GREMLIN Database
YHHI - H repeat-associated protein YhhI
UniProt: P28912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11525
Length: 378 (355)
Sequences: 498 (426)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_V206_F5.7601.00
265_S282_R4.4751.00
181_A193_F3.8741.00
152_I177_Q3.6651.00
160_N183_K3.4511.00
18_Q21_K3.4401.00
183_K187_Q3.3541.00
49_D356_R3.2591.00
149_S154_A2.9140.99
238_H261_C2.8770.99
73_T76_R2.8570.99
261_C295_F2.8420.99
168_I288_A2.6560.99
324_I333_F2.6090.99
171_T175_G2.5150.98
155_I175_G2.4330.98
32_L64_F2.3990.98
197_G203_N2.3630.97
259_K286_S2.3580.97
18_Q22_V2.3480.97
261_C286_S2.3330.97
237_L264_V2.3160.97
261_C299_I2.3040.97
42_E358_M2.2830.97
105_V170_T2.2310.96
33_T74_I2.2280.96
25_K28_D2.2270.96
104_D133_S2.2180.96
155_I180_I2.2100.96
318_N321_D2.2000.96
185_Q256_G2.1980.96
19_T22_V2.1310.95
155_I171_T2.1040.95
14_P85_K2.0850.95
194_A282_R2.0780.95
195_V200_G2.0570.94
190_D287_S2.0410.94
175_G180_I2.0360.94
33_T336_I2.0170.94
168_I192_L1.9130.92
55_L59_K1.9020.91
156_P180_I1.8950.91
128_V338_H1.8740.91
150_N174_M1.8620.90
32_L55_L1.8450.90
112_T127_H1.8400.90
317_M358_M1.8220.89
184_I189_G1.8150.89
54_H365_R1.8070.89
312_R345_T1.8070.89
13_I89_C1.7920.89
239_I262_V1.7880.89
48_E52_E1.7740.88
165_K188_G1.7610.88
238_H263_A1.7560.88
238_H296_A1.7400.87
74_I78_V1.7320.87
64_F67_G1.7110.86
115_H321_D1.7110.86
29_I77_V1.7090.86
116_S125_A1.7080.86
149_S174_M1.7040.86
347_D370_S1.6800.85
38_I340_A1.6770.85
139_V338_H1.6760.85
322_C333_F1.6580.84
71_H75_A1.6350.84
106_I131_A1.6270.83
10_I89_C1.6210.83
126_I144_K1.6040.82
170_T302_H1.6000.82
182_E186_K1.5960.82
316_V353_G1.5770.81
131_A158_L1.5680.81
264_V281_V1.5660.81
36_A41_A1.5660.81
32_L51_G1.5640.81
24_H76_R1.5520.80
238_H292_A1.5400.80
13_I30_L1.5300.79
347_D371_V1.5290.79
48_E68_I1.5290.79
6_L10_I1.4950.78
288_A295_F1.4900.77
53_T363_M1.4740.76
156_P171_T1.4690.76
149_S152_I1.4670.76
203_N207_E1.4520.75
347_D367_Y1.4490.75
75_A324_I1.4480.75
156_P175_G1.4430.75
6_L30_L1.4320.74
137_S345_T1.4210.74
113_L334_S1.4130.73
176_C282_R1.4110.73
156_P174_M1.4010.73
106_I189_G1.3940.72
146_D149_S1.3840.72
195_V285_I1.3790.71
55_L64_F1.3730.71
357_K367_Y1.3630.71
33_T78_V1.3600.70
42_E355_R1.3440.69
13_I66_N1.2890.66
334_S338_H1.2880.66
288_A291_T1.2850.66
313_L338_H1.2850.66
46_D355_R1.2840.66
145_T149_S1.2780.65
139_V309_L1.2680.65
238_H295_F1.2630.65
87_H91_I1.2530.64
182_E255_K1.2450.63
46_D359_R1.2430.63
355_R359_R1.2420.63
32_L74_I1.2340.63
111_K319_E1.2320.63
144_K331_E1.2300.62
171_T174_M1.2280.62
224_A237_L1.2270.62
221_D292_A1.2250.62
171_T193_F1.2230.62
195_V202_L1.2200.62
51_G64_F1.2110.61
304_H308_K1.2090.61
130_S305_V1.2060.61
166_G188_G1.1980.60
189_G317_M1.1980.60
222_S239_I1.1960.60
296_A299_I1.1940.60
153_T180_I1.1930.60
