GREMLIN Database
METQ - D-methionine-binding lipoprotein MetQ
UniProt: P28635 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11504
Length: 271 (258)
Sequences: 3625 (2485)
Seq/√Len: 154.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_K172_E3.6021.00
253_D257_E3.2591.00
34_K64_V3.1431.00
132_Q180_V3.1191.00
102_K235_E3.0621.00
134_A194_A3.0361.00
234_R237_N2.9661.00
36_G81_I2.9241.00
257_E261_K2.8291.00
89_K93_D2.7911.00
131_S195_Q2.6781.00
32_H60_D2.6221.00
52_V254_E2.6081.00
94_Q98_D2.4781.00
129_D176_N2.4771.00
132_Q178_K2.4321.00
119_K192_D2.4251.00
121_I128_Q2.3471.00
106_V243_V2.3331.00
57_Y245_K2.3061.00
107_G247_V2.2711.00
32_H62_E2.1941.00
237_N240_A2.0801.00
54_K60_D2.0621.00
122_K126_E2.0611.00
48_V255_V2.0491.00
136_P145_S2.0401.00
135_V142_L2.0401.00
128_Q131_S2.0341.00
167_V181_E2.0331.00
34_K62_E2.0291.00
96_L101_Y2.0261.00
104_V235_E2.0201.00
95_Q101_Y2.0091.00
133_V198_L2.0061.00
77_S102_K1.9671.00
57_Y248_Q1.9661.00
147_L150_Q1.9551.00
212_T215_K1.8561.00
103_L232_V1.8171.00
257_E260_N1.8101.00
133_V177_L1.7731.00
83_A233_T1.7581.00
116_G198_L1.7461.00
152_V219_F1.6961.00
211_L216_D1.6601.00
151_K222_D1.6491.00
154_L177_L1.6371.00
127_L198_L1.6231.00
79_G234_R1.6121.00
241_E245_K1.5751.00
47_E50_Q1.5681.00
108_N228_V1.5461.00
74_E78_K1.5321.00
253_D256_Y1.5301.00
235_E238_K1.5221.00
212_T216_D1.5011.00
83_A246_F1.4931.00
59_L245_K1.4901.00
89_K105_A1.4801.00
44_Q262_V1.4471.00
244_K248_Q1.4411.00
135_V179_I1.4121.00
115_A217_G1.4121.00
156_K171_V1.4111.00
158_K171_V1.3951.00
31_N242_N1.3931.00
52_V56_K1.3891.00
170_V179_I1.3551.00
115_A220_V1.3541.00
247_V251_Q1.3431.00
127_L131_S1.3181.00
74_E95_Q1.3181.00
70_V91_Y1.3051.00
258_A262_V1.3011.00
48_V51_K1.3011.00
48_V52_V1.3011.00
129_D175_K1.2981.00
161_V165_P1.2851.00
158_K169_D1.2801.00
239_D244_K1.2771.00
104_V238_K1.2741.00
52_V255_V1.2721.00
50_Q54_K1.2711.00
134_A190_S1.2641.00
231_I247_V1.2591.00
240_A243_V1.2581.00
77_S101_Y1.2321.00
89_K230_L1.2221.00
51_K54_K1.2001.00
33_I242_N1.1971.00
49_A52_V1.1921.00
124_L219_F1.1901.00
138_D141_N1.1771.00
123_S126_E1.1741.00
47_E63_L1.1701.00
121_I195_Q1.1681.00
43_Q65_T1.1631.00
44_Q263_F1.1591.00
36_G76_L1.1531.00
59_L242_N1.1531.00
74_E99_R1.1511.00
76_L81_I1.1251.00
96_L235_E1.1241.00
121_I131_S1.1231.00
16_G19_A1.1181.00
106_V247_V1.1131.00
105_A230_L1.1131.00
194_A199_A1.1121.00
48_V258_A1.0950.99
157_L171_V1.0880.99
96_L102_K1.0840.99
116_G200_V1.0810.99
233_T237_N1.0670.99
52_V249_A1.0650.99
37_V46_A1.0650.99
33_I59_L1.0590.99
233_T236_D1.0470.99
42_E110_F1.0430.99
79_G236_D1.0330.99
89_K108_N1.0320.99
187_L199_A1.0240.99
143_G165_P1.0210.99
150_Q156_K1.0170.99
96_L103_L1.0020.99
85_A109_T1.0020.99
93_D97_K1.0000.99
73_N87_Q0.9990.99
124_L127_L0.9990.99
