GREMLIN Database
ALR2 - Alanine racemase, catabolic
UniProt: P29012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11408
Length: 356 (346)
Sequences: 4892 (3623)
Seq/√Len: 194.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L232_V3.4331.00
158_S189_L3.3891.00
285_P292_R3.1351.00
250_R255_G2.9071.00
244_T264_R2.8321.00
177_E203_F2.7821.00
266_G308_L2.7621.00
16_Q230_R2.7291.00
239_I266_G2.6971.00
65_I94_H2.6801.00
192_S211_I2.6771.00
250_R258_T2.6751.00
246_K262_E2.6631.00
292_R331_D2.5761.00
321_E326_E2.5171.00
236_S319_P2.5081.00
265_I296_V2.4781.00
64_A96_L2.4561.00
21_V211_I2.4151.00
244_T262_E2.3901.00
29_R54_D2.2591.00
10_D13_A2.2531.00
91_Y98_T2.2521.00
256_R298_T2.2321.00
293_T311_C2.2261.00
8_S236_S2.2171.00
252_G300_S2.1741.00
257_Y263_Q2.1711.00
129_N249_E2.1711.00
31_W205_W2.0931.00
125_N129_N2.0801.00
245_L259_A2.0771.00
286_V306_V2.0501.00
237_S268_V2.0381.00
235_L270_A2.0341.00
33_V57_A2.0301.00
239_I314_A2.0111.00
173_M201_A2.0051.00
171_G175_R1.9701.00
247_A262_E1.9501.00
119_D152_G1.9401.00
215_A340_G1.9401.00
215_A344_M1.9341.00
261_D310_P1.9281.00
180_A187_R1.9231.00
289_D318_T1.8951.00
347_L351_V1.8681.00
276_Y322_L1.8451.00
20_I23_Q1.8311.00
329_I344_M1.8221.00
37_N349_L1.8071.00
44_E70_R1.8031.00
162_E255_G1.7981.00
16_Q20_I1.7921.00
182_G185_C1.7831.00
99_C157_M1.7631.00
133_F141_V1.7571.00
15_K49_A1.7361.00
32_S212_L1.7311.00
315_G318_T1.7151.00
6_Q236_S1.6561.00
246_K249_E1.6261.00
97_T154_M1.6231.00
246_K259_A1.6011.00
174_A178_Q1.5981.00
173_M203_F1.5821.00
107_K144_Q1.5781.00
18_L212_L1.5631.00
15_K51_G1.5581.00
242_V308_L1.5421.00
43_I66_T1.5331.00
110_Q148_M1.5221.00
277_P346_A1.5201.00
195_T208_P1.5201.00
121_Y188_S1.5151.00
330_D340_G1.4981.00
31_W57_A1.4971.00
124_V179_A1.4921.00
187_R204_D1.4871.00
288_V306_V1.4701.00
267_I305_A1.4611.00
162_E169_I1.4561.00
288_V293_T1.4461.00
34_V47_W1.4261.00
162_E165_H1.4221.00
13_A230_R1.4141.00
190_S201_A1.4021.00
287_L327_I1.4021.00
287_L321_E1.3891.00
14_L46_I1.3871.00
25_A28_A1.3851.00
7_A351_V1.3841.00
44_E66_T1.3831.00
300_S305_A1.3821.00
263_Q307_D1.3751.00
263_Q309_T1.3721.00
268_V304_L1.3711.00
56_F74_G1.3631.00
47_W67_L1.3511.00
284_T295_T1.3501.00
302_D350_R1.3441.00
233_M323_W1.3441.00
29_R55_G1.3341.00
95_R116_A1.3331.00
173_M177_E1.3151.00
117_P152_G1.2781.00
287_L326_E1.2761.00
256_R282_T1.2751.00
259_A263_Q1.2611.00
268_V320_V1.2591.00
119_D154_M1.2561.00
103_N144_Q1.2531.00
45_R48_S1.2511.00
103_N107_K1.2501.00
190_S202_H1.2471.00
249_E259_A1.2461.00
5_I270_A1.2301.00
41_H233_M1.2261.00
170_S200_E1.2251.00
31_W55_G1.2211.00
242_V316_I1.2181.00
163_A193_A1.2171.00
32_S53_T1.2151.00
16_Q228_G1.2071.00
135_P178_Q1.1851.00
7_A235_L1.1751.00
18_L53_T1.1741.00
