GREMLIN Database
YDCC - H repeat-associated protein YdcC
UniProt: P28917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11526
Length: 378 (354)
Sequences: 502 (431)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_V206_F5.7781.00
265_S282_R4.3981.00
181_A193_F3.8801.00
152_I177_Q3.6781.00
160_N183_K3.4161.00
183_K187_Q3.3461.00
18_Q21_K3.2901.00
49_D356_R3.2611.00
149_S154_A2.8980.99
238_H261_C2.8060.99
73_T76_R2.8010.99
261_C295_F2.7770.99
168_I288_A2.7630.99
324_I333_F2.5470.99
171_T175_G2.4640.98
105_V170_T2.4280.98
155_I175_G2.4250.98
261_C286_S2.4140.98
259_K286_S2.4050.98
197_G203_N2.3370.97
18_Q22_M2.3330.97
237_L264_V2.2700.97
104_D133_S2.2670.97
25_K28_D2.2560.97
261_C299_I2.2410.97
33_T74_I2.2200.96
14_P85_K2.2200.96
318_N321_D2.2030.96
185_Q256_G2.1940.96
155_I180_I2.1770.96
42_E358_M2.1540.96
32_L64_F2.1260.95
190_D287_S2.0580.94
194_A282_R2.0510.94
195_V200_G2.0390.94
19_A22_M2.0370.94
155_I171_T2.0290.94
168_I192_L2.0030.94
175_G180_I1.9840.93
55_P59_K1.9420.92
128_V338_H1.8940.92
156_P180_I1.8810.91
32_L55_P1.8790.91
184_I189_G1.8590.91
33_T336_I1.8560.91
239_I262_V1.8460.90
165_K188_G1.8060.89
54_H365_R1.7760.89
48_E52_E1.7720.88
112_T127_H1.7710.88
238_H263_A1.7670.88
139_V338_H1.7460.88
38_I340_A1.7260.87
74_I78_V1.7190.87
13_I89_C1.7170.87
238_H296_A1.7120.87
264_V281_V1.7110.87
312_R345_T1.7030.86
115_H321_D1.6840.86
322_C333_F1.6560.85
149_S174_M1.6530.85
150_N174_M1.6510.85
347_D370_S1.6450.84
10_I89_C1.6330.84
71_H75_A1.6250.84
13_I30_L1.6100.83
317_M358_M1.6090.83
29_I77_V1.5900.82
32_L51_G1.5900.82
64_F67_G1.5730.82
106_I131_A1.5720.82
316_V353_G1.5630.81
170_T302_H1.5580.81
347_D371_V1.5390.80
126_I144_K1.5180.79
182_E186_K1.5180.79
24_H76_R1.5180.79
149_S152_I1.5020.78
106_I189_G1.5010.78
36_A41_A1.4920.78
6_L10_I1.4750.77
75_A324_I1.4750.77
131_A158_L1.4750.77
238_H292_A1.4690.77
195_V285_I1.4500.76
48_E68_I1.4470.76
53_T363_M1.4470.76
156_P171_T1.4190.74
288_A295_F1.4160.74
55_P64_F1.4140.74
203_N207_E1.4030.73
156_P175_G1.4020.73
33_T78_V1.4000.73
176_C282_R1.3980.73
347_D367_Y1.3970.73
357_K367_Y1.3960.73
46_D355_R1.3960.73
116_S125_A1.3950.73
156_P174_M1.3840.72
146_D149_S1.3780.72
6_L30_L1.3680.71
137_S345_T1.3560.71
113_L334_S1.3390.70
221_D292_A1.3340.69
111_K319_E1.3240.69
238_H295_F1.3110.68
139_V309_L1.2900.67
358_M362_A1.2830.66
313_L338_H1.2780.66
334_S338_H1.2720.66
355_R359_R1.2710.66
171_T193_F1.2680.65
46_D359_R1.2630.65
13_I66_N1.2510.64
222_S239_I1.2500.64
288_A291_T1.2480.64
171_T174_M1.2420.64
144_K331_E1.2420.64
42_E355_R1.2410.64
87_H91_I1.2350.63
195_V202_L1.2350.63
182_E255_K1.2180.62
145_T149_S1.2130.62
130_S338_H1.2060.61
28_D63_D1.2060.61
224_A237_L1.2050.61
304_H308_K1.2050.61
243_V246_E1.1980.61
296_A299_I1.1920.61
319_E337_R1.1920.61
