YHHI - ECOLI - GREMLIN Contacts

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YHHI - H repeat-associated protein YhhI

UniProt:	P28912	Sequences: MELKKLMEHISIIPDYRQTWKVEHKLSDILLLTICAVISGAEGWEDIEDFGETHLDFLKQYGDFENGIPVHDTIARVVSCISPAKFHECFINWMRDCHSSDDKDVIAIDGKTLRHSYDKSRRRGAIHVISAFSTMHSLVIGQIKTDEKSNEITAIPELLNMLDIKGKIITTDAMGCQKDIAEKIQKQGGDYLFAVKGTQGRLNKAFEEKFPLKELNNPEHDSYAISEKSHGREEIRLHIVCDVPDELIDFTFEWKGLKKLCVAVSFRSIIAEQKKEPEMTVRYYISSADLTAEKFATAIRNHWHVENKLHWRLDVVMNEDDCKIRRGNAAELFSGIRHIAINILTNDKVFKAGLRRKMRKAAMDRNYLASVLAGSGLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11525
Length:	378 (355)
Sequences:	498 (426)
Seq/√Len:	22.6

ECOLI - YHHI YDCC YNCI YBFL YBFD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_V	206_F	5.760	1.00
265_S	282_R	4.475	1.00
181_A	193_F	3.874	1.00
152_I	177_Q	3.665	1.00
160_N	183_K	3.451	1.00
18_Q	21_K	3.440	1.00
183_K	187_Q	3.354	1.00
49_D	356_R	3.259	1.00
149_S	154_A	2.914	0.99
238_H	261_C	2.877	0.99
73_T	76_R	2.857	0.99
261_C	295_F	2.842	0.99
168_I	288_A	2.656	0.99
324_I	333_F	2.609	0.99
171_T	175_G	2.515	0.98
155_I	175_G	2.433	0.98
32_L	64_F	2.399	0.98
197_G	203_N	2.363	0.97
259_K	286_S	2.358	0.97
18_Q	22_V	2.348	0.97
261_C	286_S	2.333	0.97
237_L	264_V	2.316	0.97
261_C	299_I	2.304	0.97
42_E	358_M	2.283	0.97
105_V	170_T	2.231	0.96
33_T	74_I	2.228	0.96
25_K	28_D	2.227	0.96
104_D	133_S	2.218	0.96
155_I	180_I	2.210	0.96
318_N	321_D	2.200	0.96
185_Q	256_G	2.198	0.96
19_T	22_V	2.131	0.95
155_I	171_T	2.104	0.95
14_P	85_K	2.085	0.95
194_A	282_R	2.078	0.95
195_V	200_G	2.057	0.94
190_D	287_S	2.041	0.94
175_G	180_I	2.036	0.94
33_T	336_I	2.017	0.94
168_I	192_L	1.913	0.92
55_L	59_K	1.902	0.91
156_P	180_I	1.895	0.91
128_V	338_H	1.874	0.91
150_N	174_M	1.862	0.90
32_L	55_L	1.845	0.90
112_T	127_H	1.840	0.90
317_M	358_M	1.822	0.89
184_I	189_G	1.815	0.89
54_H	365_R	1.807	0.89
312_R	345_T	1.807	0.89
13_I	89_C	1.792	0.89
239_I	262_V	1.788	0.89
48_E	52_E	1.774	0.88
165_K	188_G	1.761	0.88
238_H	263_A	1.756	0.88
238_H	296_A	1.740	0.87
74_I	78_V	1.732	0.87
64_F	67_G	1.711	0.86
115_H	321_D	1.711	0.86
29_I	77_V	1.709	0.86
116_S	125_A	1.708	0.86
149_S	174_M	1.704	0.86
347_D	370_S	1.680	0.85
38_I	340_A	1.677	0.85
139_V	338_H	1.676	0.85