45_R355_T1.1541.00
110_Q144_Q1.1461.00
11_L355_T1.1461.00
173_M189_L1.1331.00
18_L30_V1.1321.00
265_I305_A1.1311.00
170_S174_A1.1301.00
260_R263_Q1.1261.00
5_I237_S1.1241.00
276_Y332_V1.1241.00
107_K111_N1.1231.00
69_E94_H1.1221.00
190_S194_A1.1161.00
21_V208_P1.1151.00
256_R281_P1.1151.00
171_G174_A1.1131.00
245_L251_V1.1121.00
36_A273_A1.1021.00
14_L50_I1.1001.00
323_W329_I1.0981.00
175_R178_Q1.0951.00
235_L351_V1.0941.00
177_E181_E1.0901.00
287_L292_R1.0861.00
104_W316_I1.0841.00
20_I24_A1.0751.00
139_L182_G1.0731.00
165_H168_G1.0721.00
65_I69_E1.0691.00
238_E319_P1.0651.00
211_I229_L1.0641.00
239_I242_V1.0631.00
90_I94_H1.0601.00
285_P294_M1.0561.00
22_R54_D1.0531.00
50_I212_L1.0521.00
270_A322_L1.0501.00
308_L314_A1.0481.00
67_L72_W1.0471.00
78_M96_L1.0361.00
299_V304_L1.0361.00
276_Y295_T1.0351.00
110_Q150_N1.0321.00
97_T119_D1.0251.00
75_P97_T1.0241.00
55_G97_T1.0231.00
89_E93_Q1.0221.00
134_Q249_E1.0191.00
261_D309_T1.0171.00
286_V304_L1.0151.00
125_N243_Q1.0131.00
169_I198_H1.0111.00
106_L145_L1.0111.00
336_A343_L1.0001.00
11_L49_A0.9991.00
25_A202_H0.9891.00
239_I308_L0.9891.00
199_P202_H0.9770.99
7_A233_M0.9700.99
30_V208_P0.9670.99
236_S321_E0.9650.99
195_T206_V0.9620.99
324_G327_I0.9610.99
177_E200_E0.9600.99
123_K131_L0.9600.99
18_L50_I0.9550.99
328_K331_D0.9540.99
138_V179_A0.9530.99
44_E48_S0.9490.99
285_P335_A0.9470.99
241_G316_I0.9470.99
182_G186_R0.9420.99
100_V120_I0.9420.99
52_A74_G0.9400.99
239_I288_V0.9380.99
90_I93_Q0.9380.99
6_Q354_V0.9340.99
333_A338_T0.9310.99
263_Q296_V0.9280.99
293_T309_T0.9270.99
248_G259_A0.9160.99
308_L311_C0.9130.99
89_E113_R0.9080.99
19_S51_G0.9060.99
233_M347_L0.9040.99
32_S50_I0.9020.99
168_G197_W0.9010.99
268_V286_V0.9010.99
268_V306_V0.8960.99
131_L267_I0.8950.99
68_R76_I0.8940.99
100_V106_L0.8940.99
8_S354_V0.8920.99
245_L249_E0.8810.99
293_T306_V0.8790.99
279_H337_G0.8730.99
210_I341_Y0.8670.99
237_S269_A0.8650.99
135_P175_R0.8630.99
187_R203_F0.8620.99
55_G75_P0.8590.99
277_P336_A0.8560.99
55_G205_W0.8510.99
92_D118_L0.8480.98
131_L303_M0.8430.98
6_Q238_E0.8420.98
162_E168_G0.8420.98
5_I351_V0.8410.98
95_R119_D0.8360.98
279_H336_A0.8350.98
276_Y284_T0.8340.98
184_E187_R0.8330.98
327_I331_D0.8320.98
160_F189_L0.8310.98
162_E254_G0.8300.98
15_K19_S0.8290.98
42_G355_T0.8280.98
264_R313_Q0.8270.98
158_S203_F0.8250.98
261_D307_D0.8250.98
143_Q147_A0.8240.98
48_S70_R0.8230.98
289_D315_G0.8200.98
252_G305_A0.8190.98
306_V320_V0.8120.98
156_L180_A0.8080.98
288_V320_V0.8060.98
160_F194_A0.8050.98
289_D314_A0.8040.98
155_T188_S0.8040.98
208_P211_I0.8030.98
291_V311_C0.8020.98
18_L51_G0.8020.98
106_L141_V0.8020.98
129_N134_Q0.8020.98
11_L45_R0.8010.98
195_T202_H0.8010.98
293_T310_P0.8010.98
251_V305_A0.8010.98
