GREMLIN Database
ADIA - Biodegradative arginine decarboxylase
UniProt: P28629 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11501
Length: 755 (700)
Sequences: 649 (277)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
678_E688_R7.5201.00
671_A676_N7.0571.00
604_H609_T6.2211.00
223_S398_H5.9041.00
242_M267_A5.8851.00
513_H516_E5.5441.00
159_A191_G5.4381.00
394_A430_S5.0261.00
608_N633_D4.9181.00
143_F432_D4.7811.00
181_Y188_T4.7251.00
89_F130_A4.3790.99
215_A220_A4.3770.99
159_A193_E4.3450.99
365_A380_A4.1630.99
562_W600_S4.1310.99
660_V709_N3.8950.99
610_P613_Q3.8140.99
76_I88_V3.7660.98
230_T381_T3.7290.98
608_N630_G3.6390.98
454_A582_F3.5340.98
236_T419_A3.5250.97
536_V582_F2.9260.93
237_I379_F2.8760.92
630_G633_D2.8320.91
197_L411_F2.8310.91
672_I701_I2.7990.91
244_D670_N2.7170.90
681_S684_N2.7130.89
158_A417_M2.6860.89
177_Y430_S2.6670.89
625_T637_T2.6460.88
677_V691_A2.6210.88
474_W606_D2.5930.87
191_G572_R2.5730.87
167_G438_M2.5390.86
224_W408_F2.4490.84
260_Q418_H2.4080.83
379_F411_F2.4030.83
554_V605_Y2.4020.83
206_A242_M2.3930.82
159_A192_I2.3840.82
202_D737_E2.3670.82
213_Y216_R2.3660.82
683_E722_R2.3660.82
213_Y217_V2.3510.81
576_F639_F2.3400.81
127_A295_L2.3240.80
120_A124_A2.3080.80
210_S225_S2.2940.79
566_H600_S2.2730.79
207_F428_C2.2550.78
227_V427_I2.2260.77
225_S431_N2.2110.77
457_F582_F2.2040.77
475_F606_D2.1780.76
214_A225_S2.1670.75
395_S697_Y2.1460.75
649_A653_E2.1280.74
217_V439_D2.1210.74
163_Q191_G2.1120.73
185_L426_A2.1100.73
193_E571_T2.0520.71
235_R260_Q2.0330.70
236_T595_V2.0270.70
247_V313_P1.9900.69
113_A127_A1.9550.67
259_E705_L1.9410.67
511_V527_N1.9150.65
157_W284_P1.9100.65
183_E187_R1.9070.65
420_T737_E1.9010.65
516_E551_E1.8940.65
143_F147_M1.8770.64
206_A554_V1.8430.62
158_A191_G1.8410.62
216_R439_D1.8300.62
233_S701_I1.8260.62
430_S719_S1.8260.62
646_N649_A1.8060.61
297_K301_E1.7850.60
201_L228_V1.7690.59
392_S423_P1.7650.59
257_S696_P1.7400.58
502_L506_V1.7360.58
262_L344_L1.7280.57
332_E335_D1.7280.57
197_L437_M1.7270.57
237_I267_A1.7230.57
248_V262_L1.7210.57
74_Q689_I1.7180.57
175_R179_D1.7160.57
611_L625_T1.7110.56
230_T235_R1.6990.56
140_P353_Y1.6970.56
149_Y159_A1.6810.55
185_L391_L1.6770.55
125_G153_H1.6710.55
197_L207_F1.6690.54
27_A30_Q1.6680.54
181_Y216_R1.6650.54
180_Y184_N1.6620.54
161_G395_S1.6550.54
476_F598_L1.6540.54
159_A321_C1.6480.53
251_D322_T1.6450.53
167_G389_N1.6350.53
213_Y439_D1.6150.52
420_T571_T1.6120.52
457_F536_V1.6110.52
228_V232_G1.6100.52
390_A396_Y1.6090.52