322_C	333_F	1.658	0.84
71_H	75_A	1.635	0.84
106_I	131_A	1.627	0.83
10_I	89_C	1.621	0.83
126_I	144_K	1.604	0.82
170_T	302_H	1.600	0.82
182_E	186_K	1.596	0.82
316_V	353_G	1.577	0.81
131_A	158_L	1.568	0.81
264_V	281_V	1.566	0.81
36_A	41_A	1.566	0.81
32_L	51_G	1.564	0.81
24_H	76_R	1.552	0.80
238_H	292_A	1.540	0.80
13_I	30_L	1.530	0.79
347_D	371_V	1.529	0.79
48_E	68_I	1.529	0.79
6_L	10_I	1.495	0.78
288_A	295_F	1.490	0.77
53_T	363_M	1.474	0.76
156_P	171_T	1.469	0.76
149_S	152_I	1.467	0.76
203_N	207_E	1.452	0.75
347_D	367_Y	1.449	0.75
75_A	324_I	1.448	0.75
156_P	175_G	1.443	0.75
6_L	30_L	1.432	0.74
137_S	345_T	1.421	0.74
113_L	334_S	1.413	0.73
176_C	282_R	1.411	0.73
156_P	174_M	1.401	0.73
106_I	189_G	1.394	0.72
146_D	149_S	1.384	0.72
195_V	285_I	1.379	0.71
55_L	64_F	1.373	0.71
357_K	367_Y	1.363	0.71
33_T	78_V	1.360	0.70
42_E	355_R	1.344	0.69
13_I	66_N	1.289	0.66
334_S	338_H	1.288	0.66
288_A	291_T	1.285	0.66
313_L	338_H	1.285	0.66
46_D	355_R	1.284	0.66
145_T	149_S	1.278	0.65
139_V	309_L	1.268	0.65
238_H	295_F	1.263	0.65
87_H	91_I	1.253	0.64
182_E	255_K	1.245	0.63
46_D	359_R	1.243	0.63
355_R	359_R	1.242	0.63
32_L	74_I	1.234	0.63
111_K	319_E	1.232	0.63
144_K	331_E	1.230	0.62
171_T	174_M	1.228	0.62
224_A	237_L	1.227	0.62
221_D	292_A	1.225	0.62
171_T	193_F	1.223	0.62
195_V	202_L	1.220	0.62
51_G	64_F	1.211	0.61
304_H	308_K	1.209	0.61
130_S	305_V	1.206	0.61
166_G	188_G	1.198	0.60
189_G	317_M	1.198	0.60
222_S	239_I	1.196	0.60
296_A	299_I	1.194	0.60
153_T	180_I	1.193	0.60
113_L	319_E	1.191	0.60
197_G	364_D	1.190	0.60
358_M	362_A	1.183	0.59
130_S	338_H	1.180	0.59
229_S	281_V	1.180	0.59
28_D	63_D	1.179	0.59
209_K	243_V	1.171	0.59
164_I	336_I	1.170	0.58
192_L	299_I	1.164	0.58
171_T	180_I	1.160	0.58
353_G	367_Y	1.159	0.58
293_E	297_T	1.158	0.58
53_T	364_D	1.154	0.57
154_A	180_I	1.146	0.57
157_E	286_S	1.145	0.57
44_W	78_V	1.143	0.57
149_S	153_T	1.135	0.56
338_H	341_I	1.131	0.56
261_C	288_A	1.129	0.56
319_E	337_R	1.121	0.55
174_M	180_I	1.117	0.55
349_V	357_K	1.116	0.55
118_D	323_K	1.116	0.55
55_L	63_D	1.115	0.55
209_K	246_E	1.113	0.55
44_W	50_F	1.099	0.54
112_T	116_S	1.096	0.53
57_F	368_L	1.091	0.53
130_S	231_G	1.089	0.53
69_P	111_K	1.086	0.53
243_V	246_E	1.082	0.52
86_F	90_F	1.082	0.52