68_R95_R0.7990.98
46_I50_I0.7970.98
251_V263_Q0.7950.98
121_Y155_T0.7920.98
193_A217_P0.7910.98
215_A329_I0.7890.98
280_A335_A0.7880.98
7_A347_L0.7870.98
46_I232_V0.7870.98
176_I187_R0.7860.97
124_V138_V0.7850.97
170_S198_H0.7850.97
314_A318_T0.7820.97
248_G262_E0.7820.97
240_I269_A0.7820.97
19_S52_A0.7820.97
291_V310_P0.7810.97
7_A41_H0.7790.97
21_V30_V0.7670.97
143_Q186_R0.7660.97
164_E254_G0.7650.97
67_L76_I0.7640.97
210_I215_A0.7620.97
120_I151_V0.7610.97
77_L121_Y0.7560.97
34_V56_F0.7520.97
251_V265_I0.7510.97
9_L232_V0.7460.97
219_G334_A0.7420.96
250_R259_A0.7420.96
144_Q148_M0.7420.96
288_V314_A0.7420.96
129_N245_L0.7420.96
33_V79_L0.7380.96
20_I228_G0.7350.96
278_R342_E0.7340.96
216_S227_T0.7330.96
137_R140_T0.7330.96
234_T321_E0.7320.96
173_M190_S0.7310.96
100_V109_L0.7300.96
104_W107_K0.7300.96
270_A304_L0.7290.96
286_V322_L0.7270.96
247_A260_R0.7270.96
78_M91_Y0.7260.96
278_R339_V0.7260.96
237_S304_L0.7250.96
210_I340_G0.7230.96
9_L355_T0.7200.96
103_N137_R0.7200.96
277_P343_L0.7190.96
10_D234_T0.7190.96
176_I189_L0.7180.96
11_L46_I0.7170.96
77_L97_T0.7160.96
47_W72_W0.7150.96
311_C314_A0.7150.96
259_A262_E0.7130.96
64_A94_H0.7130.96
280_A336_A0.7130.96
126_S172_A0.7100.95
138_V142_W0.7090.95
142_W183_L0.7090.95
61_L91_Y0.7060.95
193_A210_I0.7060.95
85_A108_A0.7060.95
124_V156_L0.7040.95
196_L227_T0.7030.95
57_A205_W0.7020.95
245_L265_I0.6990.95
87_D90_I0.6990.95
37_N43_I0.6940.95
84_H87_D0.6940.95
230_R325_K0.6930.95
323_W343_L0.6930.95
304_L322_L0.6930.95
22_R30_V0.6920.95
281_P284_T0.6920.95
92_D112_A0.6920.95
139_L143_Q0.6900.95
276_Y304_L0.6900.95
4_P238_E0.6890.95
331_D334_A0.6870.95
286_V320_V0.6870.95
82_F101_H0.6870.95
83_F98_T0.6840.94
319_P326_E0.6830.94
44_E72_W0.6760.94
329_I340_G0.6750.94
12_Q15_K0.6750.94
235_L347_L0.6730.94
13_A16_Q0.6730.94
73_K95_R0.6720.94
13_A229_L0.6650.94
106_L148_M0.6650.94
8_S234_T0.6640.94
50_I56_F0.6610.93
241_G267_I0.6590.93
283_G335_A0.6560.93
29_R205_W0.6540.93
101_H241_G0.6520.93
66_T349_L0.6510.93
189_L203_F0.6490.93
145_L153_E0.6430.92
43_I273_A0.6420.92
293_T314_A0.6400.92
104_W108_A0.6390.92
103_N140_T0.6390.92
61_L64_A0.6380.92
197_W218_S0.6370.92
285_P331_D0.6370.92
264_R310_P0.6370.92
291_V313_Q0.6360.92
134_Q243_Q0.6360.92
251_V296_V0.6340.92
235_L323_W0.6340.92
178_Q181_E0.6330.92
140_T143_Q0.6330.92
134_Q137_R0.6330.92
293_T308_L0.6300.92
280_A284_T0.6270.91
10_D325_K0.6250.91
28_A206_V0.6240.91
284_T335_A0.6230.91
55_G77_L0.6230.91
32_S56_F0.6190.91
34_V213_Y0.6170.91
76_I96_L0.6160.91
65_I90_I0.6150.91
183_L186_R0.6140.91
274_D350_R0.6130.91
144_Q147_A0.6120.90
242_V264_R0.6110.90
168_G198_H0.6110.90
19_S22_R0.6110.90
141_V145_L0.6100.90
160_F201_A0.6100.90
340_G344_M0.6100.90
16_Q19_S0.6090.90