285_I318_V1.6070.52
457_F585_G1.5910.51
562_W566_H1.5700.50
228_V393_Q1.5680.50
186_F261_G1.5530.49
83_Q167_G1.5480.49
247_V299_I1.5450.49
159_A163_Q1.5410.48
663_V671_A1.5380.48
397_I634_L1.5360.48
181_Y382_H1.5330.48
434_A580_F1.5310.48
76_I411_F1.5250.48
321_C739_E1.5130.47
158_A190_M1.4940.46
619_V623_P1.4900.46
284_P348_E1.4890.46
208_G212_K1.4890.46
662_E709_N1.4780.46
158_A163_Q1.4780.46
348_E351_Y1.4750.45
180_Y188_T1.4720.45
644_E730_H1.4700.45
330_A669_Y1.4620.45
244_D666_R1.4590.45
415_Y617_E1.4590.45
357_N447_T1.4560.44
26_D30_Q1.4510.44
510_W520_G1.4490.44
461_M598_L1.4470.44
562_W604_H1.4450.44
177_Y181_Y1.4370.44
163_Q193_E1.4270.43
514_P526_D1.4190.43
329_N527_N1.4180.43
382_H564_G1.4100.42
236_T248_V1.4020.42
159_A572_R1.4010.42
537_S577_Q1.3980.42
216_R566_H1.3900.41
719_S722_R1.3880.41
146_L429_A1.3860.41
214_A223_S1.3860.41
153_H243_T1.3830.41
558_L635_G1.3730.41
23_R36_I1.3610.40
194_R572_R1.3540.40
260_Q417_M1.3510.40
167_G454_A1.3480.40
111_E122_F1.3470.40
167_G536_V1.3470.40
181_Y379_F1.3380.39
392_S590_K1.3370.39
149_Y290_M1.3370.39
250_V302_S1.3310.39
573_T605_Y1.3220.38
159_A194_R1.3160.38
173_A220_A1.3120.38
148_K683_E1.3090.38
231_S260_Q1.3090.38
395_S696_P1.3010.37
142_L318_V1.2920.37
188_T673_V1.2910.37
544_G550_E1.2870.37
612_A628_N1.2820.37
331_K362_D1.2790.37
233_S598_L1.2720.36
277_N542_G1.2700.36
387_L534_I1.2700.36
161_G697_Y1.2690.36
568_I719_S1.2690.36
201_L226_V1.2640.36
542_G626_Y1.2570.36
250_V259_E1.2560.36
391_L424_L1.2530.35
236_T397_I1.2490.35
184_N295_L1.2430.35
271_Y416_M1.2310.34
337_L531_L1.2300.34
281_I479_W1.2300.34
235_R418_H1.2280.34
453_E591_W1.2280.34
265_T685_L1.2280.34
227_V261_G1.2270.34
264_L295_L1.2250.34
159_A326_V1.2220.34
635_G639_F1.2190.34
234_N697_Y1.2170.34
89_F318_V1.2150.34
279_Y589_G1.2150.34
286_Y531_L1.2150.34
186_F449_E1.2130.34
231_S423_P1.2070.33
620_E746_G1.2070.33
149_Y201_L1.2050.33
573_T705_L1.2050.33
680_V718_V1.2030.33
590_K659_P1.1950.33
363_H507_Q1.1900.33
343_R377_T1.1890.33
233_S516_E1.1850.33
235_R259_E1.1840.32
241_C379_F1.1810.32
237_I248_V1.1790.32
30_Q77_G1.1780.32
633_D719_S1.1760.32
181_Y410_R1.1760.32
159_A199_S1.1680.32
34_T63_M1.1680.32
56_C89_F1.1670.32
166_V411_F1.1660.32
295_L299_I1.1590.31
686_P712_D1.1540.31
298_K301_E1.1510.31
72_V568_I1.1480.31
230_T263_M1.1480.31
340_T377_T1.1470.31
589_G598_L1.1450.31
320_N390_A1.1440.31
111_E654_A1.1420.31
568_I689_I1.1420.31
191_G195_T1.1420.31
455_V504_T1.1420.31
440_G523_D1.1400.31
396_Y431_N1.1380.31
