GREMLIN Database
TSAA - Probable tRNA (adenine(37)-N6)-methyltransferase
UniProt: P28634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11503
Length: 235 (222)
Sequences: 939 (638)
Seq/√Len: 42.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_V127_V4.7201.00
86_M91_T4.6321.00
31_S189_E4.5351.00
74_T85_R4.3471.00
51_L110_V3.8901.00
59_I132_V3.4601.00
36_L121_L3.1721.00
51_L57_L3.1701.00
17_K128_D3.0061.00
49_R74_T2.9741.00
104_L145_L2.9581.00
108_K122_G2.8961.00
107_L119_L2.7671.00
62_V133_V2.7461.00
13_R37_H2.7301.00
106_E122_G2.6771.00
60_L100_I2.6601.00
140_P150_A2.6601.00
13_R128_D2.6511.00
14_S34_G2.5341.00
6_F99_P2.5321.00
170_E184_T2.4561.00
111_V120_K2.4551.00
109_E120_K2.3731.00
100_I133_V2.2181.00
34_G124_L2.0980.99
104_L143_E2.0760.99
33_N108_K2.0230.99
35_E118_I1.9590.99
14_S124_L1.9590.99
11_V39_I1.9510.99
6_F62_V1.8890.99
13_R35_E1.8540.99
210_A217_N1.8140.98
59_I126_L1.8050.98
191_L229_V1.7660.98
35_E120_K1.7540.98
18_E217_N1.7420.98
210_A219_R1.7080.97
36_L59_I1.6650.97
107_L110_V1.6380.97
59_I105_V1.6360.97
6_F100_I1.6350.97
191_L227_F1.6260.97
200_R205_T1.6090.96
29_V189_E1.5940.96
37_H118_I1.5890.96
60_L133_V1.5380.95
54_F151_S1.5330.95
62_V99_P1.5220.95
51_L119_L1.5200.95
166_T169_V1.4590.94
65_Q127_V1.4330.93
200_R207_K1.4280.93
48_V117_V1.4240.93
161_M227_F1.4110.93
60_L102_M1.3900.92
31_S185_L1.3820.92
6_F133_V1.3600.91
57_L105_V1.3540.91
18_E212_W1.3290.90
66_T99_P1.3140.90
221_R228_E1.3080.89
165_F188_R1.2930.89
219_R231_A1.2920.89
54_F152_Y1.2840.89
28_L193_Q1.2570.87
83_N197_P1.2540.87
8_Q11_V1.2400.87
22_V64_H1.2400.87
202_G207_K1.2360.87
12_I34_G1.2340.86
33_N120_K1.2320.86
208_T230_F1.2270.86
48_V107_L1.2220.86
221_R230_F1.2010.85
105_V121_L1.1930.85
10_G38_L1.1910.84
164_S228_E1.1880.84
167_A170_E1.1420.82
184_T188_R1.1380.82
88_V93_S1.1370.82
19_K195_P1.1230.81
17_K215_D1.1030.80
67_M99_P1.0530.76
64_H127_V1.0430.76
37_H116_S1.0370.75
38_L135_I1.0280.75
12_I132_V1.0250.74
20_F197_P1.0250.74
26_P142_A0.9940.72
46_D74_T0.9920.72
14_S126_L0.9880.72
57_L182_Q0.9870.71
208_T221_R0.9860.71
64_H186_F0.9850.71
30_K189_E0.9790.71
38_L48_V0.9720.70
186_F213_L0.9690.70
46_D85_R0.9670.70
190_V213_L0.9640.70
95_F209_Y0.9520.69
83_N95_F0.9460.68
32_A186_F0.9370.67
113_H116_S0.9350.67
79_R157_P0.9350.67
187_I218_V0.9290.67
66_T139_L0.9100.65
38_L71_W0.9050.65
55_S149_S0.9010.64
104_L141_F0.9000.64