171_T180_I1.1870.60
353_G367_Y1.1810.60
53_T364_D1.1800.60
261_C288_A1.1710.59
349_V357_K1.1680.59
154_A180_I1.1640.59
32_L74_I1.1640.59
153_T180_I1.1510.58
338_H341_I1.1490.58
44_W78_V1.1460.57
197_G364_D1.1450.57
209_K243_V1.1400.57
189_G317_M1.1390.57
352_A356_R1.1380.57
113_L319_E1.1360.57
106_I164_I1.1350.57
130_S305_V1.1320.56
149_S153_T1.1260.56
174_M180_I1.1170.55
57_F368_L1.1170.55
293_E297_T1.1170.55
192_L299_I1.1160.55
229_S281_V1.1080.55
44_W50_F1.1030.55
291_T294_K1.1010.54
263_A299_I1.0990.54
33_T37_V1.0940.54
41_A47_I1.0940.54
157_E286_S1.0850.53
241_C244_P1.0840.53
49_D360_K1.0830.53
164_I336_I1.0800.53
365_R368_L1.0790.53
10_I13_I1.0640.52
112_T116_S1.0610.52
118_D323_K1.0600.52
246_E251_T1.0540.51
55_P63_D1.0540.51
138_L342_N1.0470.51
166_G188_G1.0460.51
127_H142_Q1.0430.50
150_N177_Q1.0330.50
130_S231_G1.0270.49
179_D182_E1.0250.49
16_Y80_C1.0240.49
74_I336_I1.0220.49
64_F74_I1.0220.49
310_H314_D1.0210.49
28_D59_K1.0180.49
69_P111_K1.0060.48
116_S126_I1.0040.48
113_L128_V1.0010.47
86_F90_F1.0010.47
149_S156_P0.9940.47
51_G64_F0.9900.47
169_I293_E0.9880.47
48_E71_H0.9830.46
86_F188_G0.9800.46
358_M363_M0.9680.45
236_R300_R0.9630.45
319_E334_S0.9560.44
209_K246_E0.9540.44
43_G46_D0.9520.44
24_H28_D0.9520.44
58_L362_A0.9490.44
24_H62_G0.9480.44
87_H338_H0.9430.43
313_L357_K0.9350.43
226_S233_E0.9310.43
177_Q180_I0.9300.43
189_G278_E0.9150.42
306_E314_D0.9130.41
327_G330_A0.9030.41
105_V134_T0.9020.41
127_H174_M0.9010.41
177_Q206_F0.8990.40
42_E46_D0.8960.40
106_I183_K0.8930.40
31_L65_E0.8880.40
314_D320_D0.8860.40
347_D357_K0.8800.39
106_I140_I0.8800.39
200_G247_L0.8780.39
31_L61_Y0.8730.39
222_S237_L0.8710.39
199_Q231_G0.8710.39
83_P331_E0.8670.38
129_I155_I0.8580.38
266_F279_M0.8550.38
191_Y257_L0.8510.37
233_E268_S0.8500.37
262_V281_V0.8450.37
341_I354_L0.8400.37
30_L167_K0.8370.36
210_F262_V0.8340.36
326_R330_A0.8330.36
113_L338_H0.8320.36
153_T197_G0.8300.36
353_G356_R0.8280.36
153_T156_P0.8270.36
139_V342_N0.8260.36
51_G68_I0.8250.36
335_G338_H0.8250.36
180_I184_I0.8230.36
13_I81_I0.8220.35
199_Q285_I0.8190.35
197_G200_G0.8190.35
267_R278_E0.8180.35
112_T125_A0.8170.35
148_K280_T0.8120.35
361_A368_L0.8120.35
36_A47_I0.8100.35
260_L281_V0.8090.35
227_E344_L0.8080.35
126_I353_G0.8050.34
207_E211_P0.8040.34
209_K247_L0.8030.34
359_R363_M0.8000.34
240_V259_K0.8000.34
239_I264_V0.7980.34
303_W306_E0.7980.34
108_I131_A0.7960.34
150_N180_I0.7950.34
186_K362_A0.7940.34
31_L64_F0.7930.34
311_W315_V0.7910.33
132_F304_H0.7900.33
348_K357_K0.7900.33
32_L62_G0.7870.33
70_V80_C0.7850.33
268_S277_L0.7800.33
199_Q254_W0.7800.33
334_S337_R0.7740.32
55_P62_G0.7740.32
305_V308_K0.7740.32
33_T36_A0.7700.32
227_E305_V0.7690.32
223_Y293_E0.7680.32
189_G247_L0.7650.32
105_V298_A0.7610.32
10_I255_K0.7600.32