138_L	342_N	1.078	0.52
28_D	59_K	1.077	0.52
33_T	37_V	1.072	0.52
352_A	356_R	1.067	0.51
41_A	47_I	1.065	0.51
106_I	164_I	1.049	0.50
48_E	71_H	1.046	0.50
241_C	244_P	1.044	0.50
246_E	251_T	1.044	0.50
10_I	13_I	1.043	0.50
263_A	299_I	1.036	0.49
149_S	156_P	1.024	0.48
74_I	336_I	1.021	0.48
49_D	360_K	1.020	0.48
365_R	368_L	1.015	0.48
127_H	142_Q	1.009	0.47
16_Y	80_C	1.005	0.47
58_L	362_A	1.001	0.47
116_S	126_I	0.998	0.47
291_T	294_K	0.995	0.46
24_H	28_D	0.989	0.46
179_D	182_E	0.989	0.46
306_E	314_D	0.977	0.45
24_H	62_G	0.968	0.45
43_G	46_D	0.967	0.45
209_K	247_L	0.960	0.44
86_F	188_G	0.945	0.43
177_Q	180_I	0.943	0.43
150_N	177_Q	0.940	0.43
310_H	314_D	0.936	0.42
113_L	128_V	0.935	0.42
106_I	183_K	0.934	0.42
226_S	233_E	0.933	0.42
87_H	338_H	0.933	0.42
319_E	334_S	0.930	0.42
108_I	131_A	0.924	0.42
42_E	46_D	0.919	0.41
266_F	279_M	0.911	0.41
236_R	300_R	0.910	0.41
313_L	357_K	0.908	0.41
36_A	47_I	0.904	0.40
327_G	330_A	0.901	0.40
51_G	68_I	0.901	0.40
169_I	293_E	0.900	0.40
177_Q	206_F	0.895	0.40
13_I	81_I	0.895	0.40
189_G	278_E	0.894	0.40
30_L	167_K	0.892	0.40
347_D	357_K	0.886	0.39
191_Y	257_L	0.885	0.39
199_Q	231_G	0.870	0.38
358_M	363_M	0.865	0.38
311_W	315_V	0.863	0.38
207_E	211_P	0.863	0.38
335_G	338_H	0.851	0.37
262_V	281_V	0.851	0.37
31_L	61_Y	0.849	0.37
233_E	268_S	0.843	0.36
166_G	169_I	0.842	0.36
127_H	174_M	0.841	0.36
33_T	36_A	0.840	0.36
55_L	62_G	0.840	0.36
106_I	140_I	0.835	0.36
314_D	320_D	0.830	0.36
153_T	156_P	0.823	0.35
199_Q	254_W	0.821	0.35
326_R	330_A	0.820	0.35
344_L	371_V	0.818	0.35
83_P	331_E	0.818	0.35
10_I	255_K	0.813	0.34
227_E	344_L	0.810	0.34
132_F	304_H	0.809	0.34
112_T	125_A	0.809	0.34
268_S	277_P	0.809	0.34
113_L	338_H	0.806	0.34
70_V	80_C	0.806	0.34
150_N	180_I	0.802	0.34
305_V	308_K	0.798	0.34
64_F	74_I	0.798	0.34
240_V	259_K	0.795	0.33
141_G	155_I	0.793	0.33
359_R	363_M	0.791	0.33
31_L	65_E	0.790	0.33
348_K	357_K	0.787	0.33
24_H	31_L	0.786	0.33
32_L	62_G	0.785	0.33
105_V	134_T	0.783	0.33
334_S	337_R	0.780	0.32
78_V	210_F	0.779	0.32
64_F	70_V	0.777	0.32
51_G	55_L	0.776	0.32
31_L	64_F	0.775	0.32
225_I	286_S	0.775	0.32
200_G	247_L	0.774	0.32
223_Y	293_E	0.774	0.32
148_K	280_T	0.773	0.32
306_E	320_D	0.771	0.32
90_F	342_N	0.770	0.32
