0.5600.16
77_K356_D0.5570.16
475_L478_V0.5570.16
52_T214_N0.5570.16
136_L315_H0.5560.16
181_N276_K0.5560.16
211_S306_R0.5540.16
189_R395_R0.5530.16
342_F441_N0.5530.16
313_H342_F0.5520.16
183_G191_Q0.5520.16
207_E369_L0.5510.16
321_Q347_R0.5510.16
225_E232_A0.5500.16
109_E331_G0.5500.16
332_I341_M0.5480.16
206_E256_S0.5480.16
44_Y128_N0.5470.16
39_Y285_W0.5470.16
261_I423_R0.5470.16
388_F478_V0.5460.16
46_H119_V0.5460.16
59_A100_S0.5460.16
236_P376_M0.5440.16
272_F290_H0.5440.16
129_S368_W0.5440.16
260_E263_R0.5440.16
37_K226_E0.5440.16
280_V368_W0.5430.15
99_N141_T0.5430.15
120_M276_K0.5410.15
244_L347_R0.5410.15
105_A172_L0.5410.15
356_D364_A0.5400.15
362_D371_T0.5390.15
209_L256_S0.5390.15
245_Y249_K0.5380.15
63_V292_T0.5380.15
105_A490_Q0.5380.15
399_F457_L0.5360.15
276_K465_A0.5360.15
21_T425_I0.5350.15
261_I468_D0.5350.15
132_K384_F0.5340.15
56_M69_Y0.5330.15
114_T188_K0.5330.15
370_E491_Q0.5330.15
413_I418_N0.5330.15
101_N223_R0.5320.15
66_P111_N0.5310.15
66_P72_W0.5310.15
84_L319_V0.5310.15
73_S109_E0.5310.15
412_E474_V0.5300.15
226_E424_E0.5300.15
276_K459_Y0.5290.15
183_G382_E0.5290.15
50_V229_V0.5280.15
287_T413_I0.5280.15
197_E231_E0.5280.15
153_A336_A0.5280.15
421_G484_F0.5280.15
130_F282_N0.5270.15
45_P318_V0.5270.15
129_S380_K0.5270.15
172_L309_L0.5260.15
341_M344_D0.5260.15
393_V419_E0.5260.15
93_A184_V0.5260.15
161_E321_Q0.5250.15
247_M388_F0.5240.15
226_E250_N0.5240.15
57_M85_Y0.5230.15
39_Y176_C0.5200.15
48_I398_R0.5200.15
69_Y99_N0.5200.15
82_E427_N0.5200.15
194_S221_P0.5200.15
276_K490_Q0.5190.15
31_E38_L0.5180.15
135_Y378_D0.5180.15
93_A117_A0.5170.15
224_E229_V0.5170.15
312_L419_E0.5170.15
133_N164_Y0.5160.15
27_V232_A0.5160.15
121_A246_F0.5160.15
207_E243_L0.5160.15
315_H332_I0.5150.15
204_S430_S0.5150.15
158_T425_I0.5150.15
142_D349_C0.5150.15
53_S161_E0.5150.15
40_R436_S0.5150.15
56_M146_I0.5140.15
348_I390_S0.5130.15
176_C262_L0.5130.15
227_K233_R0.5120.15
489_E494_D0.5120.15
231_E413_I0.5110.15
190_P194_S0.5110.15
363_I372_L0.5110.15
32_I91_G0.5110.15
437_N449_L0.5090.15
67_I399_F0.5080.14
27_V493_E0.5080.14
230_A460_I0.5080.14
340_A413_I0.5070.14
285_W307_F0.5060.14
239_P246_F0.5060.14
371_T374_F0.5050.14
105_A401_T0.5050.14
50_V235_Y0.5050.14
196_Q201_R0.5050.14
269_S388_F0.5050.14
233_R431_S0.5040.14
19_D79_I0.5040.14
57_M315_H0.5040.14
289_W454_S0.5030.14
153_A315_H0.5030.14
185_D316_T0.5030.14
167_D171_R0.5020.14
407_R420_E0.5020.14
245_Y337_L0.5020.14
54_E391_P0.5000.14
193_I479_H0.5000.14
253_L450_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u24A 1 0.549 55.7 0.982 Contact Map
4g54A 1 0.102 43.7 0.983 Contact Map
2r60A 1 0.2902 43.7 0.983 Contact Map
3rjoA 1 0.1039 42.6 0.983 Contact Map
2xvcA 1 0.1059 12.2 0.987 Contact Map
2o55A 1 0.198 10.3 0.987 Contact Map
2o3aA 2 0.1118 10.2 0.987 Contact Map
3hhhA 2 0.198 9.8 0.988 Contact Map
3nkqA 1 0.1275 9.4 0.988 Contact Map
2pz0A 2 0.2 9.3 0.988 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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