73_R92_G1.1380.31
185_L554_V1.1350.31
320_N396_Y1.1350.31
101_M516_E1.1350.31
366_M394_A1.1320.30
241_C406_I1.1300.30
669_Y673_V1.1270.30
476_F537_S1.1270.30
191_G579_M1.1220.30
171_T413_Q1.1180.30
709_N713_K1.1170.30
102_D105_L1.1170.30
232_G379_F1.1170.30
641_W703_M1.1140.30
711_G717_Q1.1130.30
158_A193_E1.1090.29
188_T264_L1.1090.29
190_M528_W1.1090.29
50_S54_I1.1070.29
267_A723_S1.1030.29
327_C641_W1.1030.29
191_G194_R1.1020.29
80_H108_L1.1010.29
499_P502_L1.0980.29
88_V233_S1.0980.29
149_Y230_T1.0850.29
452_D667_E1.0850.29
192_I272_M1.0830.28
485_T508_D1.0830.28
393_Q556_A1.0820.28
286_Y705_L1.0810.28
423_P443_G1.0800.28
235_R290_M1.0790.28
250_V537_S1.0750.28
287_P525_P1.0720.28
314_S583_S1.0710.28
142_L210_S1.0660.28
21_V682_I1.0640.28
313_P454_A1.0620.28
338_E376_P1.0610.28
222_R408_F1.0600.28
391_L564_G1.0580.28
272_M290_M1.0570.28
454_A588_R1.0560.27
289_E298_K1.0560.27
143_F727_W1.0520.27
588_R592_G1.0500.27
199_S320_N1.0480.27
210_S431_N1.0460.27
30_Q73_R1.0450.27
712_D719_S1.0430.27
161_G282_I1.0420.27
201_L421_T1.0410.27
171_T228_V1.0370.27
185_L424_L1.0350.27
270_V704_L1.0330.27
636_D640_A1.0270.26
81_E86_V1.0270.26
160_P535_K1.0230.26
397_I411_F1.0200.26
89_F691_A1.0200.26
211_E241_C1.0190.26
559_V578_I1.0190.26
170_K605_Y1.0190.26
232_G672_I1.0170.26
188_T315_Y1.0130.26
513_H526_D1.0120.26
214_A266_G1.0080.26
191_G396_Y1.0080.26
228_V413_Q1.0080.26
414_A696_P1.0070.26
257_S697_Y1.0060.26
641_W645_N1.0040.26
149_Y415_Y1.0030.26
151_D513_H1.0020.25
234_N257_S0.9980.25
348_E363_H0.9970.25
398_H556_A0.9970.25
111_E225_S0.9970.25
544_G631_I0.9970.25
677_V713_K0.9940.25
348_E354_A0.9940.25
219_G348_E0.9850.25
145_A388_L0.9810.25
147_M562_W0.9790.25
348_E530_M0.9790.25
381_T393_Q0.9790.25
119_T122_F0.9780.25
217_V233_S0.9780.25
260_Q702_P0.9770.25
236_T680_V0.9730.24
98_L604_H0.9710.24
158_A327_C0.9690.24
326_V479_W0.9690.24
370_P455_V0.9690.24
78_K86_V0.9680.24
193_E528_W0.9660.24
711_G719_S0.9630.24
231_S417_M0.9620.24
288_Q294_T0.9620.24
257_S414_A0.9610.24
281_I373_H0.9600.24
199_S390_A0.9580.24
300_S644_E0.9570.24
218_F388_L0.9570.24
561_A574_T0.9540.24
660_V719_S0.9540.24
567_G604_H0.9540.24
292_P296_Q0.9540.24
145_A658_L0.9510.24
434_A680_V0.9510.24
231_S418_H0.9490.24
210_S233_S0.9490.24
197_L361_A0.9490.24
358_P532_D0.9490.24
300_S308_K0.9480.24
243_T674_D0.9470.24
382_H398_H0.9460.24
186_F570_P0.9460.24
579_M706_S0.9450.24
499_P503_L0.9430.23
384_T396_Y0.9420.23
342_D401_E0.9400.23
219_G355_R0.9400.23
200_L733_G0.9370.23
475_F577_Q0.9350.23