239_I	264_V	0.769	0.32
199_Q	285_I	0.768	0.32
267_R	278_E	0.767	0.32
129_I	155_I	0.766	0.32
341_I	354_L	0.764	0.31
303_W	306_E	0.762	0.31
361_A	368_L	0.759	0.31
241_C	246_E	0.756	0.31
186_K	362_A	0.756	0.31
240_V	288_A	0.753	0.31
353_G	356_R	0.752	0.31
155_I	174_M	0.752	0.31
228_K	233_E	0.751	0.31
250_F	255_K	0.748	0.31
189_G	199_Q	0.747	0.30
222_S	237_L	0.746	0.30
139_V	342_N	0.746	0.30
197_G	200_G	0.745	0.30
308_K	345_T	0.744	0.30
35_C	168_I	0.744	0.30
231_G	269_I	0.742	0.30
67_G	159_L	0.738	0.30
84_A	87_H	0.737	0.30
264_V	305_V	0.735	0.30
343_I	346_N	0.735	0.30
153_T	177_Q	0.735	0.30
180_I	184_I	0.735	0.30
72_D	300_R	0.732	0.30
295_F	299_I	0.731	0.30
348_K	367_Y	0.731	0.30
168_I	298_A	0.730	0.29
127_H	181_A	0.727	0.29
9_H	92_N	0.727	0.29
43_G	336_I	0.723	0.29
13_I	206_F	0.721	0.29
24_H	66_N	0.721	0.29
194_A	284_Y	0.720	0.29
367_Y	370_S	0.719	0.29
168_I	286_S	0.718	0.29
260_L	281_V	0.718	0.29
26_L	77_V	0.713	0.29
128_V	142_Q	0.712	0.28
7_M	10_I	0.711	0.28
178_K	253_E	0.709	0.28
44_W	51_G	0.707	0.28
310_H	320_D	0.707	0.28
89_C	200_G	0.703	0.28
184_I	344_L	0.703	0.28
127_H	150_N	0.703	0.28
130_S	280_T	0.701	0.28
52_E	56_D	0.701	0.28
50_F	299_I	0.700	0.28
97_C	141_G	0.700	0.28
185_Q	188_G	0.696	0.28
160_N	187_Q	0.696	0.28
48_E	51_G	0.694	0.27
333_F	339_I	0.694	0.27
194_A	299_I	0.694	0.27
138_L	311_W	0.693	0.27
45_E	71_H	0.691	0.27
24_H	233_E	0.688	0.27
147_E	225_I	0.685	0.27
159_L	354_L	0.685	0.27
44_W	75_A	0.680	0.27
135_M	160_N	0.678	0.27
223_Y	296_A	0.677	0.27
153_T	197_G	0.677	0.27
126_I	353_G	0.677	0.27
59_K	63_D	0.675	0.26
210_F	262_V	0.670	0.26
88_E	182_E	0.670	0.26
227_E	305_V	0.669	0.26
222_S	356_R	0.665	0.26
129_I	149_S	0.665	0.26
49_D	359_R	0.663	0.26
124_G	135_M	0.661	0.26
191_Y	283_Y	0.659	0.26
45_E	75_A	0.655	0.25
224_A	278_E	0.652	0.25
169_I	207_E	0.652	0.25
208_E	244_P	0.652	0.25
209_K	241_C	0.652	0.25
13_I	18_Q	0.652	0.25
176_C	193_F	0.651	0.25
58_L	61_Y	0.650	0.25
41_A	46_D	0.650	0.25
138_L	186_K	0.650	0.25
75_A	357_K	0.648	0.25
132_F	284_Y	0.648	0.25
184_I	304_H	0.646	0.25
234_E	300_R	0.646	0.25
94_M	97_C	0.643	0.25
153_T	158_L	0.643	0.25
192_L	252_F	0.643	0.25
54_H	364_D	0.642	0.25
46_D	50_F	0.642	0.25
363_M	368_L	0.642	0.25