44_Q48_V0.8930.64
164_S226_G0.8920.64
48_V51_L0.8910.63
71_W99_P0.8870.63
183_L187_I0.8810.63
212_W217_N0.8790.62
36_L57_L0.8780.62
33_N182_Q0.8720.62
56_H145_L0.8630.61
29_V36_L0.8590.61
16_Y32_A0.8560.60
162_A226_G0.8490.60
218_V232_L0.8470.60
24_R79_R0.8450.59
12_I73_P0.8420.59
121_L124_L0.8390.59
75_V79_R0.8350.58
195_P199_Y0.8340.58
32_A123_S0.8310.58
99_P133_V0.8290.58
153_A157_P0.8230.57
75_V91_T0.8190.57
200_R209_Y0.8190.57
33_N133_V0.8170.57
121_L222_V0.8130.56
27_G103_S0.8120.56
18_E127_V0.8090.56
31_S186_F0.8080.56
126_L209_Y0.7990.55
170_E174_L0.7910.54
171_K225_A0.7910.54
95_F216_F0.7810.53
156_A159_A0.7770.53
7_E41_P0.7720.53
15_P84_A0.7690.52
223_T226_G0.7600.51
49_R73_P0.7580.51
108_K120_K0.7580.51
127_V211_V0.7560.51
167_A171_K0.7560.51
61_F213_L0.7530.51
94_T142_A0.7470.50
57_L107_L0.7460.50
81_G193_Q0.7450.50
94_T102_M0.7450.50
9_I53_A0.7420.50
157_P198_A0.7310.49
170_E188_R0.7250.48
5_Q114_K0.7240.48
211_V217_N0.7230.48
17_K127_V0.7220.48
228_E232_L0.7200.48
139_L225_A0.7200.48
106_E146_P0.7190.47
93_S152_Y0.7170.47
188_R192_A0.7140.47
53_A86_M0.7130.47
121_L132_V0.7120.47
83_N209_Y0.7110.47
172_Q231_A0.7100.47
220_W227_F0.7090.47
76_R83_N0.7080.46
222_V227_F0.7040.46
51_L107_L0.7030.46
165_F173_L0.7020.46
19_K199_Y0.7010.46
32_A213_L0.6980.46
185_L188_R0.6970.45
139_L198_A0.6930.45
164_S167_A0.6900.45
24_R28_L0.6900.45
150_A211_V0.6860.44
7_E98_N0.6830.44
30_K185_L0.6770.44
15_P214_H0.6740.43
173_L216_F0.6740.43
189_E192_A0.6720.43
45_A117_V0.6690.43
200_R214_H0.6660.43
61_F98_N0.6650.42
79_R198_A0.6640.42
20_F81_G0.6610.42
167_A173_L0.6600.42
132_V180_Y0.6590.42
110_V119_L0.6560.42
102_M218_V0.6520.41
18_E210_A0.6510.41
141_F153_A0.6510.41
14_S128_D0.6510.41
104_L142_A0.6490.41
95_F200_R0.6410.40
56_H104_L0.6410.40
9_I66_T0.6370.40
20_F105_V0.6360.40
134_D143_E0.6350.40
14_S65_Q0.6340.40
157_P209_Y0.6340.40
183_L186_F0.6330.39
8_Q133_V0.6310.39
48_V119_L0.6270.39
177_E180_Y0.6260.39
21_A217_N0.6260.39
48_V110_V0.6240.39
15_P93_S0.6230.39
6_F167_A0.6230.39
56_H149_S0.6220.38
49_R85_R0.6210.38
29_V32_A0.6210.38
136_K143_E0.6070.37
163_V231_A0.6060.37
189_E218_V0.6060.37
15_P32_A0.6060.37
207_K220_W0.6050.37
214_H220_W0.6050.37
12_I121_L0.6030.37
81_G220_W0.6030.37
224_D227_F0.6020.37
54_F142_A0.6020.37
67_M71_W0.6010.37
43_N48_V0.6000.37
36_L132_V0.5990.36
35_E113_H0.5980.36
165_F169_V0.5970.36
111_V114_K0.5960.36