238_M406_I0.9350.23
159_A739_E0.9320.23
272_M615_M0.9310.23
208_G598_L0.9290.23
313_P479_W0.9280.23
306_K638_M0.9270.23
551_E730_H0.9220.23
551_E643_K0.9220.23
607_A687_G0.9190.23
519_H542_G0.9160.23
186_F571_T0.9150.23
218_F675_N0.9130.22
576_F580_F0.9120.22
157_W701_I0.9100.22
175_R641_W0.9090.22
281_I597_T0.9090.22
378_V682_I0.9090.22
247_V286_Y0.9080.22
329_N414_A0.9070.22
329_N677_V0.9070.22
291_Q336_L0.9060.22
358_P576_F0.9060.22
248_V374_N0.9060.22
295_L719_S0.9040.22
464_L725_Q0.9020.22
290_M391_L0.9000.22
192_I705_L0.8980.22
212_K270_V0.8970.22
449_E452_D0.8970.22
71_N675_N0.8960.22
88_V672_I0.8960.22
453_E582_F0.8940.22
275_S650_R0.8930.22
308_K641_W0.8930.22
101_M147_M0.8910.22
202_D319_T0.8910.22
235_R702_P0.8900.22
478_P570_P0.8890.22
534_I702_P0.8870.22
329_N507_Q0.8860.22
585_G605_Y0.8850.22
629_M637_T0.8840.22
581_L590_K0.8830.21
77_G108_L0.8810.21
200_L571_T0.8790.21
253_N390_A0.8790.21
127_A738_T0.8790.21
234_N696_P0.8780.21
108_L644_E0.8780.21
510_W718_V0.8760.21
321_C413_Q0.8760.21
132_T548_E0.8750.21
501_K680_V0.8740.21
156_S691_A0.8730.21
125_G158_A0.8730.21
44_G47_I0.8720.21
338_E352_G0.8700.21
425_Y518_W0.8690.21
537_S709_N0.8680.21
301_E411_F0.8670.21
30_Q36_I0.8660.21
607_A719_S0.8650.21
443_G446_L0.8650.21
451_I534_I0.8640.21
23_R89_F0.8630.21
420_T572_R0.8630.21
193_E572_R0.8620.21
223_S427_I0.8620.21
142_L214_A0.8620.21
262_L330_A0.8620.21
260_Q285_I0.8600.21
157_W348_E0.8590.21
475_F670_N0.8590.21
63_M75_L0.8570.21
141_P443_G0.8560.21
180_Y696_P0.8560.21
431_N574_T0.8560.21
396_Y480_N0.8550.21
474_W602_K0.8510.20
724_L728_D0.8510.20
634_L734_F0.8490.20
390_A434_A0.8470.20
268_K701_I0.8460.20
537_S639_F0.8460.20
291_Q689_I0.8460.20
254_C319_T0.8450.20
22_E26_D0.8440.20
79_L113_A0.8430.20
340_T376_P0.8430.20
451_I530_M0.8390.20
154_E391_L0.8390.20
210_S572_R0.8390.20
150_S416_M0.8370.20
620_E653_E0.8360.20
243_T685_L0.8330.20
522_K527_N0.8330.20
50_S53_A0.8320.20
35_V538_I0.8320.20
396_Y478_P0.8320.20
54_I75_L0.8310.20
93_D105_L0.8310.20
359_I530_M0.8310.20
413_Q420_T0.8300.20
122_F177_Y0.8300.20
411_F589_G0.8300.20
142_L230_T0.8290.20
21_V59_F0.8280.20
297_K300_S0.8280.20
104_D136_Q0.8280.20
326_V648_G0.8280.20
231_S392_S0.8270.20
158_A168_F0.8270.20
261_G570_P0.8250.20
326_V577_Q0.8250.20
186_F357_N0.8220.20
190_M238_M0.8220.20
340_T343_R0.8200.20
246_D314_S0.8190.20
416_M425_Y0.8190.20
215_A734_F0.8190.20
185_L378_V0.8170.19
216_R662_E0.8160.19
394_A427_I0.8150.19
596_N599_C0.8150.19
181_Y186_F0.8140.19