113_L319_E1.1910.60
197_G364_D1.1900.60
358_M362_A1.1830.59
130_S338_H1.1800.59
229_S281_V1.1800.59
28_D63_D1.1790.59
209_K243_V1.1710.59
164_I336_I1.1700.58
192_L299_I1.1640.58
171_T180_I1.1600.58
353_G367_Y1.1590.58
293_E297_T1.1580.58
53_T364_D1.1540.57
154_A180_I1.1460.57
157_E286_S1.1450.57
44_W78_V1.1430.57
149_S153_T1.1350.56
338_H341_I1.1310.56
261_C288_A1.1290.56
319_E337_R1.1210.55
174_M180_I1.1170.55
349_V357_K1.1160.55
118_D323_K1.1160.55
55_L63_D1.1150.55
209_K246_E1.1130.55
44_W50_F1.0990.54
112_T116_S1.0960.53
57_F368_L1.0910.53
130_S231_G1.0890.53
69_P111_K1.0860.53
243_V246_E1.0820.52
86_F90_F1.0820.52
138_L342_N1.0780.52
28_D59_K1.0770.52
33_T37_V1.0720.52
352_A356_R1.0670.51
41_A47_I1.0650.51
106_I164_I1.0490.50
48_E71_H1.0460.50
241_C244_P1.0440.50
246_E251_T1.0440.50
10_I13_I1.0430.50
263_A299_I1.0360.49
149_S156_P1.0240.48
74_I336_I1.0210.48
49_D360_K1.0200.48
365_R368_L1.0150.48
127_H142_Q1.0090.47
16_Y80_C1.0050.47
58_L362_A1.0010.47
116_S126_I0.9980.47
291_T294_K0.9950.46
24_H28_D0.9890.46
179_D182_E0.9890.46
306_E314_D0.9770.45
24_H62_G0.9680.45
43_G46_D0.9670.45
209_K247_L0.9600.44
86_F188_G0.9450.43
177_Q180_I0.9430.43
150_N177_Q0.9400.43
310_H314_D0.9360.42
113_L128_V0.9350.42
106_I183_K0.9340.42
226_S233_E0.9330.42
87_H338_H0.9330.42
319_E334_S0.9300.42
108_I131_A0.9240.42
42_E46_D0.9190.41
266_F279_M0.9110.41
236_R300_R0.9100.41
313_L357_K0.9080.41
36_A47_I0.9040.40
327_G330_A0.9010.40
51_G68_I0.9010.40
169_I293_E0.9000.40
177_Q206_F0.8950.40
13_I81_I0.8950.40
189_G278_E0.8940.40
30_L167_K0.8920.40
347_D357_K0.8860.39
191_Y257_L0.8850.39
199_Q231_G0.8700.38
358_M363_M0.8650.38
311_W315_V0.8630.38
207_E211_P0.8630.38
335_G338_H0.8510.37
262_V281_V0.8510.37
31_L61_Y0.8490.37
233_E268_S0.8430.36
166_G169_I0.8420.36
127_H174_M0.8410.36
33_T36_A0.8400.36
55_L62_G0.8400.36
106_I140_I0.8350.36
314_D320_D0.8300.36
153_T156_P0.8230.35
199_Q254_W0.8210.35
326_R330_A0.8200.35
344_L371_V0.8180.35
83_P331_E0.8180.35
10_I255_K0.8130.34
227_E344_L0.8100.34
132_F304_H0.8090.34
112_T125_A0.8090.34
268_S277_P0.8090.34
113_L338_H0.8060.34
70_V80_C0.8060.34
150_N180_I0.8020.34
305_V308_K0.7980.34
64_F74_I0.7980.34
240_V259_K0.7950.33
141_G155_I0.7930.33
359_R363_M0.7910.33
31_L65_E0.7900.33
348_K357_K0.7870.33
24_H31_L0.7860.33
32_L62_G0.7850.33
105_V134_T0.7830.33
334_S337_R0.7800.32
78_V210_F0.7790.32
64_F70_V0.7770.32
51_G55_L0.7760.32
31_L64_F0.7750.32
225_I286_S0.7750.32
200_G247_L0.7740.32
223_Y293_E0.7740.32
148_K280_T0.7730.32
306_E320_D0.7710.32
90_F342_N0.7700.32
239_I264_V0.7690.32
199_Q285_I0.7680.32
267_R278_E0.7670.32
129_I155_I0.7660.32
341_I354_L0.7640.31
303_W306_E0.7620.31
361_A368_L0.7590.31
241_C246_E0.7560.31
186_K362_A0.7560.31
240_V288_A0.7530.31
353_G356_R0.7520.31
155_I174_M0.7520.31