171_K229_V0.5950.36
12_I36_L0.5930.36
139_L143_E0.5910.36
67_M70_G0.5890.36
15_P34_G0.5890.36
149_S168_E0.5880.35
161_M222_V0.5880.35
207_K210_A0.5880.35
10_G132_V0.5870.35
27_G132_V0.5870.35
144_S175_T0.5810.35
164_S170_E0.5800.35
54_F150_A0.5760.34
30_K108_K0.5760.34
84_A201_K0.5750.34
5_Q158_A0.5740.34
150_A153_A0.5730.34
47_A89_F0.5720.34
61_F187_I0.5710.34
24_R193_Q0.5690.34
34_G121_L0.5690.34
102_M124_L0.5670.34
168_E189_E0.5660.34
68_E99_P0.5660.34
185_L192_A0.5650.34
199_Y220_W0.5650.34
9_I12_I0.5640.33
153_A156_A0.5620.33
20_F195_P0.5590.33
34_G98_N0.5580.33
76_R194_D0.5580.33
17_K216_F0.5570.33
38_L119_L0.5560.33
50_G86_M0.5540.33
22_V66_T0.5520.32
83_N199_Y0.5510.32
33_N122_G0.5510.32
111_V118_I0.5500.32
54_F118_I0.5490.32
223_T228_E0.5480.32
209_Y222_V0.5480.32
139_L150_A0.5470.32
116_S227_F0.5460.32
211_V232_L0.5460.32
61_F220_W0.5440.32
29_V152_Y0.5440.32
164_S223_T0.5430.32
39_I224_D0.5430.32
219_R230_F0.5420.32
29_V54_F0.5410.32
147_D167_A0.5400.31
201_K205_T0.5380.31
155_S162_A0.5370.31
8_Q60_L0.5370.31
186_F220_W0.5360.31
16_Y186_F0.5360.31
45_A114_K0.5340.31
59_I75_V0.5330.31
81_G199_Y0.5330.31
104_L140_P0.5320.31
16_Y22_V0.5320.31
76_R82_G0.5320.31
61_F95_F0.5300.31
172_Q218_V0.5290.31
126_L220_W0.5290.31
85_R201_K0.5280.30
85_R99_P0.5240.30
15_P183_L0.5230.30
24_R207_K0.5230.30
32_A42_Y0.5230.30
9_I104_L0.5230.30
6_F93_S0.5220.30
104_L144_S0.5210.30
27_G124_L0.5190.30
11_V57_L0.5190.30
9_I232_L0.5190.30
20_F76_R0.5180.30
24_R55_S0.5170.30
76_R197_P0.5150.29
202_G220_W0.5150.29
67_M94_T0.5150.29
106_E149_S0.5150.29
37_H139_L0.5150.29
67_M91_T0.5140.29
205_T209_Y0.5130.29
127_V201_K0.5120.29
175_T179_R0.5100.29
39_I119_L0.5100.29
34_G73_P0.5090.29
20_F90_A0.5080.29
46_D49_R0.5060.29
217_N225_A0.5030.28
36_L64_H0.5020.28
45_A189_E0.5010.28
75_V191_L0.5010.28
34_G177_E0.5010.28
57_L135_I0.5010.28
85_R229_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xqbA 2 0.7915 100 0.158 Contact Map
2nv4A 2 0.566 100 0.43 Contact Map
3okxA 2 0.6213 100 0.458 Contact Map
3bpqB 1 0.3021 96.2 0.932 Contact Map
4ml2A 1 0.3234 95.8 0.934 Contact Map
4lttA 1 0.3234 95.7 0.934 Contact Map
3g5oB 1 0.3277 95.7 0.934 Contact Map
4nrnA 2 0.3234 95.4 0.936 Contact Map
2a6sA 1 0.3149 95.1 0.937 Contact Map
1wmiA 2 0.3234 94.7 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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