239_Q264_L0.8130.19
196_S258_I0.8110.19
217_V435_V0.8080.19
352_G566_H0.8070.19
232_G420_T0.8050.19
574_T639_F0.8050.19
287_P527_N0.8030.19
92_G101_M0.8030.19
177_Y326_V0.8020.19
702_P723_S0.8020.19
557_A718_V0.8010.19
487_P502_L0.8010.19
263_M415_Y0.8010.19
191_G320_N0.8000.19
93_D113_A0.8000.19
107_E151_D0.7990.19
250_V254_C0.7980.19
76_I379_F0.7980.19
319_T702_P0.7980.19
476_F510_W0.7980.19
293_E297_K0.7970.19
409_S742_E0.7970.19
457_F531_L0.7970.19
317_V737_E0.7970.19
432_D547_G0.7950.19
501_K667_E0.7950.19
443_G532_D0.7940.19
421_T443_G0.7930.19
50_S337_L0.7920.19
579_M733_G0.7920.19
704_L721_L0.7920.19
709_N738_T0.7900.19
397_I668_A0.7900.19
531_L648_G0.7890.19
388_L585_G0.7880.19
158_A570_P0.7830.18
138_L173_A0.7830.18
241_C655_Y0.7830.18
551_E620_E0.7830.18
743_I746_G0.7820.18
282_I395_S0.7810.18
393_Q572_R0.7800.18
228_V572_R0.7790.18
237_I598_L0.7790.18
738_T743_I0.7770.18
316_C655_Y0.7760.18
211_E605_Y0.7760.18
44_G54_I0.7760.18
184_N230_T0.7760.18
192_I195_T0.7760.18
382_H558_L0.7750.18
256_K476_F0.7740.18
571_T739_E0.7730.18
374_N607_A0.7690.18
314_S343_R0.7660.18
181_Y599_C0.7650.18
611_L619_V0.7640.18
326_V391_L0.7620.18
326_V529_S0.7610.18
569_V694_V0.7590.18
34_T38_S0.7590.18
155_Y411_F0.7580.18
461_M599_C0.7580.18
149_Y163_Q0.7560.18
180_Y429_A0.7560.18
297_K621_Q0.7540.18
482_E691_A0.7530.18
450_V737_E0.7530.18
206_A738_T0.7530.18
185_L449_E0.7510.18
334_Q378_V0.7480.18
53_A62_Q0.7480.18
459_Q500_T0.7480.18
124_A460_A0.7470.17
352_G396_Y0.7470.17
44_G50_S0.7470.17
319_T354_A0.7470.17
230_T697_Y0.7460.17
38_S221_D0.7450.17
143_F225_S0.7450.17
438_M474_W0.7440.17
572_R739_E0.7430.17
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258_I407_N0.5620.13
303_P308_K0.5620.13
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19_N23_R0.5560.13
230_T736_H0.5560.13
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540_A571_T0.5550.13
702_P731_F0.5550.13
227_V536_V0.5550.13
75_L85_N0.5550.13
290_M351_Y0.5540.13
547_G550_E0.5540.13
508_D511_V0.5540.13
398_H659_P0.5530.13
158_A186_F0.5520.13
310_G374_N0.5520.13
139_L316_C0.5520.13
196_S544_G0.5520.13
38_S60_S0.5510.13
38_S49_S0.5510.13
233_S435_V0.5510.13
432_D443_G0.5500.13
149_Y154_E0.5500.13
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305_T308_K0.5500.13
46_A59_F0.5490.13
107_E603_R0.5480.13
188_T257_S0.5480.13
294_T559_V0.5470.13
519_H665_P0.5470.13
201_L235_R0.5460.13
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265_T666_R0.5460.13
701_I725_Q0.5450.13