251_V259_A0.6080.90
30_V206_V0.6070.90
181_E184_E0.6040.90
57_A79_L0.6000.90
260_R294_M0.5990.90
330_D334_A0.5990.90
338_T343_L0.5980.89
289_D313_Q0.5980.89
20_I227_T0.5970.89
264_R308_L0.5970.89
240_I303_M0.5950.89
295_T306_V0.5950.89
289_D311_C0.5950.89
46_I49_A0.5940.89
13_A232_V0.5930.89
53_T56_F0.5930.89
321_E324_G0.5910.89
140_T144_Q0.5900.89
66_T70_R0.5900.89
59_L302_D0.5860.88
244_T263_Q0.5860.88
310_P314_A0.5860.88
89_E112_A0.5840.88
19_S23_Q0.5830.88
331_D335_A0.5830.88
295_T299_V0.5830.88
38_A43_I0.5820.88
277_P280_A0.5800.88
31_W77_L0.5800.88
106_L110_Q0.5790.88
284_T332_V0.5790.88
105_Q109_L0.5780.88
139_L142_W0.5760.88
54_D74_G0.5750.88
36_A350_R0.5730.87
194_A198_H0.5730.87
92_D114_L0.5720.87
288_V308_L0.5700.87
332_V343_L0.5690.87
321_E327_I0.5690.87
124_V183_L0.5690.87
323_W347_L0.5640.87
28_A202_H0.5630.86
138_V141_V0.5630.86
323_W332_V0.5620.86
72_W75_P0.5580.86
307_D311_C0.5570.86
295_T304_L0.5560.86
47_W56_F0.5530.85
216_S330_D0.5530.85
82_F91_Y0.5530.85
38_A48_S0.5510.85
257_Y296_V0.5510.85
126_S161_A0.5480.85
82_F98_T0.5470.85
21_V195_T0.5460.85
12_Q16_Q0.5460.85
5_I235_L0.5460.85
164_E298_T0.5460.85
121_Y154_M0.5450.85
210_I344_M0.5440.85
251_V257_Y0.5440.85
25_A206_V0.5430.84
164_E278_R0.5430.84
54_D75_P0.5430.84
10_D230_R0.5410.84
157_M300_S0.5400.84
208_P212_L0.5400.84
176_I180_A0.5380.84
216_S228_G0.5380.84
322_L332_V0.5380.84
55_G74_G0.5360.84
158_S169_I0.5350.84
173_M198_H0.5350.84
93_Q116_A0.5340.83
44_E47_W0.5340.83
36_A302_D0.5320.83
61_L65_I0.5320.83
18_L56_F0.5290.83
292_R327_I0.5280.83
341_Y345_C0.5280.83
133_F138_V0.5270.83
20_I230_R0.5260.83
195_T211_I0.5260.83
44_E69_E0.5210.82
135_P179_A0.5210.82
146_R153_E0.5200.82
274_D302_D0.5190.82
77_L99_C0.5170.81
284_T299_V0.5160.81
126_S175_R0.5150.81
273_A348_A0.5150.81
134_Q246_K0.5140.81
122_L142_W0.5140.81
145_L151_V0.5120.81
148_M151_V0.5110.81
26_T202_H0.5100.81
273_A302_D0.5100.81
161_A172_A0.5090.80
189_L194_A0.5080.80
334_A337_G0.5080.80
14_L212_L0.5080.80
267_I303_M0.5070.80
247_A261_D0.5070.80
46_I51_G0.5050.80
290_G326_E0.5050.80
14_L213_Y0.5040.80
98_T118_L0.5030.80
177_E187_R0.5020.80
107_K140_T0.5020.80
273_A350_R0.5010.79
279_H342_E0.5010.79
11_L15_K0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bd0A 2 0.986 100 0.24 Contact Map
3hurA 4 0.9803 100 0.248 Contact Map
3e5pA 2 0.986 100 0.253 Contact Map
2rjgA 2 0.9944 100 0.254 Contact Map
4bhyA 2 0.9494 100 0.256 Contact Map
2vd8A 2 0.9438 100 0.263 Contact Map
1rcqA 2 0.9888 100 0.264 Contact Map
4a3qA 2 0.9213 100 0.268 Contact Map
3co8A 2 0.9831 100 0.272 Contact Map
3s46A 2 0.9831 100 0.273 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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