228_K233_E0.7510.31
250_F255_K0.7480.31
189_G199_Q0.7470.30
222_S237_L0.7460.30
139_V342_N0.7460.30
197_G200_G0.7450.30
308_K345_T0.7440.30
35_C168_I0.7440.30
231_G269_I0.7420.30
67_G159_L0.7380.30
84_A87_H0.7370.30
264_V305_V0.7350.30
343_I346_N0.7350.30
153_T177_Q0.7350.30
180_I184_I0.7350.30
72_D300_R0.7320.30
295_F299_I0.7310.30
348_K367_Y0.7310.30
168_I298_A0.7300.29
127_H181_A0.7270.29
9_H92_N0.7270.29
43_G336_I0.7230.29
13_I206_F0.7210.29
24_H66_N0.7210.29
194_A284_Y0.7200.29
367_Y370_S0.7190.29
168_I286_S0.7180.29
260_L281_V0.7180.29
26_L77_V0.7130.29
128_V142_Q0.7120.28
7_M10_I0.7110.28
178_K253_E0.7090.28
44_W51_G0.7070.28
310_H320_D0.7070.28
89_C200_G0.7030.28
184_I344_L0.7030.28
127_H150_N0.7030.28
130_S280_T0.7010.28
52_E56_D0.7010.28
50_F299_I0.7000.28
97_C141_G0.7000.28
185_Q188_G0.6960.28
160_N187_Q0.6960.28
48_E51_G0.6940.27
333_F339_I0.6940.27
194_A299_I0.6940.27
138_L311_W0.6930.27
45_E71_H0.6910.27
24_H233_E0.6880.27
147_E225_I0.6850.27
159_L354_L0.6850.27
44_W75_A0.6800.27
135_M160_N0.6780.27
223_Y296_A0.6770.27
153_T197_G0.6770.27
126_I353_G0.6770.27
59_K63_D0.6750.26
210_F262_V0.6700.26
88_E182_E0.6700.26
227_E305_V0.6690.26
222_S356_R0.6650.26
129_I149_S0.6650.26
49_D359_R0.6630.26
124_G135_M0.6610.26
191_Y283_Y0.6590.26
45_E75_A0.6550.25
224_A278_E0.6520.25
169_I207_E0.6520.25
208_E244_P0.6520.25
209_K241_C0.6520.25
13_I18_Q0.6520.25
176_C193_F0.6510.25
58_L61_Y0.6500.25
41_A46_D0.6500.25
138_L186_K0.6500.25
75_A357_K0.6480.25
132_F284_Y0.6480.25
184_I304_H0.6460.25
234_E300_R0.6460.25
94_M97_C0.6430.25
153_T158_L0.6430.25
192_L252_F0.6430.25
54_H364_D0.6420.25
46_D50_F0.6420.25
363_M368_L0.6420.25
24_H83_P0.6410.25
192_L286_S0.6400.25
105_V298_A0.6390.25
57_F347_D0.6380.25
74_I301_N0.6380.25
177_Q254_W0.6380.25
47_I112_T0.6360.24
16_Y183_K0.6340.24
111_K302_H0.6310.24
38_I365_R0.6280.24
6_L327_G0.6280.24
58_L292_A0.6280.24
111_K115_H0.6270.24
44_W93_W0.6260.24
192_L290_L0.6250.24
38_I181_A0.6240.24
192_L288_A0.6210.24
54_H363_M0.6200.24
144_K149_S0.6200.24
39_S205_A0.6190.24
78_V167_K0.6190.24
150_N184_I0.6190.24
361_A367_Y0.6180.24
240_V290_L0.6170.23
120_S187_Q0.6170.23
35_C274_K0.6160.23
153_T175_G0.6140.23
56_D104_D0.6140.23
178_K251_T0.6140.23
178_K199_Q0.6110.23
42_E81_I0.6110.23
225_I233_E0.6110.23
177_Q183_K0.6110.23
142_Q191_Y0.6100.23
45_E356_R0.6090.23
212_L216_N0.6090.23
109_D172_D0.6090.23
42_E353_G0.6080.23
90_F232_R0.6060.23
255_K291_T0.6060.23
328_N332_L0.6060.23
170_T192_L0.6040.23
114_R318_N0.6030.23
66_N304_H0.6020.23
201_R299_I0.5990.23
259_K288_A0.5980.23
206_F254_W0.5980.23
81_I161_M0.5970.22
149_S180_I0.5970.22
66_N285_I0.5970.22
162_L342_N0.5960.22
159_L183_K0.5950.22
252_F255_K0.5950.22
325_R330_A0.5940.22
94_M342_N0.5930.22
301_N333_F0.5930.22
148_K177_Q0.5920.22