212_L216_N0.7550.31
333_F339_I0.7540.31
310_H320_D0.7510.31
250_F255_K0.7510.31
24_H31_L0.7500.31
50_F299_I0.7490.31
194_A284_Y0.7490.31
308_K345_T0.7460.31
155_I174_M0.7430.31
111_K302_H0.7400.30
367_Y370_S0.7390.30
228_K233_E0.7390.30
13_I206_F0.7380.30
223_Y296_A0.7350.30
130_S280_T0.7350.30
153_T177_Q0.7340.30
231_G269_I0.7330.30
54_H363_M0.7310.30
43_G336_I0.7290.30
363_M368_L0.7270.30
26_L77_V0.7250.30
184_I344_L0.7240.29
225_M286_S0.7240.29
74_I301_N0.7220.29
51_G55_P0.7210.29
42_E353_G0.7180.29
168_I298_A0.7180.29
94_M342_N0.7170.29
184_I304_H0.7160.29
240_V288_A0.7160.29
128_V142_Q0.7140.29
258_K289_D0.7130.29
48_E51_G0.7110.29
84_A87_H0.7090.29
343_I346_N0.7080.29
168_I286_S0.7070.29
97_C141_G0.7050.28
176_C193_F0.7050.28
141_G155_I0.7040.28
189_G199_Q0.7040.28
241_C246_E0.7020.28
41_A46_D0.7000.28
67_G159_L0.6960.28
75_A357_K0.6960.28
9_H92_N0.6940.28
178_K253_E0.6930.28
194_A299_I0.6910.28
264_V305_V0.6900.28
35_C168_I0.6890.28
192_L252_F0.6870.27
10_I195_V0.6860.27
45_E75_A0.6850.27
52_E56_D0.6850.27
314_D319_E0.6840.27
90_F342_N0.6840.27
72_D300_R0.6840.27
127_H181_A0.6820.27
153_T158_L0.6820.27
58_L61_Y0.6800.27
89_C200_G0.6800.27
115_H124_G0.6790.27
66_N304_H0.6780.27
129_I149_S0.6780.27
44_W75_A0.6770.27
45_E71_H0.6740.27
164_I169_I0.6730.27
306_E320_D0.6720.27
112_T194_A0.6720.27
302_H310_H0.6690.26
43_G117_Y0.6690.26
177_Q254_W0.6680.26
78_V167_K0.6650.26
152_I174_M0.6650.26
148_K177_Q0.6640.26
24_H66_N0.6630.26
44_W51_G0.6630.26
23_E27_S0.6630.26
160_N187_Q0.6620.26
191_Y283_Y0.6600.26
88_E182_E0.6590.26
259_K288_A0.6570.26
295_F299_I0.6560.26
135_M160_N0.6550.26
24_H83_P0.6550.26
261_C284_Y0.6530.26
50_F195_V0.6520.26
7_M10_I0.6520.26
59_K63_D0.6490.25
348_K353_G0.6490.25
348_K367_Y0.6480.25
201_R299_I0.6480.25
58_L292_A0.6480.25
205_A208_E0.6470.25
353_G371_V0.6450.25
324_I329_A0.6420.25
236_R302_H0.6410.25
345_T348_K0.6410.25
6_L34_I0.6410.25
185_Q188_G0.6410.25
177_Q183_K0.6390.25
24_H233_E0.6390.25
153_T175_G0.6370.25
127_H150_N0.6360.25
147_E225_M0.6350.25
166_G287_S0.6330.25
162_L342_N0.6330.25
192_L288_A0.6320.24
90_F232_R0.6320.24
235_I268_S0.6310.24
44_W93_W0.6300.24
328_N332_L0.6300.24
301_N333_F0.6290.24
240_V290_L0.6290.24
192_L286_S0.6280.24
109_D172_D0.6280.24
78_V210_F0.6270.24
166_G169_I0.6270.24
344_L371_V0.6260.24
46_D50_F0.6260.24
54_H364_D0.6250.24
38_I365_R0.6250.24
143_I247_L0.6220.24
144_K149_S0.6190.24
132_F284_Y0.6190.24
178_K251_T0.6170.24
6_L327_G0.6160.24
94_M97_C0.6150.24
57_F347_D0.6150.24
361_A367_Y0.6120.23
164_I236_R0.6120.23
26_L234_E0.6110.23
149_S177_Q0.6100.23
45_E356_R0.6060.23
284_Y299_I0.6050.23
75_A79_S0.6050.23
39_S205_A0.6040.23
188_G197_G0.6030.23
13_I18_Q0.6020.23
198_N314_D0.6020.23
151_E172_D0.6010.23
331_E372_L0.6010.23
