GREMLIN Database
GLTF - Protein GltF
UniProt: P28721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11514
Length: 254 (206)
Sequences: 549 (452)
Seq/√Len: 31.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_R244_D5.8001.00
100_N246_N4.9091.00
140_Q236_G3.7071.00
97_S131_F3.6771.00
172_T179_T3.2761.00
216_I219_V3.1411.00
56_Y227_A2.9201.00
135_S141_K2.8871.00
94_A202_G2.5911.00
237_S241_I2.5911.00
64_L74_V2.5631.00
174_H179_T2.3390.99
96_T250_S2.2370.99
100_N248_T2.2080.99
56_Y243_L2.1950.99
94_A252_Q2.1450.98
172_T181_T2.1350.98
151_R222_P2.1170.98
98_K250_S2.1140.98
136_A140_Q2.1100.98
56_Y76_L2.1080.98
236_G239_E2.0020.97
63_A251_V1.9310.97
86_T218_A1.9050.97
182_W213_P1.8990.97
67_T233_T1.8900.96
65_N74_V1.8670.96
168_D209_G1.7880.95
132_G245_G1.7870.95
48_V52_G1.7720.95
145_A247_V1.7590.95
133_L227_A1.7130.94
147_I223_L1.7120.94
205_V216_I1.7000.94
229_V235_L1.6720.93
136_A236_G1.6580.93
216_I251_V1.6490.92
104_T135_S1.6460.92
65_N233_T1.6270.92
99_D131_F1.6260.92
54_V81_S1.6180.92
230_N234_I1.6030.91
32_E246_N1.6020.91
48_V249_I1.5870.91
101_R243_L1.5850.91
74_V232_N1.5790.91
92_L215_A1.5780.91
54_V83_L1.5500.90
49_T95_V1.5490.90
66_P232_N1.5470.90
80_N222_P1.5430.90
23_A84_N1.5370.90
131_F247_V1.5090.89
90_P217_T1.5030.88
236_G250_S1.4690.87
49_T82_T1.4480.86
56_Y79_K1.4380.86
215_A239_E1.4300.86
9_T12_I1.4140.85
14_A19_A1.3860.84
231_D234_I1.3190.81
167_V214_V1.3170.81
136_A239_E1.2970.80
48_V223_L1.2950.80
106_V144_A1.2900.79
206_A211_L1.2850.79
54_V76_L1.2610.78
83_L221_F1.2520.77
83_L223_L1.2360.76
65_N232_N1.2350.76
26_T36_I1.2220.75
93_I216_I1.2200.75
35_I39_Y1.2170.75
17_S21_F1.2020.74
134_G244_D1.1890.73
76_L227_A1.1860.73
28_S156_I1.1830.73
91_T160_D1.1580.71
168_D208_T1.1570.71
107_A144_A1.1470.71
18_V207_K1.1370.70
64_L229_V1.1290.69
33_L100_N1.1070.68
58_K240_T1.0950.67
27_D58_K1.0880.66
243_L249_I1.0830.66
16_L24_M1.0620.65
104_T132_G1.0570.64
170_I182_W1.0500.64
104_T139_G1.0430.63
168_D211_L1.0340.62
89_A218_A1.0260.62
31_T46_P1.0160.61
62_S173_D1.0110.61
93_I251_V1.0070.60
31_T240_T1.0060.60
152_S221_F1.0060.60
8_T11_A0.9980.60
229_V238_D0.9970.60
88_T217_T0.9740.58
160_D165_I0.9660.57
209_G223_L0.9660.57
13_C19_A0.9630.57
13_C131_F0.9610.57
37_G40_T0.9520.56
85_I238_D0.9480.56
150_D222_P0.9410.55
94_A213_P0.9370.55
170_I206_A0.9330.54
142_I237_S0.9280.54
44_C87_C0.9170.53
33_L99_D0.9120.53
56_Y226_D0.9100.53
150_D171_Q0.9080.52
170_I205_V0.9040.52
137_P142_I0.9020.52
16_L160_D0.9010.52
60_H63_A0.8970.52
95_V229_V0.8960.51
43_A182_W0.8960.51
45_T149_I0.8930.51
12_I19_A0.8880.51
153_N156_I0.8820.50
104_T202_G0.8820.50
17_S20_A0.8670.49
56_Y77_G0.8640.49
92_L251_V0.8520.48
95_V249_I0.8510.48
42_G49_T0.8460.47
101_R245_G0.8250.46
12_I218_A0.8230.46
49_T81_S0.8230.46
95_V180_P0.8190.45
247_V252_Q0.8080.44
85_I93_I0.8050.44
83_L249_I0.8050.44
9_T142_I0.8040.44
101_R132_G0.8020.44
136_A139_G0.8020.44
56_Y225_I0.7930.43
38_E212_T0.7890.43
207_K210_E0.7880.43
99_D143_G0.7870.43
45_T93_I0.7830.42
65_N68_G0.7820.42
8_T21_F0.7820.42
27_D31_T0.7810.42
174_H183_K0.7760.42
46_P64_L0.7640.41
78_R224_L0.7550.40
33_L54_V0.7510.40
102_Q156_I0.7470.40
14_A217_T0.7430.39
51_G134_G0.7430.39
21_F103_S0.7420.39
43_A213_P0.7390.39
221_F249_I0.7370.39
205_V214_V0.7320.38
23_A35_I0.7320.38
42_G91_T0.7280.38
208_T211_L0.7280.38
226_D233_T0.7180.37