24_H	83_P	0.641	0.25
192_L	286_S	0.640	0.25
105_V	298_A	0.639	0.25
57_F	347_D	0.638	0.25
74_I	301_N	0.638	0.25
177_Q	254_W	0.638	0.25
47_I	112_T	0.636	0.24
16_Y	183_K	0.634	0.24
111_K	302_H	0.631	0.24
38_I	365_R	0.628	0.24
6_L	327_G	0.628	0.24
58_L	292_A	0.628	0.24
111_K	115_H	0.627	0.24
44_W	93_W	0.626	0.24
192_L	290_L	0.625	0.24
38_I	181_A	0.624	0.24
192_L	288_A	0.621	0.24
54_H	363_M	0.620	0.24
144_K	149_S	0.620	0.24
39_S	205_A	0.619	0.24
78_V	167_K	0.619	0.24
150_N	184_I	0.619	0.24
361_A	367_Y	0.618	0.24
240_V	290_L	0.617	0.23
120_S	187_Q	0.617	0.23
35_C	274_K	0.616	0.23
153_T	175_G	0.614	0.23
56_D	104_D	0.614	0.23
178_K	251_T	0.614	0.23
178_K	199_Q	0.611	0.23
42_E	81_I	0.611	0.23
225_I	233_E	0.611	0.23
177_Q	183_K	0.611	0.23
142_Q	191_Y	0.610	0.23
45_E	356_R	0.609	0.23
212_L	216_N	0.609	0.23
109_D	172_D	0.609	0.23
42_E	353_G	0.608	0.23
90_F	232_R	0.606	0.23
255_K	291_T	0.606	0.23
328_N	332_L	0.606	0.23
170_T	192_L	0.604	0.23
114_R	318_N	0.603	0.23
66_N	304_H	0.602	0.23
201_R	299_I	0.599	0.23
259_K	288_A	0.598	0.23
206_F	254_W	0.598	0.23
81_I	161_M	0.597	0.22
149_S	180_I	0.597	0.22
66_N	285_I	0.597	0.22
162_L	342_N	0.596	0.22
159_L	183_K	0.595	0.22
252_F	255_K	0.595	0.22
325_R	330_A	0.594	0.22
94_M	342_N	0.593	0.22
301_N	333_F	0.593	0.22
148_K	177_Q	0.592	0.22
149_S	177_Q	0.591	0.22
235_I	268_S	0.591	0.22
75_A	79_S	0.591	0.22
31_L	57_F	0.590	0.22
10_I	195_V	0.590	0.22
166_G	287_S	0.590	0.22
43_G	117_Y	0.585	0.22
225_I	261_C	0.585	0.22
331_E	372_L	0.585	0.22
29_I	32_L	0.584	0.22
139_V	312_R	0.583	0.22
261_C	284_Y	0.583	0.22
138_L	257_L	0.582	0.22
151_E	172_D	0.581	0.22
152_I	174_M	0.581	0.22
28_D	67_G	0.579	0.22
200_G	206_F	0.578	0.22
9_H	43_G	0.577	0.22
18_Q	74_I	0.577	0.22
115_H	159_L	0.577	0.22
150_N	156_P	0.575	0.21
62_G	159_L	0.575	0.21
345_T	348_K	0.573	0.21
112_T	194_A	0.573	0.21
96_D	276_E	0.573	0.21
128_V	334_S	0.570	0.21
127_H	159_L	0.569	0.21
85_K	137_S	0.569	0.21
25_K	64_F	0.569	0.21
50_F	284_Y	0.567	0.21
302_H	310_H	0.566	0.21
115_H	125_A	0.565	0.21
172_D	196_K	0.565	0.21
84_A	145_T	0.564	0.21
7_M	11_S	0.562	0.21
172_D	306_E	0.561	0.21
314_D	319_E	0.558	0.21
184_I	287_S	0.557	0.21
19_T	50_F	0.556	0.21
87_H	238_H	0.554	0.20
140_I	287_S	0.554	0.20
