GREMLIN Database
YHCA - Uncharacterized fimbrial chaperone YhcA
UniProt: P28722 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11515
Length: 224 (209)
Sequences: 2865 (2161)
Seq/√Len: 149.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_R185_Y3.2041.00
56_I128_V3.0851.00
150_N155_E3.0221.00
157_S191_S2.9331.00
163_V187_L2.8751.00
97_S189_H2.8431.00
100_L185_Y2.8191.00
32_D35_R2.7761.00
187_L190_T2.7471.00
24_P126_L2.7201.00
93_V101_K2.6291.00
146_E157_S2.5571.00
147_W156_I2.5311.00
155_E193_T2.5041.00
155_E191_S2.4521.00
29_L38_A2.4441.00
129_L185_Y2.3861.00
140_E143_K2.3741.00
29_L87_F2.3441.00
153_Q193_T2.3421.00
50_S107_G2.3391.00
29_L103_V2.2971.00
210_S216_G2.2521.00
34_K133_A2.2491.00
156_I194_T2.1951.00
47_D80_G2.1691.00
129_L163_V2.0711.00
57_V125_D2.0351.00
49_P78_E2.0321.00
148_R155_E1.9111.00
55_T104_T1.8641.00
106_E123_R1.8331.00
94_P99_E1.8281.00
32_D38_A1.7941.00
49_P76_R1.7891.00
135_L162_Y1.7591.00
54_T85_V1.7571.00
58_D62_S1.7231.00
70_P85_V1.6691.00
145_L156_I1.6631.00
68_L87_F1.6621.00
141_T164_V1.6491.00
57_V104_T1.6401.00
24_P105_F1.6031.00
150_N153_Q1.5721.00
56_I66_I1.5591.00
78_E81_Q1.5431.00
100_L129_L1.5191.00
164_V208_P1.5031.00
144_F160_S1.5021.00
40_I103_V1.4881.00
33_E95_L1.4791.00
104_T125_D1.4771.00
141_T208_P1.4761.00
168_L207_Y1.4721.00
210_S214_Y1.4651.00
52_L75_I1.4251.00
145_L166_M1.4181.00
186_F192_T1.4061.00
94_P97_S1.3961.00
145_L164_V1.3601.00
148_R157_S1.3571.00
31_V38_A1.3331.00
68_L128_V1.2941.00
41_N82_V1.2731.00
37_E86_R1.2651.00
147_W206_F1.2581.00
89_L92_T1.2501.00
29_L126_L1.2431.00
165_R208_P1.2381.00
70_P87_F1.2301.00
59_L64_K1.2301.00
171_K205_E1.2191.00
89_L130_I1.2161.00
153_Q195_A1.1781.00
42_I77_V1.1741.00
173_L177_K1.1651.00
100_L165_R1.1591.00
174_P177_K1.1541.00
208_P216_G1.1521.00
46_D107_G1.1381.00
161_N189_H1.1280.99
167_T215_R1.1030.99
112_D117_R1.1020.99
58_D64_K1.0940.99
87_F128_V1.0920.99
22_M77_V1.0890.99
24_P40_I1.0840.99
57_V61_E1.0810.99
33_E133_A1.0760.99
85_V103_V1.0670.99
154_I196_L1.0610.99
142_W164_V1.0540.99
21_G107_G1.0380.99
166_M186_F1.0330.99
26_T40_I1.0320.99
55_T125_D1.0290.99
23_V26_T1.0280.99
103_V128_V1.0280.99
102_R125_D1.0240.99
75_I83_Q1.0220.99
33_E130_I1.0190.99
55_T106_E1.0060.99
107_G122_I1.0030.99
25_E41_N1.0020.99
31_V68_L0.9960.99
137_E162_Y0.9930.99
144_F159_P0.9880.99
112_D119_T0.9880.99
57_V102_R0.9830.99
140_E144_F0.9730.98
22_M52_L0.9720.98
142_W206_F0.9680.98
43_K82_V0.9440.98
56_I70_P0.9420.98
150_N193_T0.9400.98
31_V88_L0.9390.98
24_P42_I0.9260.98
85_V105_F0.9200.98
121_S147_W0.9190.98
207_Y215_R0.9010.98
127_P209_A0.8940.97
171_K175_S0.8940.97
70_P103_V0.8860.97
98_E131_H0.8750.97
54_T70_P0.8710.97
166_M208_P0.8700.97
137_E140_E0.8660.97
147_W170_F0.8580.97
157_S189_H0.8550.97
83_Q106_E0.8530.97
8_T11_I0.8530.97
59_L65_S0.8500.96
46_D50_S0.8440.96
42_I52_L0.8440.96
6_T9_V0.8340.96
102_R106_E0.8260.96
173_L178_T0.8240.96
25_E82_V0.8220.96
60_P63_N0.8190.96
154_I170_F0.8190.96
21_G45_T0.8170.96
96_Q189_H0.8140.95
28_V131_H0.8140.95
29_L40_I0.8080.95
146_E159_P0.8040.95
163_V188_P0.8030.95
100_L163_V0.7990.95
142_W208_P0.7950.95
75_I85_V0.7840.94
167_T209_A0.7830.94
77_V83_Q0.7830.94
104_T127_P0.7770.94
52_L77_V0.7700.94
56_I108_I0.7690.94
31_V89_L0.7690.94
10_F15_M0.7660.94
104_T123_R0.7590.93
59_L66_I0.7570.93
50_S106_E0.7470.93
54_T105_F0.7440.93
45_T110_P0.7440.93
21_G50_S0.7430.93
166_M214_Y0.7410.93