91_T141_K0.7170.37
152_S156_I0.7140.37
64_L95_V0.7130.37
46_P50_G0.7120.37
174_H180_P0.7070.36
95_V219_V0.7070.36
101_R167_V0.7070.36
74_V229_V0.7040.36
167_V206_A0.7040.36
47_V83_L0.7010.36
13_C20_A0.7010.36
76_L243_L0.6990.36
23_A210_E0.6960.36
147_I241_I0.6950.36
95_V221_F0.6940.35
148_G190_F0.6930.35
8_T239_E0.6910.35
156_I216_I0.6890.35
48_V81_S0.6880.35
227_A243_L0.6840.35
61_N232_N0.6780.34
220_T239_E0.6740.34
204_S213_P0.6730.34
51_G170_I0.6710.34
33_L247_V0.6710.34
40_T242_K0.6660.33
17_S22_S0.6650.33
145_A245_G0.6640.33
33_L45_T0.6640.33
182_W253_Y0.6620.33
31_T65_N0.6600.33
131_F145_A0.6590.33
46_P54_V0.6560.33
201_R205_V0.6550.33
49_T83_L0.6540.33
41_P95_V0.6490.32
75_Q228_A0.6470.32
54_V227_A0.6440.32
52_G95_V0.6440.32
85_I215_A0.6420.32
146_S230_N0.6380.31
8_T220_T0.6380.31
63_A103_S0.6350.31
52_G132_G0.6330.31
107_A249_I0.6320.31
170_I213_P0.6320.31
48_V83_L0.6280.31
37_G232_N0.6280.31
94_A254_L0.6260.31
213_P253_Y0.6200.30
13_C32_E0.6190.30
79_K230_N0.6160.30
46_P51_G0.6160.30
43_A253_Y0.6160.30
88_T184_A0.6150.30
12_I20_A0.6120.30
43_A86_T0.6110.30
44_C143_G0.6110.30
87_C143_G0.6110.30
207_K214_V0.6100.30
127_T130_A0.6080.29
41_P230_N0.6080.29
138_N165_I0.6040.29
168_D210_E0.6040.29
74_V230_N0.6020.29
28_S212_T0.6020.29
21_F24_M0.6010.29
56_Y59_H0.6010.29
225_I244_D0.6000.29
18_V21_F0.5980.29
34_T246_N0.5980.29
205_V219_V0.5950.29
23_A190_F0.5890.28
47_V66_P0.5830.28
202_G205_V0.5800.28
241_I252_Q0.5790.27
82_T222_P0.5770.27
34_T83_L0.5750.27
97_S247_V0.5740.27
203_Y207_K0.5740.27
151_R185_S0.5710.27
91_T156_I0.5700.27
9_T17_S0.5700.27
96_T102_Q0.5690.27
95_V182_W0.5690.27
147_I225_I0.5690.27
134_G243_L0.5690.27
200_E204_S0.5670.27
59_H144_A0.5660.27
68_G224_L0.5650.27
227_A236_G0.5640.26
20_A204_S0.5640.26
84_N225_I0.5630.26
89_A237_S0.5630.26
226_D234_I0.5620.26
50_G251_V0.5610.26
106_V220_T0.5600.26
229_V232_N0.5590.26
15_A18_V0.5570.26
32_E100_N0.5570.26
66_P180_P0.5530.26
49_T74_V0.5510.26
51_G79_K0.5500.26
202_G250_S0.5500.26
84_N152_S0.5500.26
60_H180_P0.5490.26
181_T190_F0.5440.25
49_T64_L0.5430.25
50_G183_K0.5430.25
165_I169_L0.5420.25
13_C18_V0.5420.25
187_N190_F0.5410.25
13_C16_L0.5410.25
32_E35_I0.5400.25
55_D58_K0.5400.25
137_P236_G0.5400.25
48_V54_V0.5390.25
208_T238_D0.5390.25
103_S135_S0.5390.25
156_I170_I0.5380.25
99_D240_T0.5360.25
67_T232_N0.5360.25
168_D184_A0.5340.25
210_E225_I0.5330.25
41_P236_G0.5320.25
41_P133_L0.5270.24
69_K106_V0.5270.24
85_I185_S0.5240.24
127_T147_I0.5220.24
140_Q239_E0.5210.24
103_S166_P0.5190.24
230_N237_S0.5180.24
46_P254_L0.5170.24
61_N74_V0.5170.24
88_T231_D0.5150.24
133_L243_L0.5140.23
34_T234_I0.5140.23
21_F59_H0.5140.23
47_V148_G0.5100.23
20_A151_R0.5080.23
81_S142_I0.5070.23
36_I139_G0.5060.23
26_T37_G0.5060.23
47_V80_N0.5060.23
171_Q181_T0.5050.23
14_A54_V0.5030.23
81_S237_S0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xg5B 1 0.5354 97.5 0.871 Contact Map
2jtyA 1 0.6102 97.4 0.874 Contact Map
2jmrA 1 0.5984 97.1 0.879 Contact Map
2uy6B 2 0.5394 96.3 0.89 Contact Map
5afoA 1 0.7087 95.9 0.894 Contact Map
1pdkB 1 0.5512 95.7 0.896 Contact Map
2w07B 1 0.4449 95.2 0.899 Contact Map
4dwhB 1 0.5276 88.9 0.917 Contact Map
3bwuF 1 0.4921 82.5 0.924 Contact Map
1n12A 1 0.5 76.8 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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