182_L190_S0.9960.99
71_L74_E0.9940.99
36_G66_F0.9830.99
76_L234_R0.9830.99
15_I18_L0.9790.99
83_A243_V0.9750.99
48_V254_E0.9690.99
37_V43_Q0.9670.99
245_K248_Q0.9600.99
23_C26_D0.9540.98
57_Y249_A0.9500.98
34_K82_D0.9450.98
19_A22_G0.9430.98
198_L218_I0.9390.98
35_V46_A0.9350.98
92_L96_L0.9330.98
173_N177_L0.9310.98
106_V233_T0.9290.98
107_G231_I0.9250.98
84_N87_Q0.9230.98
20_L23_C0.9230.98
142_L167_V0.9160.98
96_L104_V0.9140.98
92_L232_V0.9140.98
69_Y184_A0.9120.98
158_K161_V0.9100.98
116_G124_L0.9080.98
30_P60_D0.9030.98
66_F75_A0.9020.98
94_Q97_K0.9010.98
44_Q47_E0.9010.98
92_L230_L0.8960.98
182_L187_L0.8940.98
114_I200_V0.8940.98
33_I246_F0.8810.97
150_Q154_L0.8800.97
14_L17_S0.8770.97
53_A249_A0.8710.97
85_A250_Y0.8660.97
68_D71_L0.8640.97
85_A110_F0.8640.97
107_G251_Q0.8630.97
228_V270_G0.8570.97
105_A108_N0.8500.97
42_E112_Y0.8470.97
50_Q60_D0.8390.97
206_A211_L0.8380.97
95_Q99_R0.8380.97
121_I198_L0.8370.96
15_I19_A0.8350.96
245_K249_A0.8320.96
94_Q140_T0.8310.96
236_D240_A0.8310.96
212_T264_N0.8240.96
112_Y204_T0.8200.96
118_S121_I0.8180.96
74_E77_S0.8170.96
31_N59_L0.8130.96
188_P209_I0.8100.96
30_P242_N0.7920.95
73_N86_F0.7870.95
213_P216_D0.7860.95
213_P217_G0.7850.95
217_G220_V0.7800.95
109_T250_Y0.7800.95
48_V249_A0.7780.95
95_Q103_L0.7770.95
202_N229_N0.7750.95
42_E85_A0.7740.95
53_A59_L0.7740.95
120_K195_Q0.7730.95
46_A85_A0.7730.95
186_Q190_S0.7640.94
66_F81_I0.7620.94
52_V252_S0.7600.94
34_K76_L0.7600.94
256_Y260_N0.7600.94
127_L154_L0.7580.94
23_C27_E0.7560.94
76_L237_N0.7550.94
189_R192_D0.7550.94
167_V179_I0.7520.94
73_N84_N0.7480.94
109_T247_V0.7470.93
134_A187_L0.7470.93
13_A17_S0.7440.93
142_L181_E0.7430.93
138_D184_A0.7360.93
52_V57_Y0.7340.93
105_A247_V0.7330.93
184_A202_N0.7310.93
191_L199_A0.7300.93
213_P220_V0.7290.93
9_A19_A0.7290.93
212_T217_G0.7290.93
162_G165_P0.7270.93
69_Y72_P0.7260.93
190_S193_D0.7220.92
46_A61_V0.7170.92
49_A249_A0.7160.92
43_Q47_E0.7150.92
143_G147_L0.7150.92
13_A19_A0.7110.92
21_V24_G0.7110.92
86_F91_Y0.7100.92
130_G176_N0.7070.92
109_T251_Q0.7070.92
14_L19_A0.7060.91
85_A112_Y0.6980.91
159_D162_G0.6960.91
23_C29_D0.6930.91
50_Q53_A0.6930.91
166_T169_D0.6910.91
74_E101_Y0.6870.90
69_Y76_L0.6810.90
47_E51_K0.6780.90
105_A232_V0.6760.90
14_L18_L0.6740.89
145_S200_V0.6710.89
171_V174_P0.6690.89
127_L133_V0.6690.89
12_G16_G0.6680.89
167_V171_V0.6680.89
173_N176_N0.6670.89
186_Q189_R0.6660.89
88_H140_T0.6660.89
12_G15_I0.6660.89
155_I179_I0.6650.89
64_V76_L0.6620.89
134_A182_L0.6580.88
148_L152_V0.6560.88
42_E46_A0.6540.88
90_P226_P0.6530.88
260_N269_K0.6520.88
104_V233_T0.6500.88
122_K216_D0.6500.88
222_D225_S0.6490.88
17_S21_V0.6450.87
185_P205_Y0.6440.87
203_T266_G0.6430.87
112_Y267_A0.6420.87
147_L151_K0.6410.87