306_E	310_H	0.553	0.20
284_Y	299_I	0.552	0.20
9_H	12_I	0.552	0.20
149_S	175_G	0.552	0.20
106_I	141_G	0.552	0.20
205_A	241_C	0.551	0.20
115_H	124_G	0.550	0.20
90_F	144_K	0.550	0.20
134_T	257_L	0.549	0.20
10_I	133_S	0.549	0.20
46_D	356_R	0.548	0.20
268_S	275_K	0.547	0.20
11_S	305_V	0.547	0.20
23_E	27_S	0.546	0.20
83_P	313_L	0.546	0.20
38_I	58_L	0.546	0.20
164_I	169_I	0.545	0.20
189_G	247_L	0.544	0.20
294_K	297_T	0.544	0.20
104_D	135_M	0.542	0.20
50_F	195_V	0.542	0.20
38_I	344_L	0.540	0.20
282_R	311_W	0.538	0.20
59_K	368_L	0.538	0.20
114_R	280_T	0.537	0.20
141_G	158_L	0.537	0.20
316_V	339_I	0.536	0.20
230_H	299_I	0.535	0.20
166_G	190_D	0.535	0.20
357_K	361_A	0.533	0.20
246_E	259_K	0.533	0.20
23_E	34_I	0.533	0.20
39_S	60_Q	0.533	0.20
88_E	293_E	0.532	0.20
83_P	332_L	0.531	0.19
129_I	301_N	0.531	0.19
106_I	347_D	0.531	0.19
238_H	301_N	0.529	0.19
9_H	89_C	0.529	0.19
211_P	241_C	0.529	0.19
332_L	344_L	0.528	0.19
266_F	277_P	0.527	0.19
96_D	288_A	0.525	0.19
145_T	205_A	0.524	0.19
226_S	235_I	0.524	0.19
165_K	328_N	0.523	0.19
152_I	183_K	0.522	0.19
105_V	116_S	0.521	0.19
24_H	96_D	0.521	0.19
33_T	41_A	0.521	0.19
236_R	302_H	0.519	0.19
83_P	311_W	0.519	0.19
38_I	362_A	0.518	0.19
160_N	182_E	0.517	0.19
195_V	288_A	0.516	0.19
229_S	266_F	0.514	0.19
6_L	11_S	0.513	0.19
237_L	281_V	0.513	0.19
203_N	329_A	0.512	0.19
238_H	299_I	0.511	0.19
236_R	257_L	0.511	0.19
324_I	337_R	0.510	0.19
225_I	296_A	0.509	0.19
362_A	368_L	0.509	0.19
24_H	325_R	0.509	0.19
330_A	341_I	0.508	0.18
265_S	307_N	0.508	0.18
201_R	240_V	0.507	0.18
88_E	92_N	0.505	0.18
26_L	234_E	0.505	0.18
54_H	68_I	0.504	0.18
6_L	31_L	0.504	0.18
324_I	329_A	0.503	0.18
348_K	353_G	0.502	0.18
224_A	235_I	0.501	0.18
164_I	263_A	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.873	98.1	0.932	Contact Map
2abkA	1	0.3571	30.9	0.975	Contact Map
1ornA	1	0.3598	19.8	0.977	Contact Map
3dfgA	1	0.119	18.1	0.978	Contact Map
2d74B	1	0.3307	16.2	0.978	Contact Map
3cw2K	1	0.336	14.6	0.979	Contact Map
4unfA	1	0.373	14.3	0.979	Contact Map
1neeA	1	0.336	11.7	0.98	Contact Map
1tq8A	4	0.336	11.1	0.98	Contact Map
4wfzA	1	0.1852	10.7	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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