59_K368_L0.6010.23
139_V312_R0.5990.23
11_S305_V0.5970.23
50_F284_Y0.5960.23
128_V334_S0.5960.23
31_L57_F0.5930.23
200_G206_F0.5920.22
149_S180_I0.5900.22
115_H159_L0.5900.22
172_D306_E0.5890.22
206_F254_W0.5880.22
111_K115_H0.5880.22
172_D196_K0.5880.22
216_N276_E0.5880.22
28_D67_G0.5870.22
18_Q74_I0.5860.22
55_P65_E0.5860.22
85_K119_K0.5850.22
138_L311_W0.5830.22
38_I181_A0.5810.22
150_N156_P0.5810.22
16_Y183_K0.5810.22
66_N285_I0.5810.22
178_K199_Q0.5800.22
234_E300_R0.5800.22
7_M11_S0.5800.22
159_L183_K0.5790.22
114_R280_T0.5790.22
38_I58_L0.5790.22
120_S187_Q0.5780.22
229_S266_F0.5780.22
252_F255_K0.5770.22
169_I207_E0.5770.22
124_G176_C0.5730.22
9_H89_C0.5720.22
236_R257_L0.5720.22
35_C274_K0.5710.21
64_F70_V0.5710.21
17_R26_L0.5690.21
38_I362_A0.5660.21
111_K314_D0.5650.21
20_W354_L0.5650.21
42_E81_I0.5630.21
154_A174_M0.5630.21
83_P313_L0.5630.21
47_I112_T0.5620.21
266_F275_K0.5620.21
149_S175_G0.5620.21
170_T192_L0.5620.21
9_H43_G0.5610.21
255_K291_T0.5600.21
209_K241_C0.5600.21
224_A278_E0.5600.21
138_L257_L0.5590.21
192_L290_L0.5580.21
224_A235_I0.5560.21
85_K137_S0.5550.21
230_H299_I0.5550.21
24_H325_R0.5530.21
208_E244_P0.5520.21
203_N329_A0.5510.21
111_K236_R0.5500.21
211_P241_C0.5490.20
237_L281_V0.5480.20
332_L344_L0.5470.20
145_T205_A0.5450.20
330_A341_I0.5440.20
166_G190_D0.5440.20
142_Q191_Y0.5440.20
87_H238_H0.5430.20
127_H159_L0.5420.20
338_H342_N0.5420.20
211_P251_T0.5410.20
62_G159_L0.5380.20
47_I135_M0.5370.20
23_E34_I0.5370.20
79_S343_I0.5360.20
178_K225_M0.5360.20
124_G135_M0.5340.20
169_I299_I0.5340.20
90_F144_K0.5340.20
238_H299_I0.5340.20
13_I86_F0.5330.20
129_I287_S0.5320.20
225_M233_E0.5310.20
9_H12_I0.5310.20
205_A241_C0.5270.19
160_N182_E0.5270.19
362_A368_L0.5250.19
134_T257_L0.5210.19
325_R330_A0.5210.19
222_S356_R0.5180.19
129_I301_N0.5180.19
152_I183_K0.5180.19
306_E310_H0.5170.19
121_R179_D0.5170.19
109_D151_E0.5160.19
33_T41_A0.5160.19
83_P332_L0.5160.19
111_K198_N0.5160.19
29_I32_L0.5140.19
49_D359_R0.5130.19
81_I104_D0.5120.19
56_D104_D0.5110.19
34_I203_N0.5080.19
300_R319_E0.5080.19
55_P58_L0.5080.19
106_I141_G0.5070.19
81_I185_Q0.5070.19
54_H68_I0.5070.19
266_F277_L0.5070.19
109_D306_E0.5060.19
232_R310_H0.5050.19
109_D196_K0.5040.18
88_E92_N0.5040.18
210_F256_G0.5040.18
138_L186_K0.5030.18
129_I199_Q0.5010.18
226_S235_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8545 98.4 0.922 Contact Map
2abkA 1 0.3571 44.1 0.972 Contact Map
1ornA 1 0.3598 28.7 0.975 Contact Map
4unfA 1 0.373 25 0.975 Contact Map
4r3uC 1 0.336 24 0.976 Contact Map
3us6A 1 0.3677 18.3 0.977 Contact Map
1keaA 2 0.3519 13.8 0.978 Contact Map
3dfgA 1 0.119 13.4 0.978 Contact Map
1s69A 1 0.3175 10.7 0.979 Contact Map
2d74B 1 0.3307 10.3 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.