GREMLIN Database
FENR - Ferredoxin--NADP reductase
UniProt: P28861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11518
Length: 248 (219)
Sequences: 19324 (13592)
Seq/√Len: 918.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_T136_N3.2261.00
10_T25_H2.9491.00
23_T62_D2.8201.00
12_V20_F2.7311.00
6_T87_E2.6111.00
152_L156_Q2.5981.00
127_L131_L2.5331.00
21_S64_E2.5321.00
138_V169_Q2.4961.00
6_T89_Q2.4591.00
11_K23_T2.4431.00
83_K86_D2.4121.00
23_T64_E2.4001.00
15_W21_S2.3831.00
113_A121_Y2.3131.00
138_V167_R2.2891.00
8_K25_H2.2341.00
14_N20_F2.2041.00
8_K87_E2.1751.00
38_K51_A2.1491.00
126_Q154_L2.1481.00
40_G89_Q2.0781.00
9_V82_L1.9941.00
13_Q21_S1.9711.00
110_W209_V1.9671.00
114_T214_N1.9561.00
7_G90_V1.9471.00
69_T80_A1.9191.00
55_V66_Y1.8081.00
149_L172_V1.7991.00
157_E161_R1.7831.00
118_I139_L1.7511.00
187_A190_E1.7381.00
136_N167_R1.7211.00
37_T65_F1.7131.00
209_V225_L1.7021.00
11_K84_P1.6601.00
146_A175_E1.6521.00
10_T62_D1.6281.00
113_A141_H1.6021.00
222_Q226_K1.5631.00
145_Y148_D1.5501.00
209_V231_M1.5141.00
108_T138_V1.5001.00
143_A149_L1.4951.00
17_D147_A1.4811.00
22_L79_L1.4681.00
25_H62_D1.4631.00
107_E208_H1.4621.00
190_E227_E1.4381.00
226_K233_K1.4201.00
37_T90_V1.4091.00
69_T77_P1.4081.00
24_V65_F1.4031.00
211_L221_T1.3871.00
108_T207_S1.3801.00
190_E193_E1.3741.00
142_A217_M1.3741.00
107_E206_T1.3661.00
7_G24_V1.3581.00
122_L154_L1.3471.00
187_A191_S1.3281.00
112_L221_T1.3271.00
112_L217_M1.3121.00
122_L126_Q1.2921.00
13_Q23_T1.2861.00
114_T217_M1.2821.00
38_K91_V1.2511.00
37_T54_Y1.2501.00
142_A173_S1.2411.00
122_L151_Y1.2271.00
146_A152_L1.2151.00
111_M121_Y1.2151.00
156_Q159_E1.2141.00
162_Y165_K1.2111.00
149_L170_T1.2061.00
66_Y151_Y1.1971.00
129_K161_R1.1971.00
224_L227_E1.1731.00
8_K27_P1.1661.00
143_A170_T1.1511.00
9_V24_V1.1501.00
77_P80_A1.1481.00
19_L116_T1.1471.00
178_A182_T1.1431.00
215_P219_R1.1391.00
12_V22_L1.1361.00
211_L218_V1.1301.00
27_P87_E1.1261.00
12_V84_P1.1261.00
128_G137_L1.1201.00
155_M168_I1.1121.00
66_Y150_S1.1121.00
208_H237_R1.1051.00
35_Q96_G1.1021.00
21_S151_Y1.1001.00
21_S66_Y1.0911.00
111_M137_L1.0881.00
121_Y139_L1.0881.00
154_L157_E1.0811.00
59_D130_D1.0791.00
40_G49_Q1.0691.00
73_G76_S1.0651.00
223_Q227_E1.0641.00
7_G26_A1.0641.00
18_A148_D1.0631.00
140_V169_Q1.0611.00
57_S126_Q1.0501.00
149_L152_L1.0451.00
110_W207_S1.0371.00
113_A139_L1.0371.00