69_Y202_N0.6400.87
253_D260_N0.6390.87
9_A21_V0.6390.87
231_I250_Y0.6380.87
106_V232_V0.6380.87
204_T208_Q0.6350.87
39_V65_T0.6350.87
40_G44_Q0.6280.86
23_C28_K0.6280.86
191_L211_L0.6270.86
191_L194_A0.6260.86
154_L198_L0.6260.86
116_G219_F0.6230.85
49_A53_A0.6180.85
233_T240_A0.6120.84
53_A61_V0.6100.84
46_A250_Y0.6080.84
50_Q63_L0.6080.84
69_Y229_N0.6070.84
261_K264_N0.6050.84
72_P76_L0.6050.84
88_H138_D0.6050.84
88_H92_L0.6050.84
150_Q162_G0.6010.83
258_A261_K0.5990.83
121_I127_L0.5980.83
36_G75_A0.5950.83
11_V14_L0.5920.82
136_P184_A0.5920.82
141_N145_S0.5910.82
118_S126_E0.5910.82
146_L155_I0.5870.82
56_K248_Q0.5850.82
147_L165_P0.5850.82
177_L198_L0.5820.81
124_L218_I0.5810.81
91_Y95_Q0.5780.81
188_P205_Y0.5750.81
184_A188_P0.5720.80
148_L221_E0.5710.80
31_N60_D0.5700.80
88_H230_L0.5690.80
136_P200_V0.5660.80
121_I124_L0.5660.80
125_D152_V0.5650.79
153_G156_K0.5640.79
69_Y138_D0.5630.79
137_N183_E0.5600.79
240_A244_K0.5590.79
114_I203_T0.5590.79
151_K224_E0.5580.79
20_L24_G0.5570.79
233_T238_K0.5560.78
116_G127_L0.5520.78
138_D145_S0.5510.78
127_L195_Q0.5500.78
163_L167_V0.5500.78
40_G263_F0.5490.78
88_H141_N0.5490.78
180_V194_A0.5490.78
92_L103_L0.5450.77
113_P202_N0.5390.76
40_G250_Y0.5360.76
77_S95_Q0.5350.76
122_K156_K0.5340.76
142_L184_A0.5320.75
150_Q159_D0.5320.75
112_Y229_N0.5310.75
9_A15_I0.5310.75
122_K158_K0.5300.75
258_A263_F0.5280.75
167_V178_K0.5280.75
122_K125_D0.5270.75
219_F222_D0.5270.75
150_Q160_G0.5260.74
33_I61_V0.5250.74
68_D72_P0.5250.74
51_K254_E0.5240.74
9_A14_L0.5230.74
93_D96_L0.5230.74
38_I42_E0.5220.74
84_N91_Y0.5220.74
248_Q251_Q0.5210.74
256_Y269_K0.5210.74
237_N243_V0.5210.74
31_N245_K0.5210.74
188_P201_I0.5200.74
61_V246_F0.5200.74
173_N179_I0.5160.73
112_Y203_T0.5160.73
146_L157_L0.5150.73
131_S173_N0.5150.73
111_V226_P0.5140.73
191_L201_I0.5140.73
47_E65_T0.5130.73
127_L177_L0.5130.73
143_G163_L0.5130.73
45_V258_A0.5110.72
140_T145_S0.5110.72
46_A63_L0.5110.72
37_V61_V0.5100.72
136_P141_N0.5100.72
114_I202_N0.5070.72
149_L200_V0.5070.72
85_A231_I0.5060.72
95_Q100_G0.5060.72
109_T112_Y0.5050.72
97_K164_L0.5040.71
183_E188_P0.5030.71
76_L103_L0.5030.71
33_I83_A0.5020.71
35_V62_E0.5020.71
233_T243_V0.5020.71
70_V74_E0.5020.71
92_L234_R0.5000.71
106_V238_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qhqA 1 0.8782 100 0.4 Contact Map
3ir1A 3 0.8745 100 0.463 Contact Map
4ntlA 1 0.8819 100 0.479 Contact Map
3up9A 1 0.8708 100 0.482 Contact Map
4oteA 4 0.8856 100 0.485 Contact Map
3gxaA 3 0.8745 100 0.505 Contact Map
1xs5A 1 0.8819 100 0.505 Contact Map
4k3fA 1 0.8856 100 0.508 Contact Map
3tqwA 1 0.8672 100 0.509 Contact Map
4q5tA 1 0.8967 100 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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