149_S177_Q0.5910.22
235_I268_S0.5910.22
75_A79_S0.5910.22
31_L57_F0.5900.22
10_I195_V0.5900.22
166_G287_S0.5900.22
43_G117_Y0.5850.22
225_I261_C0.5850.22
331_E372_L0.5850.22
29_I32_L0.5840.22
139_V312_R0.5830.22
261_C284_Y0.5830.22
138_L257_L0.5820.22
151_E172_D0.5810.22
152_I174_M0.5810.22
28_D67_G0.5790.22
200_G206_F0.5780.22
9_H43_G0.5770.22
18_Q74_I0.5770.22
115_H159_L0.5770.22
150_N156_P0.5750.21
62_G159_L0.5750.21
345_T348_K0.5730.21
112_T194_A0.5730.21
96_D276_E0.5730.21
128_V334_S0.5700.21
127_H159_L0.5690.21
85_K137_S0.5690.21
25_K64_F0.5690.21
50_F284_Y0.5670.21
302_H310_H0.5660.21
115_H125_A0.5650.21
172_D196_K0.5650.21
84_A145_T0.5640.21
7_M11_S0.5620.21
172_D306_E0.5610.21
314_D319_E0.5580.21
184_I287_S0.5570.21
19_T50_F0.5560.21
87_H238_H0.5540.20
140_I287_S0.5540.20
306_E310_H0.5530.20
284_Y299_I0.5520.20
9_H12_I0.5520.20
149_S175_G0.5520.20
106_I141_G0.5520.20
205_A241_C0.5510.20
115_H124_G0.5500.20
90_F144_K0.5500.20
134_T257_L0.5490.20
10_I133_S0.5490.20
46_D356_R0.5480.20
268_S275_K0.5470.20
11_S305_V0.5470.20
23_E27_S0.5460.20
83_P313_L0.5460.20
38_I58_L0.5460.20
164_I169_I0.5450.20
189_G247_L0.5440.20
294_K297_T0.5440.20
104_D135_M0.5420.20
50_F195_V0.5420.20
38_I344_L0.5400.20
282_R311_W0.5380.20
59_K368_L0.5380.20
114_R280_T0.5370.20
141_G158_L0.5370.20
316_V339_I0.5360.20
230_H299_I0.5350.20
166_G190_D0.5350.20
357_K361_A0.5330.20
246_E259_K0.5330.20
23_E34_I0.5330.20
39_S60_Q0.5330.20
88_E293_E0.5320.20
83_P332_L0.5310.19
129_I301_N0.5310.19
106_I347_D0.5310.19
238_H301_N0.5290.19
9_H89_C0.5290.19
211_P241_C0.5290.19
332_L344_L0.5280.19
266_F277_P0.5270.19
96_D288_A0.5250.19
145_T205_A0.5240.19
226_S235_I0.5240.19
165_K328_N0.5230.19
152_I183_K0.5220.19
105_V116_S0.5210.19
24_H96_D0.5210.19
33_T41_A0.5210.19
236_R302_H0.5190.19
83_P311_W0.5190.19
38_I362_A0.5180.19
160_N182_E0.5170.19
195_V288_A0.5160.19
229_S266_F0.5140.19
6_L11_S0.5130.19
237_L281_V0.5130.19
203_N329_A0.5120.19
238_H299_I0.5110.19
236_R257_L0.5110.19
324_I337_R0.5100.19
225_I296_A0.5090.19
362_A368_L0.5090.19
24_H325_R0.5090.19
330_A341_I0.5080.18
265_S307_N0.5080.18
201_R240_V0.5070.18
88_E92_N0.5050.18
26_L234_E0.5050.18
54_H68_I0.5040.18
6_L31_L0.5040.18
324_I329_A0.5030.18
348_K353_G0.5020.18
224_A235_I0.5010.18
164_I263_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.873 98.1 0.932 Contact Map
2abkA 1 0.3571 30.9 0.975 Contact Map
1ornA 1 0.3598 19.8 0.977 Contact Map
3dfgA 1 0.119 18.1 0.978 Contact Map
2d74B 1 0.3307 16.2 0.978 Contact Map
3cw2K 1 0.336 14.6 0.979 Contact Map
4unfA 1 0.373 14.3 0.979 Contact Map
1neeA 1 0.336 11.7 0.98 Contact Map
1tq8A 4 0.336 11.1 0.98 Contact Map
4wfzA 1 0.1852 10.7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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