159_E162_Y1.0331.00
82_L86_D1.0321.00
139_L166_L1.0271.00
216_Q220_D1.0151.00
156_Q170_T1.0131.00
129_K162_Y1.0101.00
232_T235_L1.0041.00
111_M124_I1.0031.00
6_T27_P1.0011.00
32_T99_V0.9921.00
220_D224_L0.9881.00
19_L150_S0.9871.00
9_V22_L0.9831.00
144_R173_S0.9791.00
41_L75_L0.9791.00
152_L168_I0.9741.00
33_A127_L0.9661.00
157_E160_K0.9661.00
146_A172_V0.9591.00
220_D223_Q0.9541.00
125_L137_L0.9501.00
116_T119_G0.9461.00
145_Y174_R0.9361.00
156_Q160_K0.9321.00
18_A68_V0.9311.00
12_V83_K0.9171.00
92_S95_A0.9161.00
39_L65_F0.9141.00
16_T148_D0.9051.00
175_E178_A0.9041.00
118_I155_M0.9001.00
78_R81_A0.8881.00
10_T23_T0.8811.00
144_R174_R0.8801.00
56_N126_Q0.8741.00
48_V74_K0.8611.00
208_H235_L0.8581.00
219_R223_Q0.8581.00
188_L191_S0.8571.00
125_L155_M0.8431.00
107_E135_K0.8401.00
143_A148_D0.8401.00
100_L124_I0.8391.00
17_D148_D0.8381.00
159_E163_E0.8331.00
211_L236_R0.8331.00
109_L137_L0.8311.00
60_N126_Q0.8171.00
141_H150_S0.8161.00
9_V12_V0.8121.00
100_L109_L0.8031.00
153_P157_E0.8031.00
140_V192_G0.8011.00
142_A189_I0.7981.00
224_L229_R0.7981.00
223_Q226_K0.7951.00
151_Y154_L0.7911.00
125_L158_L0.7861.00
112_L209_V0.7851.00
140_V171_V0.7831.00
107_E235_L0.7811.00
112_L140_V0.7801.00
142_A171_V0.7761.00
222_Q236_R0.7741.00
153_P156_Q0.7741.00
162_Y166_L0.7731.00
18_A71_P0.7721.00
55_V64_E0.7681.00
203_N207_S0.7651.00
40_G47_R0.7611.00
159_E166_L0.7591.00
42_E47_R0.7561.00
129_K158_L0.7561.00
109_L128_G0.7541.00
188_L192_G0.7511.00
48_V75_L0.7501.00
183_G188_L0.7501.00
79_L82_L0.7481.00
91_V95_A0.7471.00
154_L158_L0.7441.00
185_I188_L0.7421.00
145_Y175_E0.7421.00
31_F57_S0.7421.00
152_L170_T0.7421.00
184_R188_L0.7411.00
52_Y76_S0.7391.00
38_K49_Q0.7371.00
59_D127_L0.7371.00
185_I189_I0.7331.00
125_L139_L0.7291.00
35_Q99_V0.7281.00
31_F58_P0.7251.00
72_D77_P0.7251.00
118_I151_Y0.7231.00
143_A172_V0.7121.00
25_H61_P0.7101.00
67_L79_L0.7101.00
203_N206_T0.7101.00
221_T224_L0.7081.00
31_F56_N0.7071.00
57_S130_D0.7061.00
40_G91_V0.7041.00
56_N64_E0.7021.00
127_L130_D0.7011.00
109_L135_K0.6971.00
75_L79_L0.6951.00
106_C109_L0.6921.00
57_S60_N0.6921.00
211_L222_Q0.6901.00
111_M125_L0.6891.00
19_L66_Y0.6871.00
31_F54_Y0.6861.00
125_L166_L0.6821.00
204_K207_S0.6821.00
159_E168_I0.6811.00
7_G63_L0.6791.00
114_T216_Q0.6781.00
124_I210_M0.6741.00
189_I193_E0.6731.00
193_E233_K0.6701.00
32_T35_Q0.6651.00