83_Q107_G0.7400.93
168_L171_K0.7400.93
95_L134_S0.7390.93
101_K130_I0.7370.92
26_T29_L0.7370.92
152_D198_N0.7360.92
138_E141_T0.7290.92
53_Y106_E0.7280.92
28_V127_P0.7280.92
77_V82_V0.7270.92
134_S137_E0.7230.92
171_K178_T0.7180.91
87_F103_V0.7150.91
105_F126_L0.7140.91
142_W159_P0.7110.91
23_V124_Q0.7100.91
116_S119_T0.7090.91
9_V12_T0.7060.91
127_P165_R0.7030.91
170_F194_T0.7020.90
142_W145_L0.6990.90
17_T198_N0.6970.90
50_S54_T0.6960.90
102_R127_P0.6950.90
23_V45_T0.6930.90
145_L208_P0.6870.90
41_N74_V0.6850.89
139_R143_K0.6810.89
22_M50_S0.6790.89
9_V16_N0.6790.89
127_P131_H0.6780.89
59_L63_N0.6750.89
153_Q196_L0.6750.89
147_W154_I0.6750.89
28_V132_P0.6730.89
15_M19_A0.6710.88
107_G121_S0.6690.88
142_W160_S0.6620.88
68_L99_E0.6570.87
149_K200_T0.6570.87
86_R109_P0.6530.87
99_E130_I0.6520.87
7_F10_F0.6490.87
54_T75_I0.6470.87
56_I101_K0.6430.86
58_D66_I0.6390.86
19_A154_I0.6390.86
30_L131_H0.6380.86
172_T204_V0.6360.86
96_Q131_H0.6340.85
74_V82_V0.6320.85
102_R105_F0.6300.85
35_R91_A0.6280.85
102_R165_R0.6280.85
154_I204_V0.6200.84
54_T83_Q0.6120.83
61_E125_D0.6110.83
171_K176_G0.6100.83
166_M206_F0.6080.83
186_F190_T0.6080.83
57_V116_S0.6040.83
49_P110_P0.6010.82
14_S18_L0.6000.82
97_S132_P0.5990.82
192_T195_A0.5980.82
51_L106_E0.5970.82
57_V120_V0.5960.82
68_L130_I0.5960.82
131_H211_R0.5910.81
88_L188_P0.5910.81
53_Y86_R0.5880.81
9_V15_M0.5880.81
96_Q99_E0.5870.81
39_S120_V0.5830.80
77_V81_Q0.5780.80
137_E141_T0.5750.79
60_P64_K0.5740.79
177_K181_I0.5730.79
138_E144_F0.5710.79
28_V211_R0.5700.79
199_A202_T0.5690.79
27_S131_H0.5680.79
109_P121_S0.5670.79
16_N19_A0.5670.79
118_V125_D0.5660.78
51_L162_Y0.5620.78
57_V106_E0.5610.78
209_A216_G0.5600.78
73_P108_I0.5590.78
95_L133_A0.5550.77
8_T19_A0.5530.77
30_L127_P0.5520.77
108_I122_I0.5510.77
149_K198_N0.5510.77
131_H188_P0.5500.76
173_L203_K0.5490.76
107_G206_F0.5480.76
20_T23_V0.5480.76
32_D129_L0.5470.76
55_T124_Q0.5470.76
184_T194_T0.5460.76
107_G123_R0.5440.76
93_V99_E0.5440.76
42_I110_P0.5440.76
6_T49_P0.5430.75
38_A126_L0.5430.75
14_S19_A0.5420.75
149_K152_D0.5420.75
93_V96_Q0.5390.75
182_N195_A0.5370.75
135_L161_N0.5360.75
24_P51_L0.5360.75
24_P45_T0.5350.74
80_G148_R0.5340.74
140_E146_E0.5290.74
40_I87_F0.5280.73
12_T201_D0.5280.73
64_K78_E0.5240.73
107_G165_R0.5220.73
171_K207_Y0.5180.72
195_A200_T0.5180.72
6_T16_N0.5180.72
133_A136_P0.5160.72
141_T147_W0.5150.72
73_P88_L0.5150.72
39_S49_P0.5150.72
171_K202_T0.5140.71
9_V14_S0.5140.71
82_V186_F0.5130.71
26_T106_E0.5130.71
147_W185_Y0.5130.71
156_I186_F0.5130.71
98_E211_R0.5100.71
7_F12_T0.5090.71
123_R147_W0.5080.71
132_P188_P0.5070.70
37_E67_R0.5070.70
121_S125_D0.5060.70
16_N198_N0.5060.70
122_I125_D0.5050.70
16_N209_A0.5050.70
14_S17_T0.5040.70
99_E135_L0.5030.70
152_D156_I0.5030.70
46_D106_E0.5020.70
10_F13_T0.5020.70
8_T203_K0.5020.70
125_D210_S0.5020.70
190_T199_A0.5010.70
10_F14_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2co7B 1 0.8661 100 0.115 Contact Map
1l4iA 2 0.8393 100 0.125 Contact Map
1klfA 1 0.8839 100 0.126 Contact Map
3q48A 1 0.8393 100 0.138 Contact Map
2xg5A 1 0.8929 100 0.144 Contact Map
3gfuC 1 0.875 100 0.156 Contact Map
4djmA 1 0.8839 100 0.159 Contact Map
4ay0A 2 0.8348 100 0.164 Contact Map
4ncdA 2 0.8482 100 0.222 Contact Map
2qsvA 1 0.8527 90.9 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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