653_E656_S0.5450.13
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24_L27_A0.5440.13
233_S658_L0.5430.13
400_R459_Q0.5410.13
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351_Y354_A0.5350.12
412_N720_Y0.5350.12
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227_V650_R0.5340.12
284_P530_M0.5340.12
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170_K513_H0.5330.12
301_E686_P0.5330.12
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536_V586_V0.5330.12
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251_D345_H0.5310.12
438_M602_K0.5310.12
520_G555_P0.5300.12
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572_R579_M0.5240.12
91_L499_P0.5230.12
223_S352_G0.5220.12
394_A414_A0.5220.12
360_Y457_F0.5210.12
463_R628_N0.5200.12
370_P526_D0.5200.12
288_Q559_V0.5200.12
538_I599_C0.5200.12
209_E258_I0.5190.12
476_F585_G0.5190.12
348_E380_A0.5180.12
334_Q367_R0.5180.12
526_D712_D0.5180.12
93_D649_A0.5180.12
194_R413_Q0.5180.12
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313_P577_Q0.5170.12
427_I479_W0.5170.12
430_S522_K0.5170.12
511_V531_L0.5170.12
225_S435_V0.5170.12
200_L420_T0.5170.12
299_I624_D0.5150.12
100_A108_L0.5140.12
573_T647_P0.5130.12
664_T684_N0.5130.12
35_V610_P0.5130.12
235_R419_A0.5130.12
162_H519_H0.5120.12
352_G675_N0.5120.12
454_A479_W0.5120.12
453_E476_F0.5120.12
101_M452_D0.5100.12
190_M398_H0.5100.12
480_N727_W0.5100.12
162_H189_D0.5100.12
142_L571_T0.5100.12
191_G705_L0.5090.12
218_F688_R0.5090.12
23_R103_R0.5090.12
448_Q452_D0.5090.12
340_T742_E0.5080.12
671_A689_I0.5080.12
112_F120_A0.5080.12
576_F693_S0.5070.12
86_V620_E0.5060.12
194_R739_E0.5060.12
665_P687_G0.5060.12
444_L680_V0.5060.12
233_S631_I0.5050.12
247_V295_L0.5050.12
117_E411_F0.5050.12
572_R577_Q0.5050.12
186_F679_L0.5050.12
391_L590_K0.5040.12
234_N668_A0.5040.12
156_S582_F0.5030.12
476_F702_P0.5020.12
257_S395_S0.5020.12
538_I649_A0.5020.12
225_S572_R0.5010.12
336_L345_H0.5010.12
171_T207_F0.5000.12
381_T568_I0.5000.12
177_Y687_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vycA 5 1 100 0.499 Contact Map
1c4kA 2 0.9311 100 0.559 Contact Map
3n75A 4 0.9391 100 0.561 Contact Map
2x3lA 2 0.5563 100 0.753 Contact Map
4q6rA 2 0.5391 100 0.889 Contact Map
3mc6A 2 0.5166 100 0.898 Contact Map
4w8iA 2 0.4636 99.9 0.924 Contact Map
1js3A 2 0.5417 99.8 0.937 Contact Map
3bc8A 3 0.5536 99.8 0.939 Contact Map
3k40A 2 0.5285 99.7 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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