231_M236_R0.6651.00
70_V73_G0.6621.00
183_G187_A0.6571.00
11_K21_S0.6561.00
186_P190_E0.6561.00
78_R82_L0.6551.00
66_Y119_G0.6521.00
178_A183_G0.6511.00
176_T183_G0.6501.00
26_A29_L0.6431.00
42_E46_E0.6421.00
7_G27_P0.6401.00
60_N130_D0.6381.00
98_F101_D0.6371.00
20_F69_T0.6331.00
53_S121_Y0.6321.00
159_E167_R0.6291.00
106_C134_F0.6271.00
190_E224_L0.6271.00
108_T135_K0.6261.00
109_L208_H0.6251.00
108_T206_T0.6251.00
111_M210_M0.6221.00
24_V88_V0.6211.00
49_Q91_V0.6211.00
74_K77_P0.6151.00
39_L79_L0.6141.00
216_Q219_R0.6111.00
101_D208_H0.6081.00
114_T220_D0.6051.00
43_I46_E0.6031.00
38_K95_A0.6031.00
206_T235_L0.6021.00
29_L92_S0.6011.00
102_E131_L0.6011.00
219_R222_Q0.6001.00
129_K137_L0.6001.00
110_W138_V0.5961.00
71_P77_P0.5941.00
172_V175_E0.5941.00
129_K166_L0.5921.00
14_N17_D0.5911.00
46_E74_K0.5881.00
54_Y63_L0.5871.00
76_S79_L0.5861.00
126_Q158_L0.5831.00
96_G99_V0.5821.00
146_A176_T0.5781.00
36_F51_A0.5771.00
33_A58_P0.5741.00
22_L67_L0.5731.00
211_L225_L0.5701.00
18_A69_T0.5691.00
63_L90_V0.5691.00
100_L128_G0.5631.00
37_T63_L0.5631.00
50_R75_L0.5611.00
58_P127_L0.5591.00
217_M220_D0.5581.00
136_N205_E0.5571.00
105_H135_K0.5571.00
9_V84_P0.5561.00
118_I141_H0.5541.00
31_F123_S0.5521.00
26_A63_L0.5501.00
217_M221_T0.5501.00
138_V207_S0.5491.00
122_L155_M0.5471.00
160_K163_E0.5471.00
18_A144_R0.5461.00
125_L128_G0.5431.00
173_S220_D0.5401.00
172_V176_T0.5391.00
183_G186_P0.5311.00
184_R187_A0.5291.00
56_N60_N0.5281.00
67_L76_S0.5241.00
32_T102_E0.5231.00
114_T142_A0.5201.00
105_H133_R0.5201.00
158_L162_Y0.5181.00
64_E154_L0.5171.00
156_Q168_I0.5161.00
201_P205_E0.5151.00
106_C208_H0.5141.00
163_E166_L0.5131.00
140_V189_I0.5121.00
42_E45_G0.5121.00
189_I198_I0.5101.00
24_V90_V0.5041.00
20_F80_A0.5031.00
136_N165_K0.5031.00
66_Y116_T0.5021.00
100_L105_H0.5021.00
109_L210_M0.5011.00
151_Y155_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fdrA 1 0.9798 100 0.22 Contact Map
1gvhA 3 0.9637 100 0.228 Contact Map
1cqxA 2 0.9516 100 0.244 Contact Map
3jqqA 2 0.9395 100 0.249 Contact Map
2bgiA 1 0.9718 100 0.249 Contact Map
1krhA 1 0.9234 100 0.253 Contact Map
4b4dA 2 0.9637 100 0.256 Contact Map
2qdxA 1 0.9798 100 0.259 Contact Map
4fk8A 1 0.9556 100 0.259 Contact Map
4p6vF 1 0.9435 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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